Gestational Cadmium Exposure-Induced Ovotoxicity Delays Puberty through Oxidative Stress and Impaired Steroid Hormone Levels

Journal of Medical Toxicology

Volumn 7, Issue 3, 2011, Pages 195-204

  Samuel, Jawahar B ^a   Stanley, Jone A ^b,d   Princess, Rajendran A ^a   Shanthi, Paulraj ^a   Sebastian, Maria S ^c  

^a St John's College   (India)

^b UNIVERSITY OF MADRAS   (India)

^c ST XAVIER S COLLEGE AUTONOMOUS   (India)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Anemia; Cadmium; Ovary; Oxidative stress; Puberty

Indexed keywords

CADMIUM; CATALASE; DRINKING WATER; ESTRADIOL; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HEMOGLOBIN; HYDROGEN PEROXIDE; PROGESTERONE; STEROID; SUPEROXIDE DISMUTASE; TESTOSTERONE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELAYED PUBERTY; ENZYME ACTIVITY; ERYTHROCYTE COUNT; ESTRUS CYCLE; FEMALE; FLUID INTAKE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; LIPID PEROXIDATION; MEAN CORPUSCULAR HEMOGLOBIN; NONHUMAN; ORGAN WEIGHT; OVARY TOXICITY; OVARY WEIGHT; OXIDATIVE STRESS; PRENATAL DRUG EXPOSURE; RAT; REPRODUCTIVE TOXICITY; SEXUAL MATURATION; STEROID BLOOD LEVEL; TESTOSTERONE BLOOD LEVEL; WEIGHT REDUCTION;

ANIMALS; ANTIOXIDANTS; BLOOD CELL COUNT; BODY WEIGHT; CADMIUM; ENZYMES; ESTROUS CYCLE; FEMALE; HORMONES; HYDROGEN PEROXIDE; LIPID PEROXIDATION; ORGAN SIZE; OVARIAN DISEASES; OVARY; OXIDATIVE STRESS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REPRODUCTION; SEXUAL MATURATION; STEROIDS;

EID: 79961171902     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-011-0143-9     Document Type: Article

References (47)

