Simultaneous estimation of E- and Z-isomers of guggulsterone in rabbit plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study

Biomedical Chromatography

Volumn 25, Issue 9, 2011, Pages 1054-1060

  Bhatta, R S ^a   Kumar, D ^a   Chhonker, Y S ^a   Jain, G K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Guggulsterone; LC MS MS; Preclinical pharmacokinetic; Rabbit plasma

Indexed keywords

ELECTROSPRAY IONIZATION; EXTRACTION; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE SEPARATION;

ANALYTES; GUGGULSTERONE; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; PRECLINICAL PHARMACOKINETIC; RABBIT PLASMAS; SIMULTANEOUS ESTIMATION;

PHARMACOKINETICS;

ACETONITRILE; DEXAMETHASONE; FORMIC ACID; GUGGULSTERONE; METHANOL;

ACCURACY; ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; EXPERIMENTAL RABBIT; FREEZE THAWING; ISOMER; LIQUID CHROMATOGRAPHY; LOW DRUG DOSE; MALE; MONITORING; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; SOLID PHASE EXTRACTION; STEREOSPECIFICITY; TANDEM MASS SPECTROMETRY; THERMOSTABILITY;

ORYCTOLAGUS CUNICULUS;

EID: 79961129733     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1574     Document Type: Article

References (21)

1. Antarkar D, Pande R, Athavale A, Shubhangi R, Saoji S, Shah K, Jakhmola A and Vaidya A. Phase I tolerability study of Yogaraj-guggulu-apopular ayurvedic drug. Journal of Postgraduate Medicine 1984; 30: 111-115.
2. Bajaj AG and Dev S. Chemistry of Ayurvedic crude drugs. Tetrahedrone 1982; 38: 2949-2954.
3. Chavez-Eng CM, Constanzer ML and Matuszewski BK. Simultaneous determination of Aprepitant and two metabolites in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection. Journal of Pharmacy and Biomedical Analysis 2004; 35: 1213-1229.
4. Cui J, Huang L, Zhao A, Lew JL, Yu J, Sahoo S, Meinke PT, Royo I, Pelaez F and Wright SD. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. Journal of Biological Chemistry 2003; 278: 10214-10220.
5. Deng R. Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits. Cardiovascular Drug Review 2007; 25: 375-390.
6. Dev S. A modern look at an age old Ayurvedic drug-guggul. Science Age 1987; 13-18.
7. Haque I, Kumar M and Mukhopadhyay K. A rapid and simple UPLC-MS-MS based simultaneous determination of the medicinally important E- and Z-guggulsterone from oleogum-resins of naturally occurring Commiphora wightii plants. Chromatographia 2009; 70: 1613-1619.
8. Leeman N, Rebecca J, Wheeler SE, Singh SV, Thomas SM, Seethala R, Neill DB, Panahandeh MC, Hahm ER, Joyce SC, Sen M, Cai Q, Freilino ML, Li C, Johnson DE and Grandis JR. Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis 2009; 30: 1848-1856.
9. Mester L, Mester M and Nityanand S. Inhibition of platelet aggregation by 'guggulu' steroids. Planta Medica 1979; 37: 367-369.
10. Pratap R etal. Method of treating a cognitive memory dysfunction using Gugulipid. Patent no. 6896901, 2005.
11. Sahni S, Hepfinger CA and Sauer KA. Guggulipid use in hyperlipidemia: case report and review of the literature. American Journal of Health Systems and Pharmacy 2005; 62: 1690-1692.
12. Satyavati GV. Gum guggul (Commiphora mukul)-the success story of an ancient insight leading to a modern discovery. Indian Journal of Medical Research 1988; 87: 327-335.
13. Satyavati GV, Dwarakanath C and Tripathi SN. Experimental studies on the hypocholesterolemic effect of Commiphora mukul. Engl. (Guggul). Indian Journal of Medical Research 1969; 57: 1950-1962.
14. Saxena G, Singh SP, Pal R, Singh S, Pratap R and Nath C. Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice. Pharmacology and Biochemistry of Behaviour 2007; 86: 797-805.
15. Singh BB, Mishra LC, Vinjamury SP, Aqquilinia N, Singh VJ and Shepard N. The effectiveness of Commiphora mukul for osteoartherisis of knee: an outcomes study. Alternative Therapies in Health and Medicine 2003; 9: 74-79.
16. Singh K, Chander R and Kapoor NK. Hypolipidemic and antaoxidant effects of Commiphora mukul as an adjunct to ditery therapy in patients with hypercholesterolemia. Cardiovascular Drugs Therapy 1997; 8: 659-664.
17. Urizar NL and Moore DD. GUGULIPID: a natural cholesterol-lowering agent. Annual Review of Nutrition 2003; 23: 303-313.
18. US Department of Health and Human Services, Food and Drug Administration Center for Drug Evaluation and Research Center, Center for Veterinary Medicine. Guidance for Industry, Bioanalytical Method Validation, 2001.
19. Verma N, Singh SK and Gupta RC. Pharmacokinetics of guggulsterone after intravenous and oral administration in rats. Pharmacy and Pharmacology Communications 1999; 5: 349-354.
20. Williams MG, Shobe EM, Bothwell BE and Zhong WZ. Development of a sensitive bioanalytical method for determination of PNU-83757 in rat, monkey and human plasma: from LC-UV to LC-MS/MS. Journal of Pharmacy and Biomedical Analysis 2002; 30: 429-441.
21. Wu J, Xia C, Meier AJ, Li S, Hu X and Lala DS. The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Molecular Endocrinology 2002; 16: 1590-1597.