Developing biomarkers of human exposure to mycotoxins

Determining Mycotoxins and Mycotoxigenic Fungi in Food and Feed

Volumn , Issue , 2011, Pages 225-244

  Routledge, M N ^a   Gong, Y Y ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Aflatoxin albumin adducts; Aflatoxin DNA adducts; Biomarkers of myco toxin exposure; Urinary deoxynivalenol detection; Urinary fumonisin detection

Indexed keywords

EID: 84903254407     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1533/9780857090973.3.225     Document Type: Chapter

References (78)

1. 1 induced toxicity in primary rat hepatocytes and rat liver in vivo. Toxciology 1998, 131:121-131.
2. 1 DNA adducts formed in cultured human bronchus and colon. Cancer Res. 1979, 39:694-768.
3. 1 in human urine collected in Murang'a district, Kenya. Carcinogenesis 1983, 4:1193-1195.
4. 1-guanine adduct and hepatitis B virus infection in areas with different liver cancer incidence in Kenya. Cancer Res. 1987, 47:3430-3433.
5. 1-induced DNA damage and its repair. Cancer Letters 2006, 241:174-183.
6. Bhat R.V., Beedu S.R., Ramakrishna Y., Munshi K.L. Outbreak of trichothecenes mycotoxicosis associated with consumption of mould-damaged wheat production in Kashmir Valley, India. Lancet 1989, 1:35-37.
7. Castegnaro M., Garren L., Galendo D., Gelderblom W.C., Chelule P., Dutton M.F., Wild C.P. Analytical method for the determination of sphinganine and sphingosine in serum as a potential biomarker for fumonisin exposure. J. Chromatogr. B Biomed. Sci. Appl. 1998, 720:15-24.
8. 1 in maize. Environ. Health Perspect. 2001, 109:253-256.
9. 1 and other mycotoxins in moldy corn collected from the People's Republic of China in regions with high incidences of esophageal cancer. Appl. Environ. Microbiol. 1994, 60:847-852.
10. Constable P.D., Riley R.T., Waggoner A.L., Hsiao S.-H., Foreman J.H., Tumbleson M.E., Haschek W.M. Serum Sphingosine-1-Phosphate and Sphinganine-1-phosphate are Elevated in Horses Exposed to Fumonisin B. AOAC International Midwest Section Final Program 2005, 63-64. AOAC International, Gaithersburg, MD (Abstract).
11. 1-DNA adduct formed in vivo in rat liver. Proc. Natl Acad. Sci. USA 1978, 75:1745-1749.
12. 1 treated rats. Toxicology 2006, 222:53-59.
13. 1: oxidative status and DNA damage in rats. Toxicology 2007, 232:163-169.
14. 1-N7-guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry. Chem. Res. Toxicol. 2006, 19:1191-1195.
15. Feskanich D., Rimm E.B., Giavannucci E.L., Colditz G.A., Stampfer M.J., Liton L.B., Willett W.C. Reproducibility and validity of food-intake measurements from a semi quantitative food frequency questionnaire. J. Am. Dietetic Assoc. 1993, 93:790-796.
16. 1. Carcinogenesis 1988, 9:1323-1325.
17. Gelderblom W.C., Jaskiewicz K., Marasas W.F., Thiel P.G., Horak R.M., Vleggaar R., Kriek N.P. 'Fumonisins -novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 1988, 54:1806-1811.
18. 1 in a short term rat liver carcinogenesis assay. Toxicology 2008, 250:89-95.
19. Gelineau-van Waes J., Starr L., Maddox J., Aleman F., Voss K.A., Wilberding J., Riley R.T. 'Maternal fumonisin exposure and risk for neural tube defects: Mechanisms in an in vivo mouse model'. Birth Defects Res. Part A, Clinical Mole. Teratology 2005, 73:487-497.
20. Gong Y.Y., Cardwell K., Hounsa A., Egal S., Turner P.C., Hall A.J., Wild C.P. 'Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study. Brit. Med. J. 2002, 325:20-21.
