Identification of subunits of voltage-gated calcium channels and actions of pregabalin on intrinsic primary afferent neurons in the guinea-pig ileum

Neurogastroenterology and Motility

Volumn 22, Issue 10, 2010, Pages

  Needham, K ^a   Bron, R ^a   Hunne, B ^a   Nguyen, T V ^a   Turner, K ^a   Nash, M ^b   Furness, J B ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

Author keywords

action potential currents; after hyperpolarising potentials; calcium channels; enteric neurons

Indexed keywords

CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL R TYPE; NITRIC OXIDE SYNTHASE; OMEGA CONOTOXIN; PREGABALIN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL ALPHA2DELTA1;

AFTERHYPERPOLARIZATION; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; EXCITABILITY; FEMALE; GUINEA PIG; ILEUM; IMMUNOREACTIVITY; INTESTINE INNERVATION; INTRACELLULAR RECORDING; INTRINSIC PRIMARY AFFERENT NEURON; MALE; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENSORY NERVE; SENSORY SYSTEM ELECTROPHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, N-TYPE; CALCIUM CHANNELS, R-TYPE; DNA PROBES; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; GAMMA-AMINOBUTYRIC ACID; GUINEA PIGS; ILEUM; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ION CHANNEL GATING; MALE; NEURONS, AFFERENT; NITRIC OXIDE SYNTHASE; PATCH-CLAMP TECHNIQUES;

EID: 77956319008     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2010.01567.x     Document Type: Article

References (33)

1. Camilleri M. α2δ ligand: a new, smart pill for visceral pain in patients with hypersensitive irritable bowel syndrome? Gut 2007 56 : 1337 1338.
2. Diop L, Raymond F, Fargeau H, Petoux F, Chovet M, Doherty AM. Pregabalin (CI-1008) inhibits the trinitrobenzene sulfonic acid-induced chronic colonic allodynia in the rat. J Pharmacol Exp Ther 2002 302 : 1013 1022.
3. Eutamene H, Coelho A-M, Theodorou V et al. Antinociceptive effect of pregabalin in septic shock-induced rectal hypersensitivity in rats. J Pharmacol Exp Ther 2000 295 : 162 167.
4. Million M, Wang L, Adelson DW, Roman F, Diop L, Taché Y. Pregabalin decreases visceral pain and prevents spinal neuronal activation in rats. Gut 2007 56 : 1482 1484.
5. Lee KJ, Kim JH, Cho SW. Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2005 22 : 981 988.
6. Houghton LA, Fell C, Whorwell PJ, Jones I, Sudworth DP, Gale JD. Effect of a second-generation α2δ ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome. Gut 2007 56 : 1218 1225.
7. Ravnefjord A, Brusberg M, Larsson H, Lindström E, Martínez V. Effects of pregabalin on visceral pain responses and colonic compliance in rats. Br J Pharmacol 2008 155 : 407 416.
8. 2δ subunits of voltage-gated calcium channels. Trends Pharmacol Sci 2007 28 : 220 228.
9. Dolphin AC. Calcium channel diversity: multiple roles of calcium channel subunits. Curr Opinion Neurobiol 2009 19 : 237 244.
10. 2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 2007 73 : 137 150.
11. Furness JB, Kunze WAA, Bertrand PP, Clerc N, Bornstein JC. Intrinsic primary afferent neurons of the intestine. Prog Neurobiol 1998 54 : 1 18.
12. Rugiero F, Gola M, Kunze WAA, Reynaud J-C, Furness JB, Clerc N. Analysis of whole-cell currents by patch clamp of guinea-pig myenteric neurones in intact ganglia. J Physiol (Lond) 2002 538 : 447 463.
13. Bian X, Zhou X, Galligan JJ. R-type calcium channels in myenteric neurons of guinea pig small intestine. Am J Physiol 2004 287 : G134 42.
14. Hillsley K, Kenyon JL, Smith TK. Ryanodine-sensitive stores regulate the excitability of AH neurons in the myenteric plexus of guinea-pig ileum. J Neurophysiol 2000 84 : 2777 2785.
15. Vogalis F, Furness JB, Kunze WAA. Afterhyperpolarization current in myenteric neurons of the guinea pig duodenum. J Neurophysiol 2001 85 : 1941 1951.
16. Nguyen TV, Poole DP, Harvey JR, Stebbing MJ, Furness JB. Investigation of PKC isoform-specific translocation and targeting of the current of the late afterhyperpolarising potential of myenteric AH neurons. Eur J Neurosci 2005 21 : 905 913.
17. 2δ ligands: novel modulators of neurotransmission. Trends Pharmacol Sci 2007 28 : 75 82.
18. Chiocchetti R, Poole DP, Kimura H et al. Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons. Cell Tissue Res 2003 311 : 11 22.
19. Förstermann U, Gorsky LE, Pollock JS, Schmidt HHHW, Heller M, Murad F. Regional distribution of EDRF/NO-synthesizing enzymes in rat brain. Biochem Biophys Res Commun 1991 168 : 727 732.
20. Fairman CL, Clagett Dame M, Lennon VA, Epstein ML. Appearance of neurons in the developing chick gut. Dev Dyn 1995 204 : 192 201.
21. Bron R, Klesse LJ, Shah K, Parada LF, Winter J. Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol Cell Neurosci 2003 22 : 118 132.
22. Sathianathan V, Avelino A, Charrua A et al. Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons. Eur J Neurosci 2003 18 : 2477 2486.
23. Van Nassauw L, Wu M, De Jonge F, Adriaensen D, Timmermans J-P. Cytoplasmic, but not nuclear, expression of the neuronal nuclei (NeuN) antibody is an exclusive feature of Dogiel type II neurons in the guinea-pig gastrointestinal tract. Histochem Cell Biol 2005 124 : 369 377.
24. Furness JB, Jones C, Nurgali K, Clerc N. Intrinsic primary afferent neurons and nerve circuits within the intestine. Prog Neurobiol 2004 72 : 143 164.
25. 1B channel-like immunoreactivity in intrinsic primary afferent neurons. J Comp Neurol 1999 409 : 85 104.
26. Catterall WA, Striessnig J, Snutch TP, Perez-Reyes E. International union of pharmacology XL. Compendium of voltage-gated ion channels: calcium channels. Pharmacol Rev 2003 55 : 579 581.
27. 2+-activated cation conductance in myenteric AH-neurons. Neuroscience 2002 115 : 375 393.
28. Morita K, North RA, Tokimasa T. The calcium-activated potassium conductance in guinea-pig myenteric neurones. J Physiol (Lond) 1982 329 : 341 354.
29. North RA, Tokimasa T. Persistent calcium-sensitive potassium current and the resting properties of guinea-pig myenteric neurones. J Physiol (Lond) 1987 386 : 333 353.
30. Kawai M, Nguyen TV, Stebbing MJ, Clerc N, Komori S, Furness JB. Comparison of effects of phorbol dibutyrate and of low frequency stimulation of synaptic inputs on currents that determine the excitability of myenteric AH neurons. Eur J Physiol 2003 447 : 298 304.
31. Thomas EA, Bornstein JC. Inhibitory cotransmission or after-hyperpolarizing potentials can regulate firing in recurrent networks with excitatory metabotropic transmission. Neuroscience 2003 120 : 333 352.
32. 2+-activated, intermediate-conductance potassium channels on motility of the rat small intestine, in vivo. Neurogastroenterol Motil 2007 19 : 383 389.
33. Mawe GM, Strong DS, Sharkey KA. Plasticity of enteric nerve functions in the inflamed and postinflamed gut. Neurogastroenterol Motil 2009 21 : 481 491.