The current state of mycotoxin biomarker development in humans and animals and the potential for application to plant systems

World Mycotoxin Journal

Volumn 4, Issue 3, 2011, Pages 257-270

  Baldwin, T T ^a,e   Riley, R T ^a   Zitomer, N C ^a   Voss, K A ^a   Coulombe Jr , R A ^b   Pestka, J J ^c   Williams, D E ^d   Glenn, A E ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b UTAH STATE UNIVERSITY   (United States)

^c Michigan State University   (United States)

^d OREGON STATE UNIVERSITY   (United States)

^e UNIVERSITY OF GEORGIA   (United States)

Author keywords

aflatoxin; deoxynivalenol; fumonisin; ochratoxin; trichothecenes; zearalenone

Indexed keywords

AFLATOXIN B1; AFLATOXIN M1; BIOLOGICAL MARKER; FUMONISIN B1; OCHRATOXIN; TRICHOTHECENE; VOMITOXIN; ZEARALENONE;

ECONOMIC ASPECT; ENDOPHYTE; FUNGAL COLONIZATION; FUNGAL PLANT DISEASE; FUSARIUM MONILIFORME; GENE MUTATION; HUMAN; MAIZE; NONHUMAN; PLANT; PLANT DISEASE; PLANT TISSUE; REVIEW; SEEDLING;

ANIMALIA; FUNGI; GIBBERELLA MONILIFORMIS; ZEA MAYS;

EID: 79961145730     PISSN: 18750710     EISSN: 18750796     Source Type: Journal    
DOI: 10.3920/WMJ2011.1292     Document Type: Review

References (95)

