The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Drager, Luciano F ^a,b   Lopes, Heno F ^a   Maki Nunes, Cristiane ^a   Trombetta, Ivani C ^a   Toschi Dias, Edgar ^a   Alves, Maria Janieire N N ^a   Fraga, Raffael F ^a   Jun, Jonathan C ^b   Negrão, Carlos E ^a   Krieger, Eduardo M ^a   Polotsky, Vsevolod Y ^b   Lorenzi Filho, Geraldo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID; BIOLOGICAL MARKER;

ADULT; AGE; APNEA HYPOPNEA INDEX; ARTERIAL PRESSURE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DAYTIME SOMNOLENCE; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OXYGEN SATURATION; POLYSOMNOGRAPHY; PREVALENCE; PROTEIN BLOOD LEVEL; SLEEP APNEA SYNDROME; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; RISK; STATISTICAL MODEL;

BIOLOGICAL MARKERS; HUMANS; INFLAMMATION; LINEAR MODELS; LOGISTIC MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; RISK; SLEEP APNEA, OBSTRUCTIVE;

EID: 77957795764     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012065     Document Type: Article

References (41)

1. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, et al.; American Heart Association; National Heart, Lung, and Blood Institute (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/ National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112: 2735-2752. Erratum in: Circulation;112, e297.
2. Sundstrom J, Riserus U, Byberg L, Zethelius B, Lithell H, et al. (2006) Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ 332: 878-882.
3. Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, et al. (2007) Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 49: 403-414.
4. Chen HJ, Bai CH, Yeh WT, Chiu HC, Pan WH (2006) Influence of metabolic syndrome and general obesity on the risk of ischemic stroke. Stroke 37: 1060-1064.
5. Ryan CM, Bradley TD (2005) Pathogenesis of obstructive sleep apnea. J Appl Physiol 99: 2440-2450.
6. Young T, Peppard PE, Gottlieb DJ (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 165: 1217-1239.
7. Peppard PE, Young T, Palta M, Skatrud J (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342: 1378-1384.
8. Punjabi NM, Sorkin JD, Katzel LI, Goldberg AP, Schwartz AR, et al. (2002) Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 165: 677-682.
9. Li J, Thorne LN, Punjabi NM, Sun CK, Schwartz AR, et al. (2005) Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 97: 698-706.
10. Savransky V, Jun J, Li J, Nanayakkara A, Fonti S, Moser AB, et al. (2008) Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase. Circ Res 103: 1173-1180.
11. Coughlin SR, Mawdsley L, Mugarza JA, Calverley PM, Wilding JP (2004) Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J 25: 735-741.
12. Gruber A, Horwood F, Sithole J, Ali NJ, Idris I (2006) Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state. Cardiovasc Diabetol 5: 22.
13. Kono M, Tatsumi K, Saibara T, Nakamura A, Tanabe N, et al. (2007) Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome. Chest 131: 1387-1392.
14. Sasanabe R, Banno K, Otake K, Hasegawa R, Usui K, et al. (2006) Metabolic syndrome in Japanese patients with obstructive sleep apnea syndrome. Hypertens Res 29: 315-322.
15. Parish JM, Adam T, Facchiano L (2007) Relationship of metabolic syndrome and obstructive sleep apnea. J Clin Sleep Med 13: 355-362.
16. Nock NL, Li L, Larkin EK, Patel SR, Redline S (2009) Empirical evidence for ''syndrome Z'': a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measures. Sleep 32: 615-622.
17. Venkateswaran S, Shankar P (2007) The prevalence of syndrome Z (the interaction of obstructive sleep apnoea with the metabolic syndrome) in a teaching hospital in Singapore. Postgrad Med J 83: 329-331.
18. Drager LF, Queiroz EL, Lopes HF, Genta PR, Krieger EM, et al. (2009) Obstructive sleep apnea is highly prevalent and correlates with impaired glycemic control in consecutive patients with the metabolic syndrome. J Cardiometab Syndr 4: 89-95.
