Towards improved therapeutic CORMs: Understanding the reactivity of CORM-3 with proteins

Current Medicinal Chemistry

Volumn 18, Issue 22, 2011, Pages 3361-3366

  Santos Silva, T ^a   Mukhopadhyay, A ^a   Seixas, J D ^b,c   Bernardes, G J L ^b,d   Romao C C ^b,c   Romao M J ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c Alfama Lda   (Portugal)

^d ETH ZURICH   (Switzerland)

Author keywords

CO therapy; CO RM; CORM 3; Hen Egg White Lysozyme; Metal carbonyl complex; Protein metal adduct; X ray crystallography

Indexed keywords

BACTERICIDE; BOVINE SERUM ALBUMIN; CARBON MONOXIDE; CARBON MONOXIDE RELEASING MOLECULE; CARBON MONOXIDE RELEASING MOLECULE 3; CARBONYL DERIVATIVE; HEMOGLOBIN; LYSOZYME; METAL CARBONYL COMPLEX; METAL COMPLEX; PLASMA PROTEIN; PRODRUG; PROTEIN; TRANSITION ELEMENT; UNCLASSIFIED DRUG;

ATOMIC EMISSION SPECTROMETRY; BIOCOMPATIBILITY; CHEMICAL BOND; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; CONFERENCE PAPER; DRUG DECOMPOSITION; DRUG PROTEIN BINDING; DRUG SOLUBILITY; HUMAN; INFRARED SPECTROSCOPY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OXIDATION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

EID: 79961084009     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711796504583     Document Type: Conference Paper

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