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Volumn 121, Issue 8, 2011, Pages 3289-3305

Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; DOPAMINE; EFONIDIPINE; MIBEFRADIL; NICKEL; NIFEDIPINE; NNC 55 0396; UNCLASSIFIED DRUG;

EID: 79960973258     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI46482     Document Type: Article
Times cited : (61)

References (60)
  • 1
    • 0025613142 scopus 로고
    • Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, "prefrontal" and "limbic"functions
    • Alexander GE, Crutcher MD, DeLong MR. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic"functions. Prog Brain Res. 1990;85:119-146.
    • (1990) Prog Brain Res , vol.85 , pp. 119-146
    • Alexander, G.E.1    Crutcher, M.D.2    DeLong, M.R.3
  • 2
    • 33846077467 scopus 로고    scopus 로고
    • Circuits and circuit disorders of the basal ganglia
    • DOI 10.1001/archneur.64.1.20
    • DeLong MR, Wichmann T. Circuits and circuit disorders of the basal ganglia. Arch Neurol. 2007;64(1):20-24. (Pubitemid 46072419)
    • (2007) Archives of Neurology , vol.64 , Issue.1 , pp. 20-24
    • DeLong, M.R.1    Wichmann, T.2
  • 3
    • 0028021805 scopus 로고
    • The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
    • Bergman H, Wichmann T, Karmon B, DeLong MR. The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. J Neurophysiol. 1994;72(2):507-520. (Pubitemid 24273560)
    • (1994) Journal of Neurophysiology , vol.72 , Issue.2 , pp. 507-520
    • Bergman, H.1    Wichmann, T.2    Karmon, B.3    DeLong, M.R.4
  • 4
    • 0026675529 scopus 로고
    • Subthalamic nucleus cell firing in the 6-OHDA-treated rat: Basal activity and response to haloperidol
    • Hollerman JR, Grace AA. Subthalamic nucleus cell firing in the 6-OHDA-treated rat: basal activity and response to haloperidol. Brain Res. 1992;590(1-2):291-299.
    • (1992) Brain Re , vol.590 , Issue.1-2 , pp. 291-299
    • Hollerman, J.R.1    Grace, A.A.2
  • 5
    • 0029846577 scopus 로고    scopus 로고
    • Alleviation of experimental hemiparkinsonism by high-frequency stimulation of the subthalamic nucleus in primates: A comparison with L-Dopa treatment
    • DOI 10.1002/mds.870110606
    • Benazzouz A, Boraud T, Feger J, Burbaud P, Bioulac B, Gross C. Alleviation of experimental hemiparkinsonism by high-frequency stimulation of the subthalamic nucleus in primates: a comparison with L-Dopa treatment. Mov Disord. 1996;11(6):627-632. (Pubitemid 26381931)
    • (1996) Movement Disorders , vol.11 , Issue.6 , pp. 627-632
    • Benazzouz, A.1    Boraud, T.2    Feger, J.3    Burbaud, P.4    Bioulac, B.5    Gross, C.6
  • 6
    • 0030009705 scopus 로고    scopus 로고
    • Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus
    • DOI 10.1016/0306-4522(95)00535-8
    • Hassani OK, Mouroux M, Feger J. Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus. Neuroscience. 1996;72(1):105-115. (Pubitemid 26092990)
    • (1996) Neuroscience , vol.72 , Issue.1 , pp. 105-115
    • Hassani, O.-K.1    Mouroux, M.2    Feger, J.3
  • 7
    • 0034727463 scopus 로고    scopus 로고
    • Ipsilateral and contralateral subthalamic activity after unilateral dopaminergic lesion
    • Perier C, Agid Y, Hirsch EC, Feger J. Ipsilateral and contralateral subthalamic activity after unilateral dopaminergic lesion. Neuroreport. 2000;11(14):3275-3278.
