Enhancement of Toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells

Immunology

Volumn 134, Issue 1, 2011, Pages 73-81

  Kim, Eugene ^a   Hong, Hye Jin ^a   Cho, Daeho ^b   Han, Jung Min ^c   Kim, Sunghoon ^c   Kim, Tae Sung ^a  

^a Korea University   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Aminoacyl tRNA synthetase interacting protein 1; Cytokines; Dendritic cells; Rodent; Toll like receptor 2; Toll like receptor 2 agonist

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CD40 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; RECOMBINANT AMINOACYL TRNA SYNTHETASE INTERACTING PROTEIN 1; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 6; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BONE MARROW DERIVED DENDRITIC CELL; CELL THERAPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; DENDRITIC CELL; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; CYSTEINE; CYTOKINES; DENDRITIC CELLS; DNA; DOWN-REGULATION; GENE EXPRESSION; IMMUNITY, INNATE; INTERLEUKIN-12; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIPOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRILES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGNAL TRANSDUCTION; SULFONES; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 79961207903     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2011.03468.x     Document Type: Article

References (28)

1. Miyake K. Endotoxin recognition molecules MD-2 and toll-like receptor 4 as potential targets for therapeutic intervention of endotoxin shock. Curr Drug Targets Inflamm Allergy 2004; 3:291-7.
2. Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006; 117:979-87.
3. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005; 17:1-14.
4. Beutler B. TLR4: central component of the sole mammalian LPS sensor. Curr Opin Immunol 2000; 12:20-6.
5. Quevillon S, Agou F, Robinson JC, Mirande M. The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. J Biol Chem 1997; 272:32573-9.
6. Park SG, Kang YS, Ahn YH et al. Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. J Biol Chem 2002; 277:45243-8.
7. Lee YS, Han JM, Kang T, Park YI, Kim HM, Kim S. Antitumor activity of the novel human cytokine AIMP1 in an in vivo tumor model. Mol Cells 2006; 21:213-7.
8. Ko YG, Park H, Kim T et al. A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes. J Biol Chem 2001; 276:23028-33.
9. Park SG, Shin H, Shin YK, Lee Y, Choi EC, Park BJ, Kim S. The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am J Pathol 2005; 166:387-98.
10. Barnett G, Jakobsen AM, Tas M, Rice K, Carmichael J, Murray JC. Prostate adenocarcinoma cells release the novel proinflammatory polypeptide EMAP-II in response to stress. Cancer Res 2000; 60:2850-7.
11. Kim E, Kim SH, Kim S, Cho D, Kim TS. AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability. J Immunol 2008; 180:2894-902.
12. Park SG, Kang YS, Kim JY et al. Hormonal activity of AIMP1/p43 for glucose homeostasis. Proc Natl Acad Sci USA 2006; 103:14913-8.
13. Journeay WS, Janardhan KS, Singh B. Expression and function of endothelial monocyte-activating polypeptide-II in acute lung inflammation. Inflamm Res 2007; 56:175-81.
14. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176:1693-702.
15. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983; 11:1475-89.
16. Kim TS, DeKruyff RH, Rupper R, Maecker HT, Levy S, Umetsu DT. An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production. J Immunol 1997; 158:4137-44.
17. Fan J, Frey RS, Malik AB. TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J Clin Invest 2003; 112:1234-43.
18. Qureshi ST, Lariviere L, Leveque G, Clermont S, Moore KJ, Gros P, Malo D. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 1999; 189:615-25.
19. An H, Yu Y, Zhang M et al. Involvement of ERK, p38 and NF-κB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells. Immunology 2002; 106:38-45.
20. Wang T, Lafuse WP, Zwilling BS. NF-κB and Sp1 elements are necessary for maximal transcription of toll-like receptor 2 induced by Mycobacterium avium. J Immunol 2001; 167:6924-32.
21. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388:394-7.
22. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001; 2:675-80.
23. Wang T, Lafuse WP, Zwilling BS. Regulation of toll-like receptor 2 expression by macrophages following Mycobacterium avium infection. J Immunol 2000; 165:6308-13.
24. Schluesener HJ, Seid K, Zhao Y, Meyermann R. Localization of endothelial-monocyte-activating polypeptide II (EMAP II), a novel proinflammatory cytokine, to lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis: expression by monocytes and activated microglial cells. Glia 1997; 20:365-72.
25. Farez MF, Quintana FJ, Gandhi R, Izquierdo G, Lucas M, Weiner HL. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat Immunol 2009; 10:958-64.
26. Barrenschee M, Lex D, Uhlig S. Effects of the TLR2 agonists MALP-2 and Pam3Cys in isolated mouse lungs. PLoS ONE 2010; 5:e13889.
27. Kirschning CJ, Schumann RR. TLR2: cellular sensor for microbial and endogenous molecular patterns. Curr Top Microbiol Immunol 2002; 270:121-44.
28. Brondyk WH. Selecting an appropriate method for expressing a recombinant protein. Methods Enzymol 2009; 463:131-47.