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Volumn 31, Issue 4, 2011, Pages 326-332

Focal and Segmental Glomerulosclerosis: Multiple Pathways Are Involved

Author keywords

Calcineurin inhibitors; Focal segmental glomerulosclerosis; Genetic FSGS; Glucocorticoids; Idiopathic nephrotic syndrome; Pathogenesis; Podocyte; Posttransplant recurrence; Slit diaphragm proteins

Indexed keywords

ACTIN; AGRIN; ALPHA ACTININ 4; ALPHA DYSTROGLYCAN; BEVACIZUMAB; CALCINEURIN INHIBITOR; CD2 ASSOCIATED PROTEIN; CYCLOSPORIN A; DEXAMETHASONE; ELONGATION FACTOR 1ALPHA; GLUCOCORTICOID; GLUCOSE; LAMININ; MYOSIN IIA; P CADHERIN; PHOSPHATIDYLINOSITOL 3 KINASE; PODOCALYXIN; PODOCIN; PODOPLANIN; PROTEIN ZO1; RITUXIMAB; SYNAPTOPODIN; TACROLIMUS; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TUBULIN; VASCULOTROPIN; VASCULOTROPIN C; VERY LATE ACTIVATION ANTIGEN 3; WT1 PROTEIN;

EID: 79961242353     PISSN: 02709295     EISSN: 15584488     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2011.06.003     Document Type: Article
Times cited : (17)

References (57)
  • 1
    • 33646134236 scopus 로고    scopus 로고
    • Mechanisms of disease: focal segmental glomerulosclerosis
    • Meyrier A. Mechanisms of disease: focal segmental glomerulosclerosis. Nature Clin Pract Nephrol 2005, 1:44-54.
    • (2005) Nature Clin Pract Nephrol , vol.1 , pp. 44-54
    • Meyrier, A.1
  • 2
    • 33644525974 scopus 로고    scopus 로고
    • Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants
    • Thomas D.B., Franceschini N., Hogan S.L., Ten Holder S., Jennette C.E., Falk R.J., et al. Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants. Kidney Int 2006, 69:920-926.
    • (2006) Kidney Int , vol.69 , pp. 920-926
    • Thomas, D.B.1    Franceschini, N.2    Hogan, S.L.3    Ten Holder, S.4    Jennette, C.E.5    Falk, R.J.6
  • 3
    • 34748843166 scopus 로고    scopus 로고
    • A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases
    • Barisoni L., Schnaper H.W., Kopp J.B. A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. Clin J Am Soc Nephrol 2007, 2:529-542.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 529-542
    • Barisoni, L.1    Schnaper, H.W.2    Kopp, J.B.3
  • 4
    • 34250006557 scopus 로고    scopus 로고
    • The spectrum of podocytopathies: a unifying view of glomerular diseases
    • Wiggins R.C. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int 2007, 71:1205-1214.
    • (2007) Kidney Int , vol.71 , pp. 1205-1214
    • Wiggins, R.C.1
  • 5
    • 77950517549 scopus 로고    scopus 로고
    • Toward the development of podocyte-specific drugs
    • Reiser J., Gupta V., Kistler A.D. Toward the development of podocyte-specific drugs. Kidney Int 2010, 77:662-668.
    • (2010) Kidney Int , vol.77 , pp. 662-668
    • Reiser, J.1    Gupta, V.2    Kistler, A.D.3
  • 6
    • 9644264018 scopus 로고    scopus 로고
    • Human podocytes possess a stretch-sensitive, Ca2+-activated K+ channel: potential implications for the control of glomerular filtration
    • Morton M.J., Hutchinson K., Mathieson P.W., Witherden I.R., Saleem M.A., Hunter M. Human podocytes possess a stretch-sensitive, Ca2+-activated K+ channel: potential implications for the control of glomerular filtration. J Am Soc Nephrol 2004, 5:2981-2987.