1. Abbas, H., Tanaka, T., Duke, S., Porter, J., Wray, E., Hodges, L., Sessions, A., Wang, E., Merrill Jr., A. and Riley, R., 1994. Fumonisin- and AAL-toxin-induced disruption of sphingolipid metabolism with accumulation of free sphingoid bases. Plant Physiology 106: 1085-1093. (Pubitemid 24986524)
2. Atkinson, A.J., Colburn, W.A., DeGruttola, V.G., DeMets, D.L., Downing, G.J., Hoth, D.F., Oates, J.A., Peck, C.C., Schooley, R.T., Spilker, B.A., Woodcock, J. and Zeger, S.L., 2001. Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clinical Pharmacology and Therapeutics 69: 89-95. (Pubitemid 32225406)
3. Bacon, C.W. and Hinton, D.M., 1996. Symptomless endophytic colonization of maize by Fusarium moniliforme. Canadian Journal of Botany 74: 1195-1202.
4. Bai, G.H., Desjardins, A.E. and Plattner, R.D., 2002. Deoxynivalenol-nonproducing Fusarium graminearum causes initial infection, but does not cause disease spread in wheat spikes. Mycopathologia 153: 91-98. (Pubitemid 34276145)
5. Baudrimont, I., Betbeder, A.M., Gharbi, A., Pfohl-Leszkowicz, A., Dirheimer, G. and Creppy, E.E., 1994. Effect of superoxide-dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats. Toxicology 89: 101-111. (Pubitemid 24154930)
6. Biesaga-Koscielniak, J. and Filek, M., 2010. Occurrence and physiology of zearalenone as a new plant hormone. Sustainable Agriculture Reviews 3: 419-435.
7. Biesaga-Koscielniak, J., Koscielniak, J. and Janeczko, A., 2010. The impact of zearalenone and thidiazuron on indirect plant regeneration of oilseed rape and wheat. Acta Physiologiae Plantarum 32: 1047-1053.
8. Bindschedler, L.V., Dewdney, J., Blee, K.A., Stone, J.M., Asai, T., Plotnikov, J., Denoux, C., Hayes, T., Gerrish, C., Davies, D.R., Ausubel, F.M. and Bolwell, G.P., 2006. Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance. The Plant Journal 47:851-863. (Pubitemid 44326435)
9. Boddu, J., Cho, S.H. and Muehlbauer, G.J., 2007. Transcriptome analysis of trichothecene-induced gene expression in barley. Molecular Plant-Microbe Interactions 20: 1364-1375. (Pubitemid 47612499)
10. Brandwagt, B.F., Mesbah, L.A., Takken, F.L., Laurent, P.L., Kneppers, T.J., Hille, J. and Nijkamp, H.J., 2000. A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. Proceedings of the National Academy of Sciences of the USA 97: 4961-4966. (Pubitemid 30238665)
11. Bush, B.J., Carson, M.L., Cubeta, M.A., Hagler, W.M. and Payne, G.A., 2004. Infection and fumonisin production by Fusarium verticillioides in developing maize kernels. Phytopathology 94: 88-93. (Pubitemid 38503981)
12. CAST (Council for Agricultural Science and Technology), 2003. Mycotoxins: Risks in plant and animal systems. Task Force Report No. 139, Ames, IA, USA, 199 pp.
13. Chivasa, S., Ndimba, B.K., Simon, W.J., Lindsey, K. and Slabas, A.R., 2005. Extracellular ATP functions as an endogenous external metabolite regulating plant cell viability. The Plant Cell 17: 3019-3034.
14. Chohan, J.S. and Gupta, V.K., 1968. Aflaroot: A new disease of groundnut caused by Aspergillus flavus Link. Indian Journal of Agricultural Sciences 38: 568-570.
15. Clay, K., 2009. Defensive mutualism and grass endophytes: Still valid after all these years? In: White Jr., J.F. and Torres, M.S. (eds.) Defensive mutualism in microbial symbiosis. CRC Press, Boca Raton, FL, USA, pp. 9-20.
16. Coursol, S., Fan, L.M., Le Stunff, H., Spiegel, S., Gilroy, S. and Assmann, S.M., 2003. Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. Nature 423: 651-654. (Pubitemid 36713226)
17. Coursol, S., Le Stunff, H., Lynch, D.V., Gilroy, S., Assmann, S.M. and Spiegel, S., 2005. Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. Plant Physiology 137: 724-737. (Pubitemid 43126700)
18. Desjardins, A.E. and Hohn, T.M., 1997. Mycotoxins in plant pathogenesis. Molecular Plant-Microbe Interactions 10: 147-152. (Pubitemid 27126870)
19. Desjardins, A.E., Munkvold, G.P., Plattner, R.D. and Proctor, R.H., 2002. FUM1 - a gene required for fumonisin biosynthesis but not for maize ear rot and ear infection by Gibberella moniliformis in field tests. Molecular Plant-Microbe Interactions 15: 1157-1164. (Pubitemid 36737955)
