A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD mice

Immunologic Research

Volumn 50, Issue 2-3, 2011, Pages 213-220

  Lin, Ming S ^a   Tse, Hubert M ^a   Delmastro, Meghan M ^a   Bertera, Suzanne ^a   Wong, Caterina T ^a   Lakomy, Robert ^a   He, Jing ^a   Sklavos, Martha M ^a   Coudriet, Gina M ^a   Pietropaolo, Massimo ^a   Trucco, Massimo M ^a   Piganelli, Jon D ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Autoimmunity; NOD mice; Th2; Type 1 diabetes; Vaccine

Indexed keywords

IMMUNOMODULATING AGENT; PANCREATIC ISLET LYSATE; UNCLASSIFIED DRUG; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL LYSATE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL; VACCINATION;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIBODIES; CYTOKINES; DIABETES MELLITUS, TYPE 1; FEMALE; IMMUNIZATION; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; MICE, SCID; SCHWANN CELLS; SURVIVAL ANALYSIS; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS;

EID: 79961170586     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-011-8215-0     Document Type: Article

References (40)

1. GS Eisenbarth 1986 Type I diabetes mellitus. A chronic autoimmune disease N Engl J Med 314 1360 1368 3517648 10.1056/NEJM198605223142106 1:STN:280:DyaL283gtlCrsw%3D%3D (Pubitemid 16122469)
2. MA Atkinson GS Eisenbarth 2001 Type 1 diabetes: new perspectives on disease pathogenesis and treatment Lancet 358 221 229 11476858 10.1016/S0140-6736(01)05415-0 1:CAS:528:DC%2BD3MXltlymsr0%3D (Pubitemid 32718550)
3. MJ Haller PA Gottlieb DA Schatz 2007 Type 1 diabetes intervention trials 2007: where are we and where are we going? Curr Opin Endocrinol Diabetes Obes 14 283 287 17940453 10.1097/MED.0b013e32825a673b (Pubitemid 47067112)
4. AA Like V Dirodi S Thomas DL Guberski AA Rossini 1984 Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A Am J Pathol 117 92 97 6385729 1:CAS:528:DyaL2MXhslaqtA%3D%3D (Pubitemid 15200370)
5. AD Salama G Remuzzi WE Harmon MH Sayegh 2001 Challenges to achieving clinical transplantation tolerance J Clin Invest 108 943 948 11581293 1:CAS:528:DC%2BD3MXnt1Cku7g%3D (Pubitemid 32946066)
6. CR Stiller J Dupre M Gent MR Jenner PA Keown A Laupacis R Martell NW Rodger B von Graffenried BM Wolfe 1984 Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset Science 223 1362 1367 6367043 10.1126/science.6367043 1:STN:280:DyaL2c7ks1OltA%3D%3D (Pubitemid 14161003)
7. MS Lin SB Salvin 1976 In vitro and in vivo studies on the mechanism of experimental autoimmune thyroiditis in guinea pigs Cell Immunol 27 177 187 1009583 10.1016/0008-8749(76)90227-6 1:STN:280:DyaE2s%2FovFClsg%3D%3D
8. MS Lin SB Salvin 1976 Further studies on the mechanism of experimental autoimmune thyroiditis in guinea pigs. Properties of thyroid cytotoxic factor (TCF) and its relationship to pathogenesis of the disease Cell Immunol 27 188 199 64305 10.1016/0008-8749(76)90228-8 1:CAS:528:DyaE2sXltlGntg%3D%3D (Pubitemid 8050029)
9. N Itoh T Hanafusa A Miyazaki J Miyagawa K Yamagata K Yamamoto M Waguri A Imagawa S Tamura M Inada, et al. 1993 Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients J Clin Invest 92 2313 2322 8227346 10.1172/JCI116835 1:CAS:528:DyaK2cXivFWqtQ%3D%3D (Pubitemid 23333537)
10. M Peakman L Wen GL McNab PJ Watkins KC Tan D Vergani 1994 T cell clones generated from patients with type 1 diabetes using interleukin-2 proliferate to human islet antigens Autoimmunity 17 31 39 8025212 10.3109/08916939409014656 1:STN:280:DyaK2c3pslWnsA%3D%3D (Pubitemid 24111634)
