Antineoplastic effect of mushrooms: A review

Australian Journal of Crop Science

Volumn 5, Issue 7, 2011, Pages 904-911

  Chatterjee, Soumya ^a   Biswas, Gunjan ^a   Basu, Saikat Kumar ^b   Acharya, Krishnendu ^a  

^a UNIVERSITY OF CALCUTTA   (India)

^b UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

Antiangiogenesis; Anticancer; Apoptosis; Fungi; Immunomodulators

Indexed keywords

BASIDIOMYCOTA; FUNGI;

EID: 79961072074     PISSN: 18352693     EISSN: 18352707     Source Type: Journal    
DOI: None     Document Type: Review

References (86)

1. Adachi Y, Suzuki Y, Jinushi T, Yadomae T, Ohno N (2002) Th1-oriented immunomodulating activity of gel-forming fungal (1-3)-beta-glucans. Int J Med Mushrooms 4: 95-109.
2. Ajith TA, Janardhanan KK (2003) Cytotoxic and antitumor activities of a polypore macrofungus, Phellinus rimosus (Berk) Pilat. J Ethnopharmacol 84: 157-162.
3. Berg WJ, Schwartz L, Yu R, Mazumdar M, Motzer RJ (2001) Phase II trial of irofulven (6-hydroxymethylacylfulvene) for patients with advanced renal cell carcinoma. Invest New Drugs 19: 317-320.
4. Bezivin C, Deleros JG, Fortil H, Amoros M, Boustie J (2003) Toxicity and antitumor activity of a crude extract from Lepista inverse (Scop.: Fr.) Pat. (Agaricomycetideae): A preliminary study. J Int Med Mushroom 5: 25-30.
5. Biswas G, Sarkar S, Acharya K (2011) Hepatoprotective activity of the ethanolic extract of Astraeus Hygrometricus (Pers.) Morg. Dig J Nanomater Bios 6: 637-641.
6. Biswas G, Sarkar S, Acharya K (2010) Free radical scavenging and anti-inflammatory activities of the extracts of Astraeus hygrometricus (Pers.) Morg. Latin Am J Pharm 29(4): 549-553.
7. Bluhm TL, Sarco A (1977) The triple helical structure of lentinan, a β-(1-3)-D-glucan. Canadian J Chem 55: 293-299.
8. Bongard-Levin GM (1980) In: The origin of Aryan Scythia to India, Arnold Heinemann Publishers (India) Pvt. Ltd., New Delhi.
9. Breene WW (1990) Nutritional and medical value of speciality mushrooms. J Food Prod 53: 883-894.
10. Chang ST, Miles PG (1989) The nutritional attributes and medicinal value of edible mushrooms. In: Edible mushrooms and their cultivation, CRC Press Inc., Florida, p 27-38.
11. Chang ST, Miles PG (1992) Mushroom biology- a new discipline. Mycologist 6: 64-65.
12. Chihara G, Hamuro J, Maeda Y, Arai Y, Fukuoka F (1970a) Antitumor polysaccharide derived chemically from natural glucan (pachyman). Nature 225: 943-944.
13. Chihara G, Hamuro J, Maeda YY, Arai Y, Fukuoka F (1970b) Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes. Cancer Res 30: 2776-2781.
14. Chihara G, Maeda Y, Hamuro J, Sasaki T, Fumiko F (1969) Inhibition of mouse Sarcoma 180 by polysaccharides from Lentinus edodes (Berk.)Sing. Nature 222: 687-688.
15. Chihara G (1992) Immunopharmacology of lentinan, a polysaccharide isolated from Lentinus edodes: its application as a host defense potentiator. Int J Orient Med 17: 57-77.
16. Daba AS, Ezeronye OU (2003) Anti-cancer effect of polysaccharides isolated from higher basidiomycetes mushrooms. African J Biotechnol 2(12): 672-678.
17. Deng G, Lin H, Seidman A, Fornier M, D'Andrea G, Wesa K, Yeung S, Cunningham-Rundles S, Vickers AJ, Cassileth B (2009) A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol 135: 1215-1221.
18. Fortes RC, Novaes MRCG, Recova VL, Melo AL (2009) Immunological, hematological, and glycemia effects of dietary supplementation with Agaricus sylvaticus on patients' colorectal cancer. Exp Biol Med 234: 53-62.
