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Volumn 19, Issue 8, 2011, Pages 1547-1557

MiRNA-mediated silencing in hepatocytes can increase adaptive immune responses to adenovirus vector-delivered transgenic antigens

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; MICRORNA;

EID: 79961021005     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.83     Document Type: Article
Times cited : (7)

References (50)
  • 1
    • 68249099660 scopus 로고    scopus 로고
    • New insights on adenovirus as vaccine vectors
    • Lasaro, MO and Ertl, HC (2009). New insights on adenovirus as vaccine vectors. Mol Ther 17: 1333-1339.
    • (2009) Mol Ther , vol.17 , pp. 1333-1339
    • Lasaro, M.O.1    Ertl, H.C.2
  • 2
    • 77955513770 scopus 로고    scopus 로고
    • Overview of STEP and Phambili trial results: Two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine
    • Gray, G, Buchbinder, S and Duerr, A (2010). Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine. Curr Opin HIV AIDS 5: 357-361.
    • (2010) Curr Opin HIV AIDS , vol.5 , pp. 357-361
    • Gray, G.1    Buchbinder, S.2    Duerr, A.3
  • 3
    • 38749096240 scopus 로고    scopus 로고
    • The failed HIV Merck vaccine study: A step back or a launching point for future vaccine development?
    • Sekaly, RP (2008). The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? J Exp Med 205: 7-12.
    • (2008) J Exp Med , vol.205 , pp. 7-12
    • Sekaly, R.P.1
  • 5
    • 0027166647 scopus 로고
    • 5 promote adenovirus internalization but not virus attachment
    • DOI 10.1016/0092-8674(93)90231-E
    • Wickham, TJ, Mathias, P, Cheresh, DA and Nemerow, GR (1993). Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73: 309-319. (Pubitemid 23123309)
    • (1993) Cell , vol.73 , Issue.2 , pp. 309-319
    • Wickham, T.J.1    Mathias, P.2    Cheresh, D.A.3    Nemerow, G.R.4
  • 9
    • 0038446697 scopus 로고    scopus 로고
    • Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells
    • DOI 10.1182/blood-2002-07-2146
    • De Geest, BR, Van Linthout, SA and Collen, D (2003). Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells. Blood 101: 2551-2556. (Pubitemid 36857612)
    • (2003) Blood , vol.101 , Issue.7 , pp. 2551-2556
    • De Geest, B.R.1    Van Linthout, S.A.2    Collen, D.3
  • 10
    • 0036191023 scopus 로고    scopus 로고
    • Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product
    • DOI 10.1128/JVI.76.6.2899-2911.2002
    • Mercier, S, Gahéry-Segard, H, Monteil, M, Lengagne, R, Guillet, JG, Eloit, M et al. (2002). Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product. J Virol 76: 2899-2911. (Pubitemid 34184876)
    • (2002) Journal of Virology , vol.76 , Issue.6 , pp. 2899-2911
    • Mercier, S.1    Gahery-Segard, H.2    Monteil, M.3    Lengagne, R.4    Guillet, J.-G.5    Eloit, M.6    Denesvre, C.7
  • 11
    • 77956409681 scopus 로고    scopus 로고
    • CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling
    • Lindsay, RW, Darrah, PA, Quinn, KM, Wille-Reece, U, Mattei, LM, Iwasaki, A et al. (2010). CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling. J Immunol 185: 1513-1521.
    • (2010) J Immunol , vol.185 , pp. 1513-1521
    • Lindsay, R.W.1    Darrah, P.A.2    Quinn, K.M.3    Wille-Reece, U.4    Mattei, L.M.5    Iwasaki, A.6
  • 12
    • 79251564050 scopus 로고    scopus 로고
    • CD8+ T cell expansion and maintenance following recombinant adenovirus immunization rely upon co-operation between hematopoietic and non-hematopoietic antigenpresenting cells
    • Bassett, JD, Yang, TC, Bernard, D, Millar, JB, Swift, SL, McGray, AJ et al. CD8+ T cell expansion and maintenance following recombinant adenovirus immunization rely upon co-operation between hematopoietic and non-hematopoietic antigenpresenting cells. Blood 117(4): 1146-1155.
