Cadmium exposure during pregnancy reduces birth weight and increases maternal and foetal glucocorticoids

Toxicology Letters

Volumn 188, Issue 3, 2009, Pages 186-191

  Ronco, A M ^a   Urrutia, M ^a   Montenegro, M ^a   Llanos, M N ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

11 HSD2; Birth weight; Cadmium; Corticosterone; Placenta

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; CADMIUM; CADMIUM CHLORIDE; CORTICOSTERONE; DRINKING WATER; GLUCOCORTICOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; FEMALE; FETUS; FETUS BLOOD; KIDNEY; LIVER; LOW BIRTH WEIGHT; MASS SPECTROMETRY; MATERNAL BLOOD; NONHUMAN; PLACENTA; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOMETRY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; BIRTH WEIGHT; CADMIUM CHLORIDE; CORTICOSTERONE; ENVIRONMENTAL POLLUTANTS; FEMALE; FETAL BLOOD; FETAL DEVELOPMENT; MATERNAL EXPOSURE; PLACENTA; PREGNANCY; RATS; RATS, WISTAR;

RATTUS; RODENTIA;

EID: 67349132830     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.04.008     Document Type: Article

References (51)

1. Ahokas R.A., Dilts P.V., and La Haye E.B. Cadmium-induced fetal growth retardation: protective effect of excess dietary zinc. Am. J. Obstet. Gynecol. 136 (1980) 216-221
2. Ali M.M., Murthy R.C., and Chandra S.V. Developmental and longterm neurobehavioral toxicity of low level in-utero cadmium exposure in rats. Neurobehav. Toxicol. Teratol. 8 (1986) 463-468
3. Benediktsson R., Calder A.A., Edwards C.R., and Seckl J.R. Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clin. Endocrinol. (Oxf.) 46 (1997) 161-166
4. Bhattacharyya M.H., Wilson A.K., Rajan S.S., and Jonah M. Biochemical pathways in cadmium toxicity. In: Zalup R.K., and Joropatnick J. (Eds). Molecular Biology and Toxicology of Metals (2000), Taylor and Francis, London 1-74
5. Economides D.L., Nicolaides K.H., Linton E.A., Perry L.A., and Chard T. Plasma cortisol and adrenocorticotropin in appropriate and small for gestational age fetuses. Fetal Ther. 3 (1988) 158-164
6. Edwards C.R.W., Benediktsson R., Lindsay R., and Seckl J.R. Dysfunction of the placental glucocorticoid barrier: a link between the foetal environment and adult hypertension?. Lancet 341 (1993) 355-357
7. Escher G., Vogt B., Beck T., Guntern D., Frey B.M., and Frey F.J. Reduced 11β-hydroxysteroid dehydrogenase activity in the remaining kidney following nephrectomy. Endocrinology 139 (1998) 1533-1539
8. Gagnon R. Placental insufficiency and its consequences. Eur. J. Obstet. Gynecol. Reprod. Biol. 110 (2003) S99-107
9. Gicquel C., El-Osta A., and Le-Bouc Y. Epigenetic regulation and fetal programming. Best Prac. Res. Clin. Endocrinol. Metab. 22 (2008) 1-16
10. Gilbert J.S., and Nijland M.J. Sex differences in the developmental origins of hypertension and cardiorenal disease. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 (2008) R1941-R1952
11. Goland R., Jozak S., Warren W., Conwell I., Stark R., and Tropper P. Elevated levels of umbilical cord plasma corticotrophin-releasing hormone in growth-retarded fetuses. J. Clin. Endocrinol. Metab. 77 (1993) 1174-1179
12. Goulet B.N., and Hontela A. Toxicity of cadmium, endosulfan, and atrazine in adrenal steroidogenic cells of two amphibian species, Xenopus laevis and Rana catesbeiana. Environ. Toxicol. Chem. 22 (2003) 2106-2113
13. Hazelhoff R.W., Roelofsen A.M., Herber R.F., Leene W., and Copius Peereboom-Stegeman J.H. Effects of chronic cadmium administration on placental and fetal development. J. Trace Elem. Electrolytes Health Dis. 1 (1987) 49-53
14. Henson M.C., and Chedrese P.J. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp. Biol. Med. 229 (2004) 383-392
