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Volumn 13, Issue 22, 2007, Pages 6568-6578

Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIMALARIAL AGENT; CISPLATIN; DOXORUBICIN; MEPACRINE; MESSENGER RNA; PIFITHRIN ALPHA;

EID: 36749031733     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-1591     Document Type: Article
Times cited : (53)

References (49)
  • 1
    • 33847271089 scopus 로고    scopus 로고
    • Coping with stress: Multiple ways to activate p53
    • Horn HF, Vousden KH. Coping with stress: multiple ways to activate p53. Oncogene 2007;26:1306-16.
    • (2007) Oncogene , vol.26 , pp. 1306-1316
    • Horn, H.F.1    Vousden, K.H.2
  • 2
    • 33847392378 scopus 로고    scopus 로고
    • Wild-type p53: Tumors can't stand it
    • Kastan MB. Wild-type p53: tumors can't stand it. Cell 2007;128:837-40.
    • (2007) Cell , vol.128 , pp. 837-840
    • Kastan, M.B.1
  • 3
    • 0242298117 scopus 로고    scopus 로고
    • Molecular pathogenesis of head and neck squamous cell carcinoma
    • Hardisson D. Molecular pathogenesis of head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol 2003;260:502-8.
    • (2003) Eur Arch Otorhinolaryngol , vol.260 , pp. 502-508
    • Hardisson, D.1
  • 6
    • 0032875181 scopus 로고    scopus 로고
    • Immunohistochemical detection of p53 protein accumulation in head and neck cancer: Correlation with p53 gene alterations
    • Taylor D, Koch WM, Zahurak M, Shah K, Sidransky D, Westra WH. Immunohistochemical detection of p53 protein accumulation in head and neck cancer: correlation with p53 gene alterations. Hum Pathol 1999;30:1221-5.
    • (1999) Hum Pathol , vol.30 , pp. 1221-1225
    • Taylor, D.1    Koch, W.M.2    Zahurak, M.3    Shah, K.4    Sidransky, D.5    Westra, W.H.6
  • 7
    • 0028820663 scopus 로고
    • Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer. Department of Veterans Affairs Laryngeal Cancer Study Group
    • Bradford CR, Zhu S, Wolf GT, et al. Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer. Department of Veterans Affairs Laryngeal Cancer Study Group. Otolaryngol Head Neck Surg 1995;113:408-12.
    • (1995) Otolaryngol Head Neck Surg , vol.113 , pp. 408-412
    • Bradford, C.R.1    Zhu, S.2    Wolf, G.T.3
  • 8
    • 0036060382 scopus 로고    scopus 로고
    • Prognostic value of multidrug resistance 1, glutathione-S-transferase-π and p53 in advanced nasopharyngeal carcinoma treated with systemic chemotherapy
    • Hsu CH, Chen CL, Hong RL, Chen KL, Lin JF, Cheng AL. Prognostic value of multidrug resistance 1, glutathione-S-transferase-π and p53 in advanced nasopharyngeal carcinoma treated with systemic chemotherapy. Oncology 2002;62:305-12.
    • (2002) Oncology , vol.62 , pp. 305-312
    • Hsu, C.H.1    Chen, C.L.2    Hong, R.L.3    Chen, K.L.4    Lin, J.F.5    Cheng, A.L.6
  • 10
    • 0041342137 scopus 로고    scopus 로고
    • P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines
    • Bradford CR, Zhu S, Ogawa H, et al. P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines. Head Neck 2003;25:654-61.
    • (2003) Head Neck , vol.25 , pp. 654-661
    • Bradford, C.R.1    Zhu, S.2    Ogawa, H.3
  • 11
    • 3242670907 scopus 로고    scopus 로고
    • Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
    • Braakhuis BJ, Snijders PJ, Keune WJ, et al. Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J Natl Cancer Inst 2004;96:998-1006.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 998-1006
    • Braakhuis, B.J.1    Snijders, P.J.2    Keune, W.J.3
  • 12
    • 34248350674 scopus 로고    scopus 로고
    • Case-control study of human papillomavirus and oropharyngeal cancer
    • D'Souza G, Kreimer AR, Viscidi R, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007;356:1944-56.
    • (2007) N Engl J Med , vol.356 , pp. 1944-1956
    • D'Souza, G.1    Kreimer, A.R.2    Viscidi, R.3
  • 13
    • 0642375751 scopus 로고    scopus 로고
    • Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer
    • Yeh KT, Chang JG, Lin TH, et al. Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer. Oncol Rep 2003;10:659-63.
