Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels

Pharmacological Reports

Volumn 63, Issue 3, 2011, Pages 660-669

  Gilhotra, Neeraj ^a   Dhingra, Dinesh ^a  

^a GURU JAMBHESHWAR UNIVERSITY OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

Anxiety; cGMP; GABA; Methylene blue; Nitric oxide; Thymoquinone

Indexed keywords

4 AMINOBUTYRIC ACID; DIAZEPAM; METHYLENE BLUE; NITRIC OXIDE; THYMOQUINONE;

AMINO ACID BLOOD LEVEL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANXIETY ACTIVITY; ARTICLE; BLACK CUMIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG POTENTIATION; ENZYME BLOOD LEVEL; LIGHT DARK CYCLE; MALE; MAZE TEST; MENTAL STRESS; MOUSE; NEUROMODULATION; NONHUMAN; SOCIAL INTERACTION; TREATMENT RESPONSE;

EID: 80051489613     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(11)70577-1     Document Type: Article

References (61)

1. Abdel-Fattah AM, Matsumoto K, Watanabe H: Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Eur J Pharmacol, 2000, 400, 89-97. (Pubitemid 30412113)
2. Al-Majed AA, Al-Omar FA, Nagi MN: Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. Eur J Pharmacol, 2006, 543, 40-47. (Pubitemid 44092699)
3. André M, Latado H, Felley-Bosco E: Inducible nitric oxide synthase-dependent stimulation of PKGI and phosphorylation of VASP in human embryonic kidney cells. Biochem Pharmacol, 2005, 69, 595-602.
4. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C et al.: International Union of Pharmacology. XV. Subtypes of γ-aminobutyric acid Areceptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev, 1998, 50, 291-313. (Pubitemid 28304030)
5. Beijamini V, Guimaraes FS: Activation of neurons containing the enzyme nitric oxide synthase following exposure to an elevated plus maze. Brain Res Bull, 2006, 69, 347-355.
6. Boix F, Fernandez TA, Tobea A: The anxiolytic action of benzodiazepines is not present in handling- habituated rats. Pharmacol Biochem Behav, 1988, 31, 541-546. (Pubitemid 19274246)
7. Crawley J, Goodwin FK: Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav, 1980, 13, 167-170. (Pubitemid 11225713)
8. Dawson VL, Dawson TM: Physiological and toxicological actions of nitric oxide in the central nervous system. In: Nitric oxide: biochemistry, molecular biology, and therapeutic implications. Eds. Ignarro L, Murad F, Academic Press, London, 1995, 323-330.
9. De Oliveira RW, Forestiero D, Manfrim CM, Guimaraes FS: Anxiolytic effect induced by nitric oxide synthase inhibitors microinjected at medial amygdala of rats. Psychopharmacology, 2006, 184, 166-172. (Pubitemid 43083653)
10. El-Mahmoudy A, Matsuyama H, Borgan MA, Shimizu Y, El-Sayed MG, Minamoto N, Takewaki T: Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int Immunopharmacol, 2002, 2, 1603-1611. (Pubitemid 35223241)
11. El-Mahmoudy A, Shimizu Y, Shiina T, Matsuyama H, Nikami H, Takewaki T: Macrophage-derived cytokine and nitric oxide profiles in type I, type II diabetes mellitus: effect of thymoquinone. Acta Diabetol, 2005, 42, 23-30. (Pubitemid 40655435)
12. Eroglu L, Cagalyan B: Anxiolytic and antidepressant properties of methylene blue in animal models. Pharmacol Res, 1997, 36, 381-385. (Pubitemid 28018061)
13. Faria MS, Muscara MN, Moreno JH, Teixeira SA, Dias HB, De Oliveira B, Graeff FG, De Nucci G: Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test. Eur J Pharmacol, 1997, 323, 37-43. (Pubitemid 27136435)
14. File SE: The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs. J Neurosci Methods, 1980, 2, 219-238.
15. Forestiero D, Manfrim CM, Guimarǎ;es FS, De Oliveira RM: Anxiolytic -like effects induced by nitric oxide synthase inhibitors microinjected into the medial amygdala of rats. Psychopharmacology (Berl), 2006, 184, 166-172. (Pubitemid 43083653)