19. Fortes RC, Taveira VC, Novaes MRCG (2006) The immunomodulator role of β-D-glucans as co-adjuvant for cancer therapy. Rev Bras Nutr Clin 21: 163-168.
20. Fujimiya Y, Suzuki Y, Oshiman K, Kobori H, Moriguchi K, Nakashima H, Matumoto Y, Takahara S, Ebinat T, Katakura R (1998) Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomicete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol Immunother 46: 147-159.
21. Gao Y, Zhou S, Chen G, Dai X, Ye J (2002) A phase I/II study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. extract (Ganopoly) in patients with advanced cancer. Int J Med Mushrooms 4: 207-214.
22. Gregory FJ, Healy EM, Agersborg Jr. HPK, Warren GH (1966) Studies on antitumor substances produced by Basidiomycetes. Mycologia 58: 80-90.
23. Hazama S, Oka M, Yoshino S, Iizuka N, Wadamori K, Yamamoto N (1995) Clinical effects and immunological analysis of intra abdominal and intra pleural injection of lentinan for malignant ascites and pleural effusion of gastric carcinoma. Cancer Chemother 22: 1595-1597.
24. Hirata N, Tsuzuki A, Ohno N, Saita M, Adachi Y, Yadomae T (1998) Cytokine synthesis of human monocytes stimulated by triple or single helical conformer of an antitumour (1, 3)-β-D-glucan preparation, sonifilan. Zentralbl Bakteriol 288: 403-413.
25. Ikekawa T, Nakanishi M, Uehara N, Chihara G, Fukuoka F (1968) Antitumor action of some Basidiomycetes, especially Phellinus linteus. Gann 59(2): 155-157.
26. Ikekawa T, Uehara N, Maeda Y, Nakanishi M, Fukuoka F (1969) Antitumor activity of aqueous extracts of edible mushrooms. Cancer Res 29: 734-735.
27. Jong SC, Birmingham JM, Pai SH (1991) Immunomodulatory substances of fungal origin. J Immunol Immunopharm 9(3): 115-122.
28. Jong SC, Yang XT (1999) PSP- a powerful biological response modifier for the mushroom Coriolus versicolor. In: Yang QY (ed) Advanced research in PSP, Hong Kong Association for Health Care, Hong Kong, p16-28.
29. Jose N, Ajith TA, Janardhanan, KK (2002) Antioxidant, antiinflammatory, and antitumor activities of culinarymedicinal mushroom Pleurotus pulmonarius (Fr.) Quel. (Agaricomycetideae). J Int Med Mushroom 4: 329-335.
30. Jose N, Janardhanan KK (2000) Antioxidant and antitumor activity of Pleurotus florida. Curr Sci 79(7): 941-943.
31. Karinaga R, Mizu M, Koumoto K, Anada T, Shinkai S, Kimura T, Sakurai K (2004) First observation by fluorescence polarization of complexation between mRNA and the natural polysaccharide schizophyllan. Chem Biodivers 1: 634-639.
32. Kawagishi H (1995) Mushroom lectins. Food Rev Intern 11(1): 63-68.
33. Kim H, Hall P, Smith M, Kirk M, Prasain JK, Barnes S, Grubbs C (2004) Chemoprevention by Grape Seed Extract and Genistein in Carcinogen-induced Mammary Cancer in Rats Is Diet Dependent. J Nutr 134: 3445S-3452S.
34. Kodama N, Komuta K, Nanba H (2003) Effect of maitake (Grifola frondosa) D-fraction on the activation of NK cells in cancer patients. J Med Food 6: 371-377.
35. Kodama N, Komuta K, Sakai N, Nanba H (2002) Effects of D-fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells. Biol Pharm Bull 25: 1647-1650.
36. Konno K (1995) Biological active components of poisonous mushrooms. Food Rev Intern 11(1): 83-107.
37. Lee I S, Nishikawa A (2003) Polyozellus multiplex, a Korean wild mushroom, as a potent chemopreventive agent against stomach cancer. Life Sci 73: 3225-3234.
38. Lindequist U, Niedermeyer THJ, Julich WD (2005) The pharmacological potential of mushrooms eCAM 2(3): 285-299.
39. Lowy B (1971) New records of mushroom stories in Guatemala. Mycologia 63: 983.
