Vasomotor effect of intravitreal juxta-arteriolar injection of L-Lactate on the retinal arterioles after acute branch retinal vein occlusion in minipigs

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 6, 2011, Pages 3215-3220

  Mendrinos, Efstratios ^a   Petropoulos, Ioannis K ^a   Mangioris, Georgios ^a   Tsilimbaris, Miltiadis K ^b   Papadopoulou, Domniki N ^a   Geka, Aliki ^a   Pournaras, Constantin J ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b University of Heraklion   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARGON LASER; ARTERY DILATATION; ARTICLE; BRANCH RETINAL VEIN OCCLUSION; CONTROLLED STUDY; LASER COAGULATION; MICROINJECTION; MINIPIG; NONHUMAN; PRIORITY JOURNAL; RETINA ARTERY; ACUTE DISEASE; ADRENERGIC SYSTEM; ANIMAL; ARTERIOLE; BLOOD FLOW; DRUG EFFECT; INTRAVITREAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA VEIN OCCLUSION; SWINE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ACUTE DISEASE; ANIMALS; ARTERIOLES; INTRAVITREAL INJECTIONS; LACTIC ACID; LASER COAGULATION; MICROINJECTIONS; MODELS, ANIMAL; MUSCLE, SMOOTH, VASCULAR; REGIONAL BLOOD FLOW; RETINAL ARTERY; RETINAL VEIN OCCLUSION; SWINE; SWINE, MINIATURE; VASODILATION; VASOMOTOR SYSTEM;

EID: 79960942203     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6888     Document Type: Article

References (37)

