Submerged conidiation and product formation by Aspergillus niger at low specific growth rates are affected in aerial developmental mutants

Applied and Environmental Microbiology

Volumn 77, Issue 15, 2011, Pages 5270-5277

  Jørgensen, Thomas R ^a,b,d   Nielsen, Kristian F ^c   Arentshorst, Mark ^a,b   Park, JooHae ^a   van den Hondel, Cees A ^a,b   Frisvad, Jens C ^c   Ram, Arthur F ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b KLUYVER CENTRE FOR GENOMICS OF INDUSTRIAL FERMENTATION   (Netherlands)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR PLATES; ASPERGILLUS NIGER; CONIDIATION; EXTRACELLULAR PROTEINS; FILAMENTOUS FUNGI; GENETIC PROGRAMS; INDUSTRIAL PERFORMANCE; MELANIN SYNTHESIS; NUTRIENT LIMITATIONS; POLYKETIDE SYNTHASES; PRODUCT FORMATION; SECONDARY METABOLITES; SPECIFIC GROWTH RATE; SUBMERGED CULTIVATION; SUBSTRATE LIMITATION; VEGETATIVE GROWTH; VEGETATIVE MYCELIA; WILD-TYPE STRAIN;

BIOCHEMISTRY; BIOSYNTHESIS; KETONES; METABOLISM; METABOLITES; NUTRIENTS;

ASPERGILLUS;

CHROMONE DERIVATIVE; FLAVASPERONE; FUMONISIN; FUNGAL PROTEIN; FURAN DERIVATIVE; PYRROLE DERIVATIVE; TENSIDOL B;

AERIAL SURVEY; ASEXUAL REPRODUCTION; CULTIVATION; FUEL; FUNGUS; GENETIC DIFFERENTIATION; GROWTH RATE; LIMITING FACTOR; MELANIN; MUTATION; NUTRIENT LIMITATION; PHENOTYPE; SECONDARY METABOLITE; SUBMERGENCE; ULTRAVIOLET RADIATION;

ARTICLE; ASEXUAL REPRODUCTION; ASPERGILLUS NIGER; CHEMISTRY; CULTURE MEDIUM; ENVIRONMENTAL EXPOSURE; FUNGAL GENE; FUNGUS HYPHAE; FUNGUS SPORE; GENE EXPRESSION PROFILING; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; PHYSIOLOGICAL STRESS; STARVATION;

ASPERGILLUS NIGER; CHROMONES; CULTURE MEDIA; ENVIRONMENTAL EXPOSURE; FUMONISINS; FUNGAL PROTEINS; FURANS; GENE EXPRESSION PROFILING; GENES, FUNGAL; HYPHAE; MUTATION; PYRROLES; REPRODUCTION, ASEXUAL; SPORES, FUNGAL; STARVATION; STRESS, PHYSIOLOGICAL;

ASCOMYCOTA; ASPERGILLUS NIGER; BASIDIOMYCOTA; FUNGI; FUNGI IMPERFECTI; MYCELIUM (GENUS); SCLEROTIUM (ASCOMYCOTA); SCLEROTIUM (BASIDIOMYCOTA);

EID: 79961079865     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00118-11     Document Type: Article

References (46)