20. Desjardins, A.E. and Plattner, R.D., 2000. Fumonisin B(1)-nonproducing strains of Fusarium verticillioides cause maize (Zea mays) ear infection and ear rot. Journal of Agricultural and Food Chemistry 48: 5773-5780.
21. Desjardins, A.E., Plattner, R.D. and Gordon, T.R., 2000. Gibberella fujikuroi mating population A and Fusarium subglutinans from teosinte species and maize from Mexico and Central America. Mycological Research 104: 865-872. (Pubitemid 30615177)
22. Desjardins, A.E., Plattner, R.D., Lu, M. and Claflin, L.E., 1998. Distribution of fumonisins in maize ears infected with strains of Fusarium moniliforme that differ in fumonisin production. Plant Disease 82: 953-958.
23. Desjardins, A.E., Plattner, R.D., Nelsen, T.C. and Leslie, J.F., 1995. Genetic analysis of fumonisin production and virulence of Gibberella fujikuroi mating population A (Fusarium moniliforme) on maize (Zea mays) seedlings. Applied and Environmental Microbiology 61: 79-86.
24. Desjardins, A.E., Plattner, R.D., Stessman, R.J., McCormick, S.P. and Millard, M.J., 2005. Identification and heritability of fumonisin insensitivity in Zea mays. Phytochemistry 66: 2474-2480. (Pubitemid 41427772)
25. Desjardins, A.E., Proctor, R.H., Bai, G., McCormick, S.P., Shaner, G., Buechley, G. and Hohn, T.M., 1996. Reduced virulence of trichothecene- nonproducing mutants of Gibberella zeae in wheat field tests. Molecular Plant-Microbe Interactions 9: 775-781. (Pubitemid 27015799)
26. Desmond, O., Manners, J., Stephens, A., MacLean, D., Schenk, P., Gardiner, D., Munn, A. and Kazan, K., 2008. The Fusarium mycotoxin deoxynivalenol elicits hydrogen peroxide production, programmed cell death and defense responses in wheat. Molecular Plant Pathology 9: 435-445. (Pubitemid 351832401)
27. Duncan, K.E. and Howard, R.J., 2010. Biology of maize kernel infection by Fusarium verticillioides. Molecular Plant-Microbe Interactions 23: 6-16.
28. Eaton, D.L., Beima, K.M., Bammler, T.K., Riley, R.T. and Voss, K.A., 2010. Hepatotoxic mycotoxins. In: Roth, R.A. and Ganey, P.E. (eds.) Comprehensive toxicology. Elsevier, Amsterdam, the Netherlands, pp. 527-569.
29. Fink-Gremmels, J. and Malekinejad, H., 2007. Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone. Animal Feed Science and Technology 137: 326-341. (Pubitemid 47248175)
30. Foley, D.C., 1962. Systemic infection of corn by Fusarium moniliforme. Phytopathology 52: 870-872.
31. Fox, E.M. and Howlett, B.J., 2008. Secondary metabolism: Regulation and role in fungal biology. Current Opinion in Microbiology 11: 481-487.
32. Gardiner, S.A., Boddu, J., Berthiller, F., Hametner, C., Stupar, R.M., Adam, G. and Muehlbauer, G.J., 2010. Transcriptome analysis of the barley-deoxynivalenol interaction: Evidence for a role of glutathione in deoxynivalenol detoxification. Molecular Plant-Microbe Interactions 23: 962-976.
33. Gilchrist, D.G., Ward, B., Moussato, V. and Mirocha, C.J., 1992. Genetic and physiological response to fumonisin and AAL-toxin in intact tissue of a higher plant. Mycopathologia 117: 57-64.
34. Glenn, A.E., 2007. Mycotoxigenic Fusarium species in animal feed. Animal Feed Science and Technology 137: 213-240. (Pubitemid 47248171)
35. Glenn, A.E., Zitomer, N.C., Zimeri, A.M., Williams, L.D., Riley, R.T. and Proctor, R.H., 2008. Transformation-mediated complementation of a FUM gene cluster deletion in Fusarium verticillioides restores both fumonisin production and pathogenicity on maize seedlings. Molecular Plant-Microbe Interactions 21: 87-97. (Pubitemid 350262365)
36. Groopman, J.D., Johnson, D. and Kensler, K.W., 2005. Aflatoxin and hepatitis B virus biomarkers: A paradigm for complex environmental exposures and cancer risk. Cancer Biomarkers 1: 5-14.
37. Groopman, J.D., Kensler, K.W. and Wild, C.P., 2008. Aflatoxin, hepatitis B virus and liver cancer: A paradigm for molecular epidemiology. In: Wild, C.P., Vineis, P. and Garte, S. (eds.) Molecular epidemiology of chronic diseases. John Wiley and Sons, Chichester, UK, pp. 323-342.