21. Gong Y.Y., Egal S., Hounsa A., Turner P.C., Hall A.J., Cardwell K.F., Wild C.P. Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning. Int. J. Epidemiol 2003, 32(4):556-562.
22. Gong Y.Y., Hounsa A., Egal S., Turner P.C., Sutcliffe A.E., Hall A.J., Cardwell K., Wild C.P. Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environ. Health Perspect. 2004, 112:1334-1338.
23. 1 levels in a Mexican population. Cancer Epidemiol. Biomarkers Prevention 2008, 17:688-694.
24. 1-adducted DNA. Proc. Natl Acad. Sci. USA 1981, 78:5445-5459.
25. Groopman J.D., Trudel L.J., Donahue P.R., Marshakrothstein A., Wogan G.N. High affinity monoclonal antibodies for aflatoxins and their application to solid phase immunoassays. Proc. Natl Acad. Sci. USA 1984, 81:7728-7731.
26. Groopman J.D., Donahue P.R., Zhu J., Chen J., Wogan G.N. Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography. Proc. Natl Acad. Sci. USA 1985, 82:6492-6496.
27. Groopman J.D., Cain L.G., Kensler T.W. 'Aflatoxin exposure in human-populations -measurements and relationship to cancer', CRC Crit. Rev. Toxicol. 1988, 19:113-145.
28. Groopman J.D., Hall A.J., Whittle H., Hudson G.J., Wogan G.N., Montesano R., Wild C.P. 'Molecular dosimetry of aflatoxin-N7-guanine in human urine obtained in the Gambia, West Africa', Cancer Epidemiol. Biomarkers Prevention 1992, 1:221-227.
29. Groopman J.D., Zhu J., Donahue P.R., Pikul A., Zhang L., Chen J., Wogan G.N. Molecular dosimetry of urinary aflatoxin DNA adducts in people living in Guangxi autonomous region, Peoples Republic of China. Cancer Res. 1992, 52:45-52.
30. Groopman J.D., Wild C.P., Hasler H., Chen J., Wogan G.N., Kensler T.W. Molecular epidemiology of aflatoxin exposures -validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans. Environ. Health Perspect. 1993, 99:107-113.
31. Groopman J.D., Kensler K.W., Wild C.P. Aflatoxin, hepatitis B virus and liver cancer: a paradigm for molecular epidemiology. Molecular Epidemiology of Chronic Diseases 2008, 323-342. John Wiley & Sons, Chichester. C.P. Wild, P. Vineis, S. Garte (Eds.).
32. 1-modified DNA detected by enzyme immunoassay. Proc. Natl. Acad. Sci. USA 1981, 78:4124-4127.
33. 1. Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 2002, 82:301-366. IARC, Lyon.
34. 1-albumin adduct levels and cellular immune status in Ghanaians. Int. Immunol. 2005, 17:807-814.
35. Kohlmeier L., Bellach B. Exposure assessment error and its handling in nutritional epidemiology. Annual Review of Public Health 1995, 16:43-59.
36. Linsell C.A., Peers F.G. Aflatoxins and liver-cell cancer. Trans. Royal Soc. Tropical Medicine and Hygiene 1977, 71:471-473.
37. Luo X. Food poisoning caused by Fusarium toxins. Proceedings of the SecondAsian Conference on Food Safety 1994, 129-136. International Life Sciences Institute, Chatuchak, Thailand.
38. Marasas W.F.O., Riley R.T., Hendricks K.A., Stevens V.L., Sadler T.W., Gelineau-van Waes J., Missmer S.A., Cabrera J., Torres O., Gelderblom W.C.A., Allegood J., Martinez C., Maddox J., Miller J.D., Starr L., Sullards M.C., Roman A.V., Voss K.A., Wang E., Merrill A.H. Fumonisins disrupt sphingolid metabolism, folate transport and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. J. Nutrition 2004, 134:711-716.
