Unique CRF01_AE Gag CTL epitopes associated with lower HIV-viral load and delayed disease progression in a Cohort of HIV-infected Thais

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Mori, Masahiko ^a,b   Sriwanthana, Busarawan ^c   Wichukchinda, Nuanjun ^c   Boonthimat, Chetsada ^c   Tsuchiya, Naho ^a   Miura, Toshiyuki ^d   Pathipvanich, Panita ^e   Ariyoshi, Koya ^a   Sawanpanyalert, Pathom ^c  

^a NAGASAKI UNIVERSITY   (Japan)

^b Japan Foundation for AIDS Prevention (JFAP)   (Japan)

^c MINISTRY OF PUBLIC HEALTH   (Thailand)

^d UNIVERSITY OF TOKYO   (Japan)

^e LAMPANG HOSPITAL   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD45 ANTIGEN; EPITOPE; GAG PROTEIN;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; ETHNIC GROUP; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; STATISTICAL ANALYSIS; THAI; VIRUS LOAD; VIRUS REPLICATION; ADOLESCENT; ENZYME LINKED IMMUNOSPOT ASSAY; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1; THAIS;

ADOLESCENT; ADULT; ENZYME-LINKED IMMUNOSPOT ASSAY; EPITOPES, T-LYMPHOCYTE; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD; YOUNG ADULT;

EID: 79961039913     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022680     Document Type: Article

References (37)

1. McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF, (2010) The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol 0: 11-23.
2. Kaslow RA, Carrington M, Apple R, Park L, Muñoz A, et al. (1996) Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat Med 2: 405-11.
3. Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, et al. (2004) Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature 432: 769-75.
4. Buonaguro L, Tornesello ML, Buonaguro FM, (2007) Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications. J Virol 81: 10209-19.
5. Dorrell L, Willcox BE, Jones EY, Gillespie G, Njai H, et al. (2001) Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur J Immunol 31: 1747-56.
6. Ferrari G, Humphrey W, McElrath MJ, Excler JL, Duliege AM, et al. (1997) Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers. Proc Natl Acad Sci USA 94: 1396-401.
7. Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, et al. (2007) CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat Med 13: 46-53.
8. Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, et al. (2009) Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 361: 2209-20.
9. Addo MM, Yu XG, Rathod A, Cohen D, Eldridge RL, et al. (2003) Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol 77: 2081-92.
10. Kern F, Surel IP, Faulhaber N, Frömmel C, Schneider-Mergener J, et al. (1999) Target structures of the CD8(+)-T-cell response to human cytomegalovirus: the 72-kilodalton major immediate-early protein revisited. J Virol 73: 8179-84.
11. Masemola A, Mashishi T, Khoury G, Mohube P, Mokgotho P, et al. (2004) Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load. J Virol 78: 3233-43.
12. Brumme Z, Wang B, Nair K, Brumme C, de Pierres C, et al. (2009) Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa. Clin Infect Dis 49: 956-64.
13. Geldmacher C, Currier JR, Herrmann E, Haule A, Kuta E, et al. (2007) CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients. J Virol 81: 2440-8.
14. Novitsky V, Gilbert P, Peter T, McLane MF, Gaolekwe S, et al. (2003) Association between virus-specific T-cell responses and plasma viral load in human immunodeficiency virus type 1 subtype C infection. J Virol 77: 882-90.
15. Zuñiga R, Lucchetti A, Galvan P, Sanchez S, Sanchez C, et al. (2006) Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control. J Virol 80: 3122-5.
16. Gesprasert G, Wichukchinda N, Mori M, Shiino T, Auwanit W, et al. (2010) HLA-associated immune pressure on Gag protein in CRF01_AE-infected individuals and its association with plasma viral load. PLoS One 5: e11179.
17. Martinez-Picado J, Prado JG, Fry EE, Pfafferott K, Leslie A, et al. (2006) Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. J Virol 80: 3617-23.
18. Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, et al. (2007) Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression. J Immunol 178: 2746-54.
19. Goulder PJ, Watkins DI, (2008) Impact of MHC class I diversity on immune control of immunodeficiency virus replication. Nat Rev Immunol 8: 619-30.
20. Yusim K, Kesmir C, Gaschen B, Addo MM, Altfeld M, et al. (2002) Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation. J Virol 76: 8757-68.
21. Briggs JA, Simon MN, Gross I, Kräusslich HG, Fuller SD, et al. (2004) The stoichiometry of Gag protein in HIV-1. Nat Struct Mol Biol 11: 672-5.
22. Julg B, Williams KL, Reddy S, Bishop K, Qi Y, et al. (2010) Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses. J Virol 84: 5540-9.
23. Kaslow RA, Dorak T, Tang JJ, (2005) Influence of Host Genetic Variation on Susceptibility to HIV Type 1 Infection. J Infect Dis 191: S68-77.
24. Lieberman J, Fabry JA, Fong DM, Parkerson GR 3rd, (1997) Recognition of a small number of diverse epitopes dominates the cytotoxic T lymphocytes response to HIV type 1 in an infected individual. AIDS Res Hum Retroviruses 13: 383-92.
25. Miura T, Brockman MA, Schneidewind A, Lobritz M, Pereyra F, et al. (2009) HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition. J Virol 83: 2743-55.
26. Seth A, Yasutomi Y, Jacoby H, Callery JC, Kaminsky SM, et al. (2000) Evaluation of a lipopeptide immunogen as a therapeutic in HIV type 1-seropositive individuals. AIDS Res Hum Retroviruses 16: 337-43.
27. Thakar MR, Bhonge LS, Lakhashe SK, Shankarkumar U, Sane SS, et al. (2005) Cytolytic T lymphocytes (CTLs) from HIV-1 subtype C-infected Indian patients recognize CTL epitopes from a conserved immunodominant region of HIV-1 Gag and Nef. J Infect Dis 192: 749-59.
28. Geels MJ, Dubey SA, Anderson K, Baan E, Bakker M, et al. (2005) Broad cross-clade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): importance of HLA anchor residue conservation. J Virol 79: 11247-58.
29. Gudmundsdotter L, Bernasconi D, Hejdeman B, Sandstrom E, Alaeus A, et al. (2008) Cross-clade immune responses to Gag p24 in patients infected with different HIV-1 subtypes and correlation with HLA class I and II alleles. Vaccine 26: 5182-7.
30. Malhotra U, Nolin J, Mullins JI, McElrath MJ, (2007) Comprehensive epitope analysis of cross-clade Gag-specific T-cell responses in individuals with early HIV-1 infection in the US epidemic. Vaccine 25: 381-90.
31. Yu XG, Lichterfeld M, Perkins B, Kalife E, Mui S, et al. (2005) High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level. AIDS 19: 1449-56.
32. Yokomaku Y, Miura H, Tomiyama H, Kawana-Tachikawa A, Takiguchi M, et al. (2004) Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection. J Virol 78: 1324-32.
33. Tenzer S, Wee E, Burgevin A, Stewart-Jones G, Friis L, (2009) Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance. Nat Immunol 10: 636-46.
34. Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, et al. (2004) HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. J Exp Med 200: 1547-57.
35. Meyer-Olson D, Brady KW, Bartman MT, O'Sullivan KM, Simons BC, et al. (2006) Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire. Blood 107: 2373-83.
36. Streeck H, Frahm N, Walker BD, (2009) The role of IFN-gamma Elispot assay in HIV vaccine research. Nat Protoc 4: 461-9.
37. Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, et al. (2006) HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107: 4781-9.