메뉴 건너뛰기




Volumn 143, Issue 1-2, 2011, Pages 116-124

Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strains

Author keywords

Cytokine; Herpesvirus; Horse; Innate immune response; Neonate; Pregnancy

Indexed keywords

ALPHA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4;

EID: 79961025904     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.06.032     Document Type: Article
Times cited : (37)

References (60)
  • 1
    • 0242580118 scopus 로고    scopus 로고
    • Cutting edge: different toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos
    • Agrawal S., Agrawal A., Doughty B., Gerwitz A., Blenis J., Van Dyke T., Pulendran B. Cutting edge: different toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J. Immunol. 2003, 171:4984-4989.
    • (2003) J. Immunol. , vol.171 , pp. 4984-4989
    • Agrawal, S.1    Agrawal, A.2    Doughty, B.3    Gerwitz, A.4    Blenis, J.5    Van Dyke, T.6    Pulendran, B.7
  • 2
    • 0028915808 scopus 로고
    • Major histocompatibility complex class I-restricted cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1
    • Allen G., Yeargan M., Costa L.R., Cross R. Major histocompatibility complex class I-restricted cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1. J. Virol. 1995, 69:606-612.
    • (1995) J. Virol. , vol.69 , pp. 606-612
    • Allen, G.1    Yeargan, M.2    Costa, L.R.3    Cross, R.4
  • 3
    • 57849112358 scopus 로고    scopus 로고
    • Risk factors for development of neurologic disease after experimental exposure to equine herpesvirus-1 in horses
    • Allen G.P. Risk factors for development of neurologic disease after experimental exposure to equine herpesvirus-1 in horses. Am. J. Vet. Res. 2008, 69:1595-1600.
    • (2008) Am. J. Vet. Res. , vol.69 , pp. 1595-1600
    • Allen, G.P.1
  • 6
    • 11144253690 scopus 로고    scopus 로고
    • Equine herpesvirus-1 infection induces IFN-g production by equine T lymphocyte subsets
    • Breathnach C.C., Soboll G., Suresh M., Lunn D.P. Equine herpesvirus-1 infection induces IFN-g production by equine T lymphocyte subsets. Vet. Immunol. Immunopathol. 2005, 103:207-215.
    • (2005) Vet. Immunol. Immunopathol. , vol.103 , pp. 207-215
    • Breathnach, C.C.1    Soboll, G.2    Suresh, M.3    Lunn, D.P.4
  • 7
    • 35748969112 scopus 로고    scopus 로고
    • Dysregulated interferon-gamma responses during lethal cytomegalovirus brain infection of IL-10-deficient mice
    • Cheeran M.C., Hu S., Palmquist J.M., Bakken T., Gekker G., Lokensgard J.R. Dysregulated interferon-gamma responses during lethal cytomegalovirus brain infection of IL-10-deficient mice. Virus Res. 2007, 130:96-102.
    • (2007) Virus Res. , vol.130 , pp. 96-102
    • Cheeran, M.C.1    Hu, S.2    Palmquist, J.M.3    Bakken, T.4    Gekker, G.5    Lokensgard, J.R.6
  • 9
    • 0019768536 scopus 로고
    • An outbreak of paresis in mares and geldings associated with equine herpesvirus-1
    • Crowhurst F.A., Dickinson G., Burrows R. An outbreak of paresis in mares and geldings associated with equine herpesvirus-1. Vet. Rec. 1981, 109:527-528.
    • (1981) Vet. Rec. , vol.109 , pp. 527-528
    • Crowhurst, F.A.1    Dickinson, G.2    Burrows, R.3
  • 10
    • 0022522753 scopus 로고
    • Endothelial cell infection and thrombosis in paralysis induced by equid herpesvirus-1: equine stroke
    • Edington N., Bridges C.G., Patel J.R. Endothelial cell infection and thrombosis in paralysis induced by equid herpesvirus-1: equine stroke. Arch. Virol. 1986, 90:111-124.