    • Blood , vol.117 , Issue.4 , pp. 1146-1155
    • Bassett, J.D.1    Yang, T.C.2    Bernard, D.3    Millar, J.B.4    Swift, S.L.5    McGray, A.J.6
  • 13
    • 77956419611 scopus 로고    scopus 로고
    • Assessment of route of administration and dose escalation for an adenovirus-based influenza A Virus (H5N1) vaccine in chickens
    • Steitz, J, Wagner, RA, Bristol, T, Gao, W, Donis, RO and Gambotto, A (2010). Assessment of route of administration and dose escalation for an adenovirus-based influenza A Virus (H5N1) vaccine in chickens. Clin Vaccine Immunol 17: 1467-1472.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 1467-1472
    • Steitz, J.1    Wagner, R.A.2    Bristol, T.3    Gao, W.4    Donis, R.O.5    Gambotto, A.6
  • 14
    • 0036059866 scopus 로고    scopus 로고
    • Single oral immunization with replication deficient recombinant adenovirus elicits long-lived transgene-specific cellular and humoral immune responses
    • Sharpe, S, Fooks, A, Lee, J, Hayes, K, Clegg, C and Cranage, M (2002). Single oral immunization with replication deficient recombinant adenovirus elicits long-lived transgene-specific cellular and humoral immune responses. Virology 293: 210-216.
    • (2002) Virology , vol.293 , pp. 210-216
    • Sharpe, S.1    Fooks, A.2    Lee, J.3    Hayes, K.4    Clegg, C.5    Cranage, M.6
  • 15
    • 56149115867 scopus 로고    scopus 로고
    • Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice
    • Croyle, MA, Patel, A, Tran, KN, Gray, M, Zhang, Y, Strong, JE et al. (2008). Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice. PLoS ONE 3: e3548.
    • (2008) PLoS ONE , vol.3
    • Croyle, M.A.1    Patel, A.2    Tran, K.N.3    Gray, M.4    Zhang, Y.5    Strong, J.E.6
  • 17
    • 54849176100 scopus 로고    scopus 로고
    • MiR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy
    • Suzuki, T, Sakurai, F, Nakamura, S, Kouyama, E, Kawabata, K, Kondoh, M et al. (2008). miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy. Mol Ther 16: 1719-1726.
    • (2008) Mol Ther , vol.16 , pp. 1719-1726
    • Suzuki, T.1    Sakurai, F.2    Nakamura, S.3    Kouyama, E.4    Kawabata, K.5    Kondoh, M.6
  • 18
    • 67249084276 scopus 로고    scopus 로고
    • Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells
    • Cawood, R, Chen, HH, Carroll, F, Bazan-Peregrino, M, van Rooijen, N and Seymour, LW (2009). Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells. PLoS Pathog 5: e1000440.
    • (2009) PLoS Pathog , vol.5
    • Cawood, R.1    Chen, H.H.2    Carroll, F.3    Bazan-Peregrino, M.4    Van Rooijen, N.5    Seymour, L.W.6
  • 19
    • 55549108699 scopus 로고    scopus 로고
    • Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA
    • Ylösmäki, E, Hakkarainen, T, Hemminki, A, Visakorpi, T, Andino, R and Saksela, K (2008). Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA. J Virol 82: 11009-11015.
    • (2008) J Virol , vol.82 , pp. 11009-11015
    • Ylösmäki, E.1    Hakkarainen, T.2    Hemminki, A.3    Visakorpi, T.4    Andino, R.5    Saksela, K.6
  • 20
    • 33646564701 scopus 로고    scopus 로고
    • Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer
    • Brown, BD, Venneri, MA, Zingale, A, Sergi Sergi, L and Naldini, L (2006). Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer. Nat Med 12: 585-591.
    • (2006) Nat Med , vol.12 , pp. 585-591
    • Brown, B.D.1    Venneri, M.A.2    Zingale, A.3    Sergi Sergi, L.4    Naldini, L.5
  • 21
    • 23844523406 scopus 로고    scopus 로고
    • MiR- 122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1
    • Chang, J, Nicolas, E, Marks, D, Sander, C, Lerro, A, Buendia, MA et al. (2004). miR- 122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol 1: 106-113.
    • (2004) RNA Biol , vol.1 , pp. 106-113
    • Chang, J.1    Nicolas, E.2    Marks, D.3    Sander, C.4    Lerro, A.5    Buendia, M.A.6
  • 22
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs Modulate Hematopoietic Lineage Differentiation
    • DOI 10.1126/science.1091903
    • Chen, CZ, Li, L, Lodish, HF and Bartel, DP (2004). MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83-86. (Pubitemid 38055775)
    • (2004) Science , vol.303 , Issue.5654 , pp. 83-86
    • Chen, C.-Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 23
    • 55249117284 scopus 로고    scopus 로고
    • MicroRNA-206: The skeletal muscle-specific myomiR
    • McCarthy, JJ (2008). MicroRNA-206: the skeletal muscle-specific myomiR. Biochim Biophys Acta 1779: 682-691.
