Leptin and adiponectin in pancreatic cancer: Connection with diabetes mellitus

Neoplasma

Volumn 58, Issue 1, 2011, Pages 58-64

  Krechler, T ^a   Zeman, M ^a   Vecka, M ^a   Macasek, J ^a   Jachymova, M ^b   Zima, T ^b   Zak, A ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Adiponectin; Leptin; Pancreatic cancer; Type 2 diabetes mellitus

Indexed keywords

ADIPONECTIN; LEPTIN;

ADULT; AGE DISTRIBUTION; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CANCER LOCALIZATION; CANCER RISK; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DISEASE DURATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS CANCER; SMOKING; WAIST CIRCUMFERENCE; AGED; BLOOD; INSULIN RESISTANCE; MIDDLE AGED; PANCREAS TUMOR; PILOT STUDY;

ADIPONECTIN; ADULT; AGED; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN RESISTANCE; LEPTIN; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PILOT PROJECTS;

EID: 79961105023     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: 10.4149/neo_2011_01_58     Document Type: Article

References (43)

1. Novotvary 2006. Praha, ÚZIS and NOR, 2009. (in Czech)
2. FERLAY J, AUTIER P, BONIOL M, HEANUE M, COLOM-BET M et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007; 18: 581-592. doi:10.1093/annonc/mdl498
3. American Cancer Society: Cancer Facts and Figures. Atlanta, GA. Am. Cancer Soc; 2007
4. CHARI ST. Detecting early pancreatic cancer: problems and prospects. Semin Oncol 2007; 34: 284-294. doi:10.1053/j.seminoncol.2007.05.005
5. GODSLAND IF. Insulin resistance and hyperinsulinaemia in the development and progression of cancer. Clinical Science 2010; 118: 315-332. doi:10.1042/CS20090399
6. LI D, MORRIS JS, LIU J, HASSAN, MM, DAY RS et al. Body Mass Index and Risk, Age of Onset, and Survival in Patients with Pancreatic Cancer. JAMA 2009; 301: 2553-2562.
7. KRECHLER T, JACHYMOVA M, PAVLIKOVA M, VECKA M, ZEMAN M et al. Polymorphism -23HPhI in the promoter of insulin gene and pancreatic cancer: A pilot study. Neoplasma 2009; 56: 26-32. doi:10.4149/neo_2009_01_26
8. PANNALA R, BASU A, PETERSEN GM, CHARI ST. Newonset diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol 2009; 10: 88-95. doi:10.1016/ S1470-2045(08)70337-1
9. PANNALA R, LEIRNESS JB, BAMLET WR, BASU A, PETERSEN GM et al. Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology 2008; 134: 981-987. doi:10.1053/j.gastro.2008.01.039
10. LANG K AND RATKE J. Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration. Cell Communication Signal 2009; 7: 27. doi:10.1186/1478-811X-7-27
11. MINOKOSHI Y, ALQUIER T, FURUKAWA N, KIM YB, LEE A et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428: 569-574. doi:10.1038/nature02440
12. HUANG L AND LI C. Leptin: a multifunctional hormone. Cell Research 2000; 10: 81-92. doi:10.1038/sj.cr.7290038
13. BADO A, LEVASSEUR S, ATTOUB S, KERMORGANT S, LAIGNEAU JP et al. The stomach is a source of leptin. Nature 1998; 394: 790-793. doi:10.1038/29547
14. BARATTA M. Leptin-from a signal of adiposity to a hormone mediator in peripheral tissues. Med Sci Monit 2002; 8: RA282-92.
15. MEIER U AND GRESSNER AM. Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin. Clinical Chemistry 2004; 50: 1511-1525. doi:10.1373/clinchem.2004.032482
16. GAROFALO C AND SURMACZ E. Leptin and cancer. J Cell Physiol 2006; 207: 12-22. doi:10.1002/jcp.20472
17. HOTTA K, FUNAHASHI T, ARITA Y, TAKAHASHI M, MATSUDA M et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20: 1595-1599.
18. WEYER C, FUNAHASHI T, TANAKA S, HOTTA K, MATSUZAWA Y et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: 1930-1935. doi:10.1210/jc.86.5.1930
19. BARB D, WILLIAMS CJ, NEUWIRTH AK, MANTZOROS CS. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr 2007; 86(suppl): 858S-866S.
20. DALAMAGA M, MIGDALIS I, FARGNOLI JL, PAPADAVID E, BLOOM E et al. Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. Cancer Causes Control 2009; 20: 625-633. doi:10.1007/s10552-008-9273-z
21. ALBERTI KGM and ZIMMET PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional Report of a WHO Consultation. Diabet Med 1998; 15: 539-553. doi:10.1002/(SICI)1096-9136(199807)15:7<539:: AID-DIA668>3.0.CO;2-S
