Investigation of the prevalence of neurologic equine herpes virus type 1 (EHV-1) in a 23-year retrospective analysis (1984-2007)

Veterinary Microbiology

Volumn 139, Issue 3-4, 2009, Pages 375-378

  Perkins, Gillian A ^a   Goodman, Laura B ^a   Tsujimura, Koji ^a   Van de Walle, Gerlinde R ^a   Kim, Sung G ^a   Dubovi, Edward J ^a   Osterrieder, Nikolaus ^a,b  

^a Department of Obstetrics Gynecology   (United States)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Equine herpes virus 1; Neuropathogenic; Real time PCR

Indexed keywords

ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; EQUINE HERPES VIRUS; GENOTYPE; HORSE DISEASE; INFECTION RATE; MARKER GENE; MOLECULAR EPIDEMIOLOGY; NEUROLOGIC DISEASE; NONHUMAN; NORTH AMERICA; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT DISEASE; SEQUENCE ANALYSIS; VETERINARY ABORTION; VIRUS MUTATION;

ABORTION, VETERINARY; ANIMALS; DNA-DIRECTED DNA POLYMERASE; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 1, EQUID; HORSE DISEASES; HORSES; HUMANS; NEURODEGENERATIVE DISEASES; NORTH AMERICA; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; RETROSPECTIVE STUDIES;

ANIMALIA; EQUID HERPESVIRUS 1; EQUIDAE; HERPES; HUMAN HERPESVIRUS 1;

EID: 70349907172     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2009.06.033     Document Type: Article

References (17)

1. Allen G.P., and Breathnach C.C. Quantification by real-time PCR of the magnitude and duration of leucocyte-associated viraemia in horses infected with neuropathogenic vs. non-neuropathogenic strains of EHV-1. Equine Vet. J. 38 (2006) 252-257
2. Allen G.P. Development of a real-time polymerase chain reaction assay for rapid diagnosis of neuropathogenic strains of equine herpesvirus-1. J. Vet. Diagn. Invest. 19 (2007) 69-72
3. Allen G.P. Risk factors for development of neurologic disease after experimental exposure to equine herpesvirus-1 in horses. Am. J. Vet. Res. 69 (2008) 1595-1600
4. Allen G.P., Bolin D.C., Bryant U., Carter C.N., Giles R.C., Harrison L.R., Hong C.B., Jackson C.B., Poonacha K., Wharton R., and Williams N.M. Prevalence of latent, neuropathogenic equine herpesvirus-1 in the thoroughbred broodmare population of central Kentucky. Equine Vet. J. 40 (2008) 105-110
5. Edington N., Bridges C.G., and Patel J.R. Endothelial cell infection and thrombosis in paralysis caused by equid herpes-virus-1: equine stroke. Arch. Virol. 90 (1986) 111-124
6. Goehring L.S., va Winden S.C., van Maanen C., and van Oldruitenborgh-Oosterbaan M.M.S. Equine herpesvirus type 1-associated myeloencephalopathy in the Netherlands: a four-year retrospective study (1999-2003). J. Vet. Intern. Med. 20 (2006) 601-607
7. Goodman L.B., Loregian A., Perkins G.A., Nugent J., Buckles E.L., Mercorelli B., Kydd J.H., Palu G., Smith K.C., Osterrieder N., and Davis-Poynter N. A point mutation in a herpesvirus polymerase determines neuropathogenicity. PLoS Pathogens 3 (2007) e160
8. Henninger R.W., Reed S.M., Saville W.J., et al. Outbreak of neurologic disease caused by equine herpesvirus-1 at a university equestrian center. J. Vet. Intern. Med. 21 (2007) 157-165
9. Hosmer D.W., and Lemeshow S. Applied Logistic Regression (2000), Wiley, New York
10. Jackson T.A., Oxburn B.I., Cordy D.R., and Kendrick J.W. Equine herpesvirus 1 infection of horses: studies on the experimentally induced neurologic disease. Am. J. Vet. Res. 38 (1977) 709-719
11. Leutenegger C.M., Madigan J.E., Mapes S., Thao M., Estrada M., and Pusterla N. Detection of EHV-1 neuropathogenic strains using real-time PCR in the neural tissue of horses with myeloencephalopathy. Vet. Record. 162 (2008) 688-690
12. Nugent J., Birch-Machin I., Smith K.C., Mumford A., Swann Z., Newton J.R., Bowden R.J., Allen G.P., and Davis-Poynter N.D. Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks. J. Virol. 80 (2006) 4047-4060
13. Perkins G.A., Goodman L.B., Dubovi E.J., Kim S.G., and Osterrieder N. Detection of equine herpesvirus-1 in nasal swabs of horses by quantitative real-time PCR. J. Vet. Intern. Med. 22 (2008) 1234-1238
14. Pusterla N., Wilson W.D., Mapes S., Finno C., Isbell D., Arthur R.M., and Ferraro G.L. Characterization of viral loads, strain and state of equine herpesvirus-1 using real-time PCR in horses following natural exposure at a racetrack in California. Vet. J. 179 (2009) 230-239
15. USDA-APHIS, 2007. Equine herpes virus myeloencephalopathy: a potentially emerging disease, vol. 4.
16. Van de Walle G.R., Goupil R., Wishon C., Damiani A., Perkins G.A., and Osterrieder N. A SNP in herpesvirus DNA polymerase is sufficient to cause lethal neurological disease. J. Infect. Dis. 200 (2009) 20-25
17. Whitwell K.E., and Blunden A.S. Pathologic findings in horses dying during an outbreak of the paralytic form of equid herpesvirus type 1 (EHV-1) infection. Equine Vet. J. 24 (1992) 13-19