1. Adams, T. H., J. K. Wieser, and J. H. Yu. 1998. Asexual sporulation in Aspergillus nidulans. Microbiol. Mol. Biol. Rev. 62:35-54.
2. Atoui, A., D. Mitchell, F. Mathieu, N. Magan, and A. Lebrihi. 2007. Partitioning of ochratoxin A in mycelium and conidia of Aspergillus carbonarius and the impact on toxin contamination of grapes and wine. J. Appl. Microbiol. 103:961-968.
3. Bailey, M. J., et al. 2002. Process technological effects of deletion and amplification of hydrophobins I and II in transformants of Trichoderma reesei. Appl. Microbiol. Biotechnol. 58:721-727.
4. Bok, J. W., et al. 2009. Chromatin-level regulation of biosynthetic gene clusters. Nat. Chem. Biol. 5:462-464.
5. Bos, C. J., et al. 1988. Genetic analysis and the construction of master strains for assignment of genes to six linkage groups in Aspergillus niger. Curr. Genet. 14:437-443.
6. Broderick, A. J., and R. N. Greenshields. 1981. Sporulation of Aspergillus niger and Aspergillus ochraceus in continuous submerged liquid culture. J. Gen. Microbiol. 126:193-202.
7. Brown, S. H., et al. 2009. Oxygenase coordination is required for morphological transition and the host fungus interaction of Aspergillus flavus. Mol. Plant Microbe Interact. 22:882-894.
8. Bushell, M. E., and A. T. Bull. 1999. Sporulation at minimum specific growth rate in Aspergillus nidulans chemostat culture predicted using protein synthesis efficiency estimations. J. Basic Microbiol. 39:293-298.
9. Calvo, A. M., R. A. Wilson, J. W. Bok, and N. P. Keller. 2002. Relationship between secondary metabolism and fungal development. Microbiol. Mol. Biol. Rev. 66:447-459
10. Calvo, A. M. 2008. The veA gene regulatory system and its role in morphological and chemical development in fungi. Fungal Genet. Biol. 45:1053-1061.
11. Damveld, R. A., et al. 2008. A novel screening method for cell wall mutants in Aspergillus niger identifies UDP-galactopyranose mutase as an important protein in fungal cell wall biosynthesis. Genetics 178:873-881.
12. de Cássia, R., R. Goncalves, and S. R. Pombeiro-Sponchiado. 2005. Antioxidant activity of the melanin-pigment extracted from Aspergillus nidulans. Biol. Pharm. Bull. 28:1129-1131.
13. Fisch, K. M., et al. 2009. Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger. J. Ind. Microbiol. Biotechnol. 36:1199-1213.
14. Fischer, R. 2002. Conidiation in Aspergillus nidulans, p. 59-88. In H. Osiewacz (ed.), Molecular development of fungal biology. Marcel Dekker, New York, NY.
15. Frisvad, J. C., J. Smedsgaard, R. A. Samson, T. O. Larsen, and U. Thrane. 2007. Fumonisin B2 production by Aspergillus niger. J. Agric. Food Chem. 55:9727-9732.
16. Geiser, D. M., W. E. Timberlake, and M. L. Arnold. 1996. Loss of meiosis in Aspergillus. Mol. Biol. Evol. 13:809-917.
17. Han, K. H., et al. 2001. The nsdD gene encodes a putative GATA-type transcription factor necessary for sexual development of Aspergillus nidulans. Mol. Microbiol. 41:299-309.
18. Herbert, D., P. J. Phipps, and R. E. Strange. 1969. Chemical analysis of microbial cells, p. 209-344. In J. R. Norris and D. W. Ribbons (ed.), Methods in microbiology, vol. 5B. Academic Press, London, United Kingdom.
19. Horn, B. W., J. H. Ramirez-Prado, and I. Carbone. 2009. Sexual reproduction and recombination in the aflatoxin-producing fungus Aspergillus parasiticus. Fungal Genet. Biol. 46:169-175.
20. Iversen, J. J. L., J. K. Thomsen, and R. P. Cox. 1994. On-line growth measurements in bioreactors by titrating metabolic proton exchange. Appl. Microbiol. Biotechnol. 42:256-262.
21. Jørgensen, T. R., T. Goosen, C. A. van den Hondel, A. F. J. Ram, and J. J. L. Iversen. 2009. Transcriptomic comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of the secretory pathway. BMC Genomics 10:44.
