Genetic Variation in the Autonomic Nervous System Affects Mortality: A Study of 1,095 Trauma Patients

Journal of the American College of Surgeons

Volumn 208, Issue 5, 2009, Pages 663-668

  Morris Jr , John A ^a   Norris, Patrick R ^a   Moore, Jason H ^c   Jenkins, Judith M ^a   Williams, Anna E ^a   Canter, Jeffrey A ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1A ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CATECHOL METHYLTRANSFERASE;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRONCHOSPASM; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HEART RATE VARIABILITY; HUMAN; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SCORING SYSTEM; TRAUMA RELATED INJURY SEVERITY SCORE;

ADULT; AUTONOMIC NERVOUS SYSTEM; BRONCHIAL HYPERREACTIVITY; CATECHOL O-METHYLTRANSFERASE; FEMALE; GENOTYPE; HOSPITAL MORTALITY; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA-2; SURVIVAL ANALYSIS; WOUNDS AND INJURIES;

EID: 64949109301     PISSN: 10727515     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2008.12.017     Document Type: Article

References (50)

1. Annane D., Trabold F., Sharshar T., et al. Inappropriate sympathetic activation at onset of septic shock: a spectral analysis approach. Am J Respir Crit Care Med 160 (1999) 458-465
2. Barnaby D., Ferrick K., Kaplan D.T., et al. Heart rate variability in emergency department patients with sepsis. Acad Emerg Med 9 (2002) 661-670
3. Cao H., Lake D.E., Griffin M.P., and Moorman J.R. Increased nonstationarity of neonatal heart rate before the clinical diagnosis of sepsis. Ann Biomed Eng 32 (2004) 233-244
4. Chang K.L., Monahan K.J., Griffin M.P., et al. Comparison and clinical application of frequency domain methods in analysis of neonatal heart rate time series. Ann Biomed Eng 29 (2001) 764-774
5. Ellenby M.S., McNames J., Lai S., et al. Uncoupling and recoupling of autonomic regulation of the heart beat in pediatric septic shock. Shock 16 (2001) 274-277
6. Griffin M.P., O'Shay T., Bissonette E., et al. Abnormal heart rate characteristics preceding neonatal sepsis and sepsis-like illness. Pediatr Res 53 (2003) 920-926
7. Korach M., Sharshar T., Jarrin I., et al. Cardiac variability in critically ill adults: influence of sepsis. Crit Care Med 29 (2001) 1380-1385
8. Toweill D., Sonnenthal K., Kimberly B., et al. Linear and nonlinear analysis of hemodynamic signals during sepsis and septic shock. Crit Care Med 28 (2000) 2051-2057
9. Godin P.J., and Buchman T.G. Uncoupling of biological oscillators: a complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 24 (1996) 1107-1116
10. Pontet J., Contreras P., Curbelo A., et al. Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients. J Crit Care 18 (2003) 156-163
11. Tibby S.M., Frndova H., Durward A., and Cox P.N. Novel method to quantify loss of heart rate variability in pediatric multiple organ failure. Crit Care Med 31 (2003) 2059-2067
12. Karlsson A.K., Attvall S., Jansson P.A., et al. Influence of the sympathetic nervous system on insulin sensitivity and adipose tissue metabolism: a study in spinal cord-injured subjects. Metabolism 44 (1995) 52-58
13. Lindmark S., Wiklund U., Bjerle P., and Eriksson J.W. Does the autonomic nervous system play a role in the development of insulin resistance?. A study on heart rate variability in first-degree relatives of Type 2 diabetes patients and control subjects. Diabet Med 20 (2003) 399-405
14. Paolisso G., Manzella D., Rizzo M.R., et al. Effects of insulin on the cardiac autonomic nervous system in insulin-resistant states. Clin Sci (Lond) 98 (2000) 129-136
15. Quinones M.J., Hernandez-Pampaloni M., Schelbert H., et al. Coronary vasomotor abnormalities in insulin-resistant individuals. Ann Intern Med 140 (2004) 700-708
16. Singh J.P., Sleight P., Kardos A., and Hart G. QT interval dynamics and heart rate variability preceding a case of cardiac arrest. Heart 77 (1997) 375-377
17. Voss A., Kurths J., Kleiner H.J., et al. The application of methods of non-linear dynamics for the improved and predictive recognition of patients threatened by sudden cardiac death. Cardiovasc Res 31 (1996) 419-433
18. Wichterle D., Simek J., La Rovere M.T., et al. Prevalent low-frequency oscillation of heart rate: novel predictor of mortality after myocardial infarction. Circulation 110 (2004) 1183-1190
19. Wood N.B. The prediction of a potentially fatal cardiac event in the next 2 to 24 hours and the prediction of a myocardial infarction related death or sudden death. Comput Cardiol 28 (2001) 509-512
20. Jideus L., Ericson M., Stridsberg M., et al. Diminished circadian variation in heart rate variability before surgery in patients developing postoperative atrial fibrillation. Scand Cardiovasc J 35 (2001) 238-244
21. Lombardi F., Colombo A., Basilico B., et al. Heart rate variability and early recurrence of atrial fibrillation after electrical cardioversion. J Am Coll Cardiol 37 (2001) 157-162