    • (1986) Arch. Virol. , vol.90 , pp. 111-124
    • Edington, N.1    Bridges, C.G.2    Patel, J.R.3
  • 11
    • 2542543416 scopus 로고    scopus 로고
    • Detection of EHV-1 and EHV-4 DNA in unweaned Thoroughbred foals from vaccinated mares on a large stud farm
    • Foote C.E., Love D.N., Gilkerson J.R., Whalley J.M. Detection of EHV-1 and EHV-4 DNA in unweaned Thoroughbred foals from vaccinated mares on a large stud farm. Equine Vet. J. 2004, 36:341-345.
    • (2004) Equine Vet. J. , vol.36 , pp. 341-345
    • Foote, C.E.1    Love, D.N.2    Gilkerson, J.R.3    Whalley, J.M.4
  • 12
    • 77955594335 scopus 로고    scopus 로고
    • The family of IL-10 secreting CD4+ T cells
    • Fuijo K., Okamura T., Yamamoto K. The family of IL-10 secreting CD4+ T cells. Adv. Immunol. 2010, 105:99-130.
    • (2010) Adv. Immunol. , vol.105 , pp. 99-130
    • Fuijo, K.1    Okamura, T.2    Yamamoto, K.3
  • 13
    • 0032834337 scopus 로고    scopus 로고
    • Epidemiological studies of equine herpesvirus 1 (EHV-1) in Thoroughbred foals: a review of studies conducted in the Hunter Valley of New South Wales between 1995 and 1997
    • Gilkerson J., Love D., Drummer H., Studdert M., Whalley J. Epidemiological studies of equine herpesvirus 1 (EHV-1) in Thoroughbred foals: a review of studies conducted in the Hunter Valley of New South Wales between 1995 and 1997. Vet. Microbiol. 1999, 68:15-25.
    • (1999) Vet. Microbiol. , vol.68 , pp. 15-25
    • Gilkerson, J.1    Love, D.2    Drummer, H.3    Studdert, M.4    Whalley, J.5
  • 16
    • 33646595287 scopus 로고    scopus 로고
    • IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins
    • Hu X., Paik P.K., Chen J., Yarilina A., Kockeritz L., Lu T.T., Woodgett J.R., Ivashkiv L.B. IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity 2006, 24:563-574.
    • (2006) Immunity , vol.24 , pp. 563-574
    • Hu, X.1    Paik, P.K.2    Chen, J.3    Yarilina, A.4    Kockeritz, L.5    Lu, T.T.6    Woodgett, J.R.7    Ivashkiv, L.B.8
  • 17
    • 12444251103 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9
    • Ito T., Wang Y.H., Liu Y.J. Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9. Springer Semin. Immunopathol. 2005, 26:221-229.
    • (2005) Springer Semin. Immunopathol. , vol.26 , pp. 221-229
    • Ito, T.1    Wang, Y.H.2    Liu, Y.J.3
  • 18
    • 34547136173 scopus 로고    scopus 로고
    • Experimental infection of neonatal foals with Rhodococcus equi triggers adult-like gamma interferon induction
    • Jacks S., Giguère S., Crawford P.C., Castleman W.L. Experimental infection of neonatal foals with Rhodococcus equi triggers adult-like gamma interferon induction. Clin. Vaccine Immunol. 2007, 14:669-677.
    • (2007) Clin. Vaccine Immunol. , vol.14 , pp. 669-677
    • Jacks, S.1    Giguère, S.2    Crawford, P.C.3    Castleman, W.L.4
  • 19
    • 52649162436 scopus 로고    scopus 로고
    • Effector CD4+ T-cells involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords
    • Johnson A.J., Chu C.F., Milligan G.N. Effector CD4+ T-cells involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords. J. Virol. 2008, 82:9678-9688.
    • (2008) J. Virol. , vol.82 , pp. 9678-9688
    • Johnson, A.J.1    Chu, C.F.2    Milligan, G.N.3
  • 20
    • 37349031103 scopus 로고    scopus 로고
    • Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88
    • Jung A., Kato H., Kumagai Y., Kumar H., Kawai T., Takeuchi O., Akira S. Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88. J. Virol. 2008, 82:196-206.
