Development of a sensitive bioanalytical method for determination of PNU-83757 in rat, monkey and human plasma: From LC-UV to LC-MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 30, Issue 3, 2002, Pages 429-441

  Williams, M G ^a   Shobe, E M ^a   Bothwell, B E ^a   Zhong, W Z ^a  

^a Pharmacokinetics and Bioanalytical Research   (United States)

Author keywords

Automation; Bioanalytical method; Erectile dysfunction; LC APCI MS MS; LC ESI MS MS; PNU 83757; Solid phase extraction

Indexed keywords

GUANIDINE DERIVATIVE; N CYANO N' (TERT PENTYL) N'' (3 PYRIDINYL)GUANIDINE; PNU 83757; UNCLASSIFIED DRUG;

ARTICLE; BLOOD ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY WITH ATMOSPHERIC PRESSURE CHEMICAL IONIZATION TANDEM MASS SPECTROMETRY; MASS SPECTROMETRY; MONKEY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; ULTRAVIOLET RADIATION;

ANIMALS; CHROMATOGRAPHY, LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GUANIDINE; HAPLORHINI; HUMANS; RATS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; VASODILATOR AGENTS;

EID: 0037201649     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(02)00221-2     Document Type: Article

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