메뉴 건너뛰기




Volumn 12, Issue 3, 2011, Pages 239-251

Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer

Author keywords

5 FU; Colorectal cancer; Quinacrine; Sorafenib

Indexed keywords

FLUOROURACIL; K RAS PROTEIN; MEPACRINE; PROTEIN P53; SORAFENIB;

EID: 79961231807     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.3.17034     Document Type: Article
Times cited : (40)

References (42)
  • 1
    • 0024383472 scopus 로고
    • The use of quinacrine (atabrine) in rheumatic diseases: A reexamination
    • PMID:2658071 doi:10.1016/0049-0172(89)90050-4
    • Wallace DJ. The use of quinacrine (atabrine) in rheumatic diseases: A reexamination. Semin Arthritis Rheum 1989; 18:282-96. PMID:2658071 doi:10.1016/0049-0172(89)90050-4
    • (1989) Semin Arthritis Rheum , vol.18 , pp. 282-296
    • Wallace, D.J.1
  • 2
    • 0035138082 scopus 로고    scopus 로고
    • Treatment of giardisis
    • PMID:11148005 doi:10.1128/CMR.14.1.114-128.2001
    • Gardner TB, Hill DR. Treatment of giardisis. Clin Microbiol Rev 2001; 14:114-28. PMID:11148005 doi:10.1128/CMR.14.1.114-128.2001
    • (2001) Clin Microbiol Rev , vol.14 , pp. 114-128
    • Gardner, T.B.1    Hill, D.R.2
  • 3
    • 0027279388 scopus 로고
    • 31781 Cases of non-surgical female sterilisation with quinacrine pellets in Vietnam
    • PMID:8100933 doi:10.1016/0140-6736(93)92302-A
    • Hieu DT, Vinh DQ, Tan DN, Tan TT, Nguyet PT, Than P. 31781 cases of non-surgical female sterilisation with quinacrine pellets in Vietnam. Lancet 1993; 342:213-7. PMID:8100933 doi:10.1016/0140-6736(93)92302-A
    • (1993) Lancet , vol.342 , pp. 213-217
    • Hieu, D.T.1    Vinh, D.Q.2    Tan, D.N.3    Tan, T.T.4    Nguyet, P.T.5    Than, P.6
  • 4
    • 62149105940 scopus 로고    scopus 로고
    • Safety and efficacy of quinacrine in human prion disease (PRION-1 study): A patient-preference trial
    • PMID:19278902 doi:10.1016/S1474-4422(09)70049-3
    • Collinge J, Gorhama M, Hudson F, Kennedy A, Keogh G, Pal S, et al. Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial. Lancet Neurol 2009; 8:334-44. PMID:19278902 doi:10.1016/S1474-4422(09)70049-3
    • (2009) Lancet Neurol , vol.8 , pp. 334-344
    • Collinge, J.1    Gorhama, M.2    Hudson, F.3    Kennedy, A.4    Keogh, G.5    Pal, S.6
  • 5
    • 79961238261 scopus 로고
    • Studies on the administration of quinacrine to tumor-bearing mice
    • PMID:13261076
    • Vassey JW, Edmonds J, Irvin JL, Green JA, Irvin EM. Studies on the administration of quinacrine to tumor-bearing mice. Cancer Res 1955; 15:573-8. PMID:13261076
    • (1955) Cancer Res , vol.15 , pp. 573-578
    • Vassey, J.W.1    Edmonds, J.2    Irvin, J.L.3    Green, J.A.4    Irvin, E.M.5
  • 6
    • 0015606236 scopus 로고
    • Single-dose quinacrine (atabrine) and thoracostomy in the control of pleural effusions in patients with neoplastic diseases
    • PMID:4706055 doi:10.1002/1097-0142(197304)31:4⟨899::AID- CNCR2820310421⟩3.0.CO;2-2
    • Borja ER, Pugh RP. Single-dose quinacrine (atabrine) and thoracostomy in the control of pleural effusions in patients with neoplastic diseases. Cancer 1973; 31:899-902. PMID:4706055 doi:10.1002/1097-0142(197304)31:4⟨899:: AID-CNCR2820310421⟩3.0.CO;2-2
    • (1973) Cancer , vol.31 , pp. 899-902
    • Borja, E.R.1    Pugh, R.P.2
  • 7
    • 61349141840 scopus 로고    scopus 로고
    • 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways
    • PMID:19137016 doi:10.1038/onc.2008.460
    • Guo C, Gasparian AV, Zhuang Z, Bosykh DA, Komar AA, Gudkov AV, et al. 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways. Oncogene 2009; 28:1151-61. PMID:19137016 doi:10.1038/onc.2008.460
    • (2009) Oncogene , vol.28 , pp. 1151-1161