    • (2004) J Am Soc Nephrol , vol.5 , pp. 2981-2987
    • Morton, M.J.1    Hutchinson, K.2    Mathieson, P.W.3    Witherden, I.R.4    Saleem, M.A.5    Hunter, M.6
  • 7
    • 42149122041 scopus 로고    scopus 로고
    • Properties of the glomerular barrier and mechanisms of proteinuria
    • Haraldsson B., Nyström J., Deen W.M. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 2008, 88:451-487.
    • (2008) Physiol Rev , vol.88 , pp. 451-487
    • Haraldsson, B.1    Nyström, J.2    Deen, W.M.3
  • 8
    • 24344501340 scopus 로고    scopus 로고
    • Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury
    • Matsusaka T., Xin J., Niwa S., Kobayashi K., Akatsuka A., Hashizume H., et al. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. J Am Soc Nephrol 2005, 16:1013-1023.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1013-1023
    • Matsusaka, T.1    Xin, J.2    Niwa, S.3    Kobayashi, K.4    Akatsuka, A.5    Hashizume, H.6
  • 9
    • 33645266951 scopus 로고    scopus 로고
    • Podocyte hypertrophy, "adaptation", and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction
    • Wiggins J.E., Goyal M., Sanden S.K., Wharram B.L., Shedden K.A., Misek D.E., et al. Podocyte hypertrophy, "adaptation", and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction. J Am Soc Nephrol 2005, 16:2953-2966.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2953-2966
    • Wiggins, J.E.1    Goyal, M.2    Sanden, S.K.3    Wharram, B.L.4    Shedden, K.A.5    Misek, D.E.6
  • 10
    • 33645257852 scopus 로고    scopus 로고
    • Role of podocytes in focal sclerosis: defining the point of no return
    • Kretzler M. Role of podocytes in focal sclerosis: defining the point of no return. J Am Soc Nephrol 2005, 16:2830-2832.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2830-2832
    • Kretzler, M.1
  • 11
    • 33750580852 scopus 로고    scopus 로고
    • Cellular focal segmental glomerulosclerosis: clinical and pathologic features
    • Stokes M.B., Valeri A.M., Markowitz G.S., D'Agati V.D. Cellular focal segmental glomerulosclerosis: clinical and pathologic features. Kidney Int 2006, 70:1783-1792.
    • (2006) Kidney Int , vol.70 , pp. 1783-1792
    • Stokes, M.B.1    Valeri, A.M.2    Markowitz, G.S.3    D'Agati, V.D.4
  • 14
    • 77956262242 scopus 로고    scopus 로고
    • Glomerular diseases: genetic causes and future therapeutics
    • Chiang C.K., Inagi R. Glomerular diseases: genetic causes and future therapeutics. Nat Rev Nephrol 2010, 6:539-554.
    • (2010) Nat Rev Nephrol , vol.6 , pp. 539-554
    • Chiang, C.K.1    Inagi, R.2
  • 15
    • 68349139524 scopus 로고    scopus 로고
    • Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs
    • Nabet B., Tsai A., Tobias J.W., Carstens R.P. Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs. PLoS One 2009, 4:e6491.
    • (2009) PLoS One , vol.4
    • Nabet, B.1    Tsai, A.2    Tobias, J.W.3    Carstens, R.P.4
  • 16
    • 73449132910 scopus 로고    scopus 로고
    • Dystroglycan in the molecular diagnosis of the podocytopathies
    • Kopp J.B. Dystroglycan in the molecular diagnosis of the podocytopathies. Clin J Am Soc Nephrol 2009, 4:1696-1698.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 1696-1698
    • Kopp, J.B.1
  • 19
    • 77956156963 scopus 로고    scopus 로고
    • MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
    • Kopp J.B., Winkler C.A., Nelson G.W. MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?. Semin Nephrol 2010, 30:409-417.
    • (2010) Semin Nephrol , vol.30 , pp. 409-417
    • Kopp, J.B.1    Winkler, C.A.2    Nelson, G.W.3
  • 20
    • 77956870511 scopus 로고    scopus 로고
    • A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9
    • Genovese G., Tonna S.J., Knob A.U., et al. A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. Kidney Int 2010, 78:698-704.
