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Volumn 8, Issue 3, 2011, Pages 190-199

Neuroprotective efficacy of the peroxisome proliferator-activated receptor-γ Ligand in chronic cerebral hypoperfusion

Author keywords

Chronic cerebral hypoperfusion; S100; Spatial learning; Synaptophysin

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN S100B; ROSIGLITAZONE; ROSVEL; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

EID: 80051496173     PISSN: 15672026     EISSN: 18755739     Source Type: Journal    
DOI: 10.2174/156720211796558087     Document Type: Article
Times cited : (17)

References (57)
  • 1
    • 34247507589 scopus 로고    scopus 로고
    • PPAR-: Therapeutic target for ischemic stroke
    • DOI 10.1016/j.tips.2007.03.004, PII S0165614707000727
    • Culman J, Zhao Y, Gohlke P, Herdegen T. PPAR-.: Therapeutic target for ischemic stroke. Trends Pharmacol Sci 2007; 28: 244-249. (Pubitemid 46661003)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.5 , pp. 244-249
    • Culman, J.1    Zhao, Y.2    Gohlke, P.3    Herdegen, T.4
  • 3
    • 33645323521 scopus 로고    scopus 로고
    • Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    • Luo Y, Yin W, Signore AP, et al. Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. J Neurochem 2006; 97: 435-448.
    • (2006) J Neurochem , vol.97 , pp. 435-448
    • Luo, Y.1    Yin, W.2    Signore, A.P.3
  • 4
    • 33745983234 scopus 로고    scopus 로고
    • Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats
    • DOI 10.1096/fj.05-5007com
    • Zhao Y, Patzer A, Herdegen T, Gohlke P, Culman J. Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. FASEB J 2006; 20: 1162-1175. (Pubitemid 44943912)
    • (2006) FASEB Journal , vol.20 , Issue.8 , pp. 1162-1175
    • Zhao, Y.1    Patzer, A.2    Herdegen, T.3    Gohlke, P.4    Culman, J.5
  • 5
    • 33947204503 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents
    • DOI 10.1111/j.1471-4159.2006.04376.x
    • Tureyen K, Kapadia R, Bowen KK, et al. Peroxisome proliferatoractivated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J Neurochem 2007; 101: 41-56. (Pubitemid 46426485)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.1 , pp. 41-56
    • Tureyen, K.1    Kapadia, R.2    Bowen, K.K.3    Satriotomo, I.4    Liang, J.5    Feinstein, D.L.6    Vemuganti, R.7
  • 6
    • 78650510608 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor γ, and effects of its agonist, rosiglitazone, on transient cerebral ischemic damage
    • Lee CH, Park OK, Yoo KY, et al. The role of peroxisome proliferator-activated receptor γ, and effects of its agonist, rosiglitazone, on transient cerebral ischemic damage. J Neurol Sci 2011; 300: 120-129.
    • J Neurol Sci , vol.2011 , Issue.300 , pp. 120-129
    • Lee, C.H.1    Park, O.K.2    Yoo, K.Y.3
  • 7
    • 33847093475 scopus 로고    scopus 로고
    • Thiazolidinedione class of peroxisome proliferator-activated receptor γ agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats
    • DOI 10.1124/jpet.106.113472
    • Park SW, Yi JH, Miranpuri G, et al. Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats. J Pharmacol Exp Ther 2007; 320: 1002-1012. (Pubitemid 46294061)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.3 , pp. 1002-1012
    • Park, S.-W.1    Yi, J.-H.2    Miranpuri, G.3    Satriotomo, I.4    Bowen, K.5    Resnick, D.K.6    Vemuganti, R.7
  • 8
    • 56049113451 scopus 로고    scopus 로고
    • PPARgamma agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms
    • Yi JH, Park SW, Brooks N, Lang BT, Vemuganti R. PPARgamma agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms. Brain Res 2008; 1244: 164-172.