1. WHO (1992) Cadmium, environmental health criteria no. 134. WHO, Geneva.
2. Gaweda E (2003) Chemical hazards induced by heavy metals refining processes. Med Pr 54: 543-548.
3. Henson MC, Anderson MB (2000) The effects of cadmium on placental endocrine function. Recent Res Dev Endocrinol 1: 37-47.
4. Massanyi P, Lukac N, Uhrin V et al (2007) Female reproductive toxicology of cadmium. Acta Biol Hung 58: 287-299.
5. Varga B, Zsolnai B, Paksy K, Naray M, Ungvary G (1993) Age dependent accumulation of cadmium in the human ovary. Reprod Toxicol 7: 225-228.
6. Jancova A, Massanyi P, Nad P et al (2006) Accumulation of heavy metals in selected organs of yellow-necked mouse. Ekologia 25: 19-26.
7. Korenekova B, Skalicka M, Nad P (2002) Cadmium exposure of cattle after long-term emission from polluted area. Trace Elem Electrolytes 19: 97-99.
8. Bhattacharyya MH, Wilson AK, Rajan SS, Jonah M (2000) Biochemical pathways in cadmium toxicity. In: Zalup RK, Koropatnick J (eds) Molecular biology and toxicology of metals. Taylor and Francis, London, pp 1-74.
9. U. S. Geological Survey 2010, Mineral Commodity Summaries; 36-37.
10. Sethi PK, Khandelwal D (2006) Cadmium exposure: health hazards of silver cottage industry in developing countries. J Med Toxicol 2: 14-15.
11. Panchal L, Vaideeswar P (2006) Acute lung injury due to cadmium inhalation-a case report. Indian J Pathol Microbiol 49: 265-266.
12. Henson MC, Chendrese PJ (2004) Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med 229: 383-392.
13. Bhattacharyya MH, Whelton BD, Peterson DP (1982) Gastrointestinal absorption of cadmium in mice during gestation and lactation. II. Continuous exposure studies. Toxicol Appl Pharmacol 66: 368-375.
14. Whelton BD, Toomey JM, Bhattacharyya MH (1993) Cadmium-109 metabolism in mice. IV. Diet versus maternal stores as a source of cadmium transfer to mouse fetuses and pups during gestation and lactation. J Toxicol Environ Health 40: 531-546.
15. Ekine RS, Agu GO (2005) Fetal contamination with cadmium following chronic exposure of rat dams during gestation. Afr J Appl Zool Environ Biol 7: 120-124.
16. Samawarickrama GP, Webb M (1981) The acute toxicity and teratogenecity of cadmium in pregnant rat. J Appl Toxicol 1: 264-269.
17. Levin A, Miller RK (1981) Fetal toxicity of cadmium in the rat: decreased utero-placental blood flow. Toxicol Appl Pharmacol 58: 297-306.
18. Salpietro CD, Gangemi S, Minciullo PL, Briuglia S, Merlino MV, Stelitano A, Cristani M, Trombetta D, Saija A (2002) Cadmium concentration in maternal and cord blood and infant birth weight: a study on healthy non-smoking women. J Perinat Med 30: 395-399.
19. Laudanski T, Sipowicz M, Modzelewski P, Bolinski J, Szamatowicz J, Razniewska G, Akerlund M (1991) Influence of high lead and cadmium soil content on human reproductive outcome. Int J Gynecol Obstet 366: 309-315.
20. Samuel JB, Stanley JA, Roopha DP, Vengatesh G, Anbalagan J, Banu SK, Aruldhas MM (2011) Lactational hexavalent chromium exposure-induced oxidative stress in rat uterus is associated with delayed puberty and impaired gonadotropin levels. Hum Exp Toxicol 30: 91-101.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
22. Marklund S, Marklund G (1974) Involvement of super oxide anion radical in the auto oxidation of pyrogallol and a convenient assay for super oxide dismutase. Eu J Biochem 47: 469-474.
23. Sinha AK (1972) Colorimetric assay of catalase. Anal Biochem 47: 389-394.
24. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179: 588-590.
25. Habig WH, Pabst MJ, Jakoby WB (1973) Glutathione-S-tranferase. The first enzymatic step in mercapturic formation. J Biol Chem 249: 7130-7139.
26. Stall GEJ, Vegel C (1969) Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 185: 39-48.
27. Devasagayam TPA, Tarachand V (1987) Decreased lipid peroxidation in the rat kidney during gestation. Biochem Biophys Res Comm 145: 134-138.
28. Banu SK, Samuel JB, Arosh AJ, Burghard CR, Aruldhas MM (2008) Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Toxicol Appl Pharmacol 232: 180-189.
29. Nampoothiri LP, Agarwal A, Gupta S (2007) Effect of co-exposure to lead and cadmium on antioxidant status in rat ovarian granulose cells. Arch Toxicol 81: 145-150.
30. Royce R, Samuel JB, Arosh JA, Lee J, Aruldhas MM, Banu SK (2007) Chromium toxicity induces ovarian follicular developmental arrest, apoptosis, and deregulated steroidogenesis: vitamin C restores follicular survival and function. Biol Reprod 77: 215.
31. Ronco AM, Urrutia M, Montenegro M, Llanos MN (2009) Cadmium exposure during pregnancy reduces birth weight and increases maternal and foetal glucocorticoids. Toxicol Lett 188: 186-191.
32. Parizek J (1983) Cadmium and reproduction: a perspective after 25 years. In: Clarkson TW, Nordberg GF, Sager PR (eds) Reproductive and developmental toxicity of metals. Plenum, New York, pp 310-313.
33. Paksy K, Rajczy K, Forgacs Z, Lazar P, Bernard A, Gati I, Kaali GS (1997) Effect of cadmium on morphology and steroidogenesis of cultured human ovarian granulosa cells. J Appl Toxicol 17: 321-327.
34. Priya PN, Pillai A, Gupta S (2004) Effect of simultaneous exposure to lead and cadmium on gonadotropin binding and steroidogenesis on granulosa cells: an in vitro study. Indian J Exp Biol 42: 143-148.
35. Lohmiller JL, Swing SP (2006) Reproduction and breeding. In: Suckow MA, Weisbroth SH, Franklin CL (eds) The laboratory rat, 2nd edn. Elsevier Academic, California, pp 147-164.
36. Larsson A, Haux C, Sjobeck ML (1985) Fish physiology and metal pollution: results and experiences from laboratory and field studies. Ecotoxicol Environ Saf 9: 250-281.
37. ATSDR (1999) Toxicological profile for cadmium. Agency for Toxic Substances and Disease Registry, Atlanta.
38. Dallak M (2009) Camel's milk protects against cadmium chloride-induced hypocromic microcytic anemia and oxidative stress in red blood cells of white albino rats. Am J Pharmacol Toxicol 4: 134-141.
39. Stohs SJ, Bagchi D, Hassoun E, Bagchi M (2001) Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol 20: 77-88.
40. Sugino N, Shimamura K, Takiguchi S (1996) Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and in early pregnancy. Hum Reprod 1: 1073-1078.
41. Sugiyama M (1994) Role of cellular antioxidants in metal-induced damage. Cell Biol Toxicol 10: 1-22.
42. Stajn A, Zikic RV, Ognjanovic B, Saicic ZS, Pavlovic SZ, Kostic MM, Petrovic VM (1997) Effect of cadmium and selenium on the antioxidant defense system in rat kidneys. Comp Biochem Physiol 117: 167-172.
43. Sarkar S, Yadav P, Bhatnagar D (1998) Lipid peroxidative damage on cadmium exposure and alterations in antioxidant system in rat erythrocytes: a study with relation to time. Biometals 11: 153-157.
44. Casalino E, Sblano C, Landriscina C (1996) A possible mechanism for initiation of lipid peroxidation by ascorbate in rat liver microsomes. Int J Biochem Cell Biol 28: 137-149.
45. Samanta L, Roy A, Chainy GBN (1999) Changes in rat testicular antioxidant defense profile as a function of age and its impairment by hexachlorocyclohexane during critical stages of maturation. Andrologia 31: 84-90.
46. Massanyi P, Uhrin V, Sirotkin AV, Toman R, Pivko J, Rafay J, Forgacs Z, Somosy Z (2000) Effects of cadmium on ultrastructure and steroidogenesis in cultured porcine ovarian granulosa cells. Acta Vet Brno 69: 101-106.
47. Gurel E, Caner M, Bayraktar L, Yilmazer N, Dogruman H, Demirci C (2007) Effects of artichoke extract supplementation on gonads of cadmium-treated rats. Biol Trace Elem Res 119: 51-59.