    • (2003) Oncol Rep , vol.10 , pp. 659-663
    • Yeh, K.T.1    Chang, J.G.2    Lin, T.H.3
  • 14
    • 26444582203 scopus 로고    scopus 로고
    • The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms
    • Bolt J, Vo QN, Kim WJ, et al. The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms. Oral Oncol 2005;41:1013-20.
    • (2005) Oral Oncol , vol.41 , pp. 1013-1020
    • Bolt, J.1    Vo, Q.N.2    Kim, W.J.3
  • 15
    • 9444255067 scopus 로고    scopus 로고
    • High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma
    • Reed AL, Califano J, Cairns P, et al. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 1996;56:3630-3.
    • (1996) Cancer Res , vol.56 , pp. 3630-3633
    • Reed, A.L.1    Califano, J.2    Cairns, P.3
  • 16
    • 0036373788 scopus 로고    scopus 로고
    • INK4a-ARF alterations and p53 mutations in primary and consecutive squamous cell carcinoma of the head and neck
    • Weber A, Bellmann U, Bootz F, Wittekind C, Tannapfel A. INK4a-ARF alterations and p53 mutations in primary and consecutive squamous cell carcinoma of the head and neck. Virchows Arch 2002;441:133-42.
    • (2002) Virchows Arch , vol.441 , pp. 133-142
    • Weber, A.1    Bellmann, U.2    Bootz, F.3    Wittekind, C.4    Tannapfel, A.5
  • 17
    • 0037102370 scopus 로고    scopus 로고
    • Molecular changes associated with oral dysplasia progression and acquisition of immortality: Potential for reversal by 5-azacytidine
    • McGregor F, Muntoni A, Fleming J, et al. Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for reversal by 5-azacytidine. Cancer Res 2002;62:4757-66.
    • (2002) Cancer Res , vol.62 , pp. 4757-4766
    • McGregor, F.1    Muntoni, A.2    Fleming, J.3
  • 18
    • 2442622595 scopus 로고    scopus 로고
    • 5-aza-2′-deoxycytidine activates the p53/p21 Waf1/Cip1 pathway to inhibit cell proliferation
    • Zhu WG, Hileman T, Ke Y, et al. 5-aza-2′-deoxycytidine activates the p53/p21 Waf1/Cip1 pathway to inhibit cell proliferation. J Biol Chem 2004;279:15161-6.
    • (2004) J Biol Chem , vol.279 , pp. 15161-15166
    • Zhu, W.G.1    Hileman, T.2    Ke, Y.3
  • 20
    • 0027500246 scopus 로고
    • Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
    • Fritsche M, Haessler C, Brandner G. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 1993;8:307-18.
    • (1993) Oncogene , vol.8 , pp. 307-318
    • Fritsche, M.1    Haessler, C.2    Brandner, G.3
  • 21
    • 11144234525 scopus 로고    scopus 로고
    • Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species
    • Kurz EU, Douglas P, Lees-Miller SP. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. J Biol Chem 2004;279:53272-81.
    • (2004) J Biol Chem , vol.279 , pp. 53272-53281
    • Kurz, E.U.1    Douglas, P.2    Lees-Miller, S.P.3
  • 22
    • 28444472744 scopus 로고    scopus 로고
    • Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors
    • Gurova KV, Hill JE, Guo C, et al. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci U S A 2005;102:17448-53.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17448-17453
    • Gurova, K.V.1    Hill, J.E.2    Guo, C.3
  • 23
    • 25144506616 scopus 로고    scopus 로고
    • Acridine derivatives activate p53 and induce tumor cell death through Bax
    • Wang W, Ho WC, Dicker DT, et al. Acridine derivatives activate p53 and induce tumor cell death through Bax. Cancer Biol Ther 2005;4:893-8.
    • (2005) Cancer Biol Ther , vol.4 , pp. 893-898
    • Wang, W.1    Ho, W.C.2    Dicker, D.T.3
  • 24
    • 0033017066 scopus 로고    scopus 로고
    • Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer
    • Chen Z, Malhotra PS, Thomas GR, et al. Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res 1999;5:1369-79.