40. Lucas EH, Ringler RL, Byerrum RU, Stevens JA, Clarke DA, Stock CC (1957) Tumor inhibitors in Boletus edulis and other Holobasidiomycetes. Antibiot Chemother 7: 1-14.
41. Lucas EH, Byerrum RU, Clarke DA, Reilly HC, Stevens JA, Stock CC (1959) Production of oncostatic principles in vivo and in vitro by species of genus Calvatia. Antibiot Annu 19: 493-496.
42. McMorris TC, Yu J, Lira R, Dawe R, MacDonald JR, Waters SJ, Estes LA, Kelner MJ (2001) Structure-activity of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues. J Org Chem 66: 6158-6163.
43. Miles PG, Chang ST (1997) Mushroom Biology: Concise Basics and Current Developments, World Scientific, Singapore.
44. Minato K, Mizuno M, Terai H, Tsuchida H (1999) Autolysis of lentinan, an antitumor polysaccharide, during storage of Lentinus edodes. Shiitake mushroom. J Agric Food Chem 47: 1530-1532.
45. Mizuno T, Sakai T, Chihara G (1995) Health foods and medicinal usages of mushrooms. Food Rev Int 11(1): 69-81.
46. Mizuno T (1995a) Bioactive biomolecules of mushroom-food, function and medicinal effect of mushroom fungi. Food Rev Int 11: 7-21.
47. Mizuno T (1995b) Yamabushitake, Hericium erinaceus: bioactive substances and medicinal utilization. Food Rev Int 11: 173-178.
48. Mizuno T (1996) Development of antitumor polysaccharides from mushroom fungi. Foods Food Ingred J Jpn 167: 69-85.
49. Mizuno T (1999) Extraction and development of antitumoractive polysaccharides from medicinal mushrooms in Japan. Int J Med Mushrooms 1: 9-29.
50. Mori K, Toyomasu T, Nanba H, Kuroda H (1989) Antitumor action of fruit bodies of edible mushrooms orally administered to mice. Mushroom Sci 12(1): 653-660.
51. Nanba H, Hamaguchi A, Kuroda H (1987) The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 35: 1162-1168.
52. Nasta SD, Hoff PM, George CS, Neubauer M, Cohen SC, Abbruzzese J, Winn R, Pazdur RM (2003) Phase II study of MGI-114 administered intravenously for 5 days every 28 days to patients with metastatic colorectal cancer. Am J Clin Oncol 26: 132-134.
53. Ng ML, Yap AT (2002) Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodis). J Altern Complement Med 8: 581-589.
54. Ohno N, Miura NN, Nakajima M, Yadomae T (2000) Antitumor 1.3-β-glucan from cultured fruit body of Sparassis crispa. Biol Pharm Bull 23: 866-872.
55. Okamura K, Kinukawa T, Tsumura Y, Otani T, Itoh T, Kobayashi H, Matsuura O, Kobayashi M, Fukutsu T, Ohshima S (1986) Clinical evaluation of Schizophyllan combined with irradiation in patients with cervical cancer: A randomized controlled study. Cancer 58: 865-872.
56. Ooi VEC, Liu F (1999) A review of pharmacological activities of mushroom polysaccharides. Int J Med Mushrooms 1: 195-206.
57. Pai SH, Jong SC, Lo DW (1990) Usages of mushrooms. Bioindustry 1: 126-131.
58. Pal J, Ganguly S, Tahsin KS, Acharya K (2010) In vitro free radical scavenging activity of wild edible mushroom, Pleurotus squarrosulus (Mont.) Singer. Indian J Exp Biol 47: 1210-1218.
59. Pan Ming Li MD (1992) Cancer treatment with Fu Zheng Pei Ben Principle, Fujian Science and Technology Press, China.
60. Pierson AS, Gibbs P, Richards J, Russ P, Eckhardt SG, Gonzalez R (2002) A phase II study of Irofulven (MGI 114) in patients with stage IV melanoma. Invest New Drugs 20: 357-362.
61. Prescott SM, Fitzpatrick FA (2000) Cyclooxygenase-2 and carcinogenesis. Biochim Biophys Acta 1470: M69-M78.
62. Reshetnikov SV, Wasser SP, Tan KK (2001) Higher Basidiomycota as a source of antitumor and immunostimulating polysaccharides. Int J Med Mushrooms 3: 361-394.