    • (2008) Biochim Biophys Acta , vol.1779 , pp. 682-691
    • McCarthy, J.J.1
  • 25
    • 0037096206 scopus 로고    scopus 로고
    • b-restricted HBsAg epitopes
    • Schirmbeck, R, Stober, D, El-Kholy, S, Riedl, P and Reimann, J (2002). The immunodominant, Ld-restricted T cell response to hepatitis B surface antigen (HBsAg) efficiently suppresses T cell priming to multiple Dd-, Kd-, and Kb-restricted HBsAg epitopes. J Immunol 168: 6253-6262. (Pubitemid 34620045)
    • (2002) Journal of Immunology , vol.168 , Issue.12 , pp. 6253-6262
    • Schirmbeck, R.1    Stober, D.2    El Kholy, S.3    Riedl, P.4    Reimann, J.5
  • 26
    • 50549083102 scopus 로고    scopus 로고
    • The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vectorencoded transgenic antigens
    • Schirmbeck, R, Reimann, J, Kochanek, S and Kreppel, F (2008). The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vectorencoded transgenic antigens. Mol Ther 16: 1609-1616.
    • (2008) Mol Ther , vol.16 , pp. 1609-1616
    • Schirmbeck, R.1    Reimann, J.2    Kochanek, S.3    Kreppel, F.4
  • 27
    • 73949157699 scopus 로고    scopus 로고
    • In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance
    • Annoni, A, Brown, BD, Cantore, A, Sergi, LS, Naldini, L and Roncarolo, MG (2009). In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance. Blood 114: 5152-5161.
    • (2009) Blood , vol.114 , pp. 5152-5161
    • Annoni, A.1    Brown, B.D.2    Cantore, A.3    Sergi, L.S.4    Naldini, L.5    Roncarolo, M.G.6
  • 28
    • 29644442359 scopus 로고    scopus 로고
    • Immunogenicity and protection of a recombinant human adenovirus serotype 35-based malaria vaccine against Plasmodium yoelii in mice
    • DOI 10.1128/IAI.74.1.313-320.2006
    • Ophorst, OJ, Radosevic, K, Havenga, MJ, Pau, MG, Holterman, L, Berkhout, B et al. (2006). Immunogenicity and protection of a recombinant human adenovirus serotype 35-based malaria vaccine against Plasmodium yoelii in mice. Infect Immun 74: 313-320. (Pubitemid 43023087)
    • (2006) Infection and Immunity , vol.74 , Issue.1 , pp. 313-320
    • Ophorst, O.J.A.E.1    Radosevic, K.2    Havenga, M.J.E.3    Pau, M.G.4    Holterman, L.5    Berkhout, B.6    Goudsmit, J.7    Tsuji, M.8
  • 29
    • 36849053006 scopus 로고    scopus 로고
    • A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice
    • DOI 10.1182/blood-2007-03-078493
    • Brown, BD, Cantore, A, Annoni, A, Sergi, LS, Lombardo, A, Della Valle, P et al. (2007). A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice. Blood 110: 4144-4152. (Pubitemid 351377775)
    • (2007) Blood , vol.110 , Issue.13 , pp. 4144-4152
    • Brown, B.D.1    Cantore, A.2    Annoni, A.3    Sergi, L.S.4    Lombardo, A.5    Della Valle, P.6    D'Angelo, A.7    Naldini, L.8
  • 30
    • 0035871709 scopus 로고    scopus 로고
    • Cutting edge: Recombinant adenoviruses induce CD8 T cell responses to an inserted protein whose expression is limited to nonimmune cells
    • Prasad, SA, Norbury, CC, Chen, W, Bennink, JR and Yewdell, JW (2001). Cutting edge: recombinant adenoviruses induce CD8 T cell responses to an inserted protein whose expression is limited to nonimmune cells. J Immunol 166: 4809-4812. (Pubitemid 32280685)
    • (2001) Journal of Immunology , vol.166 , Issue.8 , pp. 4809-4812
    • Prasad, S.A.1    Norbury, C.C.2    Chen, W.3    Bennink, J.R.4    Yewdell, J.W.5
  • 31
    • 0034749458 scopus 로고    scopus 로고
    • Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors
    • Sarukhan, A, Camugli, S, Gjata, B, von Boehmer, H, Danos, O and Jooss, K (2001). Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors. J Virol 75: 269-277.