15. Herba E., Pojda-Wilczek D., Pojda S.M., Brus R., and Piech A. The effect of prenatal exposure to cadmium on flash visual evoked potentials in rat offspring before and after injection of norepinephrine into the lateral brain ventricle. Klin. Oczna. 102 (2000) 233-236
16. Hidalgo J., and Armario A. Effect of Cd administration on the pituitary-adrenal axis. Toxicology 45 (1987) 113-116
17. Houdijk E.C.A.M., Engelbregyt M.J.T., Popp-Snijders C., and Delemarre-Vd Waal H.A. Endocrine regulation and extended follow up of longitudinal growth in intrauterine growth-retarded rats. J. Endocrinol. 166 (2000) 599-608
18. Jarup L., Berglund M., Elinder C.G., Nordberg G., and Vahter M. Health effects of cadmium exposure-a review of the literature and risk estimate. Scand. J. Work Environ. Health 24 Suppl. 1 (1998) 1-52
19. Jihen, el H., Irmed M., Fatima H., and Abdelhamid K. Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food Chem. Toxicol. 46 (2008) 3522-3527
20. Kajantie E., Dunkel L., Turpeinen U., Stenman U.H., Wood P.J., Nuutila M., and Anderson S. Placental 11beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants. J. Clin. Endocrinol. Metab. 88 (2003) 493-500
21. Kajantie E., Feldt K., Räikkönen K., Phillips D.I., Osmond C., Heinonen K., Pesonen A.K., Andersson S., Barker D.J., and Eriksson J.G. Body size at birth predicts hypothalamic-pituitary-adrenal axis response to psychosocial stress at age 60 to 70 years. J. Endocrinol. Metab. 92 (2007) 4094-4100
22. Kawai M., Swan K.F., Green A.E., Edwards D.E., Anderson M.B., and Henson M.C. Placental endocrine disruption induced by cadmium: effects on P450 cholesterol side-chain cleavage and 3β-hydroxysteroid dehydrogenase enzymes in cultured human trophoblasts. Biol. Reprod. 67 (2002) 178-183
23. Ketata I., Smaoui-Damak W., Guermazi F., Rebai T., and Hamza-Chaffai A. In situ endocrine disrupting effects of cadmium on the reproduction of Ruditapes decussates. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 146 (2007) 415-430
24. Lall S.B., and Dan G. Role of corticosteroids in cadmium induced immunotoxicity. Drug Chem. Toxicol. 22 (1999) 401-409
25. Leazer T.M., and Klaassen C.D. Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. Toxicol. Appl. Pharmacol. 185 (2002) 18-24
26. Lizardo-Daudt H.M., Bains O.S., Singh C.R., and Kennedy C.J. Cadmium chloride-induced disruption of testicular steroidogenesis in rainbow trout Onchorhynchus mykiss. Arch. Environ. Contam. Toxicol. 55 (2008) 103-110
27. Llanos M.N., and Ronco A.M. Fetal growth restriction is related to placental level of toxic elements but not with antioxidant activities. Reprod. Toxicol 27 (2009) 88-92
28. Mc Ternan C.L., Draper N., Nicholson H., Chalder S.M., Driver P., Hewison M., Kilby M.D., and Stewart P.M. Reduced placental 11 beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms. J. Clin. Endocrinol. Metab. 86 (2001) 4979-4983
29. Michael A.E., and Papageorghiou A.T. Potential significance of physiological and pharmacological glucocorticoids in early pregnancy. Hum. Reprod. Update 14 (2008) 497-517
30. Miller S., Chai M., Loose J., Castillo-Meléndez M., Walker D., Jenkin G., and Wallace E.M. The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus. Endocrinology 148 (2007) 1288-1295
31. Nampoothiri L.P., and Gupta S. Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta and ovary. J. Biochem. Mol. Toxicol. 22 (2008) 337-344
32. Neitzke U., Harder T., Schellong K., Melchior K., Ziska T., Rodekamp E., Dudenhausen J.W., and Plagemann A. Intrauterine growth restriction in a rodent model and developmental programming of the metabolic syndrome: a critical appraisal of the experimental evidence. Placenta 29 (2008) 246-254
