Oxysterols formation as a reflection of biochemical pathways: Summary of in vitro and in vivo studies

Chemistry and Physics of Lipids

Volumn 164, Issue 6, 2011, Pages 438-442

  Vaya, Jacob ^a,b   Szuchman, Andrea ^a,b   Tavori, Hagai ^a,b   Aluf, Yuval ^a,b  

^a MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^b Tel Hi College   (Israel)

Author keywords

Atherosclerosis; Diabetic; Oxysterols; Paraoxonase1

Indexed keywords

7 OXOCHOLESTEROL; ARYLDIALKYLPHOSPHATASE 1; CLORGYLINE; GLUTATHIONE; HEME OXYGENASE; OXYSTEROL; RASAGILINE;

ARTICLE; BIOCHEMISTRY; CARDIOVASCULAR DISEASE; CORPUS STRIATUM; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL;

ANIMALS; CHOLESTEROL; DIABETES MELLITUS; HUMANS; HYPERCHOLESTEROLEMIA; NEOSTRIATUM; OXIDATIVE STRESS; OXYGEN;

ANIMALIA; PARKINSONIA;

EID: 80051472916     PISSN: 00093084     EISSN: 18732941     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2011.03.005     Document Type: Article

References (27)

1. Y. Aluf, J. Vaya, S. Khatib, Y. Lobpda, S. kizhner, and J.P.M. Finberg Specific oxidative stress profile associated with partial striatal dopaminergic depletion by 6-hydroxydopamine as assessed by a novel multifunctional marker molecule Free Radic. Res. 44 2010 635 644
2. M. Arca, S. Natoli, F. Micheletta, S. Riggi, E. Di Angelantonio, A. Montali, T.M. Antonini, R. Antonini, U. Diczfalusy, and L. Iuliano Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy Free Radic. Biol. Med. 42 2007 698 705 (Pubitemid 46205153)
3. M. Aviram, M. Rosenblat, D. Gaitini, S. Nitecki, A. Hoffman, L. Dornfeld, N. Volkova, D. Presser, J. Attias, H. Liker, and T. Hayek Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation Clin. Nutr. 23 2004 423 433 (Pubitemid 38811681)
4. A. Babiker, O. Andersson, E. Lund, R.J. Xiu, S. Deeb, A. Reshef, E. Leitersdorf, U. Diczfalusy, and I. Bjorkhem Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport J. Biol. Chem. 272 1997 26253 26261 (Pubitemid 27458836)
5. I. Bjorkhem, and U. Diczfalusy Oxysterols: friends, foes, or just fellow passengers? Arterioscler. Thromb. Vasc. Biol. 22 2002 734 742
6. E. Cadenas, and H. Sies The lag phase Free Radic. Res. 28 1998 601 609 (Pubitemid 28454253)
7. D.I. Draganov Lactonases with organophosphatase activity: structural and evolutionary perspectives Chem. Biol. Interact. 187 2010 370 372
8. J.R. Hascalovici, J. Vaya, S. Khatib, C.A. Holcroft, H. Zukor, W. Song, Z. Arvanitakis, D.A. Bennett, and H.M. Schipper Brain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase-1 J. Neurochem. 110 2009 1241 1253
9. P. Jenner, and C.W. Olanow The pathogenesis of cell death in Parkinson's disease Neurology 66 2006 S24 S36
10. A. Jerlich, J.S. Fabjan, S. Tschabuschnig, A.V. Smirnova, L. Horakova, M. Hayn, H. Auer, H. Guttenberger, H.J. Leis, F. Tatzber, G. Waeg, and R.J. Schaur Human low density lipoprotein as a target of hypochlorite generated by myeloperoxidase Free Radic. Biol. Med. 24 1998 1139 1148 (Pubitemid 28253324)
11. M. Kawamura, J.W. Heinecke, and A. Chait Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway J. Clin. Invest. 94 1994 771 778 (Pubitemid 24251010)
12. H. Larsson, Y. Bottiger, L. Iuliano, and U. Diczfalusy In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress Free Radic. Biol. Med. 43 2007 695 701 (Pubitemid 47102124)