    • (2000) Neuroreport , vol.11 , Issue.14 , pp. 3275-3278
    • Perier, C.1    Agid, Y.2    Hirsch, E.C.3    Feger, J.4
  • 8
    • 0033959548 scopus 로고    scopus 로고
    • Evolution of changes in neuronal activity in the subthalamic nucleus of rats with unilateral lesion of the substantia nigra assessed by metabolic and electrophysiological measurements
    • DOI 10.1046/j.1460-9568.2000.00901.x
    • Vila M, et al. Evolution of changes in neuronal activity in the subthalamic nucleus of rats with unilateral lesion of the substantia nigra assessed by metabolic and electrophysiological measurements. Eur J Neurosci. 2000;12(1):337-344. (Pubitemid 30068438)
    • (2000) European Journal of Neuroscience , vol.12 , Issue.1 , pp. 337-344
    • Vila, M.1    Perier, C.2    Feger, J.3    Yelnik, J.4    Faucheux, B.5    Ruberg, M.6    Raisman-Vozari, R.7    Agid, Y.8    Hirsch, E.C.9
  • 9
    • 0025169590 scopus 로고
    • Reversal of experimental parkinsonism by lesions of the subthalamic nucleus
    • Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science. 1990;249(4975):1436-1438.
    • (1990) Science , vol.249 , Issue.4975 , pp. 1436-1438
    • Bergman, H.1    Wichmann, T.2    DeLong, M.R.3
  • 10
    • 0027479766 scopus 로고
    • Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys
    • Benazzouz A, Gross C, Féger J, Boraud T, Bioulac B. Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys. Eur J Neurosci. 1993;5(4):382-389. (Pubitemid 23108592)
    • (1993) European Journal of Neuroscience , vol.5 , Issue.4 , pp. 382-389
    • Benazzouz, A.1    Gross, C.2    Feger, J.3    Boraud, T.4    Bioulac, B.5
  • 11
    • 0029144021 scopus 로고
    • Bilateral subthalamic nucleus stimulation for severe Parkinson's disease
    • Limousin P, et al. Bilateral subthalamic nucleus stimulation for severe Parkinson's disease. Mov Disord. 1995;10(5):672-674.
    • (1995) Mov Disord , vol.10 , Issue.5 , pp. 672-674
    • Limousin, P.1
  • 12
    • 0031566830 scopus 로고    scopus 로고
    • Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson's disease
    • Krack P, Limousin P, Benabid AL, Pollak P. Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson's disease. Lancet. 1997;350(9092):1676. (Pubitemid 28036831)
    • (1997) Lancet , vol.350 , Issue.9092 , pp. 1676
    • Krack, P.1    Limousin, P.2    Benabid, A.L.3    Pollak, P.4
  • 14
    • 85052609847 scopus 로고    scopus 로고
    • Deep brain stimulation and chemical neuromodulation: Current use and perspectives for the future
    • Hamani C, Neimat JS, Lozano AM. Deep brain stimulation and chemical neuromodulation: current use and perspectives for the future. Acta Neurochir. 2007;97(pt 2):127-133.
    • (2007) Acta Neurochir , vol.97 , Issue.2 , pp. 127-133
    • Hamani, C.1    Neimat, J.S.2    Lozano, A.M.3
  • 15
    • 57149090487 scopus 로고    scopus 로고
    • Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
    • Benabid AL, Chabardes S, Mitrofanis J, Pollak P. Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Lancet Neurol. 2009;8(1):67-81.