33. Pepe G.J., Burch M.G., and Albrecht E.D. Expression of the 11beta-hydroxysteroid dehydrogenase types 1 and 2 proteins in human and baboon placental syncytiotrophoblast. Placenta 20 (1999) 575-582
34. Piasek M., Schanwald N., Blanusa M., Kostial K., and Laskey J.W. Biomarkers of heavy metal reproductive effects and interaction with essential elements in experimental studies on female rats. Arh. Hig. Rada Toksikol. 47 (1996) 245-259
35. Resnik R. Intrauterine growth restriction. Obstet. Gynecol. 99 (2002) 490-496
36. Rogerson F.M., Kayes K.M., and White P.C. Variation in placental type 2 11β-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight. Mol. Cell. Endocrinol. 128 (1997) 103-109
37. Ronco A.M., Arguello G., Muñoz L., Gras N., and Llanos M. Metals content in placentas from moderate cigarette consumers. Correlation with newborn birth weight. Biometals 18 (2005) 233-241
38. Satarug S., Baker J.R., Urbenjapol S., Haswell-Elkins M., Reilly P.E.B., Williams D.J., and Moore M.R. A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett. 137 (2003) 65-83
39. Seckl J.R., and Holmes M.C. Mechanisms of disease: glucocorticoids, their placental metabolism and fetal programming of adult pathophysiology. Nat. Clin. Pract. Endocrinol. Metab. 3 (2007) 479-488
40. Staud F., Mazancova K., Miksik I., Pavek P., Fendrich Z., and Pacha J. Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11β-hydroxysteroid dehydrogenase type 2. Placenta 27 (2006) 171-180
41. Sun K., Yang K., and Challis J.R. Differential expression of the 11 beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta and fetal membranes. J. Clin. Endocrinol. Metab. 82 (1997) 300-305
42. Takiguchi M., and Yoshihara S. New aspects of cadmium as endocrine disruptor. Environ. Sci. 13 (2006) 107-116
43. Thompson A., Han V.K., and Yang K. Spatial and temporal pattern of expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 messenger RNA and glucocorticoid receptor protein in teh murine placenta and uterus during late pregnancy. Biol. Reprod. 67 (2002) 1708-1718
44. Thompson J., and Bannigan J. Cadmium: toxic effects on the reproductive system and the embryo. Reprod. Toxicol. 25 (2008) 304-315
45. Van Beck J.P., Guan H., Julan L., and Yang K. Glucocorticoids stimulate the expression of 11β-hydroxysteroid dehydrogenase type 2 in cultured human placental trophoblast cells. J. Clin. Endocrinol. Metab. 89 (2004) 5614-5621
46. Vuguin P.M. Animal models for small for gestational age and fetal programming of adult disease. Horm. Res. 68 (2007) 113-123
47. Waddell B.J., Benediktsson R., Brown R.W., and Seckl J.R. Tissue-specific messenger ribonucleic acid expression of 11 beta-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggest exquisite local control of glucocorticoid action. Endocrinology 139 (1998) 1517-1523
48. Webster W. Iron deficiency and its role in cadmium-induced fetal growth retardation. J. Nutr. 109 (1979) 1640-1645
49. Yang K., Julan L., Rubio F., Sharma A., and Guan H. Cadmium reduces 11β-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. Am. J. Physiol. Endocrinol. Metab. 290 (2006) E135-E142
50. Zenzes M.T., Krishnan S., Krishnan B., Zhang H., and Casper R.F. Cadmium accumulation in follicular fluid of women in in vitro fertilization-embryo transfer is higher in smokers. Fertil. Steril. 65 (1995) 599-603
51. Zhang W., Pang F., Huang Y., Yan P., and Lin W. Cadmium exerts toxic effects on ovarian steroid hormone release in rats. Toxicol. Lett. 182 (2008) 18-23