    • (2008) Brain Res , vol.1244 , pp. 164-172
    • Yi, J.H.1    Park, S.W.2    Brooks, N.3    Lang, B.T.4    Vemuganti, R.5
  • 9
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-γ agonist pioglitazone in a mouse model of Parkinson's disease
    • DOI 10.1046/j.1471-4159.2002.00990.x
    • Breidert T, Callebert J, Heneka MT, Landreth G, Launay JM, Hirsch EC. Protective action of the peroxisome proliferatoractivated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. J Neurochem 2002; 82: 615-624. (Pubitemid 34831499)
    • (2002) Journal of Neurochemistry , vol.82 , Issue.3 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 10
    • 23944490153 scopus 로고    scopus 로고
    • The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice
    • DOI 10.1523/JNEUROSCI.2038-05.2005
    • Schütz B, Reimann J, Dumitrescu-Ozimek L, et al. The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. J Neurosci 2005; 25: 7805-7812. (Pubitemid 41208652)
    • (2005) Journal of Neuroscience , vol.25 , Issue.34 , pp. 7805-7812
    • Schutz, B.1    Reimann, J.2    Dumitrescu-Ozimek, L.3    Kappes-Horn, K.4    Landreth, G.E.5    Schurmann, B.6    Zimmer, A.7    Heneka, M.T.8
  • 11
  • 12
    • 78149407291 scopus 로고    scopus 로고
    • Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral glucoregulatory status
    • Rodriguez-Rivera J, Denner L, Dineley KT. Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral glucoregulatory status. Behav Brain Res 2011; 216: 255-261.
    • Behav Brain Res , vol.2011 , Issue.216 , pp. 255-261
    • Rodriguez-Rivera, J.1    Denner, L.2    Dineley, K.T.3
  • 13
    • 10044289268 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ ligands reduce inflammation and infarction size in transient focal ischemia
    • DOI 10.1016/j.neuroscience.2004.10.021, PII S0306452204009571
    • Sundararajan S, Gamboa JL, Victor NA, Wanderi EW, Lust WD, Landreth GE. Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. Neuroscience 2005; 130: 685-696. (Pubitemid 39601441)
    • (2005) Neuroscience , vol.130 , Issue.3 , pp. 685-696
    • Sundararajan, S.1    Gamboa, J.L.2    Victor, N.A.3    Wanderi, E.W.4    Lust, W.D.5    Landreth, G.E.6
  • 14
    • 33644864102 scopus 로고    scopus 로고
    • PPAR-γ agonists as regulators of microglial activation and brain inflammation
    • Berbardo A, Minghetti L. PPAR-γ agonists as regulators of microglial activation and brain inflammation. Curr Pharm Res 2006; 12: 93-109.
    • (2006) Curr Pharm Res , vol.12 , pp. 93-109
    • Berbardo, A.1    Minghetti, L.2
  • 15
    • 70349671387 scopus 로고    scopus 로고
    • Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats
    • Wang CX, Ding X, Noor R, et al. Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats. J Cereb Blood Flow Metab 2009; 29: 1683-1694.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1683-1694
    • Wang, C.X.1    Ding, X.2    Noor, R.3
  • 16
    • 12844281747 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor-γ agonist reduces infarct size in transient but not in permanent ischemia
    • DOI 10.1161/01.STR.0000152271.21943.a2
    • Shimazu T, Inoue I, Araki N, et al. A peroxisome proliferatoractivated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke 2005; 36: 353-359. (Pubitemid 40170822)
    • (2005) Stroke , vol.36 , Issue.2 , pp. 353-359
    • Shimazu, T.1    Inoue, I.2    Araki, N.3    Asano, Y.4    Sawada, M.5    Furuya, D.6    Nagoya, H.7    Greenberg, J.H.8
  • 19
    • 44649087641 scopus 로고    scopus 로고
    • Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents
    • Hyong A, Jadhav V, Lee S, et al. Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. Brain Res 2008; 1215: 218-224.
    • (2008) Brain Res , vol.1215 , pp. 218-224
    • Hyong, A.1    Jadhav, V.2    Lee, S.3
  • 20
    • 33744987670 scopus 로고    scopus 로고
    • Amelioration of age-related inflammation and oxidative stress by PPARγ activator: Suppression of NF-κB by 2,4-thiazolidinedione
    • DOI 10.1016/j.exger.2006.04.005, PII S0531556506001033
    • Sung B, Park S, Yu BP, Chung HY. Amelioration of age-related inflammation and oxidative stress by PPAR-γ activator: Suppression of NF-κB by 2,4-thiazolidinedione. Exp Gerontol 2006; 41: 590-599. (Pubitemid 43867228)
    • (2006) Experimental Gerontology , vol.41 , Issue.6 , pp. 590-599
    • Sung, B.1    Park, S.2    Yu, B.P.3    Chung, H.Y.4
  • 21
    • 0026625139 scopus 로고
    • Chronic cerebrovascular insufficiency induced dementia-like deficits in aged rats
    • De La Torre JC, Fortin T, Park GA, et al. Chronic cerebrovascular insufficiency induced dementia-like deficits in aged rats. Brain Res 1992; 582: 186-195.