13. D. Lutjohann, and K. von Bergmann 24S-hydroxycholesterol: a marker of brain cholesterol metabolism Pharmacopsychiatry 36 Suppl. 2 2003 S102 106
14. S.M. Lynch, and B. Frei Reduction of copper, but not iron, by human low density lipoprotein (LDL). Implications for metal ion-dependent oxidative modification of LDL J. Biol. Chem. 270 1995 5158 5163
15. B. Mackness, R. Hunt, P.N. Durrington, and M.I. Mackness Increased immunolocalization of paraoxonase, clusterin, and apolipoprotein A-I in the human artery wall with the progression of atherosclerosis Arterioscler. Thromb. Vasc. Biol. 17 1997 1233 1238 (Pubitemid 27329844)
16. S.A. Marchitti, R.A. Deitrich, and V. Vasiliou Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase Pharmacol. Rev. 59 2007 125 150 (Pubitemid 46855437)
17. L.P. Precourt, D. Amre, M.C. Denis, J.C. Lavoie, E. Delvin, E. Seidman, and E. Levy The three-gene paraoxonase family: physiologic roles, actions and regulation Atherosclerosis 214 2011 20 36
18. J.T. Salonen, K. Nyyssonen, R. Salonen, E. Porkkala-Sarataho, T.P. Tuomainen, U. Diczfalusy, and I. Bjorkhem Lipoprotein oxidation and progression of carotid atherosclerosis Circulation 95 1997 840 845 (Pubitemid 27091523)
19. H.M. Schipper Heme oxygenase expression in human central nervous system disorders Free Radic. Biol. Med. 37 2004 1995 2011 (Pubitemid 39491319)
20. A. Szuchman, M. Aviram, R. Musa, S. Khatib, and J. Vaya Characterization of oxidative stress in blood from diabetic vs. hypercholesterolaemic patients, using a novel synthesized marker Biomarkers 13 2008 119 131
21. A. Szuchman, M. Aviram, S. Tamir, and J. Vaya Cholesterol, linoleic acid or/and tyrosine yield different spectra of products when oxidized alone or in a mixture: studies in various oxidative systems Free Radic. Res. 37 2003 1277 1288 (Pubitemid 37441711)
22. H. Tavori, M. Aviram, S. Khatib, R. Musa, D. Mannheim, R. Karmeli, and J. Vaya Human carotid lesion linoleic acid hydroperoxide inhibits paraoxonase 1 (PON1) activity via reaction with PON1 free sulfhydryl cysteine 284 Free Radic. Biol. Med. 50 2011 148 156
23. H. Tavori, M. Aviram, S. Khatib, R. Musa, D. Mannheim, R. Karmeli, and J. Vaya Paraoxonase 1 protect macrophages from the atherogenicity of specific triglyceride isolated from Human carotid lesion Free Radic. Biol. Med. 2011 10.1016/j.freeradbiomed.2011.03.041
24. H. Tavori, M. Aviram, S. Khatib, R. Musa, S. Nitecki, A. Hoffman, and J. Vaya Human carotid atherosclerotic plaque increases oxidative state of macrophages and low-density lipoproteins, whereas paraoxonase 1 (PON1) decreases such atherogenic effects Free Radic. Biol. Med. 46 2009 607 615
25. H. Tavori, S. Khatib, M. Aviram, and J. Vaya Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity Bioorg. Med. Chem. 16 2008 7504 7509
26. J. Vaya Novel designed probes for the characterization of oxidative stress in biological fluids, cells, and tissues Methods Mol. Biol. 477 2008 3 13
27. J. Vaya, W. Song, S. Khatib, G. Geng, and H.M. Schipper Effects of heme oxygenase-1 expression on sterol homeostasis in rat astroglia Free Radic. Biol. Med. 42 2007 864 871 (Pubitemid 46274172)