    • Guo, C.1    Gasparian, A.V.2    Zhuang, Z.3    Bosykh, D.A.4    Komar, A.A.5    Gudkov, A.V.6
  • 8
    • 0033601370 scopus 로고    scopus 로고
    • Pharmacological rescue of mutant p53 conformation and function
    • PMID:10617466 doi:10.1126/science.286.5449.2507
    • Foster BA, Coffey HA, Morin MJ, Rastinejad F. Pharmacological rescue of mutant p53 conformation and function. Science 1999; 286:2507-10. PMID:10617466 doi:10.1126/science.286.5449.2507
    • (1999) Science , vol.286 , pp. 2507-2510
    • Foster, B.A.1    Coffey, H.A.2    Morin, M.J.3    Rastinejad, F.4
  • 9
    • 25144506616 scopus 로고    scopus 로고
    • Acridine derivatives activate p53 and induce tumor cell death through bax
    • PMID:16177561 doi:10.4161/cbt.4.8.2134
    • Wang W, Ho WC, Dicker DT, MacKinnon C, Winkler JD, Marmorstein R, et al. Acridine derivatives activate p53 and induce tumor cell death through bax. Cancer Biol Ther 2005; 4:893-8. PMID:16177561 doi:10.4161/cbt.4.8.2134
    • (2005) Cancer Biol Ther , vol.4 , pp. 893-898
    • Wang, W.1    Ho, W.C.2    Dicker, D.T.3    MacKinnon, C.4    Winkler, J.D.5    Marmorstein, R.6
  • 11
    • 37549048249 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Opposing activities that mediate cell death
    • PMID:18097445 doi:10.1038/nrm2308
    • Youle RJ, Strasser A. The Bcl-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9:47-59. PMID:18097445 doi:10.1038/nrm2308
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 13
    • 42949142609 scopus 로고    scopus 로고
    • Systemic treatment of colorectal cancer
    • PMID:18471507 doi:10.1053/j.gastro.2008.02.098
    • Wolpin BM, Mayer RJ. Systemic treatment of colorectal cancer. Gastroenterology 2008; 134:1296-310. PMID:18471507 doi:10.1053/j.gastro.2008.02. 098
    • (2008) Gastroenterology , vol.134 , pp. 1296-1310
    • Wolpin, B.M.1    Mayer, R.J.2
  • 14
    • 28444472744 scopus 로고    scopus 로고
    • Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors
    • PMID:16287968 doi:10.1073/pnas.0508888102
    • Gurova KV, Hill JE, Guo C, Prokvolit A, Burdelya LG, Samoylova E, et al. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci USA 2005; 102:17448-53. PMID:16287968 doi:10.1073/pnas.0508888102
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17448-17453
    • Gurova, K.V.1    Hill, J.E.2    Guo, C.3    Prokvolit, A.4    Burdelya, L.G.5    Samoylova, E.6
  • 15
    • 77953533783 scopus 로고    scopus 로고
    • Inhibition of NF-κB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin
    • PMID:20424169 doi:10.1074/jbc.M109.091645
    • Jani TS, DeVecchio J, Mazumdar T, Agyeman A, Houghton JA. Inhibition of NF-κB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin. J Biol Chem 2010; 285:19162-72. PMID:20424169 doi:10.1074/jbc.M109.091645
    • (2010) J Biol Chem , vol.285 , pp. 19162-19172
    • Jani, T.S.1    DeVecchio, J.2    Mazumdar, T.3    Agyeman, A.4    Houghton, J.A.5
  • 16
    • 0001877793 scopus 로고
    • The structure of the DNA-acridine complex
    • PMID:13929834 doi:10.1073/pnas.49.1.94
    • Lerman LS. The structure of the DNA-acridine complex. Proc Natl Acad Sci USA 1963; 49:94-102. PMID:13929834 doi:10.1073/pnas.49.1.94
    • (1963) Proc Natl Acad Sci USA , vol.49 , pp. 94-102
    • Lerman, L.S.1
  • 17
    • 61349176648 scopus 로고    scopus 로고
    • Deciphering the antitumoral activity of quinacrine: Binding to and inhibition of Bcl-xL
    • PMID:19237284 doi:10.1016/j.bmcl.2009.02.020
    • Orzáez M, Mondragón L, García-Jareño A, Mosulén S, Pineda-Lucena A, Pérez-Paya E. Deciphering the antitumoral activity of quinacrine: Binding to and inhibition of Bcl-xL. Bioorg Med Chem Lett 2009; 19:1592-5. PMID:19237284 doi:10.1016/j.bmcl.2009.02.020