19. Chin K, Oga T, Takahashi K, Takegami M, Nakayama-Ashida Y, et al. (2010) Associations between obstructive sleep apnea, metabolic syndrome, and sleep duration, as measured with an actigraph, in an urban male working population in Japan. Sleep 33: 89-95.
20. Lam JC, Lam B, Lam CL, Fong D, Wang JK, et al. (2006) Obstructive sleep apnea and the metabolic syndrome in community-based Chinese adults in Hong Kong. Respir Med 100: 980-987.
21. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, et al.; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institure; National High Blood Pressure Education Program Coordinating Committee. (2003) Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42: 1206-1252.
22. Drager LF, Bortolotto LA, Lorenzi MC, Figueiredo AC, Krieger EM, et al. (2005) Early Signs of Atherosclerosis in Obstructive Sleep Apnea. Am J Respir Crit Care Med 172: 613-618.
23. Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14: 540-545.
24. Linn S, Fulwood R, Rifkind B, Carroll M, Muesing R, et al. (1991) Serum total cholesterol: HDL cholesterol ratios in US white and black adults by selected demographic and socioeconomic variables (HANES II). Am J Public Health 81: 1038-1043.
25. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, et al. (2003) Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 139: 802-809.
26. Ridker PM, Buring JE, Cook NR, Rifai N (2003) C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year followup of 14 719 initially healthy American women. Circulation 107: 391-397.
27. Lee K, Song YM, Sung J (2008) Which obesity indicators are better predictors of metabolic risk?: healthy twin study. Obesity (Silver Spring) 16: 834-840.
28. Drager LF, Bortolotto LA, Maki-Nunes C, Trombetta IC, Alves MJ, et al. (2010) The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome. Atherosclerosis 208: 490-495.
29. Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, et al. (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24: 683-689.
30. Arnlöv J, Ingelsson E, Sundström J, Lind L (2010) Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 121: 230-236.
31. Foster GD, Sanders MH, Millman R, Zammit G, Borradaile KE, et al. (2009) Obstructive sleep apnea among obese patients with type 2 diabetes. Diabetes Care 32: 1017-1019.
32. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, et al. (2000) Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 85: 1151-1158.
33. Prospective Studies Collaboration, Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, et al. (2007) Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 370: 1829-1839. Erratum in: Lancet.2008;372:292.
34. Ruggiero C, Cherubini A, Miller E 3rd, Maggio M, Najjar SS, et al. (2007) Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years. Am J Cardiol 100: 115-121.
35. Santos RD, Nasir K, Orakzai R, Meneghelo RS, Carvalho JA, et al. (2007) Relation of uric acid levels to presence of coronary artery calcium detected by electron beam tomography in men free of symptomatic myocardial ischemia with versus without the metabolic syndrome. Am J Cardiol 99: 42-45.
36. Bos MJ, Koudstaal PJ, Hofman A, Witteman JCM, Breteker MMB (2006) Uric acid is a risk factor for myocardial infarction and stroke. Stroke 37: 1503-1507.
37. Tsouli SG, Liberopoulos EN, Mikhailidis DP, Athyros VG, Elisaf MS (2006) Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander? Metab Clin Exp 55: 1293-1301.
38. Steiropoulos P, Kotsianidis I, Nena E, Tsara V, Gounari E, et al. (2009) Longterm effect of continuous positive airway pressure therapy on inflammation markers of patients with obstructive sleep apnea syndrome. Sleep 32: 537-543.
39. Lui MM, Lam JC, Mak HK, Xu A, Ooi C, et al. (2009) C-reactive protein is associated with obstructive sleep apnea independent of visceral obesity. Chest 135: 950-956. Erratum in: Chest. 2009;135:1406.
40. Ryan S, Taylor CT, McNicholas WT (2005) Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112: 2660-2667.
41. Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, et al. (2008) Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep 31: 1071-1078.