Cytokine gene signatures in neural tissue of horses with equine protozoal myeloencephalitis or equine herpes type 1 myeloencephalopathy

Veterinary Record

Volumn 159, Issue 11, 2006, Pages 341-346

  Pusterla, N ^a   Wilson, W D ^a   Conrad, P A ^a   Barr, B C ^b   Ferraro, G L ^a   Daft, B M ^b   Leutenegger, C M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; FORMALDEHYDE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; PARAFFIN; PROTOZOAL DNA; RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRANIAL NERVE; DNA DETERMINATION; ENCEPHALOMYELITIS; GENE AMPLIFICATION; GENE EXPRESSION; GENE LOCATION; GENETIC TRANSCRIPTION; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS 1; HORSE DISEASE; HOUSEKEEPING GENE; NEOSPORA; NEOSPORA HUGHESI; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTOZOAL INFECTION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SARCOCYSTIS NEURONA; SENSITIVITY AND SPECIFICITY; SIGNAL DETECTION; SPINAL CORD; TISSUE DISTRIBUTION; TISSUE PREPARATION;

EQUID HERPESVIRUS 1; EQUIDAE; HERPES; NEOSPORA HUGHESI; SARCOCYSTIS NEURONA;

EID: 33748990863     PISSN: 00424900     EISSN: None     Source Type: Journal    
DOI: 10.1136/vr.159.11.341     Document Type: Article

References (42)