    • (2010) Kidney Int , vol.78 , pp. 698-704
    • Genovese, G.1    Tonna, S.J.2    Knob, A.U.3
  • 21
    • 65649089840 scopus 로고    scopus 로고
    • An update on the treatment options of focal segmental glomerulosclerosis
    • Meyrier A. An update on the treatment options of focal segmental glomerulosclerosis. Expert Opin Pharmacother 2009, 10:315-328.
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 315-328
    • Meyrier, A.1
  • 22
    • 73349132341 scopus 로고    scopus 로고
    • Mutations in the formin protein INF2 causes focal segmental glomerulosclerosis
    • Brown E.J., Schlöndorff J.S., Becker D.J., et al. Mutations in the formin protein INF2 causes focal segmental glomerulosclerosis. Nat Genet 2010, 42:72-76.
    • (2010) Nat Genet , vol.42 , pp. 72-76
    • Brown, E.J.1    Schlöndorff, J.S.2    Becker, D.J.3
  • 23
    • 48049090083 scopus 로고    scopus 로고
    • Young Investigator Award: TRP'ing into a new era for glomerular diseases
    • Winn M.P. Young Investigator Award: TRP'ing into a new era for glomerular diseases. J Am Soc Nephrol 2008, 19:1071-1075.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1071-1075
    • Winn, M.P.1
  • 24
    • 77949351029 scopus 로고    scopus 로고
    • New insights into epithelial-mesenchymal transition in kidney
    • Liu Y. New insights into epithelial-mesenchymal transition in kidney. J Am Soc Nephrol 2010, 21:2122.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 2122
    • Liu, Y.1
  • 25
    • 33747852615 scopus 로고    scopus 로고
    • Glomerular epithelial cells transform to myofibroblasts: early but not late removal of TGF-beta1 reverses transformation
    • Sam R., Wanna L., Gudehithlu K.P., Garber S.L., Dunea G., Arruda J.A. Glomerular epithelial cells transform to myofibroblasts: early but not late removal of TGF-beta1 reverses transformation. Transl Res 2006, 148:142-148.
    • (2006) Transl Res , vol.148 , pp. 142-148
    • Sam, R.1    Wanna, L.2    Gudehithlu, K.P.3    Garber, S.L.4    Dunea, G.5    Arruda, J.A.6
  • 26
    • 78049369136 scopus 로고    scopus 로고
    • Renal fibrosis: novel insights into mechanisms and therapeutic targets
    • Boor P., Ostendorf T., Floege J. Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol 2010, 6:643-656.
    • (2010) Nat Rev Nephrol , vol.6 , pp. 643-656
    • Boor, P.1    Ostendorf, T.2    Floege, J.3
  • 29
    • 77957869134 scopus 로고    scopus 로고
    • VEGF receptors and glomerular function
    • Parikh S.M., Pollack M.R. VEGF receptors and glomerular function. J Am Soc Nephrol 2010, 21:1599-1600.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1599-1600
    • Parikh, S.M.1    Pollack, M.R.2
  • 31
    • 35948934636 scopus 로고    scopus 로고
    • Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    • Isermann B., Vinnikov I.A., Madhusudhan T., Hersog S., Kashif M., Blautzik J., et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 2007, 13:1349-1358.
    • (2007) Nat Med , vol.13 , pp. 1349-1358
    • Isermann, B.1    Vinnikov, I.A.2    Madhusudhan, T.3    Hersog, S.4    Kashif, M.5    Blautzik, J.6
  • 33
    • 69449093150 scopus 로고    scopus 로고
    • Impaired transcription factor interplay in addition to advanced glycation end products suppress podocalyxin expression in high glucose-treated human podocytes
    • Drossopoulou G.I., Tsotakos N.E., Tsilibary E.C. Impaired transcription factor interplay in addition to advanced glycation end products suppress podocalyxin expression in high glucose-treated human podocytes. Am J Physiol Renal Physiol 2009, 297:F594-F603.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Drossopoulou, G.I.1    Tsotakos, N.E.2    Tsilibary, E.C.3
  • 34
    • 0016266173 scopus 로고
    • Pathogenesis of lipoid nephrosis: a disorder of T cell function
    • Shalhoub R.J. Pathogenesis of lipoid nephrosis: a disorder of T cell function. Lancet 1974, 2:556-559.