1. Winkler BS. Glycolytic and oxidative metabolism in relation to retinal function. J Gen Physiol. 1981;77:667-692.
2. Garhofer G, Zawinka C, Resch H, Menke M, Schmetterer L, Dorner GT. Effect of intravenous administration of sodium-lactate on retinal blood flow in healthy subjects. Invest Ophthalmol Vis Sci. 2003;44:3972-3976.
3. Ido Y, Chang K, Williamson JR. NADH augments blood flow in physiologically activated retina and visual cortex. Proc Natl Acad Sci U S A. 2004;101:653-658.
4. Ido Y, Chang K, Woolsey TA, Williamson JR. NADH: sensor of blood flow need in brain, muscle, and other tissues. FASEB J. 2001;15:1419-1421.
5. Brazitikos PD, Pournaras CJ, Munoz JL, Tsacopoulos M. Microinjection of L-lactate in the preretinal vitreous induces segmental vasodilation in the inner retina of miniature pigs. Invest Ophthalmol Vis Sci. 1993;34:1744-1752.
6. Hein TW, Xu W, Kuo L. Dilation of retinal arterioles in response to lactate: role of nitric oxide, guanylyl cyclase, and ATP-sensitive potassium channels. Invest Ophthalmol Vis Sci. 2006;47: 693-699.
7. Yamanishi S, Katsumura K, Kobayashi T, Puro DG. Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature. Am J Physiol Heart Circ Physiol. 2006;290:H925-H934.
8. Pournaras CJ, Rungger-Brandle E, Riva CE, Hardarson SH, Stefansson E. Regulation of retinal blood flow in health and disease. Prog Retin Eye Res. 2008;27:284-330.
9. Mendrinos E, Petropoulos IK, Mangioris G, Papadopoulou DN, Stangos AN, Pournaras CJ. Lactate-induced retinal arteriolar vasodilation implicates neuronal nitric oxide synthesis in minipigs. Invest Ophthalmol Vis Sci. 2008;49:5060-5066.
10. Pournaras CJ, Tsacopoulos M, Strommer K, Gilodi N, Leuenberger PM. Experimental retinal branch vein occlusion in miniature pigs induces local tissue hypoxia and vasoproliferative microangiopathy. Ophthalmology. 1990;97:1321-1328.
11. Donati G, Pournaras CJ, Munoz JL, Poitry S, Poitry-Yamate CL, Tsacopoulos M. Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci. 1995;36:2228-2237.
12. 2. Invest Ophthalmol Vis Sci. 2004;45:3669-3677.
13. Kohner EM, Dollery CT, Shakib M, et al. Experimental retinal branch vein occlusion. Am J Ophthalmol. 1970;69:778-825.
14. Donati G, Pournaras CJ, Pizzolato GP, Tsacopoulos M. Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion. Invest Ophthalmol Vis Sci. 1997;38:1450-1457.
15. Donati G, Pournaras CJ, Tsacopoulos M. Effect of nitroprusside on arteriolar constriction after retinal branch vein occlusion. Invest Ophthalmol Vis Sci. 1998;39:1910-1917.
16. Stangos AN, Petropoulos IK, Pournaras JA, Mendrinos E, Pournaras CJ. The vasodilatory effect of juxta-arteriolar microinjection of endothelinA receptor inhibitor in healthy and acute branch retinal vein occlusion minipig retinas. Invest Ophthalmol Vis Sci. 2010; 51:2185-2190.
17. Mendrinos E, Petropoulos IK, Mangioris G, Papadopoulou DN, Pournaras CJ. Intravitreal L-Arginine injection reverses the retinal arteriolar vasoconstriction that occurs after experimental acute branch retinal vein occlusion. Exp Eye Res. 2010;91:205-210.
18. Vilser W, Nagel E, Lanzl I. Retinal Vessel Analysis-new possibilities. Biomed Tech (Berl). 2002;47(suppl 1):682-685.
19. Seifertl BU, Vilser W. Retinal Vessel Analyzer (RVA)-design and function. Biomed Tech (Berl). 2002;47(suppl 1):678-681.
20. Riva CE, Grunwald JE, Sinclair SH, Petrig BL. Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci. 1985;26:1124-1132.
21. Bloodworth JM, Jr, Gutgesell HP Jr, Engerman RL. Retinal vasculature of the pig. Light and electron microscope studies. Exp Eye Res. 1965;4:174-178.
22. Beauchemin ML. The fine structure of the pig's retina. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1974;190:27-45.
23. Pournaras CJ, Riva CE, Tsacopoulos M, Strommer K. Diffusion of O2 in the retina of anesthetized miniature pigs in normoxia and hyperoxia. Exp Eye Res. 1989;49:347-360.
24. Jeppesen P, Sanye-Hajari J, Bek T. Increased blood pressure induces a diameter response of retinal arterioles that increases with decreasing arteriolar diameter. Invest Ophthalmol Vis Sci. 2007; 48:328-331.
25. Polak K, Dorner G, Kiss B, et al. Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol. 2000;84:1285-1290.
26. Papadopoulou DN, Mangioris G, Petropoulos I, et al. Retinal vessel diameter can be reliably determined in minipigs using Retinal Vessel Analyzer™ with a microscope-mounted fundus camera. Acta Ophthalmol. Published online September 23, 2010.
27. Tornquist P, Alm A. Retinal and choroidal contribution to retinal metabolism in vivo: a study in pigs. Acta Physiol Scand. 1979;106: 351-357.
28. Wang L, Tornquist P, Bill A. Glucose metabolism of the inner retina in pigs in darkness and light. Acta Physiol Scand. 1997;160:71-74.
29. Wang L, Kondo M, Bill A. Glucose metabolism in cat outer retina: effects of light and hyperoxia. Invest Ophthalmol Vis Sci. 1997;38:48-55.
30. Garhofer G, Kopf A, Polska E, et al. Influence of exercise induced hyperlactatemia on retinal blood flow during normo-and hyperglycemia. Curr Eye Res. 2004;28:351-358.
31. Dorner GT, Garhofer G, Kiss B, et al. Nitric oxide regulates retinal vascular tone in humans. Am J Physiol Heart Circ Physiol. 2003;285: H631-H636.
32. Brazitikos PD, Pournaras CJ, Tsacopoulos M, Munoz JL. Metabolic factors of vasomotor regulation of the inner retina (in German). Klin Monatsbl Augenheilkd. 1992;200:502-503.
33. Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J. 1999;343 Pt 2:281-299.
34. Gerhart DZ, Leino RL, Drewes LR. Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina. Neuroscience. 1999;92:367-375.
35. Goldstein IM, Ostwald P, Roth S. Nitric oxide: a review of its role in retinal function and disease. Vision Res. 1996;36:2979-2994.
36. Haverkamp S, Kolb H, Cuenca N. Endothelial nitric oxide synthase (eNOS) is localized to Muller cells in all vertebrate retinas. Vision Res. 1999;39:2299-2303.
37. Goureau O, Hicks D, Courtois Y, De Kozak Y. Induction and regulation of nitric oxide synthase in retinal Muller glial cells. J Neurochem. 1994;63:310-317.