    • (1992) Brain Res , vol.582 , pp. 186-195
    • De La Torre, J.C.1    Fortin, T.2    Park, G.A.3
  • 22
    • 33947646259 scopus 로고    scopus 로고
    • Permanent, bilateral common carotid artery occlusion in the rat: A model for chronic cerebral hypoperfusion-related neurodegenerative diseases
    • DOI 10.1016/j.brainresrev.2007.01.003, PII S0165017307000021
    • Farkas E, Luiten PG, Bari F. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev 2007; 54: 162-180. (Pubitemid 46498166)
    • (2007) Brain Research Reviews , vol.54 , Issue.1 , pp. 162-180
    • Farkas, E.1    Luiten, P.G.M.2    Bari, F.3
  • 23
    • 33646795324 scopus 로고    scopus 로고
    • Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats
    • DOI 10.1016/j.brainres.2006.02.115, PII S0006899306005178
    • Liu J, Jin DZ, Xiao L, Zhu XZ. Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats. Brain Res 2006; 1089: 162-170. (Pubitemid 43766365)
    • (2006) Brain Research , vol.1089 , Issue.1 , pp. 162-170
    • Liu, J.1    Jin, D.-Z.2    Xiao, L.3    Zhu, X.-Z.4
  • 24
    • 33746148924 scopus 로고    scopus 로고
    • Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats
    • Guang HM, Du GH. Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats. Eur J Pharmacol 2006; 542: 77-83.
    • (2006) Eur J Pharmacol , vol.542 , pp. 77-83
    • Guang, H.M.1    Du, G.H.2
  • 25
    • 58149389909 scopus 로고    scopus 로고
    • Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat
    • Vicente E, Degerone D, Bohn L, et al. Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat. Brain Res 2009; 1251: 204-212.
    • (2009) Brain Res , vol.1251 , pp. 204-212
    • Vicente, E.1    Degerone, D.2    Bohn, L.3
  • 26
    • 27744472653 scopus 로고    scopus 로고
    • Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment
    • DOI 10.1016/j.molbrainres.2005.05.014
    • Liu HX, Zhang JJ, Zheng P, Zhang Y. Altered expression of MAP- 2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment. Brain Res Mol Brain Res 2005; 139: 169-177. (Pubitemid 41583599)
    • (2005) Molecular Brain Research , vol.139 , Issue.1 , pp. 169-177
    • Liu, H.-X.1    Zhang, J.-J.2    Zheng, P.3    Zhang, Y.4
  • 27
    • 36148938725 scopus 로고    scopus 로고
    • Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats
    • DOI 10.1016/j.pbb.2007.08.006, PII S0091305707002560
    • Kuang X, Du JR, Liu YX, Zhang GY, Peng HY. Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. Pharmacol Biochem Behav 2008; 88: 213-221. (Pubitemid 350116248)
    • (2008) Pharmacology Biochemistry and Behavior , vol.88 , Issue.3 , pp. 213-221
    • Kuang, X.1    Du, J.-R.2    Liu, Y.-X.3    Zhang, G.-Y.4    Peng, H.-Y.5
  • 28
    • 49249120035 scopus 로고    scopus 로고
    • Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats
    • Kumaran D, Udayabanu M, Kumar M, Aneja R, Katyal A. Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats. Neuroscience 2008; 155: 626-639.
    • (2008) Neuroscience , vol.155 , pp. 626-639
    • Kumaran, D.1    Udayabanu, M.2    Kumar, M.3    Aneja, R.4    Katyal, A.5
  • 30
    • 31844454079 scopus 로고    scopus 로고
    • Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion
    • DOI 10.1002/jnr.20727
    • Cho KO, La HO, Cho YJ, Sung KW, Kim SY. Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion. J Neurosci Res 2006; 83: 285-291. (Pubitemid 43184392)
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.2 , pp. 285-291
    • Cho, K.-O.1    La, H.O.2    Cho, Y.-J.3    Sung, K.-W.4    Kim, S.Y.5
  • 31
    • 33645845665 scopus 로고    scopus 로고
    • Neuroprotection by cilostazol, a phosphodiesterase type 3 inhibitor, against apoptotic white matter changes in rat after chronic cerebral hypoperfusion
    • Lee JH, Park SY, Shin Y, et al. Neuroprotection by cilostazol, a phosphodiesterase type 3 inhibitor, against apoptotic white matter changes in rat after chronic cerebral hypoperfusion. Brain Res 2006; 1082: 182-191.