16. Garthwaite J: Glutamate, nitric oxide and cell-cell signaling in the nervous system. Trends Neurosci, 1991, 14, 60-67.
17. Gilhotra N, Dhingra D: GABAergic and nitriergic modulation by curcumin for its antianxiety-like activity in mice. Brain Res, 2010, 1352, 167-175.
18. Gilhotra N, Dhingra D: Involvement of NO-cGMP pathway in antianxiety effect of aminoguanidine in stressed mice. Prog Neuropsychopharmacol Biol Psychiatry, 2009, 33, 1502-1507.
19. Gilhotra N, Jain H, Dhingra D: Differential effects of nitric oxide synthase inhibitors on anxiety in unstressed and stressed mice. Indian J Exp Biol, 2010,48, 365-372.
20. Gow AJ, Farkouh CR, Munson DA, Posencheg MA, Ischiropoulos H: Biological significance of nitric oxide-mediated protein modifications. Am J Physiol Lung Cell Mol Physiol, 2004, 287, L262-L268. (Pubitemid 38943907)
21. Goyal R, Kumar A: Protective effect of alprazolam in acute immobilization stress-induced certain behavioral and biochemical alterations in mice. Pharmacol Rep, 2007, 59, 284-290. (Pubitemid 47299729)
22. 15N]-labelled nitrate in biological fluids. Anal Biochem, 1982, 126, 131-138.
23. Hamdy NM, Taha RA: Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats. Pharmacology, 2009, 84, 127-134.
24. Harvey BH, Oosthuizen F, Brand L, Wegener G, Stein DJ: Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus. Psychopharmacology, 2004, 175, 494-502. (Pubitemid 39362049)
25. Hassan M, El-Dakhakhny M: Effect of some Nigella sativa constituents on chemical carcinogenesis in hamster cheek pouch. J Egypt Soc Pharmacol Exp Ther, 1992, 11, 675-677.
26. Hosseinzadeh H, Parvardeh S: Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine, 2004, 11, 56-64. (Pubitemid 38196797)
27. Houghton PJ, Zarka R, Heras BDL, Hoult JRS: Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med, 1995, 61, 33-36.
28. A receptors in the amygdala blocks the acquisition and expression of conditioned defeat in Syrian hamsters. Brain Res, 2001, 920, 142-150.
29. Kontos HA, Wei EP: Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583. Stroke, 1993, 24, 427-434. (Pubitemid 23070051)
30. Kulkarni SK: Handbook of Experimental Pharmacology, 3rd ed., Vallabh Prakashan, Delhi, 1999, 135-137.
31. Kumari B, Kumar A, Dhir A: Protective effect of nonselective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. Pharmacol Rep, 2007, 59, 699-707. (Pubitemid 351586561)
32. Lee CY, Cheng HM, Sim SM: Mulberry leaves protect rat tissues from immobilization stress-induced inflammation. Biofactors, 2007, 31, 25-33.
33. Lowe IP, Robins E, Eyerman GS: The fluorimetric measurement of glutamic decarboxylase and its distribution in brain. J Neurochem, 1958, 3, 8-16.
34. Madrigal JL, Moro MA, Lizasoain I, Lorenzo P, Leza JC: Stress-induced increase in extracellular sucrose space in rats is mediated by nitric oxide. Brain Res, 2002, 938, 87-91. (Pubitemid 34603114)
35. Madrigal JLM, Olivia HO, Moro MA, Lizasoain I, Lorenzo P, Castrillo A: The increase in TNF-α levels is implicated in NF-κB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress. Neuropsychopharmacology, 2002, 26, 155-163. (Pubitemid 34093078)
36. Manzanares PAR, Isoardi NA, Carrer HF, Molina VA: Previous stress facilitates fear memory, attenuates GABAergic inhibition, and increases synaptic plasticity in the rat basolateral amygdale. J Neurosci, 2005, 25, 8725-8734. (Pubitemid 41362051)
37. McHugh SB, Deacon RM, Rawlins JN, Bannerman DM: Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. Behav Neurosci, 2004, 118, 63-78. (Pubitemid 38222524)
38. McNaughton N, Corr PJ: A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance. Neurosci Biobehav Rev, 2004, 28, 285-305. (Pubitemid 38844377)
39. Mohammad A, Afridi DM, Garani O, Tucci M: Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis. Biomed Sci Instrum, 2005, 41, 388-393.