    • (1974) Lancet , vol.2 , pp. 556-559
    • Shalhoub, R.J.1
  • 35
    • 68949206323 scopus 로고    scopus 로고
    • Treatment of focal segmental glomerulosclerosis with immunophilin modulation: when did we stop thinking about pathogenesis?
    • Meyrier A. Treatment of focal segmental glomerulosclerosis with immunophilin modulation: when did we stop thinking about pathogenesis?. Kidney Int 2009, 76:487-491.
    • (2009) Kidney Int , vol.76 , pp. 487-491
    • Meyrier, A.1
  • 36
    • 78650364370 scopus 로고    scopus 로고
    • Posttransplant recurrence of primary glomerulonephritis
    • Ponticelli C., Glassock R.J. Posttransplant recurrence of primary glomerulonephritis. Clin J Am Soc Nephrol 2010, 5:2363-2372.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 2363-2372
    • Ponticelli, C.1    Glassock, R.J.2
  • 37
    • 3242795082 scopus 로고    scopus 로고
    • NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplantation recurrence
    • Weber S., Gribouval O., Esquivel E.L., Morinière V., Tête M.J., Legendre C. NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplantation recurrence. Kidney Int 2004, 66:571-579.
    • (2004) Kidney Int , vol.66 , pp. 571-579
    • Weber, S.1    Gribouval, O.2    Esquivel, E.L.3    Morinière, V.4    Tête, M.J.5    Legendre, C.6
  • 39
    • 0036707885 scopus 로고    scopus 로고
    • Molecular identification of SV40 infection in human subjects and possible association with kidney disease
    • Li R.M., Branton M.H., Tanawattanacharoen S., Falk R.A., Jennette J.C., Kopp J.B. Molecular identification of SV40 infection in human subjects and possible association with kidney disease. J Am Soc Nephrol 2002, 13:2320-2330.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2320-2330
    • Li, R.M.1    Branton, M.H.2    Tanawattanacharoen, S.3    Falk, R.A.4    Jennette, J.C.5    Kopp, J.B.6
  • 41
    • 71149119200 scopus 로고    scopus 로고
    • Nephrin mutations cause childhood-and adult-onset focal segmental glomerulosclerosis
    • Santin S., Garcia-Maset R., Ruiz P., Giménez I., Zamora I., Pena A. Nephrin mutations cause childhood-and adult-onset focal segmental glomerulosclerosis. Kidney Int 2009, 76:1268-1276.
    • (2009) Kidney Int , vol.76 , pp. 1268-1276
    • Santin, S.1    Garcia-Maset, R.2    Ruiz, P.3    Giménez, I.4    Zamora, I.5    Pena, A.6
  • 42
    • 36649027617 scopus 로고    scopus 로고
    • Cyclosporin in idiopathic glomerular disease associated with the nephrotic syndrome: workshop recommendations
    • Cattran D.C., Alexopoulos E., Heering P., Hoyer P.F., Johnston A., Meyrier A., et al. Cyclosporin in idiopathic glomerular disease associated with the nephrotic syndrome: workshop recommendations. Kidney Int 2007, 72:1429-1447.
