High body mass alters colonic sensory-motor function and transit in humans

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 295, Issue 2, 2008, Pages

  Delgado Aros, Silvia ^b   Camilleri, Michael ^a,c   Garcia, Montse Andreu ^b   Burton, Duane ^a   Busciglio, Irene ^a  

^a Clinical Enteric Neuroscience Translational and Epidemiological Research Mayo Clinic   (United States)

^b INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^c MAYO CLINIC   (United States)

Author keywords

Colon; Motility; Sensation

Indexed keywords

ADULT; ARTICLE; BAROSTAT; BODY MASS; COLON DILATATION; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GASTROINTESTINAL TRANSIT; HUMAN; INTESTINE FUNCTION; MAJOR CLINICAL STUDY; MALE; NOCICEPTION; OBESITY; PAIN THRESHOLD; PRIORITY JOURNAL; SCINTIGRAPHY; SENSORIMOTOR FUNCTION; COLON; COMPLIANCE (PHYSICAL); MIDDLE AGED; PAIN; PATHOPHYSIOLOGY; PERCEPTIVE THRESHOLD; PHYSIOLOGY; PRESSURE;

ADULT; BODY MASS INDEX; COLON; COMPLIANCE; FEMALE; GASTROINTESTINAL TRANSIT; HUMANS; MALE; MIDDLE AGED; OBESITY; PAIN; PRESSURE; SENSORY THRESHOLDS;

EID: 52449117159     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90286.2008     Document Type: Article

References (55)