11. LC Harrison MC Honeyman HJ DeAizpurua RS Schmidli PG Colman BD Tait DS Cram 1993 Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes Lancet 341 1365 1369 8098789 10.1016/0140-6736(93)90940-I 1:STN:280:DyaK3s3mvVSitA%3D%3D (Pubitemid 23159984)
12. BO Roep G Duinkerken GM Schreuder H Kolb RR de Vries S Martin 1996 HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus Eur J Immunol 26 1285 1289 8647206 10.1002/eji.1830260616 1:CAS:528:DyaK28Xks1egsbs%3D (Pubitemid 26001063)
13. S Bertera ML Crawford AM Alexander GD Papworth SC Watkins PD Robbins M Trucco 2003 Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes Diabetes 52 387 393 12540612 10.2337/diabetes.52.2.387 1:CAS:528:DC%2BD3sXhtFans70%3D (Pubitemid 36173194)
14. MM Sklavos S Bertera HM Tse R Bottino J He JN Beilke MG Coulombe RG Gill JD Crapo M Trucco JD Piganelli 2010 Redox modulation protects islets from transplant-related injury Diabetes 59 1731 1738 20413509 10.2337/db09-0588 1:CAS:528:DC%2BC3cXpsVOls7k%3D
15. L Yu DT Robles N Abiru P Kaur M Rewers K Kelemen GS Eisenbarth 2000 Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes Proc Natl Acad Sci USA 97 1701 1706 10677521 10.1073/pnas.040556697 1:CAS:528:DC%2BD3cXhsFCrtro%3D (Pubitemid 30118506)
16. JD Piganelli SC Flores C Cruz J Koepp I Batinic-Haberle J Crapo B Day R Kachadourian R Young B Bradley K Haskins 2002 A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone Diabetes 51 347 355 11812741 10.2337/diabetes.51.2. 347 1:CAS:528:DC%2BD38XhtVaquro%3D (Pubitemid 34764789)
17. TL van Belle KT Coppieters MG von Herrath 2011 Type 1 diabetes: etiology, immunology, and therapeutic strategies Physiol Rev 91 79 118 21248163 10.1152/physrev.00003.2010
18. SW Christianson LD Shultz EH Leiter 1993 Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors Diabetes 42 44 55 8093606 10.2337/diabetes.42.1.44 1:STN:280:DyaK3s7jtFSrsA%3D%3D (Pubitemid 23013794)
19. B Bergman K Haskins 1997 Autoreactive T-cell clones from the nonobese diabetic mouse Proc Soc Exp Biol Med 214 41 48 9012359 1:CAS:528: DyaK2sXnvFWgsQ%3D%3D
20. J Cantor K Haskins 2005 Effector function of diabetogenic CD4 Th1 T cell clones: a central role for TNF-alpha J Immunol 175 7738 7745 16301684 1:CAS:528:DC%2BD2MXht1ent7vO (Pubitemid 41713474)
21. J Cantor K Haskins 2007 Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: evidence for involvement of CCR8 and CCL1 J Immunol 179 5760 5767 17947648 1:CAS:528:DC%2BD2sXhtFylu7nP
22. K Haskins D Wegmann 1996 Diabetogenic T-cell clones Diabetes 45 1299 1305 8826963 10.2337/diabetes.45.10.1299 1:CAS:528:DyaK28XmtFCnsbo%3D (Pubitemid 26332890)
23. JD Peterson R Berg JD Piganelli M Poulin K Haskins 1998 Analysis of leukocytes recruited to the pancreas by diabetogenic T cell clones Cell Immunol 189 92 98 9790722 10.1006/cimm.1998.1377 1:CAS:528:DyaK1cXnt1aksbY%3D (Pubitemid 28507249)
24. C Sia 2005 Imbalance in Th cell polarization and its relevance in type 1 diabetes mellitus Rev Diabet Stud 2 182 186 17491692 10.1900/RDS.2005.2.182
25. KA Saunders T Raine A Cooke CE Lawrence 2007 Inhibition of autoimmune type 1 diabetes by gastrointestinal helminth infection Infect Immun 75 397 407 17043101 10.1128/IAI.00664-06 1:CAS:528:DC%2BD2sXjsV2jtQ%3D%3D (Pubitemid 46047916)