39. McCoy L.F., Scholl P.F., Sutcliffe A.E., Kieszak S.M., Powers C.D., Rogers H.S., Gong Y.Y., Groopman J.D. Human aflatoxin albumin adducts quantitatively compared by ELISA, HPLC with fluorescence detection, and HPLC with isotope dilution mass spectrometry. Cancer Epidemiol. Biomarkers Prevention 2008, 17:1653-1657.
40. Meky F.A., Hardie L.J., Evans S.W., Wild C.P. Deoxynivalenol induced immunomodulation of human lymphocyte proliferation and cytokine production. Food and Chemical Toxicology 2001, 39:827-836.
41. Meky F.A., Turner P.C., Ashcroft A.E., Miller J.D., Qiao Y.L., Roth M.J., Wild C.P. Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem, Toxicol. 2003, 41:265-273.
42. 1 when fed to weanling piglets. J. Animal Sci 2005, 83:1939-1947.
43. Qian G.S., Ross R.K., Yu M.C., Yuan J.M., Gao Y.T., Henderson B.E., Wogan G.N., Groopman J.D. 'A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, Peoples Republic of China', Cancer Epidemiol. Biomarkers Prevention 1994, 3:3-10.
44. 1. Food Addit. Contam. 2001, 18:263-269.
45. 32P-labeling test for DNA damage. Proc. Natl Acad. Sci. USA 1981, 78:6126-6129.
46. Randerath K., Randerath E., Agrawal H.P., Gupta R.C., Schurdak M.E., Reddy M.V. Postlabeling methods for carcinogen-DNA adduct analysis. Environ. Health Perspect. 1985, 62:57-65.
47. Rheeder J.P., Marasas W.F.O., Thiel P.G., Sydenham E.W., Shephard G.S., Van Schalkwyk D.J. Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology 1992, 82:353-437.
48. Riley R.T., Voss K.A. Differential sensitivity of rat kidney and liver to fumonisin toxicity: Organ-specific differences in toxin accumulation and sphingoid base metabolism. Toxicol. Sci. 2006, 92:335-345.
49. 32P-Postlabelling Assay 1991, University of York, UK, PhD Thesis.
50. Sabbioni G., Ambs S., Wogan G.N., Groopman J.D. The aflatoxin-lysine adduct quantified by high-performance liquid chromatography from human serum albumin samples. Carcinogenesis 1990, 11:2063-2066.
51. Sewram V., Mshicileli N., Shephard G.S., Marasas W.F.O. Fumonisin mycotoxins in human hair. Biomarkers 2003, 8(2):110-118.
52. Shephard G.S., Leggott N.L., Stockenstrom S., Somdyala N.I.M., Marasas W.F.O. Preparation of South African maize porridge: effect on fumonisin mycotoxin levels. South African J. Sci. 2002, 98:393-396.
53. Solfrizzo M., Chulz S.N., Malmann C., Visconti A., De Girolamo A., Rojo F., Torres A. Comparison of urinary sphingolipids in human populations with high and low maize consumption as a possible biomarker of fumonisin dietary exposure. Food Addit. Contam. Part A -Chem. Anal. Control Exposure and Risk Assess. 2004, 21:1090-1095.
54. 32P-postlabelling methods. A review. Collection of Czechoslovak Chem. Commun. 2004, 69:476-498.
55. Stockmann-Juvala H., Savolainen K. A review of the toxic effects and mechanisms of action of fumonisin B-1. Human Experiment. Toxicol. 2008, 27:799-809.
56. Stora C. L'aflatoxine est presente dans des cancers primitifs du foie developpés chez les habitants du Zaire. Compte. R. Hebd. Seances Acad. Sci. Ser. D 1978, 286:917-920.
57. Strickland P.T., Routledge M.N., Dipple A. Methodologies for measuring carcinogen adducts in humans. Cancer Epidemiol Biomarkers Prevention 1993, 2:607-619.
58. Swenberg J.A., Fryar-Tita E., Jeong Y.C., Boysen G., Starr T., Walker V.E., Albertini R.J. Biomarkers in toxicology and risk assessment: Informing critical dose-response relationships. Chem. Res. Toxicol. 2008, 21:253-265.