1. Begum N, Song Y, Rienzie J, Ragolia L. Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension. Am J Physiol Cell Physiol 275: C42-C49, 1998.
2. Bharucha AE, Camilleri M, Haydock S, Ferber I, Burton D, Cooper S, Tompson D, Fitzpatrick K, Higgins R, Zinsmeister AR. Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans. Gut 47: 667-674, 2000.
3. Bharucha AE, Camilleri M, Zinsmeister AR, Hanson RB. Adrenergic modulation of human colonic motor and sensory function. Am J Physiol Gastrointest Liver Physiol 273: G997-G1006, 1997.
4. Camilleri M, Colemont LJ, Phillips SF, Brown ML, Thomforde GM, Chapman N, Zinsmeister AR. Human gastric emptying and colonic filling of solids characterized by a new method. Am J Physiol Gastrointest Liver Physiol 257: G284-G290, 1989.
5. Chial HJ, Camilleri M, Burton D, Thomforde G, Olden KW, Stephens D. Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health. Am J Physiol Gastrointest Liver Physiol 284: G130-G137, 2003.
6. Chial HJ, Camilleri M, Ferber I, Delgado-Aros S, Burton D, McKinzie S, Zinsmeister AR. Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans. Clin Gastroenterol Hepatol 1: 211-218, 2003.
7. Cremonini F, Mullan BP, Camilleri M, Burton DD, Rank MR. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment Pharmacol Ther 16: 1781-1790, 2002.
8. Delaney CA, Mouser JV, Westerman RA. Insulin sensitivity and sensory nerve function. Clin Exp Neurol 31: 19-37, 1994.
9. Delgado-Aros S, Chial HJ, Camilleri M, Szarka LA, Weber FT, Jacob J, Ferber I, McKinzie S, Burton DD, Zinsmeister AR. Effects of a κ-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans. Am J Physiol Gastrointest Liver Physiol 284: G558-G566, 2003.
10. Delgado-Aros S, Cremonini F, Castillo JE, Chial HJ, Burton DD, Ferber I, Camilleri M. Independent influences of body mass and gastric volumes on satiation in humans. Gastroenterology 126: 432-440, 2004.
11. Delgado-Aros S, Locke GR, Camilleri M, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd. Obesity is associated with increased risk of gastrointestinal symptoms: a population-based study. Am J Gastroenterol 99: 1801-1806, 2004.
12. Distrutti E, Azpiroz F, Soldevilla A, Malagelada JR. Gastric wall tension determines perception of gastric distention. Gastroenterology 116: 1035-1042, 1999.
13. Erdmann J, Leibl M, Wagenpfeil S, Lippl F, Schusdziarra V. Ghrelin response to protein and carbohydrate meals in relation to food intake and glycerol levels in obese subjects. Regul Pept 135: 23-29, 2006.
14. Esfandyari T, Camilleri M, Busciglio I, Burton D, Baxter K, Zinsmeister AR. Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study. Am J Physiol Gastrointest Liver Physiol 293: G137-G145, 2007.
15. Esfandyari T, Camilleri M, Ferber I, Burton D, Baxter K, Zinsmeister AR. Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study. Neurogastroenterol Motil 18: 831-838 2006.
16. Ford MJ, Camilleri M, Zinsmeister AR, Hanson RB. Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. Gastroenterology 109: 1772-1780, 1995.
17. French SJ, Murray B, Rumsey RD, Sepple CP, Read NW. Preliminary studies on the gastrointestinal responses to fatty meals in obese people. Int J Obes Relat Metab Disord 17: 295-300, 1993.
18. Gautier JF, Chen K, Salbe AD, Bandy D, Pratley RE, Heiman M, Ravussin E, Reiman EM, Tataranni PA. Differential brain responses to satiation in obese and lean men. Diabetes 49: 838-846, 2000.
19. Gautier JF, Del Parigi A, Chen K, Salbe AD, Bandy D, Pratley RE, Ravussin E, Reiman EM, Tataranni PA. Effect of satiation on brain activity in obese and lean women. Obes Res 9: 676-684, 2001.
20. Geliebter A, Hashim SA. Gastric capacity in normal, obese, and bulimic women. Physiol Behav 74: 743-746, 2001.
21. Geliebter A, Westreich S, Gage D. Gastric distention by balloon and test-meal intake in obese and lean subjects. Am J Clin Nutr 48: 592-594, 1988.
22. Gonenne J, Camilleri M, Ferber I, Burton D, Baxter K, Keyashian K, Foss J, Wallin B, Du W, Zinsmeister AR. Effect of alvimopan and codeine on gastrointestinal transit: a randomized controlled study. Clin Gastroenterol Hepatol 3: 784-791, 2005.
23. Gryback P, Naslund E, Hellstrom PM, Jacobsson H, Backman L. Gastric emptying of solids in humans: improved evaluation by Kaplan-Meier plots, with special reference to obesity and gender. Eur J Nucl Med 23: 1562-1567, 1996.
24. Hammer HF, Phillips SF, Camilleri M, Hanson RB. Rectal tone, distensibility, and perception: reproducibility and response to different distensions. Am J Physiol Gastrointest Liver Physiol 274: G584-G590, 1998.
25. Horowitz M, Collins PJ, Cook DJ, Harding PE, Shearman DJ. Abnormalities of gastric emptying in obese patients. Int J Obes 7: 415-421, 1983.
26. Horowitz M, Collins PJ, Shearman DJ. Effect of increasing the caloric/osmotic content of the liquid component of a mixed solid and liquid meal on gastric emptying in obese subjects. Hum Nutr Clin Nutr 40: 51-56, 1986.