26. CQ Xia R Peng Y Qiu M Annamalai D Gordon MJ Clare-Salzler 2007 Transfusion of apoptotic beta-cells induces immune tolerance to beta-cell antigens and prevents type 1 diabetes in NOD mice Diabetes 56 2116 2123 17496235 10.2337/db06-0825 1:CAS:528:DC%2BD2sXos12qsLk%3D (Pubitemid 47195837)
27. SA Greeley M Katsumata L Yu GS Eisenbarth DJ Moore H Goodarzi CF Barker A Naji H Noorchashm 2002 Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice Nat Med 8 399 402 11927947 10.1038/nm0402-399 1:CAS:528:DC%2BD38XivVGmu7o%3D (Pubitemid 34407036)
28. S Forsgren A Andersson V Hillorn A Soderstrom D Holmberg 1991 Immunoglobulin-mediated prevention of autoimmune diabetes in the non-obese diabetic (NOD) mouse Scand J Immunol 34 445 451 1925409 10.1111/j.1365-3083. 1991.tb01567.x 1:STN:280:DyaK38%2Fit1eguw%3D%3D
29. H Noorchashm N Noorchashm J Kern SY Rostami CF Barker A Naji 1997 B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice Diabetes 46 941 946 9166663 10.2337/diabetes.46.6.941 1:CAS:528: DyaK2sXjsVKhsb4%3D (Pubitemid 27220992)
30. DV Serreze HD Chapman DS Varnum MS Hanson PC Reifsnyder SD Richard SA Fleming EH Leiter LD Shultz 1996 B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice J Exp Med 184 2049 2053 8920894 10.1084/jem.184.5.2049 1:CAS:528:DyaK28XmvFait78%3D (Pubitemid 26404497)
31. DV Serreze SA Fleming HD Chapman SD Richard EH Leiter RM Tisch 1998 B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice J Immunol 161 3912 3918 9780157 1:CAS:528:DyaK1cXmsFyrt74%3D (Pubitemid 28468965)
32. PA Silveira DV Serreze ST Grey 2007 Invasion of the killer B's in type 1 diabetes Front Biosci 12 2183 2193 17127455 10.2741/2221 1:CAS:528: DC%2BD28Xht1WgsbbJ
33. TW Kay IL Campbell LC Harrison 1991 Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse J Autoimmun 4 263 276 1679332 10.1016/0896-8411(91)90023-6 1:STN:280:DyaK3MzlsVCmsg%3D%3D
34. TW Kay HL Chaplin JL Parker LA Stephens HE Thomas 1997 CD4+ and CD8+ T lymphocytes: clarification of their pathogenic roles in diabetes in the NOD mouse Res Immunol 148 320 327 9352596 10.1016/S0923-2494(97)87241-0 1:CAS:528:DyaK2sXnsl2nt7c%3D (Pubitemid 27435916)
35. HE Thomas R Darwiche JA Corbett TW Kay 1999 Evidence that beta cell death in the nonobese diabetic mouse is Fas independent J Immunol 163 1562 1569 10415060 1:CAS:528:DyaK1MXkslOgsLY%3D (Pubitemid 29352780)
36. HE Thomas TW Kay 2000 Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse Diabetes Metab Res Rev 16 251 261 10934453 10.1002/1520-7560(200007/08)16:4<251::AID-DMRR126>3. 0.CO;2-C 1:STN:280:DC%2BD3cvis1GksA%3D%3D (Pubitemid 30611785)
37. S Hussain TL Delovitch 2007 Intravenous transfusion of BCR-activated B cells protects NOD mice from type 1 diabetes in an IL-10-dependent manner J Immunol 179 7225 7232 18025164 1:CAS:528:DC%2BD2sXhtlajt77J
38. WL Suarez-Pinzon A Rabinovitch 2001 Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits Int J Exp Diabetes Res 2 3 17 12369724 10.1155/EDR.2001.3 1:STN:280:DC%2BD38nhtlSluw%3D%3D
39. J Mangada T Pearson MA Brehm LS Wicker LB Peterson LD Shultz DV Serreze AA Rossini DL Greiner 2009 Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice Diabetes 58 165 173 18984741 10.2337/db08-0275 1:CAS:528:DC%2BD1MXptVCgtA%3D%3D
40. T Pearson P Weiser TG Markees DV Serreze LS Wicker LB Peterson AM Cumisky LD Shultz JP Mordes AA Rossini DL Greiner 2004 Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3 Diabetes 53 1972 1978 15277375 10.2337/diabetes.53.8.1972 1:CAS:528: DC%2BD2cXmtFGqsbw%3D (Pubitemid 38970744)