Simultaneous determination of Aprepitant and two metabolites in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 5, 2004, Pages 1213-1229

  Chavez Eng, C M ^a   Constanzer, M L ^a   Matuszewski, B K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aprepitant; High performance liquid chromatography; Plasma

Indexed keywords

ACETONITRILE; ANTIEMETIC AGENT; APREPITANT; DRUG METABOLITE; NEUROKININ 1 RECEPTOR; TRIFLUOROACETIC ACID;

ARTICLE; ATMOSPHERIC PRESSURE; CHROMATOGRAPHY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG SAFETY; DRUG TOLERABILITY; FLOW RATE; HEATING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NEBULIZER; NORMAL HUMAN; PH; PRIORITY JOURNAL; REACTION ANALYSIS; STANDARD; TANDEM MASS SPECTROMETRY;

ANTIEMETICS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUG STORAGE; FREEZING; HUMANS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; MORPHOLINES;

EID: 4344616067     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.03.020     Document Type: Article

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