    • (2001) J Virol , vol.75 , pp. 269-277
    • Sarukhan, A.1    Camugli, S.2    Gjata, B.3    Von Boehmer, H.4    Danos, O.5    Jooss, K.6
  • 32
    • 0031969428 scopus 로고    scopus 로고
    • Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers
    • Jooss, K, Yang, Y, Fisher, KJ and Wilson, JM (1998). Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers. J Virol 72: 4212-4223. (Pubitemid 28188726)
    • (1998) Journal of Virology , vol.72 , Issue.5 , pp. 4212-4223
    • Jooss, K.1    Yang, Y.2    Fisher, K.J.3    Wilson, J.M.4
  • 34
    • 0035871784 scopus 로고    scopus 로고
    • Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells
    • Rea, D, Havenga, MJ, van Den Assem, M, Sutmuller, RP, Lemckert, A, Hoeben, RC et al. (2001). Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells. J Immunol 166: 5236-5244. (Pubitemid 32280740)
    • (2001) Journal of Immunology , vol.166 , Issue.8 , pp. 5236-5244
    • Rea, D.1    Havenga, M.J.E.2    Van Den Assem, M.3    Sutmuller, R.P.M.4    Lemckert, A.5    Hoeben, R.C.6    Bout, A.7    Melief, C.J.M.8    Offringa, R.9
  • 36
    • 4444321570 scopus 로고    scopus 로고
    • Muscle stem cells can act as antigen-presenting cells: Implication for gene therapy
    • DOI 10.1038/sj.gt.3302293
    • Cao, B, Bruder, J, Kovesdi, I and Huard, J (2004). Muscle stem cells can act as antigenpresenting cells: implication for gene therapy. Gene Ther 11: 1321-1330. (Pubitemid 39213997)
    • (2004) Gene Therapy , vol.11 , Issue.17 , pp. 1321-1330
    • Cao, B.1    Bruder, J.2    Kovesdi, I.3    Huard, J.4
  • 37
    • 64049084841 scopus 로고    scopus 로고
    • Effect of tissue-specific promoters and microRNA recognition elements on stability of transgene expression after hydrodynamic naked plasmid DNA delivery
    • Wolff, LJ, Wolff, JA and Sebestyén, MG (2009). Effect of tissue-specific promoters and microRNA recognition elements on stability of transgene expression after hydrodynamic naked plasmid DNA delivery. Hum Gene Ther 20: 374-388.
    • (2009) Hum Gene Ther , vol.20 , pp. 374-388
    • Wolff, L.J.1    Wolff, J.A.2    Sebestyén, M.G.3
  • 38
    • 0034031683 scopus 로고    scopus 로고
    • Local control of the immune response in the liver
    • DOI 10.1034/j.1600-065X.2000.174001021.x
    • Knolle, PA and Gerken, G (2000). Local control of the immune response in the liver. Immunol Rev 174: 21-34. (Pubitemid 30201376)
    • (2000) Immunological Reviews , vol.174 , pp. 21-34
    • Knolle, P.A.1    Gerken, G.2
  • 40
    • 34547498762 scopus 로고    scopus 로고
    • + T cells in tolerance to the transgene product following hepatic in vivo gene transfer
    • DOI 10.1182/blood-2007-02-073304
    • Cao, O, Dobrzynski, E, Wang, L, Nayak, S, Mingle, B, Terhorst, C et al. (2007). Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer. Blood 110: 1132-1140. (Pubitemid 47281408)
    • (2007) Blood , vol.110 , Issue.4 , pp. 1132-1140
    • Cao, O.1    Dobrzynski, E.2    Wang, L.3    Nayak, S.4    Mingle, B.5    Terhorst, C.6    Herzog, R.W.7
  • 41
    • 2342561729 scopus 로고    scopus 로고
    • Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice
    • DOI 10.1182/blood-2003-09-3217
    • Follenzi, A, Battaglia, M, Lombardo, A, Annoni, A, Roncarolo, MG and Naldini, L (2004). Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice. Blood 103: 3700-3709. (Pubitemid 38596285)
    • (2004) Blood , vol.103 , Issue.10 , pp. 3700-3709
    • Follenzi, A.1    Battaglia, M.2    Lombardo, A.3    Annoni, A.4    Roncarolo, M.G.5    Naldini, L.6
  • 42
    • 0035080378 scopus 로고    scopus 로고
    • Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice
    • DOI 10.1038/sj.gt.3301409
    • Fields, PA, Armstrong, E, Hagstrom, JN, Arruda, VR, Murphy, ML, Farrell, JP et al. (2001). Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice. Gene Ther 8: 354-361. (Pubitemid 32243465)
    • (2001) Gene Therapy , vol.8 , Issue.5 , pp. 354-361
    • Fields, P.A.1    Armstrong, E.2    Hagstrom, J.N.3    Arruda, V.R.4    Murphy, M.L.5    Farrell, J.P.6    High, K.A.7    Herzog, R.W.8
  • 44
    • 17044387019 scopus 로고    scopus 로고
    • Rapid functional exhaustion and deletion of CTL following immunization with recombinant adenovirus
    • Krebs, P, Scandella, E, Odermatt, B and Ludewig, B (2005). Rapid functional exhaustion and deletion of CTL following immunization with recombinant adenovirus. J Immunol 174: 4559-4566.