    • (2008) J. Virol. , vol.82 , pp. 196-206
    • Jung, A.1    Kato, H.2    Kumagai, Y.3    Kumar, H.4    Kawai, T.5    Takeuchi, O.6    Akira, S.7
  • 22
    • 0842328805 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    • Krug A., Luker G.D., Barchet W., Leib D.A., Akira S., Colonna M. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 2004, 103:1433-1437.
    • (2004) Blood , vol.103 , pp. 1433-1437
    • Krug, A.1    Luker, G.D.2    Barchet, W.3    Leib, D.A.4    Akira, S.5    Colonna, M.6
  • 24
    • 0028541129 scopus 로고
    • Distribution of equid herpesvirus-1 (EHV-1) in the respiratory tract associated lymphoid tissue: implications for cellular immunity
    • Kydd J., Smith K.C., Hannant D., Livesay G.J., Mumford J.A. Distribution of equid herpesvirus-1 (EHV-1) in the respiratory tract associated lymphoid tissue: implications for cellular immunity. Equine Vet. J. 1994, 26:470-473.
    • (1994) Equine Vet. J. , vol.26 , pp. 470-473
    • Kydd, J.1    Smith, K.C.2    Hannant, D.3    Livesay, G.J.4    Mumford, J.A.5
  • 25
    • 0142195817 scopus 로고    scopus 로고
    • Pre-infection frequencies of equine herpesvirus-1 specific, cytotoxic T lymphocytes correlate with protection against abortion following experimental infection of pregnant mares
    • Kydd J.H., Wattrang E., Hannant D. Pre-infection frequencies of equine herpesvirus-1 specific, cytotoxic T lymphocytes correlate with protection against abortion following experimental infection of pregnant mares. Vet. Immunol. Immunopathol. 2003, 96:207-217.
    • (2003) Vet. Immunol. Immunopathol. , vol.96 , pp. 207-217
    • Kydd, J.H.1    Wattrang, E.2    Hannant, D.3
  • 26
    • 33645957829 scopus 로고    scopus 로고
    • The equine immune response to equine herpesvirus-1: the virus and its vaccines
    • Kydd J.H., Townsend H.G., Hannant D. The equine immune response to equine herpesvirus-1: the virus and its vaccines. Vet. Immunol. Immunopathol. 2006, 111:15-30.
    • (2006) Vet. Immunol. Immunopathol. , vol.111 , pp. 15-30
    • Kydd, J.H.1    Townsend, H.G.2    Hannant, D.3
  • 27
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J., Sato A., Akira S., Medzhitov R., Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 2003, 198:513-520.
    • (2003) J. Exp. Med. , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 29
    • 4344658402 scopus 로고    scopus 로고
    • Induction and regulation of IFNs during viral infection
    • Malmgaard L. Induction and regulation of IFNs during viral infection. J. Interferon Cytokine Res. 2004, 24:439-454.
    • (2004) J. Interferon Cytokine Res. , vol.24 , pp. 439-454
    • Malmgaard, L.1
  • 30
    • 70349255946 scopus 로고    scopus 로고
    • Multifaceted evasion of the interferon response by cytomegalovirus
    • Marshall E.E., Gaballe A.P. Multifaceted evasion of the interferon response by cytomegalovirus. J. Interferon Cytokine Res. 2009, 29:609-619.
    • (2009) J. Interferon Cytokine Res. , vol.29 , pp. 609-619
    • Marshall, E.E.1    Gaballe, A.P.2
  • 33
    • 0842343435 scopus 로고    scopus 로고
    • Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections
    • Mitre E., Taylor R.T., Kubofcik J., Nutman T.B. Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections. J. Immunol. 2004, 172:2439-2445.
    • (2004) J. Immunol. , vol.172 , pp. 2439-2445
    • Mitre, E.1    Taylor, R.T.2    Kubofcik, J.3    Nutman, T.B.4
  • 35
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    • Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989, 7:145-173.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 36
    • 33845428041 scopus 로고    scopus 로고
    • Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in an atherosclerotic plaque through interferon-alpha
    • Niessner A., Sato K., Chaikof E.L., Colmegna I., Goronzy J.J., Weyand C.M. Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in an atherosclerotic plaque through interferon-alpha. Circulation 2006, 114:2482-2489.