    • (2006) Brain Res , vol.1082 , pp. 182-191
    • Lee, J.H.1    Park, S.Y.2    Shin, Y.3
  • 32
    • 33745153095 scopus 로고    scopus 로고
    • Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion
    • DOI 10.1161/01.STR.0000221783.08037.a9, PII 0000767020060600000045
    • Watanabe T, Zhang N, Liu M, Tanaka R, Mizuno Y, Urabe T. Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion. Stroke 2006; 37: 1539-1545. (Pubitemid 44305739)
    • (2006) Stroke , vol.37 , Issue.6 , pp. 1539-1545
    • Watanabe, T.1    Zhang, N.2    Liu, M.3    Tanaka, R.4    Mizuno, Y.5    Urabe, T.6
  • 33
    • 34548495793 scopus 로고    scopus 로고
    • Pre-treatment and post-treatment with α-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusion
    • DOI 10.1016/j.ejphar.2007.05.048, PII S0014299907006553
    • Annahazi A, Mracsko E, Sule Z, et al. Pre-treatment and posttreatment with alpha-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusion. Eur J Pharmacol 2007; 571: 120-128. (Pubitemid 47379685)
    • (2007) European Journal of Pharmacology , vol.571 , Issue.2-3 , pp. 120-128
    • Annahazi, A.1    Mracsko, E.2    Sule, Z.3    Karg, E.4    Penke, B.5    Bari, F.6    Farkas, E.7
  • 34
    • 34248560915 scopus 로고    scopus 로고
    • L-3-n-butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats
    • DOI 10.1124/jpet.106.118760
    • Peng Y, Xu S, Chen G, Wang L, Feng Y, Wang X. l-3-nbutylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats. J Pharmacol Exp Ther 2007; 321: 902-910. (Pubitemid 46762705)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.321 , Issue.3 , pp. 902-910
    • Peng, Y.1    Xu, S.2    Chen, G.3    Wang, L.4    Feng, Y.5    Wang, X.6
  • 35
    • 4344702044 scopus 로고    scopus 로고
    • Relationship between S100β and GFAP expression in astrocytes during infarction and glial scar formation after mild transient ischemia
    • Yasuda Y, Tateishi N, Shimoda T, Satoh S, Ogitani E, Fujita S. Relationship between S100β and GFAP expression in astrocytes during infarction and glial scar formation after mild transient ischemia. Brain Res 2004; 1021: 21-31.
    • (2004) Brain Res , vol.1021 , pp. 21-31
    • Yasuda, Y.1    Tateishi, N.2    Shimoda, T.3    Satoh, S.4    Ogitani, E.5    Fujita, S.6
  • 36
    • 33846641320 scopus 로고    scopus 로고
    • Expression of S100 protein and protective effect of arundic acid on the rat brain in chronic cerebral hypoperfusion
    • DOI 10.1016/j.brainres.2006.11.084, PII S0006899306035062
    • Ohtani R, Tomimoto H, Wakita H, Kitaguchi H, Nakaji K, Takahashi R. Expression of S100 protein and protective effect of arundic acid on the rat brain in chronic cerebral hypoperfusion. Brain Res 2007; 1135: 195-200. (Pubitemid 46176817)
    • (2007) Brain Research , vol.1135 , Issue.1 , pp. 195-200
    • Ohtani, R.1    Tomimoto, H.2    Wakita, H.3    Kitaguchi, H.4    Nakaji, K.5    Takahashi, R.6
  • 37
    • 0036209235 scopus 로고    scopus 로고
    • Chronic cerebral hypoperfusion induces striatal alterations due to the transient increase of NO production and the depression of glutathione content
    • DOI 10.1023/A:1014967414468
    • Tanaka K, Wada-Tanaka N, Miyazaki I, Nomura M, Ogawa N. Chronic cerebral hypoperfusion induces striatal alterations due to the transient increase of NO production and the depression of glutathione content. Neurochem Res 2002; 27: 331-336. (Pubitemid 34273576)
    • (2002) Neurochemical Research , vol.27 , Issue.4 , pp. 331-336
    • Tanaka, K.-I.1    Wada-Tanaka, N.2    Miyazaki, I.3    Nomura, M.4    Ogawa, N.5
  • 38
    • 43049101090 scopus 로고    scopus 로고
    • Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
    • DOI 10.1007/s10571-007-9165-x
    • He Z, Liao Y, Zheng M, Zeng FD, Guo LJ. Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Cell Mol Neurobiol 2008; 28: 613-627. (Pubitemid 351624502)
    • (2008) Cellular and Molecular Neurobiology , vol.28 , Issue.4 , pp. 613-627
    • He, Z.1    Liao, Y.2    Zheng, M.3    Zeng, F.-D.4    Guo, L.-J.5
  • 39
    • 78149469425 scopus 로고    scopus 로고
    • Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats
    • Chao X, Zhou J, Chen T, et al. Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats. Brain Res 2010; 1363: 206-11.