1. COLAHAN, P. T., KOLLIAS-BAKER, T. C., LEUTENEGGER, C. M. & JONES, J. H. (2002) Does training affect mRNA transcription for cytokine production in circulating leucocytes? Equine Veterinary Journal Supplement 34, 154-158
2. DAFT, B. M., BARR, B. C., GARDNER, I. A., READ, D., BELL, W., PEYSER, K. G., ARDANS, A., KINDE, H. & MORROW, J. K. (2002) Sensitivity and specificity of western blot testing of cerebrospinal fluid and serum for diagnosis of equine protozoal myeloencephalitis in horses with and without neurologic abnormalities. Journal of the American Veterinary Medical Association 221, 1007-1013
3. DENKERS, E. Y. & GAZZINELLI, R. T. (1998) Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clinical Microbiology Reviews 11, 569-588
4. DENNEY, C. F., ECKMANN, L. & REED, S. L. (1999) Chemokine secretion of human cells in response to Toxoplasma gondii infection. Infection and Immunity 67, 1547-1552
5. DUARTE, P.C., DAFT, B.M., CONRAD, P.A., PACKHAM, A.E. & GARDNER, I.A. (2003) Comparison of a serum indirect fluorescent antibody test with two Western blot tests for the diagnosis of equine protozoal myeloencephalitis. Journal of Veterinary Diagnostic Investigation 15, 8-13
6. DUARTE, P.C., CONRAD, P.A., WILSON, W.D., FERRARO, G.L., PACKHAM, A. E., BOWERS-LEPORE, J., CARPENTER, T. E. & GARDNER, I. A. (2004) Risk of postnatal exposure to Sarcocystis neurona and Neospora hughesi in horses. American Journal of Veterinary Research 65, 1047-1052
7. DUBEY, J. P., LINDSAY, D. S., SAVILLE, W. J., REED, S. M., GRANSTROM, D. E. & SPEER, C. A. (2001a) A review of Sarcocystis neurona and equine protozoal myeloencephalitis (EPM). Veterinary Parasitology 95, 89-131
8. DUBEY, J. P., GARNER, M. M., STETTER, M. D., MARSH, A. E. & BARR, B. C. (2001b) Acute Sarcocystis falcatula-like infection in a carmine bee-eater (Merops nubicus) and immunohistochemical cross reactivity between Sarcocystis falcatula and Sarcocystis neurona. Journal of Parasitology 87, 824-832
9. ECKMANN, L., KAGNOFF, M. F. & FIERER, J. (1993) Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infection and Immunity 61, 4569-4574
10. EDINGTON, N., SMYTH, B. & GRIFFITHS, L. (1991) The role of endothelial cell infection in the endometrium, placenta and foetus of equid herpesvirus 1 (EHV-1) abortions. Journal of Comparative Pathology 104, 379-387
11. FINLAY, B. B. & FALKOW, S. (1988) Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication. Biochimie 70, 1089-1099
12. FOLEY, J. E., RAND, C. & LEUTENEGGER, C. M. (2003) Inflammation and changes in cytokine levels in neurological feline infectious peritonitis. Journal of Feline Medicine and Surgery 5, 313-322
13. FRITZ, D. L. & DUBEY, J. P. (2002) Pathology of Sarcocystis neurona in interferon-gamma gene knockout mice. Veterinary Pathology 39, 137-140
14. GAZZINELLI, R. T., ELTOUM, I., WYNN, T. A. & SHER, A. (1993) Acute cerebral toxoplasmosis is induced by in vitro neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. Journal of Immunology 151, 3672-3681
15. GRANSTROM, D. E., DUBEY, J. P., DAVIS, S. W., FAYER, R., FOX, J. C., POONACHA, K. B., GILES, R. C. & COMER, P. F. (1993) Equine protozoal myeloencephalitis: antigen analysis of cultured Sarcocystis neurona merozoites. Journal of Veterinary Diagnostic Investigation 5, 88-90
16. HACKETT, S. J., THOMSON, A. P. & HART, C. A. (2001) Cytokines, chemokines and other effector molecules involved in meningococcal disease. Journal of Medical Microbiology 50, 847-859
17. HSU, D. H., DE WAAL MALEFYT, R., FIORENTINO, D. F., DANG, M. N., VIEIRA, P., DE VRIES, J., SPITS, H., MOSMAN, T. R. & MOORE, K. W. (1990) Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Science 250, 830-832
18. HUNTER, C. A., ROBERTS, C. W. & ALEXANDER, J. (1992a) Kinetics of cytokine mRNA production in the brains of mice with progressive toxoplasmic encephalitis. European Journal of Immunology 22, 2317-2322
19. HUNTER, C. A., ROBERTS, C. W., MURRAY, M. & ALEXANDER, J. (1992b) Detection of cytokine mRNA in the brains of mice with toxoplasmic encephalitis. Parasite Immunology 14, 405-413
20. JACKSON, T. A., OSBURN, B. I., CORDY, D. R. & KENDRICK, J. W. (1977) Equine herpesvirus 1 infection of horses: studies on the experimentally induced neurologic disease. American Journal of Veterinary Research 38, 709-719
21. JOHNSON, P. J. & CONSTANTINESCU, G. M. (2001) Analysis of cerebrospinal fluid in horses. Compendium on Continuing Education for the Practicing Veterinarian 23 (Suppl), 15-21
22. JUNG, H. C., ECKMANN, L., YANG, S.K., PANJA, A., FIERER, J., MORZYCKAWROBLEWSKA, E. & KAGNOFF, M. F. (1995) A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. Journal of Clinical Investigation 95, 55-65