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 1592-1595
    • Orzáez, M.1    Mondragón, L.2    García-Jareño, A.3    Mosulén, S.4    Pineda-Lucena, A.5    Pérez-Paya, E.6
  • 18
    • 79955799029 scopus 로고    scopus 로고
    • Beyond DNA binding - A review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
    • In press. PMID:21569639 doi:10.1186/1478-811X-9-13
    • Ehsanian R, Van Waes C, Feller SM. Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers. Cell Commun Signal 2011; 9: In press. PMID:21569639 doi:10.1186/1478-811X-9-13
    • (2011) Cell Commun Signal , vol.9
    • Ehsanian, R.1    Van Waes, C.2    Feller, S.M.3
  • 19
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • PMID:9488723 doi:10.1074/jbc.273.10.5858
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273:5858-68. PMID:9488723 doi:10.1074/jbc.273.10.5858
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 20
    • 0031298259 scopus 로고    scopus 로고
    • Cleavage of poly(ADP-ribose) polymerase: A sensitive parameter to study cell death
    • PMID:9493956 doi:10.1139/o97-043
    • Duriez PJ, Shah GM. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem Cell Biol 1997; 75:337-49. PMID:9493956 doi:10.1139/o97-043
    • (1997) Biochem Cell Biol , vol.75 , pp. 337-349
    • Duriez, P.J.1    Shah, G.M.2
  • 21
    • 26444605834 scopus 로고    scopus 로고
    • IKK/NF-κB signaling: Balancing life and death - A new approach to cancer therapy
    • PMID:16200195 doi:10.1172/JCI26322
    • Luo J-L, Kamata H, Karin M. IKK/NF-κB signaling: balancing life and death - a new approach to cancer therapy. J Clin Invest 2005; 115:2625-32. PMID:16200195 doi:10.1172/JCI26322
    • (2005) J Clin Invest , vol.115 , pp. 2625-2632
    • Luo, J.-L.1    Kamata, H.2    Karin, M.3
  • 23
    • 35548930209 scopus 로고    scopus 로고
    • The emerging roles of forkhead box (Fox) proteins in cancer
    • PMID:17943136 doi:10.1038/nrc2223
    • Myatt SS, Lam EW-F. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 2007; 7:847-59. PMID:17943136 doi:10.1038/nrc2223
    • (2007) Nat Rev Cancer , vol.7 , pp. 847-859
    • Myatt, S.S.1    Lam, E.W.-F.2
  • 24
    • 0032587495 scopus 로고    scopus 로고
    • P27(kip1): A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
    • PMID:10027389 doi:10.1016/S0002-9440(10)65277-7
    • Lloyd RV, Erickson LA, Jin L, Kulig E, Qian X, Cheville JC, et al. P27(kip1): A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 1999; 154:313-23. PMID:10027389 doi:10.1016/S0002-9440(10)65277-7
    • (1999) Am J Pathol , vol.154 , pp. 313-323
    • Lloyd, R.V.1    Erickson, L.A.2    Jin, L.3    Kulig, E.4    Qian, X.5    Cheville, J.C.6
  • 25
    • 11144357466 scopus 로고    scopus 로고
    • IκB Kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • PMID:15084260 doi:10.1016/S0092-8674(04)00302-2
    • Hu MC-T, Lee D-F, Xia W, Golfman LS, Ou-Yang F, Yang J-Y, et al. IκB Kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117:225-37. PMID:15084260 doi:10.1016/S0092-8674(04)00302-2
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.-T.1    Lee, D.-F.2    Xia, W.3    Golfman, L.S.4    Ou-Yang, F.5    Yang, J.-Y.6
  • 26
    • 0030915889 scopus 로고    scopus 로고
    • Enhancement of paclitaxel activity against hormone-refractory prostate in vitro and in vivo by quinacrine
    • PMID:9184173 doi:10.1038/bjc.1997.272
    • de Souza PL, Castillo M, Myers CE. Enhancement of paclitaxel activity against hormone-refractory prostate in vitro and in vivo by quinacrine. Br J Cancer 1997; 75:1593-600. PMID:9184173 doi:10.1038/bjc.1997.272
    • (1997) Br J Cancer , vol.75 , pp. 1593-1600
    • De Souza, P.L.1    Castillo, M.2    Myers, C.E.3