38. Harris, L.J., Desjardins, A.E., Plattner, R.D., Nicholson, P., Butler, G., Young, J.C., Weston, G., Proctor, R.H. and Hohn, T.M., 1999. Possible role of trichothecene mycotoxins in virulence of Fusarium graminearum on maize. Plant Disease 83: 954-960.
39. Harvey, J.J., Lincoln, J.E. and Gilchrist, D.G., 2008. Programmed cell death suppression in transformed plant tissue by tomato cDNAs identified from an Agrobacterium rhizogenes-based functional screen. Molecular Genetics and Genomics 279: 509-521.
40. Howes, A.W., Dutton, M.F. and Chuturgoon, A.A., 1991. Metabolism of aflatoxin B1 by Petroselinum crispum (parsley). Mycopathologia 113: 25-29.
41. Jansen, C., Von Wettstein, D., Schafer, W., Kogel, K.H., Felk, A. and Maier, F.J., 2005. Infection patterns in barley and wheat spikes inoculated with wild-type and trichodiene synthase gene disrupted Fusarium graminearum. Proceedings of the National Academy of Sciences of the USA 102: 16892-16897. (Pubitemid 41688873)
42. Kensler, T.W., Roebuck, B.D., Wogan, G.N. and Groopman, J.D. 2011. Aflatoxin: A 50-year odyssey of mechanistic and translational toxicology. Toxicological Sciences 120 Suppl. 1: S28-S48.
43. Kimura, M., Tokai, T., Takahashi-Ando, N., Ohsato, S. and Fujimura, M., 2007. Molecular and genetic studies of Fusarium trichothecene biosynthesis: Pathways, genes, and evolution. Bioscience, Biotechnology, and Biochemistry 71: 2105-2123. (Pubitemid 350113090)
44. Kommedahl, T. and Windels, C.E., 1981. Root-, stalk-, and ear-infecting Fusarium species on corn in the USA. In: Nelson, P.E., Toussoun, T.A. and Cook, R.J. (eds.) Fusarium: Diseases, biology and taxonomy. The Pennsylvania State University Press, University Park, PA, USA, pp. 94-103.
45. Koscielniak, J., Biesaga-Koscielniak, J., Janeczko, A., Filek, W. and Kalaji, H., 2009. Can the Gibberella zeae toxin zearalenone affect the photosynthetic productivity and increase yield formation in spring wheat and soybean plants? Photosynthetica 47: 586-594.
46. Kuroyanagi, M., Yamada, K., Hatsugai, N., Kondo, M., Nishimura, M. and Hara-Nishimura, I., 2005. Vacuolar processing enzyme is essential for mycotoxin-induced cell death in Arabidopsis thaliana. Journal of Biological Chemistry 280: 32914-32920. (Pubitemid 41368341)
47. Kussak, A., Andersson, B., Andersson, K. and Nilsson C.-A., 1998. Determination of aflatoxicol in human urine by immunoaffinity column clean-up and liquid chromatography. Chemosphere 36: 1841-1848. (Pubitemid 28084938)
48. Lee, C.C., Liu, J.Y., Lin, J.K., Chu, J.S. and Shew, J.Y., 1998. p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions. Cancer Letters 125: 1-7.
49. Leslie, J.F., 1995. Gibberella fujikuroi: Available populations and variable traits. Canadian Journal of Botany 73: S282-S291.
50. Leslie, J.F., Pearson, C.A.S., Nelson, P.E. and Toussoun, T.A., 1990. Fusarium spp. from corn, sorghum, and soybean fields in the central and eastern United States. Phytopathology 80: 343-350.
51. Leslie, J.F., Zeller, K.A., Logrieco, A., Mulè, G., Moretti, A. and Ritieni, A., 2004. Species diversity of and toxin production by Gibberella fujikuroi species complex strains isolated from native prairie grasses in Kansas. Applied and Environmental Microbiology 70: 2254-2262. (Pubitemid 38500527)
52. Li, F., Asami, T., Wu, X., Tsang, E. and Cutler, A.J., 2007. A putative hydroxysteriod dehydrogenase involved in regulating plant growth and development. Plant Physiology 145: 87-97. (Pubitemid 47416481)
53. Lin, S.S, Martin, R., Mongrand, S., Vandenabeele, S., Chen, K.C., Jang, I.C. and Chua, N.H., 2008. RING1 E3 ligase localizes to plasma membrane lipid rafts to trigger FB1-induced programmed cell death in Arabidopsis. The Plant Journal 56:550-561.
54. Liu, S., Zhang, X., Pumphrey, M.O., Stack, R.W., Gill, B.S. and Anderson, J.A., 2006. Complex microcolinearity among wheat, rice and barley revealed by fine mapping of the genomic region harboring a major QTL for resistance to Fusarium head blight in wheat. Functional and Integrative Genomics 6: 83-89.
55. Logrieco, A., Mulè, G., Moretti, A. and Bottalico, A., 2002. Toxigenic Fusarium species and mycotoxins associated with maize ear rot in Europe. European Journal of Plant Pathology 108: 597-609. (Pubitemid 35293881)