63. Sasaki T, Takasuka N (1976) Further study of the structure of lentinan, an antitumor polysaccharide from Lentinus edodes. Carbohydr Res 47: 99-104.
64. Schilder RJ, Blessing JA, Pearl ML, Rose PG (2004) Evaluation of irofulven (MGI-114) in the treatment of recurrent or persistent endometrial carcinoma: a phase II study of the Gynecologic oncology group. Invest New Drugs 22: 343-349.
65. Sharma N (2003) Medicinal uses of macrofungi. Ethnobotan 15: 97-99.
66. Sherman CA, Herndon JE 2nd, Watson DM, Green MR (2004) A phase II trial of 6-hydroxymethylacylfulvene (MGI-114, irofulven) in patients with relapsed or refractory non-small cell lung cancer. Lung Cancer 45: 387-392.
67. Sliva D, Jedinak A, Kawasaki J, Harvey K, Slivova V (2008) Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signaling. Brit J Cancer 98: 1348-1356.
68. Sporn MB, Suh N (2002) Chemoprevention of Cancer. Carcinogenesis 21: 524-530.
69. Sullivan R, Smith JE, Rowan NJ (2006) Medicinal mushrooms and cancer therapy. Perspect Biol Med 49: 159-170.
70. Takaku T, Kimura Y, Okuda H (2001) Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr 131: 1409-1413.
71. Toth JO, Luu B, Ourisson G (1983) Ganoderic acid T and Z: cytotoxic triterpenes from Ganoderma lucidum (Polyporaceae). Tetrahedron Lett 24: 1081-1084.
72. Tsang KW, Lam CL, Yan C, Mak JC, Ooi GC, Ho JC, Lam B, Man R, Sham JS, Lam WK (2003) Coriolus versicolor polysaccharide peptide slows progression of advanced nonsmall cell lung cancer. Respir Med 97: 618-624.
73. Ukawa Y, Ito H, Hisamatsu M (2000) Antitumor effects of (1-3)-β-D-gulcan and (1-6)-β-D-gulcan purified from newly cultivated mushroom, Hatakeshimeji (Lyophillum decastes Sing.). J Biosci Bioeng 90: 98-104.
74. Wasser SP, Weis AL (1997a) Reishi mushroom [Ganoderma lucidum (Curt.: Fr.)P.Karst.]. In: Nevo E (ed) Medicinal mushrooms, Peledfus, Haifa, Israel, p 39.
75. Wasser SP, Weis AL (1997b) Shiitake mushrooms [Lentinus edodes (Berk.)Sing.]. In: Nevo E (ed) Medicinal mushrooms, Peledfus, Haifa, Israel, p 96.
76. Wasser SP, Weiss AL (1999) Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: current perspectives. Int J Med Mushrooms 1: 31-62.
77. Yang QY, Jong SC. 1989. Medicinal mushrooms in China. Mushr Sci. 9(1): 631-643.
78. Ying J, Mao X, Ma Q, Zong Y, Wen H (1987) Icones of medicinal fungi from China, Yuehan X, trans. Science Press, Beijing, p 575.
79. Yoshida TO, Rising AJ, Nungester JW (1962) A tumor inhibitor in Lampteromyces japonicus. Soc Expt Biol Med 111: 676-679.
80. Zaidman BZ, Wasser SP, Nevo E, Mahajna J (2007) Androgen receptordependent and independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells. Int J Oncol 4: 959-967.
81. Zaidman BZ, Yassin M, Mahajna J, Wasser SP (2005) Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67: 453-468.
82. Zakany J, Chihara G, Fachet J (1980) Effect of lentinan on tumor growth in murine allogenic and synergic host. Int J Cancer 25: 371-376.
83. Zhang Y, Mills GL, Nair MG (2002) Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. J Agric Food Chem 50: 7581-7585.
84. Zhou S, Gao Y (2002) The immunomodulating effects of Ganoderma lucidum (Curt.: Fr.) P. Karst (Ling Zhi, Reishi Mushroom) (Aphylloromycetidae). Int J Med Mushrooms 4: 1-11.
85. Zhuang C, Wasser SP (2004) Medicinal value of culinarymedicinal Maitake mushroom Grifola frondosa (Dicks.:Fr.) S. F. Gray (Aphyllophoromycetideae). Int J Med Mushrooms 6: 287-314.
86. Zjawiony J (2004) Biologically active compounds from Aphyllophorales (Polypore) fungi. J Nat Prod 67: 300-310.