    • (2006) Circulation , vol.114 , pp. 2482-2489
    • Niessner, A.1    Sato, K.2    Chaikof, E.L.3    Colmegna, I.4    Goronzy, J.J.5    Weyand, C.M.6
  • 38
    • 22044435412 scopus 로고    scopus 로고
    • Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1
    • Paillot R., Daly J.M., Juillard V., Minke J.M., Hannant D., Kydd J.H. Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1. Vaccine 2005, 23:4541-4551.
    • (2005) Vaccine , vol.23 , pp. 4541-4551
    • Paillot, R.1    Daly, J.M.2    Juillard, V.3    Minke, J.M.4    Hannant, D.5    Kydd, J.H.6
  • 39
    • 32544437654 scopus 로고    scopus 로고
    • Characterisation of CTL and IFN-γ synthesis in ponies following vaccination with a NYVAC-based construct coding for EHV-1 immediate early gene, followed by challenge infection
    • Paillot R., Ellis S.A., Daly J.M., Audonnet J.C., Minke J.M., Davis-Poynter N., Hannant D., Kydd J. Characterisation of CTL and IFN-γ synthesis in ponies following vaccination with a NYVAC-based construct coding for EHV-1 immediate early gene, followed by challenge infection. Vaccine 2006, 24:1490-1500.
    • (2006) Vaccine , vol.24 , pp. 1490-1500
    • Paillot, R.1    Ellis, S.A.2    Daly, J.M.3    Audonnet, J.C.4    Minke, J.M.5    Davis-Poynter, N.6    Hannant, D.7    Kydd, J.8
  • 40
    • 33748928959 scopus 로고    scopus 로고
    • Frequency and phenotype of EHV-1 specific, IFN-gamma synthesizing lymphocytes in ponies: the effects of age, pregnancy and infection
    • Paillot R., Daly J.M., Luce R., Montesso F., Davis-Poynter N., Hannant D., Kydd J.H. Frequency and phenotype of EHV-1 specific, IFN-gamma synthesizing lymphocytes in ponies: the effects of age, pregnancy and infection. Dev. Comp. Immunol. 2007, 31:202-214.
    • (2007) Dev. Comp. Immunol. , vol.31 , pp. 202-214
    • Paillot, R.1    Daly, J.M.2    Luce, R.3    Montesso, F.4    Davis-Poynter, N.5    Hannant, D.6    Kydd, J.H.7
  • 41
    • 70349235719 scopus 로고    scopus 로고
    • Mechanisms employed by herpes simplex virus 1 to inhibit the interferon response
    • Paladino P., Mossman K.L. Mechanisms employed by herpes simplex virus 1 to inhibit the interferon response. J. Interferon Cytokine Res. 2009, 29:599-607.
    • (2009) J. Interferon Cytokine Res. , vol.29 , pp. 599-607
    • Paladino, P.1    Mossman, K.L.2
  • 42
    • 21444441071 scopus 로고    scopus 로고
    • Equine herpesviruses 1 (EHV-1) and 4 (EHV-4)-epidemiology, disease and immunoprophylaxis: a brief review
    • Patel J.R., Heldens J. Equine herpesviruses 1 (EHV-1) and 4 (EHV-4)-epidemiology, disease and immunoprophylaxis: a brief review. Vet. J. 2005, 170:14-23.
    • (2005) Vet. J. , vol.170 , pp. 14-23
    • Patel, J.R.1    Heldens, J.2
  • 43
    • 70349907172 scopus 로고    scopus 로고
    • Investigation of the prevalence of neurologic equine herpes virus type 1 (EHV-1) in a 23-year retrospective analysis (1984-2007)
    • Perkins G.A., Goodman L.B., Tsujimura K., Van de Walle G.R., Kim S.G., Dubovi E.J., Osterrieder N. Investigation of the prevalence of neurologic equine herpes virus type 1 (EHV-1) in a 23-year retrospective analysis (1984-2007). Vet. Microbiol. 2009, 139:375-378.