    • (2007) Kidney Int , vol.72 , pp. 1429-1447
    • Cattran, D.C.1    Alexopoulos, E.2    Heering, P.3    Hoyer, P.F.4    Johnston, A.5    Meyrier, A.6
  • 43
    • 34447530705 scopus 로고    scopus 로고
    • Tacrolimus in the treatment of idiopathic nephrotic syndrome
    • Westhoff T.H., Van der Giet M. Tacrolimus in the treatment of idiopathic nephrotic syndrome. Expert Opin Investig Drugs 2007, 16:1099-1110.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 1099-1110
    • Westhoff, T.H.1    Van der Giet, M.2
  • 45
    • 55849126739 scopus 로고    scopus 로고
    • Paradox of B cell-targeted therapies
    • Kurosaki T. Paradox of B cell-targeted therapies. J Clin Invest 2008, 118:3260-3263.
    • (2008) J Clin Invest , vol.118 , pp. 3260-3263
    • Kurosaki, T.1
  • 46
    • 33646133214 scopus 로고    scopus 로고
    • The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases
    • Fujii Y., Khoshnoodi J., Takenaka H., Hosoyamada M., Nakajo A., Bessho F., et al. The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases. Kidney Int 2006, 69:1350-1359.
    • (2006) Kidney Int , vol.69 , pp. 1350-1359
    • Fujii, Y.1    Khoshnoodi, J.2    Takenaka, H.3    Hosoyamada, M.4    Nakajo, A.5    Bessho, F.6
  • 48
    • 57349158456 scopus 로고    scopus 로고
    • Proteinuria and autoimmunity-an overstated relationship?
    • Mathieson P.W. Proteinuria and autoimmunity-an overstated relationship?. N Engl J Med 2008, 359:2492-2494.
    • (2008) N Engl J Med , vol.359 , pp. 2492-2494
    • Mathieson, P.W.1
  • 49
    • 51349162919 scopus 로고    scopus 로고
    • The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporin A
    • Faul C., Donnelly M., Merscher-Gomez S., Chang Y.H., Franz S., Delfgaauw J., et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporin A. Nat Med 2008, 14:931-938.
    • (2008) Nat Med , vol.14 , pp. 931-938
    • Faul, C.1    Donnelly, M.2    Merscher-Gomez, S.3    Chang, Y.H.4    Franz, S.5    Delfgaauw, J.6
  • 51
    • 50249165289 scopus 로고    scopus 로고
    • Reversal of proteinuric renal disease and the emerging role of endothelin
    • Barton M. Reversal of proteinuric renal disease and the emerging role of endothelin. Nat Clin Pract Nephrol 2008, 4:490-501.
    • (2008) Nat Clin Pract Nephrol , vol.4 , pp. 490-501
    • Barton, M.1
  • 52
    • 44649185777 scopus 로고    scopus 로고
    • Recurrent glomerulonephritis after renal transplantation: an unsolved problem
    • Golgert W.A., Appel G.B., Hariharan S. Recurrent glomerulonephritis after renal transplantation: an unsolved problem. Pediatr Nephrol 2008, 3:800-807.
    • (2008) Pediatr Nephrol , vol.3 , pp. 800-807
    • Golgert, W.A.1    Appel, G.B.2    Hariharan, S.3
  • 53
    • 33847355663 scopus 로고    scopus 로고
    • Recurrence of nephrotic syndrome/focal segmental glomerulosclerosis following transplantation in children
    • Fine R. Recurrence of nephrotic syndrome/focal segmental glomerulosclerosis following transplantation in children. Pediatr Nephrol 2007, 22:496-502.
    • (2007) Pediatr Nephrol , vol.22 , pp. 496-502
    • Fine, R.1
  • 56
    • 33644817221 scopus 로고    scopus 로고
    • Preemptive plasmapheresis and recurrence of FSGS in high-risk renal transplantation recipients
    • Gohh R.Y., Yango A.F., Morrissey P.E., Monaco A.P., Gautam A., Sharma M., et al. Preemptive plasmapheresis and recurrence of FSGS in high-risk renal transplantation recipients. Am J Transpl 2005, 5:2907-2912.
    • (2005) Am J Transpl , vol.5 , pp. 2907-2912
    • Gohh, R.Y.1    Yango, A.F.2    Morrissey, P.E.3    Monaco, A.P.4    Gautam, A.5    Sharma, M.6


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