Fluorescence probe for lysophospholipase C/NPP6 activity and a potent NPP6 inhibitor

Journal of the American Chemical Society

Volumn 133, Issue 31, 2011, Pages 12021-12030

  Kawaguchi, Mitsuyasu ^a,b   Okabe, Takayoshi ^a   Okudaira, Shinichi ^c   Hanaoka, Kenjiro ^a,b   Fujikawa, Yuuta ^a,b   Terai, Takuya ^a,b   Komatsu, Toru ^a,b   Kojima, Hirotatsu ^a,b   Aoki, Junken ^c   Nagano, Tetsuo ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY ASSAYS; BIOLOGICAL FUNCTIONS; CELL LYSATES; CELL-BASED; CONTROL-CELL; ECTOENZYMES; EXTRACELLULAR NUCLEOTIDES; FLUORESCENCE IMAGING; FLUORESCENCE PROBES; HIGH-THROUGHPUT; HIGHLY SENSITIVE; LYSOPHOSPHATIDYL-CHOLINE; NUCLEOTIDE PYROPHOSPHATASES/PHOSPHODIESTERASES; PHOSPHODIESTERASES; SELECTIVE FLUORESCENCE; SELECTIVE INHIBITORS; SPHINGOMYELIN; STRUCTURE-ACTIVITY RELATIONSHIPS; TRANSFECTED CELLS;

ASSAYS; HYDROLYSIS; NUCLEOTIDES; PHOSPHOLIPIDS; PROBES;

FLUORESCENCE;

LYSOPHOSPHOLIPASE; NUCLEOTIDE PYROPHOSPHATASE; NUCLEOTIDE PYROPHOSPHATASE 6; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STRUCTURE; FLUORESCENCE IMAGING; HYDROLYSIS; IMAGING SYSTEM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FLUORESCENT DYES; HEK293 CELLS; HELA CELLS; HUMANS; LYSOPHOSPHOLIPASE; MICE; MOLECULAR STRUCTURE; NIH 3T3 CELLS; PHOSPHORIC DIESTER HYDROLASES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79961140910     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja201028t     Document Type: Article

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