    • (1999) Clin Cancer Res , vol.5 , pp. 1369-1379
    • Chen, Z.1    Malhotra, P.S.2    Thomas, G.R.3
  • 25
    • 0035421326 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
    • Dong G, Chen Z, Li ZY, Yeh NT, Bancroft CC, Van Waes C. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res 2001;61:5911-8.
    • (2001) Cancer Res , vol.61 , pp. 5911-5918
    • Dong, G.1    Chen, Z.2    Li, Z.Y.3    Yeh, N.T.4    Bancroft, C.C.5    Van Waes, C.6
  • 26
    • 33746160746 scopus 로고    scopus 로고
    • Protein kinase casein kinase 2 mediates inhibitor-κB kinase and aberrant nuclear factor-κB activation by serumfactor(s) in head and neck squamous carcinoma cells
    • Yu M, Yeh J, VanWaes C. Protein kinase casein kinase 2 mediates inhibitor-κB kinase and aberrant nuclear factor-κB activation by serumfactor(s) in head and neck squamous carcinoma cells. Cancer Res 2006;66:6722-31.
    • (2006) Cancer Res , vol.66 , pp. 6722-6731
    • Yu, M.1    Yeh, J.2    VanWaes, C.3
  • 27
    • 34548815292 scopus 로고    scopus 로고
    • Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, NF-κB and other signal transcription factors in head and neck squamous cell carcinoma
    • Yan B, Yang X, Lee TL, et al. Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, NF-κB and other signal transcription factors in head and neck squamous cell carcinoma. Genome Biol 2007;8:R78.
    • (2007) Genome Biol , vol.8
    • Yan, B.1    Yang, X.2    Lee, T.L.3
  • 28
    • 23844435559 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma
    • Worden B, Yang XP, Lee TL, et al. Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma. Cancer Res 2005;65:7071-80.
    • (2005) Cancer Res , vol.65 , pp. 7071-7080
    • Worden, B.1    Yang, X.P.2    Lee, T.L.3
  • 29
    • 33644867711 scopus 로고    scopus 로고
    • Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas
    • Lee TL, Yeh J, Van Waes C, Chen Z. Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas. Mol Cancer Ther 2006;5:8-19.
    • (2006) Mol Cancer Ther , vol.5 , pp. 8-19
    • Lee, T.L.1    Yeh, J.2    Van Waes, C.3    Chen, Z.4
  • 30
    • 27644590943 scopus 로고    scopus 로고
    • Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry
    • Nenutil R, Smardova J, Pavlova S, et al. Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry. J Pathol 2005;207:251-9.
    • (2005) J Pathol , vol.207 , pp. 251-259
    • Nenutil, R.1    Smardova, J.2    Pavlova, S.3
  • 31
    • 0036145018 scopus 로고    scopus 로고
    • Multiple roles of the tumor suppressor p53
    • Bargonetti J, Manfredi JJ. Multiple roles of the tumor suppressor p53. Curr Opin Oncol 2002;14:86-91.
    • (2002) Curr Opin Oncol , vol.14 , pp. 86-91
    • Bargonetti, J.1    Manfredi, J.J.2
  • 32
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 33
    • 0033543728 scopus 로고    scopus 로고
    • A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
    • Komarov PG, Komarova EA, Kondratov RV, et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999;285:1733-7.
    • (1999) Science , vol.285 , pp. 1733-1737
    • Komarov, P.G.1    Komarova, E.A.2    Kondratov, R.V.3
  • 34
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002;296:550-3.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 35
    • 0026487109 scopus 로고
    • Low p53 level in immortal, non-tumorigenic oral keratinocytes harboring HPV-16 DNA
    • Li SL, Kim MS, Cherrick HM, Park NH. Low p53 level in immortal, non-tumorigenic oral keratinocytes harboring HPV-16 DNA. Eur J Cancer B Oral Oncol 1992;28B:129-34.
    • (1992) Eur J Cancer B Oral Oncol , vol.28 B , pp. 129-134
    • Li, S.L.1    Kim, M.S.2    Cherrick, H.M.3    Park, N.H.4
  • 36
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-36.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 37
    • 0036599406 scopus 로고    scopus 로고
    • p53 stabilization is decreased upon NFκB activation: A role for NFκB in acquisition of resistance to chemotherapy
    • Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. p53 stabilization is decreased upon NFκB activation: a role for NFκB in acquisition of resistance to chemotherapy. Cancer Cell 2002;1:493-503.