    • (2009) Lancet Neurol , vol.8 , Issue.1 , pp. 67-81
    • Benabid, A.L.1    Chabardes, S.2    Mitrofanis, J.3    Pollak, P.4
  • 16
    • 0033198222 scopus 로고    scopus 로고
    • Mechanisms underlying spontaneous oscillation and rhythmic firing in rat subthalamic neurons
    • Bevan MD, Wilson CJ. Mechanisms underlying spontaneous oscillation and rhythmic firing in rat subthalamic neurons. J Neurosci. 1999;19(17):7617-7628. (Pubitemid 29404617)
    • (1999) Journal of Neuroscience , vol.19 , Issue.17 , pp. 7617-7628
    • Bevan, M.D.1    Wilson, C.J.2
  • 17
    • 0037561112 scopus 로고    scopus 로고
    • Subthreshold sodium currents and pacemaking of subthalamic neurons: Modulation by slow inactivation
    • DOI 10.1016/S0896-6273(03)00360-X
    • Do MT, Bean BP. Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron. 2003;39(1):109-120. (Pubitemid 36830952)
    • (2003) Neuron , vol.39 , Issue.1 , pp. 109-120
    • Do, M.T.H.1    Bean, B.P.2
  • 18
    • 0034120333 scopus 로고    scopus 로고
    • Slowly inactivating sodium current (I(NaP)) underlies single-spike activity in rat subthalamic neurons
    • Beurrier C, Bioulac B, Hammond C. Slowly inactivating sodium current (I(NaP)) underlies singlespike activity in rat subthalamic neurons. J Neurophysiol. 2000;83(4):1951-1957. (Pubitemid 30198651)
    • (2000) Journal of Neurophysiology , vol.83 , Issue.4 , pp. 1951-1957
    • Beurrier, C.1    Bioulac, B.2    Hammond, C.3
  • 19
    • 0023603578 scopus 로고
    • Electrical membrane properties of rat subthalamic neurons in an in vitro slice preparation
    • DOI 10.1016/0006-8993(87)91524-1
    • Nakanishi H, Kita H, Kitai ST. Electrical membrane properties of rat subthalamic neurons in an in vitro slice preparation. Brain Res. 1987;437(1):35-44. (Pubitemid 18029686)
    • (1987) Brain Research , vol.437 , Issue.1 , pp. 35-44
    • Nakanishi, H.1    Kita, H.2    Kitai, S.T.3
  • 20
    • 0033549810 scopus 로고    scopus 로고
    • A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus
    • Plenz D, Kital ST. A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus. Nature. 1999;400(6745):677-682.
    • (1999) Nature , vol.400 , Issue.6745 , pp. 677-682
    • Plenz, D.1    Kital, S.T.2
  • 21
    • 0036092946 scopus 로고    scopus 로고
    • Regulation of the timing and pattern of action potential generation in rat subthalamic neurons in vitro by GABA-A IPSPs
    • Bevan MD, Magill PJ, Hallworth NE, Bolam JP, Wilson CJ. Regulation of the timing and pattern of action potential generation in rat subthalamic neurons in vitro by GABA-A IPSPs. J Neurophysiol. 2002;87(3):1348-1362. (Pubitemid 34670802)
    • (2002) Journal of Neurophysiology , vol.87 , Issue.3 , pp. 1348-1362
    • Bevan, M.D.1    Magill, P.J.2    Hallworth, N.E.3    Bolam, J.P.4    Wilson, C.J.5
  • 22
    • 0036813078 scopus 로고    scopus 로고
    • The switch of subthalamic neurons from an irregular to a bursting pattern does not solely depend on their GABAergic inputs in the anesthetic-free rat
    • Urbain N, Rentero N, Gervasoni D, Renaud B, Chouvet G. The switch of subthalamic neurons from an irregular to a bursting pattern does not solely depend on their GABAergic inputs in the anestheticfree rat. J Neurosci. 2002;22(19):8665-8675. (Pubitemid 35387607)
    • (2002) Journal of Neuroscience , vol.22 , Issue.19 , pp. 8665-8675
    • Urbain, N.1    Rentero, N.2    Gervasoni, D.3    Renaud, B.4    Chouvet, G.5
  • 23
    • 0042922907 scopus 로고    scopus 로고
    • Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro
    • Hallworth NE, Wilson CJ, Bevan MD. Apaminsensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro. J Neurosci. 2003;23(20):7525-7542. (Pubitemid 37034069)
    • (2003) Journal of Neuroscience , vol.23 , Issue.20 , pp. 7525-7542
    • Hallworth, N.E.1    Wilson, C.J.2    Bevan, M.D.3
  • 24
    • 0037322540 scopus 로고    scopus 로고
    • D5 (not D1) dopamine receptors potentiate burst-firing in neurons of the subthalamic nucleus by modulating an L-type calcium conductance
    • Baufreton J, et al. D5 (not D1) dopamine receptors potentiate burst-firing in neurons of the subthalamic nucleus by modulating an L-type calcium conductance. J Neurosci. 2003;23(3):816.
    • (2003) J Neurosci , vol.23 , Issue.3 , pp. 816
    • Baufreton, J.1
  • 26
    • 0028915751 scopus 로고
    • Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro
    • Bal T, von Krosigk M, McCormick DA. Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. J Physiol. 1995;483(pt 3):641-663.