23. KORNELISSE, R. F., HAZELZET, J. A., SAVELKOUL, H. F., HOP, W. C., SUUR, M. H., BORSBOOM, A. N., RISSEEUW-APPEL, I. M., VAN DER VOORT, E. & DE GROOT, R. (1996) The relationship between plasminogen activator inhibitor-1 and proinflammatory and counterinflammatory mediators in children with meningococcal septic shock. Journal of Infectious Diseases 173, 1148-1156
24. LAURENT, F., ECKMANN, K., SAVIDGE, T. C., MORGAN, G., THEODOS, C., NACIRI, M. & KAGNOFF, M. F. (1997) Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines. Infection and Immunity 65, 5067-5073
25. LEUTENEGGER, C. M., HIGGINS, J., MATTHEWS, T., TARANTAL, A. F., LUCIW, P., PEDERSEN, N. C. & NORTH, T. W. (2001) Real-time TaqMan PCR as a specific and more sensitive alternative to the branched-chain DNA assay for quantitation of simian immunodeficiency virus RNA. AIDS Research and Human Retroviruses 17, 243-251
26. LEUTENEGGER, C. M., MISLIN, C. N., SIGRIST, B., EHRENGRUBER, M. U., HOFMANN-LEHMANN, R. & LUTZ, H. (1999a) Quantitative real-time PCR for the measurement of feline cytokine mRNA. Veterinary Immunology and Immunopathology 71, 291-305
27. LEUTENEGGER, C.M., VON RECHENBERG, B., HUDER, J.B., ZLINSKY, K., MISLIN, C., AKENS, M.K., AUER, J. & LUTZ, H. (1999b) Quantitative real-time PCR for equine cytokine mRNA in nondecalcified bone tissue embedded in methyl methacrylate. Calcified Tissue International 65, 378-383
28. LEWANDOWSKI, G., HOBBS, M. & GELLER, A. (1998) Evidence that deficient IFN-gamma production is a biological basis of herpes simplex virus type-2 neurovirulence. Journal of Neuroimmunology 81, 66-75
29. MCCARTAN, C. G., RUSSELL, M. M., WOOD, J. L. & MUMFORD, J. A. (1995) Clinical, serological and virological characteristics of an outbreak of paresis and neonatal foal disease due to equine herpesvirus-1 on a stud farm. Veterinary Record 136, 7-12
30. MARSH, A. E., BARR, B. C., MADIGAN, J., LAKRITZ, J., NORDHAUSEN, R. & CONTRAD, P. A. (1996) Neosporosis as a cause of equine protozoal myeloencephalitis. Journal of the American Veterinary Medical Association 209, 1907-1913
31. MAYHEW, I. G., DE LAHUNTA, A. & WHITLOCK, R. H. (1976) Equine protozoal myeloencephalitis. In Proceedings of the 22nd Annual Convention of the American Association of Equine Practitioners. Dallas, USA. pp 107-114
32. NOROSE, K., MUN, H. S., AOSAI, F., CHEN, M., PIAO, L. X., KOBAYASHI, M., IWAKURA, Y. & YANO, A. (2003) IFN-gamma-regulated Toxoplasma gondii distribution and load in the murine eye. Investigative Ophthalmology and Visual Science 44, 4375-4381
33. OSTERRIEDER, N. (2004) Equine herpesvirus 1 (EHV-1): pathogenesis, epidemiology and control. In Proceedings of the 22nd Annual American College of Veterinary Internal Medicine Forum. Minneapolis, USA, November 28 to December 1, 2004. pp 201-203
34. PUSTERLA, N., LEUTENEGGER, C. M., WILSON, W. D., WATSON, J. L., FERRARO, G. L. & MADIGAN, J. E. (2005) Equine herpesvirus-4 kinetics in peripheral blood leukocytes and nasopharyngeal secretions and in foals using quantitative real-time TaqMan PCR. Journal of Veterinary Diagnostic Investigation 17, 578-581
35. RAPPOCCIOLO, G., BIRCH, J. & ELLIS, S.A. (2003) Down-regulation of MHC class I expression by equine herpesvirus-1. Journal of General Virology 84, 293-300
36. RASMUSSEN, S. J., ECKMANN, L., QUAYLE, A. J., SHEN, L., ZHANG, Y. X., ANDERSON, D. J., FIERER, J., STEPHENS, R. S. & KAGNOFF, M. F. (1997) Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. Journal of Clinical Investigation 99, 77-87
37. RODE, H. J., JANSSEN, W., ROSEN-WOLFF, A., BUGERT, J. J., THEIN, P., BECKER, Y. & DARAI, G. (1993) The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL-10)-like gene. Virus Genes 7, 111-116
38. SCHULTHEISS, P. C., COLLINS, J. K. & HOTALING, S. F. (1997) Immunohistochemical demonstration of equine herpesvirus-1 antigen in neurons and astrocytes of horses with acute paralysis. Veterinary Pathology 34, 52-54
39. SELLON, D., HINES, M., LONG, M., GREINER, E., MACKAY, R. & KNOWLES, D. (2002) Parasitemia without neurologic disease in severe combined immune deficient (SCID) foals and mice infected with Sarcocystis neurona. In Proceedings of the 20th Annual American College of Veterinary Internal Medicine Forum. Dallas, USA, May 28 to June 1, 2002. p 769
40. SHERWOOD, E. R. & PROUGH, D. S. (2000) Interleukin-8, neuroinflammation, and secondary brain injury. Critical Care Medicine 28, 1221-1223
41. VARDELEON, D., MARSH, A. E., THORNE, J. G., LOCH, W., YOUNG, R. & JOHNSON, P. J. (2001) Prevalence of Neospora hughesi and Sarcocystis neurona antibodies in horses from various geographical locations. Veterinary Parasitology 95, 273-282
42. WITONSKY, S. G., GOGAL, R. M., DUNCAN, R. B. & LINDSAY, D. S. (2003) Immunopathologic effects associated with Sarcocystis neurona-infected interferon-gamma knockout mice. Journal of Parasirology 89, 932-940