    • (2002) Cancer Cell , vol.1 , pp. 493-503
    • Tergaonkar, V.1    Pando, M.2    Vafa, O.3    Wahl, G.4    Verma, I.5
  • 38
    • 0034702232 scopus 로고    scopus 로고
    • Compromised HOXA5 function can limit p53 expression in human breast tumours
    • Raman V, Martensen SA, Reisman D, et al. Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature 2000;405:974-8.
    • (2000) Nature , vol.405 , pp. 974-978
    • Raman, V.1    Martensen, S.A.2    Reisman, D.3
  • 39
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998;92:725-34.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 40
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • Banin S, Moyal L, Shieh S, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998;281:1674-7.
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1    Moyal, L.2    Shieh, S.3
  • 41
    • 0032954928 scopus 로고    scopus 로고
    • Transcriptional cross talk between NF-κB and p53
    • Webster GA, Perkins ND. Transcriptional cross talk between NF-κB and p53. Mol Cell Biol 1999;19:3485-95.
    • (1999) Mol Cell Biol , vol.19 , pp. 3485-3495
    • Webster, G.A.1    Perkins, N.D.2
  • 43
    • 35348918435 scopus 로고    scopus 로고
    • A novel NF-κB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status
    • Lee TL, Yang XP, Yan B, et al. A novel NF-κB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status. Clin Cancer Res 2007;13:5680-91.
    • (2007) Clin Cancer Res , vol.13 , pp. 5680-5691
    • Lee, T.L.1    Yang, X.P.2    Yan, B.3
  • 44
    • 0036024720 scopus 로고    scopus 로고
    • Acridine derivatives as chemotherapeutic agents
    • Denny, WA. Acridine derivatives as chemotherapeutic agents. Curr Med Chem 2002;9:1655-65.
    • (2002) Curr Med Chem , vol.9 , pp. 1655-1665
    • Denny, W.A.1
  • 45
    • 0020033516 scopus 로고
    • Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine antitumor agents
    • Denny WA, Cain BF, Atwell GJ, Hansch C, Panthananickal A, Leo A. Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine antitumor agents. J Med Chem 1982;25:276-315.
    • (1982) J Med Chem , vol.25 , pp. 276-315
    • Denny, W.A.1    Cain, B.F.2    Atwell, G.J.3    Hansch, C.4    Panthananickal, A.5    Leo, A.6
  • 46
    • 0018166959 scopus 로고
    • Phase 1 clinical investigation of 4′-(9-acridinylamino)methanesulfon-m-anisidide (NSC 249992), a new acridine derivative
    • Legha SS, Gutterman JU, Hall SW, et al. Phase 1 clinical investigation of 4′-(9-acridinylamino)methanesulfon-m-anisidide (NSC 249992), a new acridine derivative. Cancer Res 1978;38:3712-6.
    • (1978) Cancer Res , vol.38 , pp. 3712-3716
    • Legha, S.S.1    Gutterman, J.U.2    Hall, S.W.3
  • 47
    • 0019523932 scopus 로고
    • Initial experience with AMSA as single agent treatment against malignant lymphoproliferative disorders
    • Cabanillas F, Legha SS, Bodey GP, Freireich EJ. Initial experience with AMSA as single agent treatment against malignant lymphoproliferative disorders. Blood 1981;57:614-6.
    • (1981) Blood , vol.57 , pp. 614-616
    • Cabanillas, F.1    Legha, S.S.2    Bodey, G.P.3    Freireich, E.J.4
  • 48
    • 0023218399 scopus 로고    scopus 로고
    • Sebolt JS, Scavone SV, Pinter CD, Hamelehle KL, Von Hoff DD, Jackson RC. Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro. Cancer Res 1987;47:4299-304.
    • Sebolt JS, Scavone SV, Pinter CD, Hamelehle KL, Von Hoff DD, Jackson RC. Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro. Cancer Res 1987;47:4299-304.
  • 49
    • 0029045628 scopus 로고
    • Phase I and pharmacologic studies of pyrazoloacridine, a novel DNA intercalating agent, on single-dosing and multiple-dosing schedules
    • Rowinsky EK, Noe DA, Grochow LB, et al. Phase I and pharmacologic studies of pyrazoloacridine, a novel DNA intercalating agent, on single-dosing and multiple-dosing schedules. J Clin Oncol 1995;13:1975-84.
    • (1995) J Clin Oncol , vol.13 , pp. 1975-1984
    • Rowinsky, E.K.1    Noe, D.A.2    Grochow, L.B.3


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