Effects of 6 weeks of quercetin supplementation on energy, fatigue, and sleep in ROTC cadets

Military Medicine

Volumn 176, Issue 5, 2011, Pages 565-572

  Bigelman, Kevin A ^a   Chapman, Donald P ^a   Freese, Eric C ^a   Trilk, Jennifer L ^a   Cureton, Kirk J ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; PLACEBO; QUERCETIN;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENERGY METABOLISM; FATIGUE; FEMALE; HUMAN; MALE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SLEEP; SOLDIER; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANTIOXIDANTS; DOUBLE-BLIND METHOD; ENERGY METABOLISM; FATIGUE; FEMALE; HUMANS; MALE; MILITARY PERSONNEL; PLACEBOS; QUERCETIN; QUESTIONNAIRES; SLEEP; TREATMENT OUTCOME;

EID: 79960956693     PISSN: 00264075     EISSN: None     Source Type: Journal    
DOI: 10.7205/MILMED-D-09-00230     Document Type: Article

References (33)

1. Alexander SP: Flavonoids as antagonists at A1 adenosine receptors. Phytother Res 2006; 20 (11): 1009-1012.
2. Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC: A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 2007; 45 (11): 2179-2205.
3. Nieman DC, et al: Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol 2007; 103 (5): 1728-1735.
4. United States Department of Agriculture. USDA Database for the Flavonoid Content of Selected Foods, Release 2.1. 2007, Nutrient Data Laboratory.
5. Theodoratou E, et al: Dietary fl avonoids and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2007; 16 (4): 684-693.
6. Middleton E Jr., Kandaswami C, Theoharides TC: The effects of plant fl avonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 2000; 42 (4): 673-751.
7. Erlund I, Freese R, Marniemi J, Hakala P, Alfthan G: Bioavailability of quercetin from berries and the diet. Nutr Cancer 2006; 54 (1): 13-17.
8. Nieman DC, et al: Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc 2007; 39 (9): 1561-1569.
9. Davis JM, Murphy EA, McClellan JL, Carmichael MD, Gangemi JD: Quercetin reduces susceptibility to infl uenza infection following stressful exercise. Am J Physiol Regul Integr Comp Physiol 2008; 295 (2): R505-R509.
10. Naidu PS, Singh A, Kulkarni SK: Reversal of reserpine-induced orofacial dyskinesia and cognitive dysfunction by quercetin. Pharmacology 2004; 70 (2): 59-67.
11. Patil CS, Singh VP, Satyanarayan PS, Jain NK, Singh A, Kulkarni SK: Protective effect of fl avonoids against aging- and lipopolysaccharideinduced cognitive impairment in mice. Pharmacology 2003; 69 (2): 59-67.
12. Singh A, Naidu PS, Kulkarni SK: Reversal of aging and chronic ethanolinduced cognitive dysfunction by quercetin a biofl avonoid. Free Radic Res 2003; 37 (11): 1245-1252.
13. Davis JM, Murphy EA, Carmichael MD, Davis B: Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol 2009; 296: R1071-R1077.
14. Rocheleau CA, et al: The benefi ts of quercetin on cognitive functioning after intense exercise [abstract]. Med Sci Sports Exerc 2007; 39: S165.
15. Olson CA: Mood and vigilance following quercetin supplementation, p 79. Davis, Department of Nutrition, University of California, 2002.
16. Joseph JA, Shukitt-Hale B, Lau FC: Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Ann N Y Acad Sci 2007; 1100: 470-485.
17. Dunne CP, Zambraski E: Effects of quercetin on human health, physical and cognitive performance: status of the science. Paper presented at: Conference on Quercetin/AIBS Review. Natick Conference Center, Natick, MA, September 22-23, 2008.
18. Park I, Schutz RW: '';Quick and easy''; forumulae for approximating statistical power in repeated measures ANOVA. Meas Phys Educ Exerc Sci 1999; 3 (4): 249-270.
19. Blair SN, et al: Assessment of habitual physical activity by a sevenday recall in a community survey and controlled experiments. Am J Epidemiol 1985; 122 (5): 794-804.
20. O'Connor PJ: Mental and Physical State and Trait Energy and Fatigue Scales: Preliminary Manual. Athens, GA, University of Georgia, 2004.
21. Rockett HR, Colditz GA: Assessing diets of children and adolescents. Am J Clin Nutr 1997; 65 (Suppl 4): 1116S-1122S.
22. Rockett HR, et al: Validation of a youth/adolescent food frequency questionnaire. Prev Med 1997; 26 (6): 808-816.
23. Moon YJ, et al: Quercetin pharmacokinetics in humans. Biopharm Drug Dispos 2008; 29 (4): 205-217.
24. McNair DM, Heuchert JP: Profile of Mood States: Technical Update. North Tonawanda, NY, Multi-Health Systems, Inc, 2007.
25. O'Connor PJ: Evaluation of four highly cited energy and fatigue mood measures. J Psychosom Res 2004; 57 (5): 435-441.
26. Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ: The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28 (2): 193-213.
27. Åstrand PO, Rodahl K: Textbook of Work Physiology, p 341. New York, McGraw-Hill, 1977.
28. Ishii K, Furuta T, Kasuya Y: High-performance liquid chromatographic determination of quercetin in human plasma and urine utilizing solidphase extraction and ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci 2003; 794: 49-56.
29. Dishman RK, Steinhardt M: Reliability and concurrent validity for a 7-d re-call of physical activity in college students. Med Sci Sports Exerc 1988; 20 (1): 14-25.
30. de Boer VC, et al: Tissue distribution of quercetin in rats and pigs. J Nutr 2005; 135 (7): 1718-1725.
31. Reagan-Shaw S, Nihal M, Ahmad N: Dose translation from animal to human studies revisited. FASEB J 2008; 22 (3): 659-661.
32. Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL, Tulley R: Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology 2002; 164 (3): 250-261.
33. Nieman DC, et al: Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. Med Sci Sports Exerc 2009; 41: 1467-1475.