The effects of low-level Pb on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary

Toxicological Sciences

Volumn 77, Issue 1, 2004, Pages 35-40

  Srivastava, Vinod ^a   Dearth, Robert K ^a   Hiney, Jill K ^a   Ramirez, Lisa M ^a   Bratton, Gerald R ^a   Les Dees, W ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Estradiol; Fisher 344 rats; Lead (Pb) toxicity; Luteinizing hormone; Pubertal development; Steroidogenic acute regulatory protein

Indexed keywords

ACETIC ACID; ESTRADIOL; GONADOTROPIN; LEAD ACETATE; LUTEINIZING HORMONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREEDING; CONTROLLED STUDY; ESTROGEN SYNTHESIS; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GONADOTROPIN BLOOD LEVEL; HORMONAL REGULATION; HORMONE RESPONSE; LUTEINIZING HORMONE BLOOD LEVEL; NONHUMAN; OVARY; PREPUBERTY; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; RAT; RAT STRAIN; STATISTICAL ANALYSIS; WEANING;

ANIMALS; BLOTTING, NORTHERN; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; GENE EXPRESSION; GONADOTROPINS, EQUINE; MATERNAL EXPOSURE; MITOCHONDRIA; ORGANOMETALLIC COMPOUNDS; OVARY; PHOSPHOPROTEINS; RATS; RATS, INBRED F344; RNA, MESSENGER; SEXUAL MATURATION;

ANIMALIA; MARTES PENNANTI;

EID: 1642463901     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg249     Document Type: Article

References (34)

