Oral administration of bis(aspirinato)zinc(II) complex ameliorates hyperglycemia and metabolic syndrome-like disorders in spontaneously diabetic KK-A y mice: Structure-activity relationship on zinc-salicylate complexes

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 8, 2011, Pages 972-977

  Yoshikawa, Yutaka ^a   Adachi, Yusuke ^a   Yasui, Hiroyuki ^a   Hattori, Masakazu ^b   Sakurai, Hiromu ^c  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION KYOTO MEDICAL CENTER   (Japan)

^c SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Anti diabetic agent; Anti metabolic syndrome agent; Inorganic medicine; Zn aspirin complex

Indexed keywords

5 NITROSALICYLIC ACID; ACETYLSALICYLIC ACID; ADIPONECTIN; ALANINE AMINOTRANSFERASE; ANTIHYPERTENSIVE AGENT; ASPARTATE AMINOTRANSFERASE; BIS(ASPIRINATO)ZINC COMPLEX; CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; INSULIN; MESALAZINE; NITROGEN; ORAL ANTIDIABETIC AGENT; SALICYLIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ZINC COMPLEX; ZINC SULFATE;

ADIPOCYTE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE THERAPY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD PRESSURE REGULATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HYPERGLYCEMIA; HYPERTENSION; IC 50; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; INSULIN RESISTANCE; LIGAND BINDING; MALE; METABOLIC SYNDROME X; MORNING DOSAGE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN BLOOD LEVEL; STRUCTURE ACTIVITY RELATION; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; ZINC BLOOD LEVEL;

ADIPONECTIN; ADMINISTRATION, ORAL; ANIMALS; ASPIRIN; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 2; GLUCOSE TOLERANCE TEST; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LEPTIN; MALE; METABOLIC SYNDROME X; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC COMPOUNDS;

EID: 79961114704     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.972     Document Type: Article

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