  • 27
    • 36749031733 scopus 로고    scopus 로고
    • Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer
    • PMID:18006756 doi:10.1158/1078-0432.CCR-07-1591
    • Friedman J, Nottigham L, Duggal P, Pernas FG, Yan B, Yang XP, et al. Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer. Clin Cancer Res 2007; 13:6568-78. PMID:18006756 doi:10.1158/1078-0432.CCR-07-1591
    • (2007) Clin Cancer Res , vol.13 , pp. 6568-6578
    • Friedman, J.1    Nottigham, L.2    Duggal, P.3    Pernas, F.G.4    Yan, B.5    Yang, X.P.6
  • 28
    • 79956344228 scopus 로고    scopus 로고
    • FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-κB
    • PMID:21518868 doi:10.1073/pnas.1105369108
    • Guo C, Stark GR. FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-κB. Proc Natl Acad Sci USA 2011; 108:7968-73. PMID:21518868 doi:10.1073/pnas.1105369108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 7968-7973
    • Guo, C.1    Stark, G.R.2
  • 29
    • 0036440658 scopus 로고    scopus 로고
    • Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse
    • PMID:12462986 doi:10.4067/S0716-97602002000300008
    • Illanes J, Dabancens A, Acuña O, Fuenzalida M, Guerrero A, Lopez C, et al. Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse. Biol Res 2002; 35:339-45. PMID:12462986 doi:10.4067/S0716- 97602002000300008
    • (2002) Biol Res , vol.35 , pp. 339-345
    • Illanes, J.1    Dabancens, A.2    Acuña, O.3    Fuenzalida, M.4    Guerrero, A.5    Lopez, C.6
  • 30
    • 65249141108 scopus 로고    scopus 로고
    • Constitutive NF-κB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth
    • PMID:19276252 doi:10.1158/1078-0432.CCR-08-1383
    • Sakamoto K, Maeda S, Hikiba Y, Nakagawa H, Hayakawa Y, Shibata W, et al. Constitutive NF-κB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. Clin Cancer Res 2009; 15:2248-58. PMID:19276252 doi:10.1158/1078-0432.CCR-08-1383
    • (2009) Clin Cancer Res , vol.15 , pp. 2248-2258
    • Sakamoto, K.1    Maeda, S.2    Hikiba, Y.3    Nakagawa, H.4    Hayakawa, Y.5    Shibata, W.6
  • 31
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • PMID:16618717 doi:10.1158/0008-5472.CAN-06-0191
    • Lièvre A, Bachet J-B, Le Corre D, Boige V, Landi B, Emile J-F, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006; 66:3992-5. PMID:16618717 doi:10.1158/0008-5472.CAN-06-0191
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lièvre, A.1    Bachet, J.-B.2    Le Corre, D.3    Boige, V.4    Landi, B.5    Emile, J.-F.6
  • 32
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • PMID:21376230 doi:10.1016/j.cell.2011.02.013
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011; 144:646-74. PMID:21376230 doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 33
    • 42049116091 scopus 로고    scopus 로고
    • Mcl-1: A gateway to TRAIL sensitization
    • PMID:18381408 doi:10.1158/0008-5472.CAN-07-6278
    • Kim SH, Ricci MS, El-Deiry WS. Mcl-1: A gateway to TRAIL sensitization. Cancer Res 2008; 68:2062-4. PMID:18381408 doi:10.1158/0008-5472.CAN-07-6278
    • (2008) Cancer Res , vol.68 , pp. 2062-2064
    • Kim, S.H.1    Ricci, M.S.2    El-Deiry, W.S.3
  • 34
    • 34347246278 scopus 로고    scopus 로고
    • Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death
    • PMID:17613437 doi:10.1016/j.ccr.2007.05.006
    • Ricci MS, Kim SH, Ogi K, Plastaras JP, Ling J, Wang W, et al. Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell 2007; 12:66-80. PMID:17613437 doi:10.1016/j.ccr.2007.05.006
    • (2007) Cancer Cell , vol.12 , pp. 66-80
    • Ricci, M.S.1    Kim, S.H.2    Ogi, K.3    Plastaras, J.P.4    Ling, J.5    Wang, W.6
  • 35
    • 77049248049 scopus 로고