22. Jørgensen, T. R., et al. 2010. Transcriptomic insights into the physiology of Aspergillus niger approaching a specific growth rate of zero. Appl. Environ. Microbiol. 76:5344-5355.
23. Jørgensen, T. R., et al. 2011. The molecular and genetic basis of conidial pigmentation in Aspergillus niger. Fungal Genet. Biol. 48:544-553.
24. Kim, H. R., K. S. Chae, K. H. Han, and D. M. Han. 2009. The nsdC gene encoding aputative C2H2-type transcription factor is a key activator of sexual development in Aspergillus nidulans. Genetics 182:771-783.
25. Kind, T., et al. 2009. Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal. Chem. 81:10038-10048.
26. Kozakiewicz, Z. 1989. Aspergillus species on stored products. CAB International, Wallingford, United Kingdom.
27. 6, a new fumonisin from Aspergillus niger. J. Agric. Food Chem. 58:949-953.
28. Nielsen, J. 2001. Metabolic engineering. Appl. Microbiol. Biotechnol. 55: 263-283.
29. Nielsen, K. F., and J. Smedsgaard. 2003. Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography-UV-mass spectrometry methodology. J. Chromatogr. A 1002:111-136.
30. Nielsen, K. F., J. M. Mogensen, M. Johansen, T. O. Larsen, and J. C. Frisvad. 2009. Review of secondary metabolites and mycotoxins from the Aspergillus niger group. Anal. Bioanal. Chem. 395:1225-1242.
31. Panagiotou, G., et al. 2009. Studies on the production of fungal polyketides in Aspergillus nidulans using systems biology tools. Appl. Environ. Microbiol. 75:2212-2220.
32. Pel, H. J., et al. 2007. Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat. Biotechnol. 25:221-231.
33. Pirt, S. J. 1965. The maintenance energy of bacteria in growing cultures. Proc. R. Soc. Lond. B Biol. Sci. 163:224-231.
34. Ruijter, G. J. G., C. P. Kubicek, and J. Visser. 2002. Production of organic acids by fungi, p. 213-230. In H. D. Osiewacz (ed.), The Mycota X. Springer-Verlag, Berlin, Germany.
35. Samson, R. A., et al. 2007. Diagnostic tools to identify black aspergilli. Stud. Mycol. 59:129-145.
36. Schuster, E., N. Dunn-Coleman, J. C. Frisvad, and P. W. M. van Dijck. 2002. On the safety of Aspergillus niger-a review. Appl. Microbiol. Biotechnol. 59:426-435.
37. Skromne, I., O. Sánchez, and J. Aquirre. 1995. Starvation stress modulates the expression of the Aspergillus nidulans brlA regulatory gene. Microbiology 141:21-28.
38. Standing, C. N., A. G. Fredrickson, and H. M. Tsuchiya. 1972. Batch- and continuous-culture transients for two substrate systems. Appl. Microbiol. 23:354-359.
39. Stein, S. J. 1999. An integrated method for spectrum extraction and compound identification from gas chromatography/mass spectrometry data. Am. Soc. Mass Spectrom. 10:770-781.
40. Twumasi-Boateng, K., et al. 2009. Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus. Eukaryot. Cell 8:104-115.
41. van Verseveld, H. W., et al. 1986. Modelling of microbial substrate conversion, growth and product formation in a recycling fermentor. Antonie Van Leeuwenhoek 52:325-342.
42. Varga, J., et al. 2007. Aspergillus brasiliensis sp. nov., a biseriate black Aspergillus species with world-wide distribution. Int. J. Syst. Evol. Microbiol. 57: 1925-1932.
43. Vishniac, W., and M. Santer. 1957. The thiobacilli. Bacteriol. Rev. 21:195-213.
44. Wicklow, D. T. 1983. Taxonomic features and ecological significance of sclerotia. South. Coop. Ser. Bull. 279:6-12.
45. Wicklow, D. T., and O. L. Shotwell. 1983. Intrafungal distribution of aflatoxins among conidia and sclerotia of Aspergillus flavus and Aspergillus parasiticus. Can. J. Microbiol. 29:1-5.
46. Yu, J. H., and N. P. Keller. 2005. Regulation of secondary metabolism in filamentous fungi. Annu. Rev. Phytopathol. 43:437-458.