56. Mally, A. and Dekant, W., 2009. Mycotoxins and the kidney: Modes of action for renal tumor formation by ochratoxin A in rodents. Molecular Nutrition and Food Research 53: 467-478.
57. Mantle, P.G., Faucet-Marquis, V., Manderville, R.A., Squillaci, B. and Pfohl-Leszkowicz, A., 2010. Structures of covalent adducts between DNA and ochratoxin A: A new factor in debate about genotoxicity and human risk assessment. Chemical Research in Toxicology 23: 89-98.
58. Mariën, K., Moyer, R., Loveland, P., Van Holde, K. and Bailey, G., 1987. Comparative binding and sequence interaction specificities of aflatoxin B1, aflatoxicol, aflatoxin M1, and aflatoxicol M1 with purified DNA. Journal of Biological Chemistry 262: 7455-7462.
59. Marin-Kuan, M., Cavin, C., Delatour, T. and Schilter, B., 2008. Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms. Toxicon 52: 195-202.
60. Masuda, D., Ishida, M., Yamaguchi, K., Yamaguchi, I., Kimura, M. and Nishiuchi, T., 2007. Phytotoxic effects of trichothecenes on the growth and morphology of Arabidopsis thaliana. Journal of Experimental Botany 58: 1617-1626. (Pubitemid 47355999)
61. McLean, M., 1994a. Aflatoxin B1-induced ultrastructural alterations in mature Zea mays embryos. Mycopathologia 128: 181-192.
62. McLean, M., 1994b. The phytotoxic effects of aflatoxin B1 - a review (1984-1994). South African Journal of Science 90: 385-390. (Pubitemid 2154774)
63. McLean, M., Watt, M.P., Berjak, P. and Dutton, M.F., 1995. Aflatoxin B1 - its effects on an in vitro plant system. Food Additives and Contaminants 12: 435-443.
64. Munkvold, G.P., 2003. Epidemiology of Fusarium diseases and their mycotoxins in maize ears. European Journal of Plant Pathology 109: 705-713. (Pubitemid 37325510)
65. Norholm, M.H., Nour-Eldin, H.H., Brodersen, P., Mundy, J. and Haulkier, B.A., 2006. Expression of the Arabidopsis high-affinity hexose transporter STP13 correlates with programmed cell death. FEBS Letters 580: 2381-2387.
66. O'Brien, E. and Dietrich, D.R., 2005. Ochratoxin A: The continuing enigma. Critical Reviews in Toxicology 35: 33-60. (Pubitemid 40179900)
67. O'Donnell, K., Cigelnik, E. and Nirenberg, H.I., 1998. Molecular systematics and phylogeography of the Gibberella fujikuroi species complex. Mycologia 90: 465-493. (Pubitemid 28273436)
68. Peng, X.-L., Xu, W.-T., Wang, Y., Huang, K.-L., Liang, Z.-H., Zhao, W.-W. and Luo, Y.-B., 2010. Mycotoxin ochratoxin A-induced cell death and changes in oxidative metabolism. Plant Cell Reports 29: 153-161.
69. Pestka, J.J., 2010a. Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin Journal 3: 323-347.
70. Pestka, J.J., 2010b. Deoxynivalenol: Mechanisms of action, human exposure, and toxicological relevance. Archives of Toxicology 84: 663-679.
71. Pfohl-Leszkowicz, A. and Manderville, R.A., 2007. Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans. Molecular Nutrition and Food Research 51: 61-99. (Pubitemid 46144764)
72. Poppenberger, B., Berthiller, F., Lucyshyn, D., Sieberer, T., Schuhmacher, R., Krska, R., Kuchler, K., Glossl, J., Luschnig, C. and Adam, G., 2003. Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana. Journal of Biological Chemistry 278: 47905-47914. (Pubitemid 37523239)
73. Proctor, R.H., Hohn, T.M. and McCormick, S.P., 1995. Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene. Molecular Plant-Microbe Interactions 8: 593-601.
74. Reverberi, M., Ricelli, A., Zjalic, S., Fabbri, A.A. and Fanelli, C., 2010. Natural functions of mycotoxins and control of their biosynthesis in fungi. Applied Microbiology and Biotechnology 87: 899-911.
75. Riley, R.T., Voss, K.A., Coulombe, R.A., Pestka, J.J. and Williams, D.E., 2011. Developing mechanism-based and exposure biomarkers for mycotoxins in animals. In: De Saeger, S. (ed.) Determining mycotoxins and mycotoxigenic fungi in food and feed. Woodhead Publishing Limited, Cambridge, UK, pp. 245-275.
76. Rivkina, M.B., Cullen, J.M., Robinson, W.S. and Marion, P.L., 1994. State of p53 gene in hepatocellular carcinoma of ground squirrels and woodchucks with past and ongoing infection with hepadnavirus. Cancer Research 54: 5430-5437. (Pubitemid 24336037)