    • The distribution of mepacrine in the organs of animal species, and in the components of liver cells
    • PMID:13329341
    • Snow GA, Hurst EW. The distribution of mepacrine in the organs of animal species, and in the components of liver cells. Br J Pharmacol Chemother 1956; 11:209-14. PMID:13329341
    • (1956) Br J Pharmacol Chemother , vol.11 , pp. 209-214
    • Snow, G.A.1    Hurst, E.W.2
  • 36
    • 33745234824 scopus 로고    scopus 로고
    • Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein
    • PMID:16581945 doi:10.1124/dmd.105.008664
    • Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, et al. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos 2006; 34:1136-44. PMID:16581945 doi:10.1124/dmd.105.008664
    • (2006) Drug Metab Dispos , vol.34 , pp. 1136-1144
    • Huang, Y.1    Okochi, H.2    May, B.C.3    Legname, G.4    Prusiner, S.B.5    Benet, L.Z.6
  • 37
    • 0022969737 scopus 로고
    • Haematogenous metastastic patterns in colonic carcinoma: An analysis of 1541 necropsies
    • PMID:3806280 doi:10.1002/path.1711500308
    • Weiss L, Grundmann E, Torhorst J, Hartveit F, Moberg I, Eder M, et al. Haematogenous metastastic patterns in colonic carcinoma: An analysis of 1541 necropsies. J Pathol 1986; 150:195-203. PMID:3806280 doi:10.1002/path.1711500308
    • (1986) J Pathol , vol.150 , pp. 195-203
    • Weiss, L.1    Grundmann, E.2    Torhorst, J.3    Hartveit, F.4    Moberg, I.5    Eder, M.6
  • 38
    • 33846974021 scopus 로고    scopus 로고
    • Cost of cancer care: Issues and implications
    • PMID:17210937 doi:10.1200/JCO.2006.09.6081
    • Meropol NJ, Schulman KA. Cost of cancer care: Issues and implications. J Clin Oncol 2007; 25:180-6. PMID:17210937 doi:10.1200/JCO.2006.09.6081
    • (2007) J Clin Oncol , vol.25 , pp. 180-186
    • Meropol, N.J.1    Schulman, K.A.2
  • 39
    • 34249801215 scopus 로고    scopus 로고
    • Antimalarials may influence the risk of malignancy in systemic lupus erythematosus
    • PMID:17204564 doi:10.1136/ard.2006.067777
    • Ruiz-Irastorza G, Ugarte A, Egurbide MV, Garmendia M, Pijoan JI, Martinez-Berriotxoa A, et al. Antimalarials may influence the risk of malignancy in systemic lupus erythematosus. Ann Rheum Dis 2007; 66:815-7. PMID:17204564 doi:10.1136/ard.2006.067777
    • (2007) Ann Rheum Dis , vol.66 , pp. 815-817
    • Ruiz-Irastorza, G.1    Ugarte, A.2    Egurbide, M.V.3    Garmendia, M.4    Pijoan, J.I.5    Martinez-Berriotxoa, A.6
  • 40
    • 0031415302 scopus 로고    scopus 로고
    • p53 et cancers colorecteaux
    • PMID:9769952
    • Hamelin R, Laurent-Puig P. p53 et cancers colorecteaux. Pathol Biol (Paris) 1997; 45:876-81. PMID:9769952
    • (1997) Pathol Biol (Paris) , vol.45 , pp. 876-881
    • Hamelin, R.1    Laurent-Puig, P.2
  • 41
    • 0141976400 scopus 로고    scopus 로고
    • Bioluminescent molecular imaging of endogenous and exogenous p53-mediated transcription in vitro and in vivo using an HCT116 human colon carcinoma xenograft model
    • PMID:12750563 doi:10.4161/cbt.2.2.347
    • Wang W, El-Deiry WS. Bioluminescent molecular imaging of endogenous and exogenous p53-mediated transcription in vitro and in vivo using an HCT116 human colon carcinoma xenograft model. Cancer Biol Ther 2003; 2:196-202. PMID:12750563 doi:10.4161/cbt.2.2.347
    • (2003) Cancer Biol Ther , vol.2 , pp. 196-202
    • Wang, W.1    El-Deiry, W.S.2
  • 42
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • PMID:16968952 doi:10.1124/pr.58.3.10
    • Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 2006; 58:621-81. PMID:16968952 doi:10.1124/pr.58.3.10
    • (2006) Pharmacol Rev , vol.58 , pp. 621-681
    • Chou, T.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.