    • (2005) J Immunol , vol.174 , pp. 4559-4566
    • Krebs, P.1    Scandella, E.2    Odermatt, B.3    Ludewig, B.4
  • 45
    • 77952754236 scopus 로고    scopus 로고
    • Quality of the transgene-specific CD8+ T cell response induced by adenoviral vector immunization is critically influenced by virus dose and route of vaccination
    • Holst, PJ, Ørskov, C, Thomsen, AR and Christensen, JP (2010). Quality of the transgene-specific CD8+ T cell response induced by adenoviral vector immunization is critically influenced by virus dose and route of vaccination. J Immunol 184: 4431-4439.
    • (2010) J Immunol , vol.184 , pp. 4431-4439
    • Holst, P.J.1    Ørskov, C.2    Thomsen, A.R.3    Christensen, J.P.4
  • 46
    • 37549043879 scopus 로고    scopus 로고
    • Fully detargeted polyethylene glycol-coated adenovirus vectors are potent genetic vaccines and escape from pre-existing anti-adenovirus antibodies
    • Wortmann, A, Vöhringer, S, Engler, T, Corjon, S, Schirmbeck, R, Reimann, J et al. (2008). Fully detargeted polyethylene glycol-coated adenovirus vectors are potent genetic vaccines and escape from pre-existing anti-adenovirus antibodies. Mol Ther 16: 154-162.
    • (2008) Mol Ther , vol.16 , pp. 154-162
    • Wortmann, A.1    Vöhringer, S.2    Engler, T.3    Corjon, S.4    Schirmbeck, R.5    Reimann, J.6
  • 47
    • 0034655133 scopus 로고    scopus 로고
    • Ongoing murine T1 or T2 immune responses to the hepatitis B surface antigen are excluded from the liver that expresses transgene-encoded hepatitis B surface antigen
    • Schirmbeck, R, Wild, J, Stober, D, Blum, HE, Chisari, FV, Geissler, M et al. (2000). Ongoing murine T1 or T2 immune responses to the hepatitis B surface antigen are excluded from the liver that expresses transgene-encoded hepatitis B surface antigen. J Immunol 164: 4235-4243. (Pubitemid 30215083)
    • (2000) Journal of Immunology , vol.164 , Issue.8 , pp. 4235-4243
    • Schirmbeck, R.1    Wild, J.2    Stober, D.3    Blum, H.E.4    Chisari, F.V.5    Geissler, M.6    Reimann, J.7
  • 48
    • 0034633740 scopus 로고    scopus 로고
    • Efficient transformation of primary human amniocytes by E1 functions of Ad5: Generation of new cell lines for adenoviral vector production
    • Schiedner, G, Hertel, S and Kochanek, S (2000). Efficient transformation of primary human amniocytes by E1 functions of Ad5: generation of new cell lines for adenoviral vector production. Hum Gene Ther 11: 2105-2116.
    • (2000) Hum Gene Ther , vol.11 , pp. 2105-2116
    • Schiedner, G.1    Hertel, S.2    Kochanek, S.3
  • 49
    • 0036019186 scopus 로고    scopus 로고
    • A DNA-based method to assay total and infectious particle contents and helper virus contamination in high-capacity adenoviral vector preparations
    • DOI 10.1089/104303402320138934
    • Kreppel, F, Biermann, V, Kochanek, S and Schiedner, G (2002). A DNA-based method to assay total and infectious particle contents and helper virus contamination in high-capacity adenoviral vector preparations. Hum Gene Ther 13: 1151-1156. (Pubitemid 34746695)
    • (2002) Human Gene Therapy , vol.13 , Issue.10 , pp. 1151-1156
    • Kreppel, F.1    Biermann, V.2    Kochanek, S.3    Schiedner, G.4
  • 50
    • 78650881455 scopus 로고    scopus 로고
    • Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells
    • Prill, JM, Espenlaub, S, Samen, U, Engler, T, Schmidt, E, Vetrini, F et al. (2011). Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells. Mol Ther 19: 83-92.
    • (2011) Mol Ther , vol.19 , pp. 83-92
    • Prill, J.M.1    Espenlaub, S.2    Samen, U.3    Engler, T.4    Schmidt, E.5    Vetrini, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.