1. Centers for Disease Control (1997). Update: Blood lead levels-United States, 1991-1994. Morbid Mortal Wkly Rep. 46, 141-146.
2. Centers for Disease Control (1991). Preventing Lead Poisoning in Children. U.S. Department. of Health and Human Services, Atlanta, GA.
3. Chung, P. H., Sandhoff, T. W., and McLean, M. P. (1998). Hormone and prostaglandin F2α regulation of messenger ribonucleic acid encoding steroidogenic acute regulatory protein in human corpora lutea. Endocrine 8, 153-160.
4. Clark, B. J., Soo, S. C., Caron, K. M., Ikeda, Y., Parker, K. L., and Stocco, D. M. (1995). Hormonal and developmental regulation of the steroidogenic acute regulatory protein. Mol. Endocrinol. 9, 1346-1355.
5. Dearth, R. K., Hiney, J. K., Srivastava, V. K., Burdick, S. B., Bratton, G. R., and Dees, W. L. (2002). Effects of lead (Pb) exposure during gestation and lactation on female pubertal development. Reprod. Toxicol. 16, 343-352.
6. Dees, W. L., Hiney, J. K., Fuentes, F., and Forrest, D. W. (1990). Ethanol alters vasoactive intestinal peptide-induced steroid secretion from immature rat ovaries in vitro. Life Sci. 46, 165-172.
7. Epstein, L. F., and Orme-Johnson, N. R. (1991). Regulation of steroid hormone biosynthesis. Identification of precursors of phosphoprotein targeted to the mitochondria in stimulated rat adrenal cortex cells. J. Biol. Chem. 266, 739-745.
8. Franks, P. A., Laughlin, N. K., Dierschke, D. J., Bowman, R. E., and Meller, P. A. (1989). Effects of lead on luteal function in rhesus monkeys. Bio. Reprod. 41, 1055-1062.
9. Hilderbrand, D. C., Der, R., Griffin, W. T., and Fahim, M. S. (1973). Effect of lead acetate on reproduction. Am. J. Obstet. Gynecol. 115, 1055-1065.
10. Huang, B. M., Stocco, D. M., Li, P. H., Yang, H. Y., Wu, C. M., and Norman, R. L. (1997). Corticotropin-releasing hormone stimulates the expression of the steroidogenic acute regulatory protein in MA-10 mouse cells. Biol. Reprod. 57, 547-551.
11. Huang, B. M., Tsai, M. L., Li, P. H., and Liu, M. Y. (2002). Concentration dependency in lead-inhibited steroidogenesis in MA-10 mouse Leydig tumor cells. J. Toxicol. Environ. Health 65, 557-567.
12. Huang, B. M., Tsai, M. L., Li, P. H., Yang, H. T., and Liu, M. Y. (1997). The effects of lead on StAR protein expression and steroidogenesis in MA-10 cells. Biol. Reprod. 56(Suppl.), 201.
13. Kempinas, W. G., Farvaretto, A. L. V., Melo, V. R., Lamano, K., Carvalho, T. L, Petenusci, S. O, and Oliveira-Filho, R. M. (1994). Time-dependent effects of lead on rat reproductive functions. J. Appl. Toxicol. 14, 427-433.
14. King, S. R., Ronen-Fuhramann, T., Timberg, R., Clark, B. J., Orly, J., and Stocco, D. M. (1995). Steroid production following the in vitro transcription, translation, and mitochondrial processing of the protein products of the cDNA for the steroidogenic acute regulatory (StAR) protein. Endocrinology 136, 5165-5176.
15. Lin, T., Sugawara, T., Strauss III, J. F., Clark, B. J., Stocco, D. M., Saenger, P., Rogol, A., Miller, W. L. (1995). Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267, 1828-1831.
16. Luo, L., Chen, H., Stocco, D. M., and Zirkin, B. R. (1998). Leydig cell protein synthesis and steroidogenesis in response to acute stimulation by luteinizing hormone in rats. Biol. Reprod. 59, 263-270.
17. McGivern, R. F., Sokol, R. Z., and Berman, N. G. (1991). Prenatal lead exposure in the rat during the third week of gestation: Long-term behavioral, physiological, and anatomical effects associated with reproduction. Toxicol. Appl. Pharmacol. 110, 206-215.
18. Miller, W. L. (1988). Molecular biology of steroid hormone synthesis. Endocr. Rev. 9, 295-318.
19. Mizutani, T., Sonoda, Y., Minegishi, T., Wakabayashi, K., and Miyamoto, K. (1997). Molecular cloning, characterization and cellular distribution of rat steroidogenic acute regulatory protein (StAR) in the ovary. Life Sci. 61, 1497-1506.
20. Mushak, P. (1992). Defining lead as the premiere environmental health issue for children in America: Criteria and their quantitative application. Environ. Res. 59, 281-309.
21. Ojeda, S. R., Urbanski, H. F., and Ahmed, C. E. (1986a). The onset of female puberty: Studies in the rat. Recent Prog. Horm. Res. 42, 385-442.
22. Ojeda, S. R., Urbanski, H. F., Katz, K. H., and Costa, M. E. (1986b). Activation of estradiol-positive feedback at puberty: Estradiol sensitizes the LHRH-releasing system at two different biochemical steps. Neuroendocrinology 43, 259-265.
23. Orly, J., and Stocco, D. M. (1999). The role of the steroidogenic acute regulatory (StAR) protein in female reproductive tissues. Horm. Metab. Res. 31, 389-398.
24. Pescador, N., Houde, A., Stocco, D. M., and Murphy, B. D. (1997). Follicle-stimulating hormone and intracellular second messengers regulate steroidogenic acute regulatory protein messenger ribonucleic acid in luteinized porcine granulose cells. Biol. Reprod. 57, 660-668.
25. Ronis, M. J. J., Badger, T. M., Shema, S. J., Roberson, P. K., and Shaikh, F. (1996). Reproductive toxicity and growth effects in rats exposed to lead at different periods during development. Toxicol. Appl. Pharmacol. 136, 361-371.
26. Ronis, M. J. J., Badger, T. M., Shema, S. J., Roberson, P. K., Templer, L., Ringer, D., and Thomas, P. K. (1998). Endocrine mechanisms underlying the growth effects of developmental lead exposure in the rat. J. Toxicol. Environ. Health 54, 101-120.
27. Sandhoff, T. W., and McLean, M. P. (1996). Hormonal regulation of steroidogenic acute regulatory (StAR) protein messenger ribonucleic acid expression in the rat ovary. Endocrine 4, 259-267.
28. Srivastava, V., Hiney, J. K., Dearth, R. K., and Dees, W. L. (2001). Acute effects of ethanol exposure on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary. Alcoholism Clin. Exp. Res. 25, 1500-1505.
29. Stocco, D. M., and Clark, B. J. (1997). The role of the steroidogenic acute regulatory protein in steroidogenesis. Steroids 62, 29-36.
30. Stocco, D. M., and Sodeman, T. C. (1991). The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors. J. Biol. Chem. 266, 19731-19738.
31. 1 lead-toxic rats. Fertil. Steril. 22, 755-760.
32. Sugawara, T., Lin, D., Holt, J. A., Martin, K. O., Javitt, N. B., Miller, W. L., and Strauss III, J. F. (1995). Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity. Biochemistry 34, 12506-12512.
33. Wiebe, J. P., Barr, K. J., and Buckingham, K. D. (1982). Lead administration during pregnancy and lactation affects steroidogenesis and hormone receptors in the testis of offspring. J. Toxicol. Environ. Health 10, 653-660.
34. Wiebe, J. P., Barr, K. J., and Buckingham, K. D. (1988). Effect of prenatal and neonatal exposure to lead on gonadotropin receptors and steroidogenesis in rat ovaries. J. Toxicol. Environ. Health 24, 461-476.