    • Brain Res , vol.2010 , Issue.1363 , pp. 206-211
    • Chao, X.1    Zhou, J.2    Chen, T.3
  • 41
    • 0036753272 scopus 로고    scopus 로고
    • Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
    • DOI 10.1016/S0197-4580(01)00340-2, PII S0197458001003402
    • Butterfield DA, Castegna A, Lauderback CM, Drake J. Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol Aging 2002; 23: 655-664. (Pubitemid 35217687)
    • (2002) Neurobiology of Aging , vol.23 , Issue.5 , pp. 655-664
    • Allan Butterfield, D.1    Castegna, A.2    Lauderback, C.M.3    Drake, J.4
  • 42
    • 46749115113 scopus 로고    scopus 로고
    • PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease
    • DOI 10.1016/j.nurt.2008.05.003, PII S1933721308000925
    • Landreth G, Jiang Q, Mandrekar S, Heneka M. PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics 2008; 5: 481-489. (Pubitemid 351952487)
    • (2008) Neurotherapeutics , vol.5 , Issue.3 , pp. 481-489
    • Landreth, G.1    Jiang, Q.2    Mandrekar, S.3    Heneka, M.4
  • 44
    • 33645088680 scopus 로고    scopus 로고
    • Dynamic regulation of microglial functions by the non-steroidal antiinflammatory drug NCX 2216: Implications for chronic treatments of neurodegenerative diseases
    • Bernardo A, Gasparini L, Ongini E, Minghetti L. Dynamic regulation of microglial functions by the non-steroidal antiinflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. Neurobiol Dis 2006; 22: 25-32.
    • (2006) Neurobiol Dis , vol.22 , pp. 25-32
    • Bernardo, A.1    Gasparini, L.2    Ongini, E.3    Minghetti, L.4
  • 45
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: Inhibition of β- amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
    • Combs C, Johnson D, Karlo C, Cannady S, Landreth G. Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid stimulated proinflammatory responses and neurotoxicity by PPARγ agonists. J Neurosci 2000; 20: 558-567. (Pubitemid 30225558)
    • (2000) Journal of Neuroscience , vol.20 , Issue.2 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 46
    • 0034813578 scopus 로고    scopus 로고
    • Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease
    • DOI 10.1016/S0197-0186(01)00048-1, PII S0197018601000481
    • Peskind ER, Griffin WS, Akama KT, Raskind MA, Van Eldik LJ. Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease. Neurochem Int 2001; 39: 409-413. (Pubitemid 32907405)
    • (2001) Neurochemistry International , vol.39 , Issue.5-6 , pp. 409-413
    • Peskind, E.R.1    Griffin, W.S.T.2    Akama, K.T.3    Raskind, M.A.4    Van Eldik, L.J.5
  • 47
    • 62149151394 scopus 로고    scopus 로고
    • Vitamine E S100B-mediated microglial activation in an S100Boverexpressing mouse model of pathological aging
    • Bialowas-Mcgoey LA, Lesicka A, Whitaker-Azmitia PM. Vitamine E S100B-mediated microglial activation in an S100Boverexpressing mouse model of pathological aging. Glia 2008; 56: 1780-1790.