59. 2 to rat liver DNA and ribosomal RNA in vivo. Cancer Res. 1977, 37:172-181.
60. 1 in serum samples of male Japanese subjects by RIA and high performance liquid chromatography. Cancer Res. 1984, 44:1231-1234.
61. Turner P.C., Mendy M., Whittle H., Fortuin M., Hall A.J., Wild C.P. Hepatitis B infection and aflatoxin biomarker levels in Gambian children. Tropical Medicine Int. Health 2000, 5:837-841.
62. Turner P.C., Sylla A., Gong Y.Y., Diallo M.S., Sutcliffe A.E., Hall A.J., Wild C.P. Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in west africa: a community-based intervention study. Lancet 2005, 365:1950-1956.
63. Turner P.C., Rothwell J.A., White K.L.M., Gong Y.Y., Cade J.E., Wild C.P. Urinary deoxynivalenol is correlated with cereal intake in individuals from the United Kingdom. Environ. Health Perspect. 2008, 116:21-25.
64. Turner P.C., Burley V.J., Rothwell J.A., White K.L.M., Cade J.E., Wild C.P. Dietary wheat reduction decreases the level of urinary deoxynivalenol in UK adults. J. Exposure Sci. Environ. Epidemiol. 2008, 18:392-399.
65. Van der Westhuizen L., Brown N.L., Marasas W.F., Swanevelder S., Shephard G.S. Sphinganine/sphingosine ratio in plasma and urine as a possible biomarker for fumonisin exposure in humans in rural areas of Africa. Food Chem. Toxicol. 1999, 37:1153-1158.
66. Van der Westhuizen L, Shephard GS, Burger HM, Rheeder JP, Gelderblom WCA, Wild CP and Gong YY (20xx) 'Fumonisin B1 as a urinary biomarker of exposure in a subsistence maize intervention study', submitted.
67. Vineis P., Garte S. Biomarker validation. Molecular Epidemiology of Chronic Diseases 2008, 71-82. John Wiley & Sons, Chichester. C.P. Wild, P. Vineis, S. Garte (Eds.).
68. 1: a mycotoxin produced by Fusarium moniliforme (=verticillioides). Cancer Detect. Prevention 2002, 26:1-9.
69. Wild C.P. Environmental exposure measurement in cancer epidemiology. Mutagenesis 2009, 24:117-125.
70. Wild C.P., Gong Y.Y. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis 2010, 31:71-82.
71. Wild C.P., Hall A.J. Primary prevention of hepatocellular carcinoma in developing countries. Mutation Res. 2000, 462:381-393.
72. Wild C.P., Turner P.C. The toxicology of aflatoxins as a basis for public health decisions. Mutagenesis 2002, 17:471-481.
73. 1 binding to plasma albumin and liver DNA upon chronic administration to rats. Carcinogenesis 1986, 7:853-858.
74. Wild C.P., Jiang Y.Z., Allen S.J., Jansen L.A.M., Hall A.J., Montesano R. Aflatoxin albumin adducts in human sera from different regions of the world. Carcinogenesis 1990, 11:2271-2274.
75. Wild C.P., Hudson G.J., Sabbioni R., Chapot B., Hall A.J., Wogan G.N., Whittle H., Montesano R., Groopman J.D. 'Dietary-intake of aflatoxins and the level of albumin bound aflatoxin in peripheral blood in the Gambia, West Africa', Cancer Epidemiol. Biomarkers Prevention 1992, 1:229-234.
76. Wild C.P., Law G.R., Roman E. Molecular epidemiology and cancer: promising areas for future research in the post-genomic era. Mutation Res. 2002, 499:3-12.
77. Molecular Epidemiology of Chronic Diseases 2008, John Wiley & Sons, Chicester. C.P. Wild, P. Vineis, S. Garte (Eds.).
78. Yeh F.-S., Yu M.C., Mo C.-C., Luo S., Tong M.-J., Henderson B.E. Hepatitis B virus, aflatoxins and hepatocellular carcinoma in southern Guangx, China. Cancer Res. 1989, 49:2506-2509.