Effect of the α2δ ligand, pregabalin, on colonic sensory and motor functions in healthy adults

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 2, 2011, Pages

  Iturrino, Johanna ^a,b   Camilleri, Michael ^a,b   Busciglio, Irene ^a   Burton, Duane ^a   Zinsmeister, Alan R ^c  

^a Clinical Enteric Neuroscience Translational and Epidemiological Research Mayo Clinic   (United States)

^b MAYO CLINIC   (United States)

^c Mayo Clinic   (United States)

Author keywords

Colonic compliance; Gas sensation; Pain sensation

Indexed keywords

PLACEBO; PREGABALIN;

ADULT; AGE; AGED; AROUSAL; ARTICLE; BODY MASS; COLON; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RESPONSE; ENERGY; GENDER; HUMAN; HUMAN EXPERIMENT; INTESTINE CONTRACTION; INTESTINE PRESSURE; INTUBATION; LIVER METABOLISM; MAXIMUM ALLOWABLE CONCENTRATION; NORMAL HUMAN; PAIN THRESHOLD; PARALLEL DESIGN; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSORIMOTOR FUNCTION; SINGLE DRUG DOSE; STRESS; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADULT; ANALGESICS; COLON; COMPLIANCE; DIZZINESS; DOUBLE-BLIND METHOD; FASTING; FEMALE; GAMMA-AMINOBUTYRIC ACID; GASTROINTESTINAL MOTILITY; HUMANS; LIGANDS; MALE; PAIN THRESHOLD; POSTPRANDIAL PERIOD; PRESSURE; PROPORTIONAL HAZARDS MODELS; SENSATION; YOUNG ADULT;

EID: 79960972768     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00085.2011     Document Type: Article

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