22. La Rovere M.T., Pinna G.D., Maestri R., et al. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation 107 (2003) 565-570
23. Lin J.L., Chan H.L., Du C.C., et al. Long-term beta-blocker therapy improves autonomic nervous regulation in advanced congestive heart failure: a longitudinal heart rate variability study. Am Heart J 137 (1999) 658-665
24. Nolan J., Batin P.D., Andrews R., et al. Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation 98 (1998) 1510-1516
25. Dillon J.F., Plevris J.N., Nolan J., et al. Autonomic function in cirrhosis assessed by cardiovascular reflex tests and 24-hour heart rate variability. Am J Gastroenterol 89 (1994) 1544-1547
26. Haji-Michael P.G., Vincent J.L., Degaute J.P., and van de Borne P. Power spectral analysis of cardiovascular variability in critically ill neurosurgical patients. Crit Care Med 28 (2000) 2578-2583
27. Inoue K., Miyake S., Kumashiro M., et al. Power spectral analysis of heart rate variability in traumatic quadriplegic humans. Am J Physiol 258 (1990) H1722-H1726
28. King M.L., Lichtman S.W., Seliger G., et al. Heart-rate variability in chronic traumatic brain injury. Brain Inj 11 (1997) 445-453
29. Rapenne T., Moreau D., Lenfant F., et al. Could heart rate variability predict outcome in patients with severe head injury?. A pilot study. J Neurosurg Anesthesiol 13 (2001) 260-268
30. Winchell R.J., and Hoyt D.B. Analysis of heart-rate variability: a noninvasive predictor of death and poor outcome in patients with severe head injury. J Trauma 43 (1997) 927-933
31. Morris Jr. J.A., Norris P.R., Waitman L.R., et al. Adrenal insufficiency, heart rate variability, and complex biologic systems: a study of 1,871 critically ill trauma patients. J Am Coll Surg 204 (2007) 885-892
32. Boyd C.R., Tolson M.A., and Copes W.S. Evaluating trauma care: the TRISS method. Trauma Score and the Injury Severity Score. J Trauma 27 (1987) 370-378
33. Buchman T.G., Stein P.K., and Goldstein B. Heart rate variability in critical illness and critical care. Curr Opin Crit Care 8 (2002) 311-315
34. Winchell R.J., and Hoyt D.B. Spectral analysis of heart rate variability in the ICU: a measure of autonomic function. J Surg Res 63 (1996) 11-16
35. Andriessen P., Schoffelen R.L., Berendsen R.C., et al. Noninvasive assessment of blood pressure variability in preterm infants. Pediatr Res 55 (2004) 220-223
36. Cooke W.H., Salinas J., Convertino V.A., et al. Heart rate variability and its association with mortality in prehospital trauma patients. J Trauma 60 (2006) 363-370
37. Norris P.R., Anderson S.M., Jenkins J.M., et al. Heart rate multiscale entropy at three hours predicts hospital mortality in 3,154 trauma patients. Shock 30 (2008) 17-22
38. Griffin M.P., Lake D.E., Bissonette E.A., et al. Heart rate characteristics: novel physiomarkers to predict neonatal infection and death. Pediatrics 116 (2005) 1070-1074
39. Tateishi Y., Oda S., Nakamura M., et al. Depressed heart rate variability is associated with high IL-6 blood level and decline in the blood pressure in septic patients. Shock 28 (2007) 549-553
40. Papaioannou V.E., Maglaveras N., Houvarda I., et al. Investigation of altered heart rate variability, nonlinear properties of heart rate signals, and organ dysfunction longitudinally over time in intensive care unit patients. J Crit Care 21 (2006) 95-103
41. Schmidt H., Muller-Werdan U., Hoffmann T., et al. Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups. Crit Care Med 33 (2005) 1994-2002
42. Baguley I.J., Heriseanu R.E., Felmingham K.L., and Cameron I.D. Dysautonomia and heart rate variability following severe traumatic brain injury. Brain Inj 20 (2006) 437-444
43. Mowery N.T., Norris P.R., Riordan W., et al. Cardiac uncoupling and heart rate variability are associated with intracranial hypertension and mortality: a study of 145 trauma patients with continuous monitoring. J Trauma 65 (2008) 621-627
44. Proctor K.G., Atapattu S.A., and Duncan R.C. Heart rate variability index in trauma patients. J Trauma 63 (2007) 33-43
45. Aboab J., Polito A., Orlikowski D., et al. Hydrocortisone effects on cardiovascular variability in septic shock: a spectral analysis approach. Crit Care Med 36 (2008) 1481-1486
46. Cotton B.A., Snodgrass K.B., Fleming S.B., et al. Beta-blocker exposure is associated with improved survival after severe traumatic brain injury. J Trauma 62 (2007) 26-33
47. Riordan Jr. W.P., Cotton B.A., Norris P.R., et al. Beta-blocker exposure in patients with severe traumatic brain injury (TBI) and cardiac uncoupling. J Trauma 63 (2007) 503-510
48. Egan M.F., Goldberg T.E., Kolachana B.S., et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98 (2001) 6917-6922
49. O'Connell T.D., Swigart P.M., Rodrigo M.C., et al. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest 116 (2006) 1005-1015
50. Taylor D.R., and Kennedy M.A. Genetic variation of the beta (2)-adrenoceptor: its functional and clinical importance in bronchial asthma. Am J Pharmacogenomics 1 (2001) 165-174