    • (2008) Glia , vol.56 , pp. 1780-1790
    • Bialowas-Mcgoey, L.A.1    Lesicka, A.2    Whitaker-Azmitia, P.M.3
  • 48
    • 0032960553 scopus 로고    scopus 로고
    • Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment
    • DOI 10.1016/S0306-4522(98)00659-9, PII S0306452298006599
    • De Jong GI, Farkas E, Stienstra CM, et al. Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment. Neuroscience 1999; 91: 203-210. (Pubitemid 29170459)
    • (1999) Neuroscience , vol.91 , Issue.1 , pp. 203-210
    • De Jong, G.I.1    Farkas, E.2    Stienstra, C.M.3    Plass, J.R.M.4    Keijser, J.N.5    De La Torre, J.C.6    Luiten, P.G.M.7
  • 49
    • 12744259336 scopus 로고    scopus 로고
    • Neuroprotective effect of Azadirachta indica on cerebral postischemic reperfusion and hypoperfusion in rats
    • Yanpallewar S, Rai S, Kumar M, Chauhan S, Acharya SB. Neuroprotective effect of Azadirachta indica on cerebral postischemic reperfusion and hypoperfusion in rats. Life Sci 2005; 76: 1325-1338.
    • (2005) Life Sci , vol.76 , pp. 1325-1338
    • Yanpallewar, S.1    Rai, S.2    Kumar, M.3    Chauhan, S.4    Acharya, S.B.5
  • 50
    • 34948814091 scopus 로고    scopus 로고
    • Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats
    • DOI 10.1016/j.ejphar.2007.07.019, PII S0014299907007893
    • Institoris A, Farkas E, Berczi S, Sule Z, Bari F. Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats. Eur J Pharmacol 2007; 574: 29-38. (Pubitemid 47516584)
    • (2007) European Journal of Pharmacology , vol.574 , Issue.1 , pp. 29-38
    • Institoris, A.1    Farkas, E.2    Berczi, S.3    Sule, Z.4    Bari, F.5
  • 51
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • DOI 10.1016/S0891-5849(96)00629-6, PII S0891584996006296
    • Markesbery WR. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 1997; 23: 134-147. (Pubitemid 27217017)
    • (1997) Free Radical Biology and Medicine , vol.23 , Issue.1 , pp. 134-147
    • Markesbery, W.R.1
  • 52
    • 0029026392 scopus 로고
    • The synaptic vesicle cycle: A cascade of protein-protein interactions
    • Sudhof TC. The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 1995; 375: 645-646.
    • (1995) Nature , vol.375 , pp. 645-646
    • Sudhof, T.C.1
  • 53
    • 0030758943 scopus 로고    scopus 로고
    • Expression of synaptophysin in sprouting neurons after entorhinal lesion in the rat
    • DOI 10.1007/s002210050201
    • Bergmann M, Post A, Rittel I, Bechmann I, Nitsch R. Expression of synaptophysin in sprouting neurons after entorhinal lesion in the rat. Exp Brain Res 1997; 117: 80-86. (Pubitemid 27448033)
    • (1997) Experimental Brain Research , vol.117 , Issue.1 , pp. 80-86
    • Bergmann, M.1    Post, A.2    Rittel, I.3    Bechmann, I.4    Nitsch, R.5
  • 54
    • 44649203399 scopus 로고    scopus 로고
    • Purple sweet potato color repairs D-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins
    • Wu DM, Lu J, Zheng YL, Zhou Z, Shan Q, Maa DF. Purple sweet potato color repairs D-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins. Neurobiol Learning Memory 2008; 90: 19-27.
    • (2008) Neurobiol Learning Memory , vol.90 , pp. 19-27
    • Wu, D.M.1    Lu, J.2    Zheng, Y.L.3    Zhou, Z.4    Shan, Q.5    Maa, D.F.6
  • 57
    • 0038313134 scopus 로고    scopus 로고
    • Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke
    • DOI 10.1161/01.STR.0000071108.00234.0E
    • Kernan WN, Inzucchi SE, Viscoli CM, et al. Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke. Stroke 2003; 34: 1431-1436. (Pubitemid 36693512)
    • (2003) Stroke , vol.34 , Issue.6 , pp. 1431-1436
    • Kernan, W.N.1    Inzucchi, S.E.2    Viscoli, C.M.3    Brass, L.M.4    Bravata, D.M.5    Shulman, G.I.6    McVeety, J.C.7    Horwitz, R.I.8


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