27. Le DS, Pannacciulli N, Chen K, Del Parigi A, Salbe AD, Reiman EM, Krakoff J. Less activation of the left dorsolateral prefrontal cortex in response to a meal: a feature of obesity. Am J Clin Nutr 84: 725-731, 2006.
28. Levy RL, Linde JA, Feld KA, Crowell MD, Jeffery RW. The association of gastrointestinal symptoms with weight, diet, and exercise in weight-loss program participants. Clin Gastroenterol Hepatol 3: 992-996, 2005.
29. Mackey RH, Sutton-Tyrrell K, Vaitkevicius PV, Sakkinen PA, Lyles MF, Spurgeon HA, Lakatta EG, Kuller LH. Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study. Am J Hypertens 15: 16-23, 2002.
30. Maddox A, Horowitz M, Wishart J, Collins P. Gastric and oesophageal emptying in obesity. Scand J Gastroenterol 24: 593-598, 1989.
31. Matsuda M, Liu Y, Mahankali S, Pu Y, Mahankali A, Wang J, DeFronzo RA, Fox PT, Gao JH. Altered hypothalamic function in response to glucose ingestion in obese humans. Diabetes 48: 1801-1806, 1999.
32. Montagnani M, Quon MJ. Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension. Diabetes Obes Metab 2: 285-292, 2000.
33. Morley JE, Levine AS. The role of the endogenous opiates as regulators of appetite. Am J Clin Nutr 35: 757-761, 1982.
34. National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults - the evidence report. Obes Res 6, Suppl 2: 51S-209S, 1998
35. Oda A, Taniguchi T, Yokoyama M. Leptin stimulates rat aortic smooth muscle cell proliferation and migration. Kobe J Med Sci 47: 141-150, 2001.
36. O'Hare JA, Minaker KL, Meneilly GS, Rowe JW, Pallotta JA, Young JB. Effect of insulin on plasma norepinephrine and 3,4- dihydroxyphenylalanine in obese men. Metabolism 38: 322-329, 1989.
37. Portincasa P, Di Ciaula A, Palmieri V, Van Berge-Henegouwen GP, Palasciano G. Effects of cholestyramine on gallbladder and gastric emptying in obese and lean subjects. Eur J Clin Invest 25: 746-753, 1995.
38. Report of a WHO Expert Committee. Physical status: the use, and interpretation of anthropometry. World Health Organ Tech Rep Ser 854: 1-452, 1995.
39. Singhal A, Farooqi IS, Cole TJ, O'Rahilly S, Fewtrell M, Kattenhorn M, Lucas A, Deanfield J. Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 106: 1919-1924, 2002.
40. Stenvinkel P, Bolinder J, Alvestrand A. Effects of insulin on renal haemodynamics and the proximal and distal tubular sodium handling in healthy subjects. Diabetologia 35: 1042-1048, 1992.
41. Sutton-Tyrrell K, Newman A, Simonsick EM, Havlik R, Pahor M, Lakatta E, Spurgeon H, Vaitkevicius P. Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition. Hypertension 38: 429-433, 2001.
42. Talley NJ, Howell S, Poulton R. Obesity and chronic gastrointestinal tract symptoms in young adults: a birth cohort study. Am J Gastroenterol 99: 1807-1814, 2004.
43. Talley NJ, Quan C, Jones MP, Horowitz M. Association of upper and lower gastrointestinal tract symptoms with body mass index in an Australian cohort. Neurogastroenterol Motil 16: 413-419, 2004.
44. ter Maaten JC, Bakker SJ, Serne EH, ter Wee PM, Donker AJ, Gans RO. Insulin's acute effects on glomerular filtration rate correlate with insulin sensitivity whereas insulin's acute effects on proximal tubular sodium reabsorption correlation with salt sensitivity in normal subjects. Nephrol Dial Transplant 14: 2357-2363, 1999.
45. Tosetti C, Corinaldesi R, Stanghellini V, Pasquali R, Corbelli C, Zoccoli G, Di Febo G, Monetti N, Barbara L. Gastric emptying of solids in morbid obesity. Int J Obes Relat Metab Disord 20: 200-205, 1996.
46. Vazquez Roque MI, Camilleri M, Stephens DA, Jensen MD, Burton DD, Baxter KL, Zinsmeister AR. Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people. Gastroenterology 131: 1717-1724, 2006.
47. Verdich C, Toubro S, Buemann B, Lysgard MJ, Juul HJ, Astrup A. The role of postprandial releases of insulin and incretin hormones in meal-induced satiety - effect of obesity and weight reduction 1. Int J Obes Relat Metab Disord 25: 1206-1214, 2001.
48. Viramontes BE, Camilleri M, McKinzie S, Pardi DS, Burton D, Thomforde GM. Gender-related differences in slowing colonic transit by a 5-HT3 antagonist in subjects with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 96: 2671-2676, 2001,
49. Wildman RP, Mackey RH, Bostom A, Thompson T, Sutton-Tyrrell K. Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension 42: 468-473, 2003.
50. Wisen O, Johansson C. Gastrointestinal function in obesity: motility, secretion, and absorption following a liquid test meal. Metabolism 41: 390-395, 1992.
51. Wright RA, Krinsky S, Fleeman C, Trujillo J, Teague E. Gastric emptying and obesity. Gastroenterology 84: 747-751, 1983.
52. Young JB. Effect of experimental hyperinsulinemia on sympathetic nervous system activity in the rat. Life Sci 43: 193-200, 1988.
53. Zahorska-Markiewicz B, Jonderko K, Lelek A, Skrzypek D. Gastric emptying in obesity. Hum Nutr Clin Nutr 40: 309-313, 1986.
54. Zahorska-Markiewicz B, Kucio C, Pyszkowska J. Obesity and pain. Hum Nutr Clin Nutr 37: 307-310, 1983.
55. Zahorska-Markiewicz B, Zych P, Kucio C. Pain sensitivity in obesity. Acta Physiol Pol 39: 183-187 1988.