To go or not to go: The "itchy" effect on the destiny of hematopoietic stem cells

Cell Research

Volumn 21, Issue 8, 2011, Pages 1161-1163

  Aki, Daisuke ^a   Liu, Yun Cai ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ITCH PROTEIN, MOUSE; NOTCH RECEPTOR; UBIQUITIN PROTEIN LIGASE;

ANIMAL; ARTICLE; CYTOLOGY; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; CYTOKINES; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 79961208901     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.95     Document Type: Article

References (15)

1. Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem 1998; 67:425-479. (Pubitemid 28411135)
2. Rathinam C, Thien CB, Langdon WY, Gu H, Flavell RA. The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. Genes Dev 2008; 8:992-997. (Pubitemid 351544238)
3. Matsuoka S, Oike Y, Onoyama I, et al. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of TALL. Genes Dev 2008; 8:986-991. (Pubitemid 351544237)
4. Thompson BJ, Jankovic V, Gao J, et al. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med 2008; 6:1395-1408. (Pubitemid 351831495)
5. Rathinam C, Matesic LE, Flavell RA. The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells. Nat Immunol 2011; 5:399-407.
6. Shizuru JA, Negrin RS, Weissman IL. Hematopoietic stem and progenitor cells: Clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med 2005; 56:509-538. (Pubitemid 40305275)
7. Blank U, Karlsson G, Karlsson S. Signaling pathways governing stem-cell fate. Blood 2008; 2:492-503.
8. Radtke F, Fasnacht N, Macdonald HR. Notch signaling in the immune system. Immunity 2010; 1:14-27.
9. Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003; 6960:841-846. (Pubitemid 37351468)
10. Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 2002; 7:2369-2378. (Pubitemid 34525422)
11. Duncan AW, Rattis FM, DiMascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 2005; 3:314-322. (Pubitemid 41724769)
12. Qiu L, Joazeiro C, Fang N, et al. Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. J Biol Chem 2000; 46:35734-35737.
13. Matesic LE, Haines DC, Copeland NG, Jenkins NA. Itch genetically interacts with Notch1 in a mouse autoimmune disease model. Hum Mol Genet 2006; 24:3485-3497. (Pubitemid 44884116)
14. Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: Balancing proliferation and quiescence. Cell Cycle 2008; 5:586-591. (Pubitemid 351506325)
15. Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol 2008; 5:380-390. (Pubitemid 351595220)