77. Routledge, M.N. and Gong, Y.Y., 2011. Developing biomarkers of human exposure to mycotoxins. In: De Saeger, S. (ed.) Determining mycotoxins and mycotoxigenic fungi in food and feed. Woodhead Publishing Limited, Cambridge, UK, pp. 225-244.
78. Scott, P.M., 2005. Biomarkers of human exposure to ochratoxin A. Food Additives and Contaminants 22 Suppl. 1: 99-107. (Pubitemid 44574579)
79. Shephard, G.S., Van der Westhuizen, L. and Sewram, V., 2007. Biomarkers of exposure to fumonisin mycotoxins: A review. Food Additives and Contaminants 24: 1196-1201. (Pubitemid 47471159)
80. Shi, L., Bielawski, J., Mu, J., Dong, H., Teng, C., Zhang, J., Yang, X., Tomishige, N., Hanada, K., Hannun, Y.A. and Zuo, J., 2007. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. Cell Research 17: 1030-1040. (Pubitemid 350261800)
81. Smela, M.E., Currier, S.S., Bailey, E.A. and Essigmann, J.M., 2001. The chemistry and biology of aflatoxin B1: From mutational spectrometry to carcinogenesis. Carcinogenesis 22: 535-545. (Pubitemid 32288652)
82. Spassieva, S.D., Markham, J.E. and Hille, J., 2002. The plant disease resistance gene Asc-1 prevents disruption of sphingolipid metabolism during AAL-toxin-induced programmed cell death. The Plant Journal 32: 561-572. (Pubitemid 36814963)
83. Tanaka, A., Tapper, B.A., Popay, A., Parker, E.J. and Scott, B., 2005. A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory. Molecular Microbiology 57: 1036-1050. (Pubitemid 41139864)
84. Tong, W.M., Lee, M.K., Galendo, D., Wang, Z.Q. and Sabapathy, K., 2006. Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock in) mice. International Journal of Cancer 119: 745-749. (Pubitemid 44051436)
85. Turner, P.C., 2010. Deoxynivalenol and nivalenol occurrence and exposure assessment. World Mycotoxin Journal 3: 315-321.
86. Wang, H., Jones, C., Ciacci-Zanella, J.R., Holt, T., Gilchrist, D.G. and Dickman, M.B., 1996. Fumonisins and Alternaria alternata lycopersici toxins: Sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. Proceedings of the National Academy of Sciences of the USA 93: 3461-3465. (Pubitemid 26125642)
87. Watanabe, N. and Lam, E., 2006. Arabidopsis Bax inhibitor-1 functions as an attenuator of biotic and abiotic types of cell death. The Plant Journal 45: 884-894. (Pubitemid 43344751)
88. White, D.G., 1999. Compendium of corn diseases. 3rd edition. APS Press, St. Paul, MN, USA.
89. Wild, C.P. and Gong, Y.Y., 2010. Mycotoxins and human disease: A largely ignored global health issue. Carcinogenesis 31: 71-82.
90. Williams, L.D., Glenn, A.E., Bacon, C.W., Smith, M.A. and Riley, R.T., 2006. Fumonisin production and bioavailability to maize seedlings grown from seeds inoculated with Fusarium verticillioides and grown in natural soils. Journal of Agricultural and Food Chemistry 54: 5694-5700. (Pubitemid 44195759)
91. Williams, L.D., Glenn, A.E., Zimeri, A.M., Bacon, C.W., Smith, M.A. and Riley, R.T., 2007. Fumonisin disruption of ceramide biosynthesis in maize roots and the effects on plant development and Fusarium verticillioides-induced seedling disease. Journal of Agricultural and Food Chemistry 55: 2937-2946. (Pubitemid 46668302)
92. Wolpert, T.J., Dunkle, L.D. and Ciuffetti, L.M., 2002. Host-selective toxins and avirulence determinants: What's in a name? Annual Review of Phytopathology 40: 251-285. (Pubitemid 35235582)
93. Wong, Z.A. and Hsieh, D.P., 1978. Aflatoxicol: Major aflatoxin B1 metabolite in rat plasma. Science 200: 325-327. (Pubitemid 8326064)
94. Zitomer, N.C., Glenn, A.E., Bacon, C.W. and Riley, R.T., 2008. A single extraction method for the analysis by liquid chromatography/tandem mass spectrometry of fumonisins and biomarkers of disrupted sphingolipid metabolism in tissues of maize seedlings. Analytical and Bioanalytical Chemistry 391: 2257-2263.
95. Zitomer, N.C., Jones, S., Bacon, C., Glenn, A.E., Baldwin, T. and Riley, R.T., 2010. Translocation of sphingoid bases and their 1-phosphates, but not fumonisins, from roots to aerial tissues of maize seedlings watered with fumonisins. Journal of Agricultural and Food Chemistry 58: 7476-7481.