    • (1995) J Physiol , vol.483 , Issue.3 , pp. 641-663
    • Bal, T.1    Von Krosigk, M.2    McCormick, D.A.3
  • 27
    • 0033555825 scopus 로고    scopus 로고
    • Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode
    • Beurrier C, Congar P, Bioulac B, Hammond C. Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode. J Neurosci. 1999;19(2):599.
    • (1999) J Neurosci , vol.19 , Issue.2 , pp. 599
    • Beurrier, C.1    Congar, P.2    Bioulac, B.3    Hammond, C.4
  • 29
    • 22644444450 scopus 로고    scopus 로고
    • Voltage-dependent calcium channels
    • Lacinova L. Voltage-dependent calcium channels. Gen Physiol Biophys. 2005;24(suppl 1):1-78. (Pubitemid 41025303)
    • (2005) General Physiology and Biophysics , vol.24 , Issue.SUPPL. 1 , pp. 1-78
    • Lacinova, L.1
  • 30
    • 0031698556 scopus 로고    scopus 로고
    • Molecular characterization of a novel family of low voltage-activated, T-type, calcium channels
    • DOI 10.1023/A:1021981420839
    • Perez-Reyes E. Molecular characterization of a novel family of low voltage-activated, T-type, calcium channels. J Bioenerg Biomembr. 1998;30(4):313-318. (Pubitemid 28436153)
    • (1998) Journal of Bioenergetics and Biomembranes , vol.30 , Issue.4 , pp. 313-318
    • Perez-Reyes, E.1
  • 31
    • 0029917477 scopus 로고    scopus 로고
    • Low-threshold calcium currents in central nervous system neurons
    • Huguenard JR. Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol. 1996;58:329-348. (Pubitemid 26106724)
    • (1996) Annual Review of Physiology , vol.58 , pp. 329-348
    • Huguenard, J.R.1
  • 32
    • 0031466388 scopus 로고    scopus 로고
    • Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker
    • Clozel JP, Ertel EA, Ertel SI. Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J Hypertens Suppl. 1997;15(5):S17-S25. (Pubitemid 28034980)
    • (1997) Journal of Hypertension, Supplement , vol.15 , Issue.5
    • Clozel, J.-P.1    Ertel, E.A.2    Ertel, S.I.3
  • 33
    • 0032795085 scopus 로고    scopus 로고
    • Nickel block of three cloned T-type calcium channels: Low concentrations selectively block alpha1H
    • Lee JH, Gomora JC, Cribbs LL, Perez-Reyes E. Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H. Biophys J. 1999;77(6):3034-3042.
    • (1999) Biophys J , vol.77 , Issue.6 , pp. 3034-3042
    • Lee, J.H.1    Gomora, J.C.2    Cribbs, L.L.3    Perez-Reyes, E.4
  • 34
    • 0034054666 scopus 로고    scopus 로고
    • Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels
    • DOI 10.1074/jbc.275.9.6090
    • Monteil A, Chemin J, Bourinet E, Mennessier G, Lory P, Nargeot J. Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels. J Biol Chem. 2000;275(9):6090-6100. (Pubitemid 30129892)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.9 , pp. 6090-6100
    • Monteil, A.1    Chemin, J.2    Bourinet, E.3    Mennessier, G.4    Lory, P.5    Nargeot, J.6
  • 36
    • 0037121628 scopus 로고    scopus 로고
    • High-frequency stimulation of the subthalamic nucleus silences subthalamic neurons: A possible cellular mechanism in Parkinson's disease
    • DOI 10.1016/S0306-4522(02)00538-9, PII S0306452202005389
    • Magarinos-Ascone C, Pazo JH, Macadar O, Buno W. High-frequency stimulation of the subthalamic nucleus silences subthalamic neurons: a possible cellular mechanism in Parkinson's disease. Neuroscience. 2002;115(4):1109-1117. (Pubitemid 35351701)
    • (2002) Neuroscience , vol.115 , Issue.4 , pp. 1109-1117
    • Magarios-Ascone, C.1    Pazo, J.H.2    Macadar, O.3    Buo, W.4
  • 37
    • 1642397011 scopus 로고    scopus 로고
    • NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-Benzimidazol-2-yl)propyl]-N-methylamino) ethyl)-6-fluoro-1, 2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A New Selective Inhibitor of T-Type Calcium Channels
    • DOI 10.1124/jpet.103.060814
    • Huang L, et al. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl) propyl]-N-methylamino)ethyl)- 6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004;309(1):193-199. (Pubitemid 38393130)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.309 , Issue.1 , pp. 193-199
    • Huang, L.1    Keyser, B.M.2    Tagmose, T.M.3    Hansen, J.B.4    Taylor, J.T.5    Zhuang, H.6    Zhang, M.7    Ragsdale, D.S.8    Li, M.9
  • 38
    • 24644491717 scopus 로고    scopus 로고
    • Towards selective antagonists of T-type calcium channels: Design, characterization and potential applications of NNC 55-0396
    • Li M, Hansen JB, Huang L, Keyser BM, Taylor JT. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovasc Drug Rev. 2005;23(2):173-196. (Pubitemid 41278975)
    • (2005) Cardiovascular Drug Reviews , vol.23 , Issue.2 , pp. 173-196
    • Li, M.1    Hansen, J.B.2    Huang, L.3    Keyser, B.M.4    Taylor, J.T.5
  • 39
    • 46449117880 scopus 로고    scopus 로고
    • The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil
    • DOI 10.1124/dmd.107.020115
    • Bui PH, Quesada A, Handforth A, Hankinson O. The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil. Drug Metab Dispos. 2008;36(7):1291-1299. (Pubitemid 351929313)
    • (2008) Drug Metabolism and Disposition , vol.36 , Issue.7 , pp. 1291-1299
    • Bui, P.H.1    Quesada, A.2    Handforth, A.3    Hankinson, O.4
  • 40
    • 0034018917 scopus 로고    scopus 로고
    • Regulation of the calcium channel alpha(1G) subunit by divalent cations and organic blockers
    • DOI 10.1016/S0028-3908(99)00202-6, PII S0028390899002026
    • Lacinova L, Klugbauer N, Hofmann F. Regulation of the calcium channel alpha(1G) subunit by divalent cations and organic blockers. Neuropharmacology. 2000;39(7):1254-1266. (Pubitemid 30173189)
    • (2000) Neuropharmacology , vol.39 , Issue.7 , pp. 1254-1266
    • Lacinova, L.1    Klugbauer, N.2    Hofmann, F.3
  • 44
    • 0028364018 scopus 로고
    • Single unit analysis of the human ventral thalamic nuclear group. Tremor-related activity in functionally identified cells
    • Lenz FA, Kwan HC, Martin RL, Tasker RR, Dostrovsky JO, Lenz YE. Single unit analysis of the human ventral thalamic nuclear group. Tremor-related activity in functionally identified cells. Brain. 1994;117(pt 3):531-543.
    • (1994) Brain , vol.117 , Issue.3 , pp. 531-543
    • Lenz, F.A.1    Kwan, H.C.2    Martin, R.L.3    Tasker, R.R.4    Dostrovsky, J.O.5    Lenz, Y.E.6
  • 47
    • 0034176717 scopus 로고    scopus 로고
    • Origins of tremor
    • Elble RJ. Origins of tremor. Lancet. 2000;355(9210):1113-1114. (Pubitemid 30172927)
    • (2000) Lancet , vol.355 , Issue.9210 , pp. 1113-1114
    • Elble, R.J.1
  • 48
    • 0037224553 scopus 로고    scopus 로고
    • The cerebral oscillatory network of parkinsonian resting tremor
    • DOI 10.1093/brain/awg022
    • Timmermann L, Gross J, Dirks M, Volkmann J, Freund HJ, Schnitzler A. The cerebral oscillatory network of parkinsonian resting tremor. Brain. 2003;126(pt 1):199-212. (Pubitemid 36068570)
    • (2003) Brain , vol.126 , Issue.1 , pp. 199-212
    • Timmermann, L.1    Gross, J.2    Dirks, M.3    Volkmann, J.4    Freund, H.-J.5    Schnitzler, A.6
  • 49
    • 48749115233 scopus 로고    scopus 로고
    • Tremor-correlated neuronal activity in the subthalamic nucleus of Parkinsonian patients
    • Amtage F, et al. Tremor-correlated neuronal activity in the subthalamic nucleus of Parkinsonian patients. Neurosci Lett. 2008;442(3):195-199.