    • (2009) Vet. Microbiol. , vol.139 , pp. 375-378
    • Perkins, G.A.1    Goodman, L.B.2    Tsujimura, K.3    Van de Walle, G.R.4    Kim, S.G.5    Dubovi, E.J.6    Osterrieder, N.7
  • 44
    • 33748990863 scopus 로고    scopus 로고
    • Cytokine gene signatures in neural tissue of horses with equine protozoalmyeloencephalitis or equine herpes type 1 myeloencephalopathy
    • Pusterla N., Wilson W.D., Conrad P.A., Barr B.C., Ferraro G.L., Daft B.M., Leutenegger C.M. Cytokine gene signatures in neural tissue of horses with equine protozoalmyeloencephalitis or equine herpes type 1 myeloencephalopathy. Vet. Rec. 2006, 159:341-346.
    • (2006) Vet. Rec. , vol.159 , pp. 341-346
    • Pusterla, N.1    Wilson, W.D.2    Conrad, P.A.3    Barr, B.C.4    Ferraro, G.L.5    Daft, B.M.6    Leutenegger, C.M.7
  • 45
    • 33750371447 scopus 로고    scopus 로고
    • Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details
    • Rebenko-Molla N., Liua L., Cardona A., Ransohoff R. Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details. Curr. Opin. Immunol. 2006, 18:683-689.
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 683-689
    • Rebenko-Molla, N.1    Liua, L.2    Cardona, A.3    Ransohoff, R.4
  • 46
    • 0001551701 scopus 로고    scopus 로고
    • Herpesviridae
    • Lippincott-Raven Press, Philadelphia, New York, B.N. Fields, D.M. Knipe, P.M. Howley (Eds.)
    • Roizman B. Herpesviridae. Virology 1996, 2221-2230. Lippincott-Raven Press, Philadelphia, New York. B.N. Fields, D.M. Knipe, P.M. Howley (Eds.).
    • (1996) Virology , pp. 2221-2230
    • Roizman, B.1
  • 47
    • 0000595684 scopus 로고    scopus 로고
    • Herpes simplex viruses and their replication
    • Lippincott-Raven Press, Philadelphia, New York, B.N. Fields, D.M. Knipe, P.M. Howley (Eds.)
    • Roizman B., Sears A.E. Herpes simplex viruses and their replication. Virology 1996, 2231-2295. Lippincott-Raven Press, Philadelphia, New York. B.N. Fields, D.M. Knipe, P.M. Howley (Eds.).
    • (1996) Virology , pp. 2231-2295
    • Roizman, B.1    Sears, A.E.2
  • 48
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M., O'Garra A. The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 2010, 10:170-181.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 49
    • 33751206873 scopus 로고    scopus 로고
    • Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells
    • Sato A., Linehan M.M., Iwasaki A. Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:17343-17348.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 17343-17348
    • Sato, A.1    Linehan, M.M.2    Iwasaki, A.3
  • 50
    • 0027963656 scopus 로고
    • The trigeminal ganglion is a location for equine herpesvirus1 latency and reactivation in the horse
    • Slater J.D., Borchers K., Thackray A.M., Field H.J. The trigeminal ganglion is a location for equine herpesvirus1 latency and reactivation in the horse. J. Gen. Virol. 1994, 75:2007-2016.
    • (1994) J. Gen. Virol. , vol.75 , pp. 2007-2016
    • Slater, J.D.1    Borchers, K.2    Thackray, A.M.3    Field, H.J.4
  • 51
    • 39449133957 scopus 로고    scopus 로고
    • A mechanism for the initiation of allergen-induced Thelper type 2 responses
    • Sokol C.L., Barton G.M., Farr A.G., Medzhitov R. A mechanism for the initiation of allergen-induced Thelper type 2 responses. Nat. Immunol. 2008, 9:310-318.
    • (2008) Nat. Immunol. , vol.9 , pp. 310-318
    • Sokol, C.L.1    Barton, G.M.2    Farr, A.G.3    Medzhitov, R.4
  • 52
    • 39349111657 scopus 로고    scopus 로고
    • The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity
    • Szabo G., Dolganiuc A. The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity. Crit. Rev. Immunol. 2008, 28:61-94.
