Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide: The impact of smoking

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 5, 1996, Pages 1519-1529

  Pedersen, Bente ^b   Dahl, Ronald ^b   Karlström, Roberta ^b   Peterson, Christer G B ^b   Venge, Per ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; EOSINOPHIL CATIONIC PROTEIN; LACTOFERRIN; MYELOPEROXIDASE; NEUROTOXIN; THEOPHYLLINE;

ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EOSINOPHIL; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMOKING; STEROID THERAPY;

EID: 0029985810     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.5.8630596     Document Type: Article

References (26)

1. Barnes, P. J., I. Rodger, and N. Thomson, editors. 1992. Asthma. Basic Mechanisms and Clinical Management, 2nd ed. Academic Press, London.
2. Vandenplas, O., J. Malo, M. Saetta, C. E. Mapp, and L. M. Fabbri. 1993. Occupational asthma and extrinsic alveolitis due to isocyanates: current status and perspectives. Br. J. Ind. Med. 50:213-228.
3. Kallenbach, J., R. Baynes, B. Fine, D. Dajee, and W. Bezwoda. 1992. Persistent neutrophil activation in mild asthma. J. Allergy Clin. Immunol. 90:272-274.
4. Dahl, R., P. Venge, and K. Fredens. 1992. The eosinophil. In P. J. Barnes, I. Rodger, and N. Thomson, editors. Asthma: Basic Mechanisms and Clinical Management, 2nd ed. Academic Press, London. 111-124.
5. Venge, P., H. Bergstrand, and L. Håkansson. 1992. Neutrophils and eosinophils. In W. N. Kelley, E. D. Harris, S. Ruddy, and C. B. Sledge, editors. Textbook of Rheumatology, 4th ed. W. B. Saunders, Philadelphia. 269-285.
6. Venge, P. 1993. Human eosinophil granule proteins: structure function and release. In H. Smith and R. M. Cook, editors. Immunopharmacology of Eosinophils. Academic Press, London. 43-55.
7. Venge, P. 1993. Serum measurements of eosinophil cationic protein (ECP) in bronchial asthma. Clin. Exp. Allergy 23(Suppl. 2):3-7.
8. Venge, P. 1994. Soluble markers of allergic inflammation. Allergy 5: 128-134.
9. Carlson, M., L. Håkansson, M. Kämpe, G. Stålenheim, C. Peterson, and P. Venge. 1992. Degranulation of eosinophils from pollen-atopic patients with asthma is increased during pollen season. J. Allergy Clin. Immunol. 89(1, Part 1):131-139.
10. Lacoste, J.-Y., J. Bousquet, P. Chanez, T. Van Vyve, J. Simony-Lafontaine, N. Lequeu, P. Vic, I. Enander, P. Godard, and F.-B. Michel. 1993. Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 92(No. 4):537-548.
11. Cockcroft, D. W., D. N. Killian, J. J. A. Mellon, and F. E. Hargreave. 1977. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin. Allergy 7:235-243.
12. Olofsson, T., I. Olsson, P. Venge, and B. Elgefors. 1977. Serum myeloperoxidase and lactoferrin in neutropenia. Scand. J. Haematol. 18: 73-80.
13. Juel Jensen, E., B. Pedersen, E. Schmidt, P. Venge, and R. Dahl. 1994. Serum-ECP and Serum-Lactoferrin in non-atopic smokers, nonsmokers and recent ex-smokers; relation to lung function, airway symptoms and smoking history. Eur. Respir. J. (In press)
14. Juniper, E. F., P. A. Kline, M. A. Vanzieleghem, E. H. Ramsdale, P. M. O'Byrne, and F. E. Hargreave. 1990. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am. Rev. Respir. Dis. 142:832-836.
15. Juniper, E. F., P. A. Kline, M. A. Vanzieleghem, and F. E. Hargreave. 1991. Reduction of budesonide after a year of increased use: A randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintained. J. Allergy Clin. Immunol. 87:483-489.
16. Venge, P., A. Strömberg, J. H. Braconier, L.-E. Roxin, and I. Olsson. 1978. Neutrophil and eosinophil granulocytes in bacterial infection: sequential studies of cellular and serum levels of granule proteins. Br. J. Haematol. 38:475-483.
17. Ädelroth, E., L. Rosenhall, S.-Å. Johansson, M. Linden, and P. Venge. 1990. Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage: the effects of antiasthmatic treatment with budesonide or terbutaline. Am. Rev. Respir. Dis. 142:91-99.
18. Jeffery, P. K., R. W. Godfrey, E. Ädelroth, F. Nelson, A. Rogers, and S. Johansson. 1990. Effects of treatment on airway inflammation and thickening of reticular collagen in asthma: a quantitative light and electron microscopic study and correlation with BAL. In E. Ädelroth, editor. Cells, Mediators and Mucosal Inflammation in Asthma. Umea University Medical Dissertations, Umeå, Sweden. 59-71.
19. Corrigan, C. J., A. Haczku, V. Gemou-Engesaeth, S. Doi, Y. Kikuchi, K. Takatsu, S. R. Durham, and A. B. Kay. 1993. CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5: effect of glucocorticoid therapy. Am. Rev. Respir. Dis. 147:540-547.
20. Venge, P., and R. Dahl. 1989. Are blood eosinophil number and activity important for the development of the late asthmatic reaction after allergen challenge? Eur. Respir. J. 2(Suppl. 6):430s-434s.
21. Kita, H., R. Abu-Ghazaleh, C. J. Sanderson, and G. J. Gleich. 1991. Effect of steroids on immunoglobulin-induced eosinophil degranulation. J. Allergy Clin. Immunol. 87(1, Part 1):70-77.
22. Gleich, G. J. 1990. The eosinophil and bronchial asthma: current understanding. J. Allergy Clin. Immunol. 85:422-436.
23. Djukanovic, R., W. R. Roche, J. W. Wilson, C. R. W. Beasley, O. P. Twentyman, P. H. Howarth, and S. T. Holgate. 1990. Mucosal inflammation in asthma. Am. Rev. Respir. Dis. 142:434-457.
24. Bousquet, J., P. Chanez, J. Y. Lacoste, G. Barnéon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and F.-B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
25. Holgate, S. T., W. R. Roche, and M. K. Church. 1991. The role of the eosinophil in asthma. Am. Rev. Respir. Dis. 143(Suppl.):S66-S70.
26. Gleich, G. J., C. R. Adolphson, and K. M. Leiferman. 1993. The biology of the eosinophilic leukocyte. Annu. Rev. Med. 44:85-101.