Study on toxicity of danshensu in beagle dogs after 3-month continuous intravenous infusion Study on toxicity of danshensu in beagle dogs Guisheng Li et al.

Toxicology Mechanisms and Methods

Volumn 19, Issue 6-7, 2009, Pages 441-446

  Li, Guisheng ^a,b   Gao, Yonglin ^b,c   Li, Shenjun ^b   Li, Chunmei ^a,b   Zhu, Xiaoyin ^a,b   Li, Min ^a   Liu, Zhifeng ^b  

^a YANTAI UNIVERSITY   (China)

^b Shandong Luye Research and Development for Natural Drugs Co Ltd   (China)

^c OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

Danshensu; Dogs; Intravenous infusion; Subchronic toxicity

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD CHEMISTRY; BODY TEMPERATURE; BODY WEIGHT; CONTINUOUS INFUSION; CONTROLLED STUDY; DOG; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; QRS COMPLEX; QT INTERVAL; RR INTERVAL; TOXICITY TESTING; URINALYSIS;

ANIMALS; BODY WEIGHT; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; LACTATES; LETHAL DOSE 50; MALE; MEDICINE, CHINESE TRADITIONAL; MOLECULAR STRUCTURE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

CANIS FAMILIARIS; SALVIA MILTIORRHIZA;

EID: 70350434483     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510903150623     Document Type: Article

References (19)

1. Gao YL, Liu ZF, Li GS, Li CM, Li M, Li BF. 2009. Acute and subchronic toxicity of danshensu in mice and rats. Toxicol Mech Method, DOI: 10.1080/15376510902810672.
2. Ge YR, Fang L, Li J. 2002. Review of research on pharmacopoeia prescription preparation of compound salvia. Zhong Cheng Yao 24:872-875.
3. Hamid R, Jaouad E, Zafar HI, Badiâa L. 2008. Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J Ethnopharmacol 118:378-386.
4. Hu XR, Cao FM. 2003. An investigation of Danshen root: pharmacology study, clinical application and preparation. Zhongguo Xinyiyao 2:54-55.
5. Jiang WD, Chen YH, Wang YP, Dong ZT, Yuan LX, Lu YQ, Wei SJ, Wang Y, Liu SZ. 1982. Effect of 'danshensu' and other two water-soluble components of salvia miltiorrhiza on dog ischemic myocardium and isolated coronary artery. Acta Acdemial Medicinal Primae Shanghai 9:13-19.
6. Kim JC, Kang BH, Shin CC, Kim YB, Lee HS, Kim CY, Han J, Kim KS, Chung DW, Chung MK. 2002. Subchronic toxicity of plant sterol esters administered by gavage to Sprague-Dawley rats. Food Chem Toxicol 40:1369-1380.
7. Lei YQ. 2005. Determination of the content of przewatanshinquinone in Salvia Miltiorrhiza by HPLC. Guiding J TCM 11:59-61.
8. Li LN. 1998. Biologically active components from traditional Chinese medicines. Pure Appl Chem 70:547-554.
9. Liu XQ, Luo XT, Ouyang XA. 2001. Research advance of FufangDanshen dosage forms. Shizhen Guoyi Guoyao 12:474-475.
10. Pan JY, Zhao XP, Shao Q. 2008. Pharmacokinetics and bioavailability study of danshensu in rat. Chin J Chin Mater Med 33:146-149.
11. Shi YM, Jin QL. 1982. Therapeutic observation of danshensu on 13 cases of persisting pneumonia. J Trad Chin Med 12:27-28.
12. Tian JW, Li GS, Liu ZF, Zhang SM, Qu GW, Jiang WL, Fu FH. 2008. ND-309, a novel compound, ameliorates cerebral infarction in rats by antioxidant action. Neurosci Lett 442:279-283.
13. Yang XY, Yao RM, Dai LD, Han BF. 1981. Clinical observation and pharmacological experiment study of dansensu. Chin Tradit Pat Med 2:35-37,45.
14. Yang Y, Xue X, Liu ZP. 2009. Protective effect of danshensu on focal cerebral ischemia-reperfusion injury in rats. Food Drug 11:24-26.
15. You JS, Pan TL, Lee YS. 2007. Protective effects of danshen (Salvia miltiorrhiza) on adriamycin-induced cardiac and hepatic toxicity in rat. Phytother Res 21:1146-1152.
16. Zhang JX, Tian JW. 2007. Safety evaluation of danshensu injection. J Toxicol 4:314.
17. Zhang T, Wang CY, Tian JW, Fu FH, Liu K. 2005. Protection of danshensu on brain damage in rats. Chin Trad Herbal Drugs 36:1041-1043.
18. Zhao GR, Zhang H-M, Ye TX, Xiang ZJ, Yuan YJ, Guo ZX, Zhao LB. 2008. Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B. Food Chem Toxicol 46:73-81.
19. Zhou L, Zuo Z, Chow MSS. 2005. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 45:1345-1359.