    • (2008) Crit. Rev. Immunol. , vol.28 , pp. 61-94
    • Szabo, G.1    Dolganiuc, A.2
  • 53
    • 0035914926 scopus 로고    scopus 로고
    • Regulatory role of T cells producing both interferon gamma and interleukin 10 in persistent infection
    • Trinchieri G. Regulatory role of T cells producing both interferon gamma and interleukin 10 in persistent infection. J. Exp. Med. 2001, 194:F53-F57.
    • (2001) J. Exp. Med. , vol.194
    • Trinchieri, G.1
  • 54
    • 38849178806 scopus 로고    scopus 로고
    • CCL3 and viral chemokine-binding protein gG modulate pulmonary inflammation and virus replication during equine herpesvirus type 1 (EHV-1) infection
    • Van de Walle G.R., Sakamoto K., Osterrieder N. CCL3 and viral chemokine-binding protein gG modulate pulmonary inflammation and virus replication during equine herpesvirus type 1 (EHV-1) infection. J. Virol. 2008, 82:1714-1722.
    • (2008) J. Virol. , vol.82 , pp. 1714-1722
    • Van de Walle, G.R.1    Sakamoto, K.2    Osterrieder, N.3
  • 55
    • 74149093531 scopus 로고    scopus 로고
    • A vectored equine herpesvirus type 1 (EHV-1) vaccine elicits protective immune responses against EHV-1 and H3N8 equine influenza virus
    • Van de Walle G.R., Maya M.A., Petersa S.T., Metzgera S.M., Rosasa C.T., Osterrieder N. A vectored equine herpesvirus type 1 (EHV-1) vaccine elicits protective immune responses against EHV-1 and H3N8 equine influenza virus. Vaccine 2010, 28:1048-1055.
    • (2010) Vaccine , vol.28 , pp. 1048-1055
    • Van de Walle, G.R.1    Maya, M.A.2    Petersa, S.T.3    Metzgera, S.M.4    Rosasa, C.T.5    Osterrieder, N.6
  • 56
    • 58249112776 scopus 로고    scopus 로고
    • Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horses
    • Wagner B., Freer H. Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horses. Vet. Immunol. Immunopathol. 2009, 127:242-248.
    • (2009) Vet. Immunol. Immunopathol. , vol.127 , pp. 242-248
    • Wagner, B.1    Freer, H.2
  • 57
    • 74449088246 scopus 로고    scopus 로고
    • Induction of interleukin-4 production in neonatal IgE+ cells after crosslinking of maternal IgE
    • Wagner B., Stokol T., Ainsworth D.M. Induction of interleukin-4 production in neonatal IgE+ cells after crosslinking of maternal IgE. Dev. Comp. Immunol. 2010, 34:436-444.
    • (2010) Dev. Comp. Immunol. , vol.34 , pp. 436-444
    • Wagner, B.1    Stokol, T.2    Ainsworth, D.M.3
  • 58
    • 77953819520 scopus 로고    scopus 로고
    • Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals
    • Wagner B., Burton A., Ainsworth D.M. Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals. Vet. Res. 2010, 41:47.
    • (2010) Vet. Res. , vol.41 , pp. 47
    • Wagner, B.1    Burton, A.2    Ainsworth, D.M.3
  • 59
    • 79952194541 scopus 로고    scopus 로고
    • Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression
    • Wimer C.L., Damiani A., Osterrieder N., Wagner B. Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression. Vet. Immunol. Immunopathol. 2011, 140:266-274.
    • (2011) Vet. Immunol. Immunopathol. , vol.140 , pp. 266-274
    • Wimer, C.L.1    Damiani, A.2    Osterrieder, N.3    Wagner, B.4
  • 60
    • 42649116149 scopus 로고    scopus 로고
    • The role of chemokines during herpes simplex virus-1 infection
    • Wuest T., Carr D.J. The role of chemokines during herpes simplex virus-1 infection. Front. Biosci. 2008, 13:4862-4872.
    • (2008) Front. Biosci. , vol.13 , pp. 4862-4872
    • Wuest, T.1    Carr, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.