22. AJCC Cancer staging Handbook The 6th edition, New York: Springer Verlag 2002.
23. ROSE DP, KOMNINOU D, STEPHENSON GD. Obesity, adipocytokines, and insulin resistance in breast cancer. Obesity Reviews 2004; 5: 153-165. doi:10.1111/j.1467-789X.2004.00142.x
24. SHARMA D, SAXENA NK, VERTINO PM, ANANIA FA. Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways. Endocr Relat Cancer 2006; 13: 629-640. doi:10.1677/erc.1.01169
25. SOMASUNDAR P, FRANKENBERRY KA, SKINNER, H. VEDULA G, MCFADDEN DW et al. Prostate cancer cell proliferation is influenced by leptin. J Surg Res 2004; 118: 71-82. doi:10.1016/j.jss.2004.01.017
26. TESSITORE L, VIZIO B, JENKINS O, DE STEFANO I, RITOSSA C et al. Leptin expression in colorectal and breast cancer patients. Int J Mol Med 2000; 5: 421-426.
27. ARPACI F, YILMAZ MI, OZET A, AYTA H, OZTURK B, et al. Low serum leptin level in colon cancer patients without significant weight loss. Tumori 2002; 88: 147-149.
28. BOLUKBAS FF, KILIC H, BOLUKBAS C, GUMUS M, HOROZ M et al. Serum leptin concentration and advanced gastrointestinal cancers: a case controlled study. BMC Cancer 2004; 4: 29. doi:10.1186/1471-2407-4-29
29. BROWN DR, BERKOWITZ DE, BRESLOW MJ. Weight loss is not associated with hyperleptinemia in humans with pancreatic cancer. J Clin Endocrinol Metab 2001; 86: 162-166. doi:10.1210/jc.86.1.162
30. BARBER MD, MCMILLAN DC, WALLACE AM, ROSS JA, PRESTON T et al. The response of leptin, interleukin- 6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer. Br J Cancer 2004; 90: 1129-1132. doi:10.1038/sj.bjc.6601712
31. CHANG MC, CHANG YT, SU TC, YANG WS, CHEN CL et al. Adiponectin as a potential differential marker to distinguish pancreatic cancer and chronic pancreatitis. Pancreas 2007; 35: 16-21. doi:10.1097/MPA.0b013e3180547709
32. STOLZENBERG-SOLOMON RZ, PIETINEN P, TAYLOR PR, VIRTAMO J, ALBANES D. A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland). Cancer Causes Control 2002; 13: 417-426. doi:10.1023/A:1015729615148
33. Mitri J, Castillo J, PITTAS AG. Diabetes and risk of Non-Hodgkin's lymphoma: a meta-analysis of observational studies. Diabetes Care 2008; 31: 2391-2397. doi:10.2337/dc08-1034
34. PETRIDOU ET, SERGENTANIS TN, DESSYPRIS N, VLACHANTONI IT, TSELENI-BALAFOUTA S et al. Serum Adiponectin As a Predictor of Childhood Non-Hodgkin's Lymphoma: A Nationwide Case-Control Study. J Clin Oncol 2009; 27: 5049-5055. doi:10.1200/JCO.2008.19.7525
35. BELLONE G, TURLETTI A, ARTUSIO E, MARESCHI K, CARBONE A et al. Tumor-Associated Transforming Growth Factor-b and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients. Am J Pathol 1999; 155: 537-547.
36. WOLF I, SADETZKI S, KANETY H, KUNDEL Y, PARIENTE C et al. Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients. Cancer 2006; 106: 966-973. doi:10.1002/cncr.21690
37. GARCEA G, DENNISON AR, STEWARD WP, BERRY DP. Role of inflammation in pancreatic carcinogenesis and the implications for future therapy. Pancreatology 2005; 5: 514-529. doi:10.1159/000087493
38. NKHATA KJ, RAY A, SCHUSTER TF, GROSSMANN ME, CLEARY MP. Effects of adiponectin and leptin co-treatment on human breast cancer growth. Oncology Rep 2009; 21: 1611-1619.
39. CHEN DC, CHUNG YF, YEH YT, CHAUNG HC, KOU FC et al. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 2006; 237: 109-114. doi:10.1016/j.canlet.2005.05.047
40. YAMAJI T, IWASAKI M, SASAZUKI S, TSUGANE S. Interaction between Adiponectin and Leptin Influences the Risk of Colorectal Adenoma. Endocrine Abstracts 2007; 14: P136.
41. INOUE M, MAEHATA E, YANO M, TANIYAMA M, SUZUKI S. Correlation between the diponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism Clin Exp 2005; 54: 281-286.
42. NORATA GD, RASELLI S, GRIGORE L, GARLASCHELLI K, DOZIO E et al. Leptin: Adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery. Stroke 2007; 38: 2844-2846. doi:10.1161/STROKEAHA.107.485540
43. ZEMAN M, JIRAK R, JACHYMOVA M, VECKA M, TVRZICKA E et al. Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. Neuroendocrinol Lett 2009; 30: 387-395.