40. Mosaddeghi M, Burke TF, Moerschbaecher JM: Chronic brief restraint decreases in vivo binding of benzodiazepine receptor ligand to mouse brain. Mol Chem Neuropathol, 1993, 18, 115-121. (Pubitemid 23128996)
41. Nagao K, Takenaka S, Yamaji R, Inui H, Nakano Y: Nitric oxide synthase induction, cGMP levation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1β in hypoxia. J Biochem, 2003, 133, 501-505. (Pubitemid 36604696)
42. Nakashima MN, Ajiki K, Nakashima K, Takahashi M: Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice. J Pharmacol Sci, 2003, 91, 47-52. (Pubitemid 36575554)
43. Niehoff DL, Kuhar M; Benzodiazepine receptors: localization in rat amygdala. J Neurosci, 1983, 3, 2091-2097.
44. Pellow S, Chopin P, File SE, Briley M: Validation of open-closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods, 1985, 14, 149-167. (Pubitemid 16239568)
45. Perveen T, Haider S, Kanwal S, Haleem DJ: Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats. Pak J Pharm Sci, 2009, 22, 139-144.
46. Raza M, El-hadiyah TM, Al-shabanah OA: Nigella sativa seed constituents and anxiety relief in experimental models. J Herbs Spices Med Plants, 2006, 12, 153-164. (Pubitemid 46030938)
47. A receptor function in the rat cerebral cortex and cerebellar granule cells. Neuroscience, 1996, 74, 99-105.
48. Sevgi S, Ozek M, Eroglu L: L-NAME prevents anxiety-like and depression-like behavior in rats exposed to restraint stress. Methods Find Exp Clin Pharmacol, 2006, 28, 95-99.
49. Shiah IS, Yatham LN: GABAfunction in mood disorder: an update and critical review. Life Sci, 1998, 63, 1289-1303.
50. Spolidório PC, Echeverry MB, Iyomasa M, Guimarǎ;es FS, Del Bel EA: Anxiolytic effects induced by inhibition of the nitric oxide-cGMP pathway in the rat dorsal hippocampus. Psychopharmacology (Berl), 2007, 195, 183-192. (Pubitemid 350045842)
51. Sun AY, Li DX, Wang YL: Stress-induced changes of central GABAergic function in rats. Zhongguo Yao Li Xue Bao, 1991, 12, 387-390.
52. Talarek S, Orzelska J, Listos J, Fidecka S: Effects of sildenafil treatment on the development of tolerance to diazepam-induced motor impairment and sedation in mice. Pharmacol Rep, 2010, 62, 627-634.
53. Tanaka M, Ikeda T, Hayashi S, Iijima N, Amaya F, Hisa Y: Nitriergic neurons in the medial amygdala project to the hypothalamic paraventricular nucleus of the rat. Brain Res, 1997, 777, 13-21. (Pubitemid 28015727)
54. Thomas M, Feron O: Nitric oxide synthases: which, where, how, and why? J Clin Invest, 1997, 100, 2146-2152.
55. 1A receptor agonists and benzodiazepine anxiolytics on the emotional state of naive and stressed mice: a study using the hole-board test. Psychopharmacology (Berl), 2000, 152,157-166.
56. Vincent SR: Nitric oxide: a radical neurotransmitter in the central nervous system. Prog Neurobiol, 1994, 42, 129-160.
57. Volke V, Soosaar A, Ko{combining double acute accent}ks S, Vasar E, Männistö PT: L-Arginine abolishes the anxiolytic-like effect of diazepam in the elevated plus-maze test in rats. Eur J Pharmacol, 1998, 351, 287-290. (Pubitemid 28321463)
58. Volke V, Wegener G, Bourin M, Vasar E: Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2- trifluoromethylphenyl)-imidazole in mice. Behav Brain Res, 2003, 140, 141-147. (Pubitemid 36313249)
59. Volke V, Soosar A, Koks S, Bourin M, Mannisto PT, Vasar E: 7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety. Psychopharmacology (Berl), 1997, 131, 399-405. (Pubitemid 27348707)
60. Weizman AM, Bidder FF, Gavish M: Food deprivation modulates gamma-butyric acid receptors and peripheral benzodiazepine binding sites in rats. Brain Res, 1990, 535, 96-100.
61. A receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase. J Neurosci, 1998, 18, 2342-2349.