    • (2008) Neurosci Lett , vol.442 , Issue.3 , pp. 195-199
    • Amtage, F.1
  • 50
    • 59149088903 scopus 로고    scopus 로고
    • Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson's disease
    • Reck C, et al. Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson's disease. Eur J Neurosci. 2009;29(3):599-612.
    • (2009) Eur J Neurosci , vol.29 , Issue.3 , pp. 599-612
    • Reck, C.1
  • 51
    • 0028021805 scopus 로고
    • The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
    • Bergman H, Wichmann T, Karmon B, DeLong M. The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. J Neurophysiol. 1994;72(2):507.
    • (1994) J Neurophysiol , vol.72 , Issue.2 , pp. 507
    • Bergman, H.1    Wichmann, T.2    Karmon, B.3    DeLong, M.4
  • 52
    • 69449095866 scopus 로고    scopus 로고
    • Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: Results in 89 patients followed for up to 36 months
    • Alvarez L, et al. Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 months. J Neurol Neurosurg Psychiatry. 2009;80(9):979-985.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , Issue.9 , pp. 979-985
    • Alvarez, L.1
  • 54
    • 0035869337 scopus 로고    scopus 로고
    • 2+ channels in rat thalamic neurons
    • 2+ channels in rat thalamic neurons. J Neurosci. 2001;21(6):1884-1892.
    • (2001) J Neurosci , vol.21 , Issue.6 , pp. 1884-1892
    • Kuo, C.C.1    Yang, S.2
  • 55
    • 76649120197 scopus 로고    scopus 로고
    • Deep brain stimulation does not silence neurons in subthalamic nucleus in Parkinson's patients
    • Carlson JD, Cleary DR, Cetas JS, Heinricher MM, Burchiel KJ. Deep brain stimulation does not silence neurons in subthalamic nucleus in Parkinson's patients. J Neurophysiol. 2010;103(2):962-967.
    • (2010) J Neurophysiol , vol.103 , Issue.2 , pp. 962-967
    • Carlson, J.D.1    Cleary, D.R.2    Cetas, J.S.3    Heinricher, M.M.4    Burchiel, K.J.5
  • 56
    • 0034719056 scopus 로고    scopus 로고
    • Mechanism of action of deep brain stimulation
    • Benazzouz A, Hallett M. Mechanism of action of deep brain stimulation. Neurology. 2000;55(12 suppl 6):S13-S16. (Pubitemid 32103937)
    • (2000) Neurology , vol.55 , Issue.12 SUPPL. 6
    • Benazzouz, A.1    Hallett, M.2
  • 57
    • 26444597024 scopus 로고    scopus 로고
    • A new approach to understand the pathophysiology of Parkinson's disease
    • DOI 10.1007/s00415-005-4002-y
    • Nambu A. A new approach to understand the pathophysiology of Parkinson's disease. J Neurol. 2005;252(suppl 4):IV1-IV4. (Pubitemid 41437715)
    • (2005) Journal of Neurology , vol.252 , Issue.SUPPL. 4
    • Nambu, A.1
  • 58
    • 0020767828 scopus 로고
    • Physiology and pharmacology of calcium channel
    • Akaike N. [Physiology and pharmacology of calcium channel]. Nippon Seirigaku Zasshi. 1983;45(6):261-278.
    • (1983) Nippon Seirigaku Zasshi , vol.45 , Issue.6 , pp. 261-278
    • Akaike, N.1
  • 59
    • 0023159105 scopus 로고
    • Kinetics and selectivity of a low-voltage-activated calcium current in chick and rat sensory neurones
    • Carbone E, Lux HD. Kinetics and selectivity of a low-voltage-activated calcium current in chick and rat sensory neurones. J Physiol. 1987;386:547-570. (Pubitemid 17059735)
    • (1987) Journal of Physiology , vol.VOL. 386 , pp. 547-570
    • Carbone, E.1    Lux, H.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.