Ginkgo biloba extract enhances noncontact erection in rats: The role of dopamine in the paraventricular nucleus and the mesolimbic system

Neuroscience

Volumn 189, Issue , 2011, Pages 199-206

  Yeh, K Y ^a   Wu, C H ^b   Tai, M Y ^c   Tsai, Y F ^c  

^a HUNGKUANG UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Dopamine; EGb 761; Noncontact erection; Nucleus accumbens; Paraventricular nucleus; Ventral tegmental area

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; DOPAMINE; GINKGO BILOBA EXTRACT; NORADRENALIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE NERVE CELL; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINERGIC ACTIVITY; FEMALE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMMUNOHISTOCHEMISTRY; LIMBIC SYSTEM; MALE; NONHUMAN; NORADRENALIN BRAIN LEVEL; OPTIMAL DRUG DOSE; PENIS ERECTION; PLANT LEAF; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOPAMINE; FEMALE; GINKGO BILOBA; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; NOREPINEPHRINE; NUCLEUS ACCUMBENS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PENILE ERECTION; PLANT EXTRACTS; RATS; RATS, LONG-EVANS; SEXUAL BEHAVIOR, ANIMAL; VENTRAL TEGMENTAL AREA;

EID: 79960908461     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.05.025     Document Type: Article

References (51)

1. Argiolas A., Melis M.R. The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals. Physiol Behav 2004, 83:309-317.
2. Argiolas A., Melis M.R. Central control of penile erection: role of the paraventricular nucleus of the hypothalamus. Prog Neurobiol 2005, 76:1-21.
3. Baskerville T.A., Douglas A.J. Interactions between dopamine and oxytocin in the control of sexual behaviour. Prog Brain Res 2008, 170:277-290.
4. Brackett N.L., Iuvone P.M., Edwards D.A. Midbrain lesions, dopamine and male sexual behavior. Behav Brain Res 1986, 20:231-240.
5. Bubser M., Deutch A.Y. Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens. Brain Res 1998, 787:304-310.
6. Buijs R.M., Geffard M., Pool C.W., Hoorneman E.M. The dopaminergic innervation of the supraoptic and paraventricular nucleus. A light and electron microscopical study. Brain Res 1984, 323:65-72.
7. Buijs R.M., Swaab D.F., Dogterom J., van Leeuwen F.W. Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Cell Tissue Res 1978, 186:423-433.
8. Eaton R.C., Markowski V.P., Lumley L.A., Thompson J.T., Moses J., Hull E.M. D2 receptors in the paraventricular nucleus regulate genital responses and copulation in male rats. Pharmacol Biochem Behav 1991, 39:177-181.
9. Giuliano F., Allard J. Dopamine and male sexual function. Eur Urol 2001, 40:601-608.
10. Hull E.M., Meisel M.R., Sachs B.D. Male sexual behavior. Hormones, brain and behavior 2002, Vol. 1:3-137. Academic Press, New York. D.W. Pfaff, A.P. Amold, A.M. Etgen, S.E. Fahrbach, R.T. Rubin (Eds.).
11. Hull E.M., Wood R.I., McKenna K.E. The neurobiology of male sexual behavior. The physiology of reproduction 2006, 1729-1824. Elsevier Press, New York. J.D. Neill, D.W. Pfaff (Eds.).
12. Kippin T.E., Sotiropoulos V., Badih J., Pfaus J.G. Opposing roles of the nucleus accumbens and anterior lateral hypothalamic area in the control of sexual behaviour in the male rat. Eur J Neurosci 2004, 19:698-704.
13. Lindvall O., Bjorklund A., Skagerberg G. Selective histochemical demonstration of dopamine terminal systems in rat di- and telencephalon: new evidence for dopaminergic innervation of hypothalamic neurosecretory nuclei. Brain Res 1984, 306:19-30.
14. Liu Y.C., Sachs B.D., Salamone J.D. Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacol Biochem Behav 1998, 60:585-592.
15. Liu Y.C., Salamone J.D., Sachs B.D. Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats. Behav Neurosci 1997, 111:1361-1367.
16. Louilot A., Gonzalez-Mora J.L., Guadalupe T., Mas M. Sex-related olfactory stimuli induce a selective increase in dopamine release in the nucleus accumbens of male rats. A voltammetric study. Brain Res 1991, 553:313-317.
17. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
18. MacLean P.D., Ploog D.W. Cerebral presentation of penile erection. J Neurophysiol 1962, 25:29-55.
19. Mas M., Gonzalez-Mora J.L., Louilot A., Sole C., Guadalupe T. Increased dopamine release in the nucleus accumbens of copulating male rats as evidenced by in vivo voltammetry. Neurosci Lett 1990, 110:303-308.
20. Melis M.R., Argiolas A., Gessa G.L. Apomorphine-induced penile erection and yawning: site of action in brain. Brain Res 1987, 415:98-104.
21. Melis M.R., Melis T., Cocco C., Succu S., Sanna F., Pillolla G., Boi A., Ferri G.L., Argiolas A. Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats. Eur J Neurosci 2007, 26:1026-1035.
22. Melis M.R., Spano M.S., Succu S., Argiolas A. The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats. Neurosci Lett 1999, 265:171-174.
23. Melis M.R., Stancampiano R., Argiolas A. Nitric oxide synthase inhibitors prevent N-methyl-d-aspartic acid-induced penile erection and yawning in male rats. Neurosci Lett 1994, 179:9-12.
24. Melis M.R., Succu S., Mascia M.S., Cortis L., Argiolas A. Extra-cellular dopamine increases in the paraventricular nucleus of male rats during sexual activity. Eur J Neurosci 2003, 17:1266-1272.
25. Otake K., Nakamura Y. Single midline thalamic neurons projecting to both the ventral striatum and the prefrontal cortex in the rat. Neuroscience 1998, 86:635-649.
26. Palkovits M. Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res 1973, 59:449-450.
27. Parsons M.P., Li S., Kirouac G.J. Functional and anatomical connection between the paraventricular nucleus of the thalamus and dopamine fibers of the nucleus accumbens. J Comp Neurol 2007, 500:1050-1063.
28. Paxinos G., Watson C. The rat brain in sterotaxic coordinates 1986, Academic Press, Orlando.
29. Pfaus J.G., Damsma G., Nomikos G.G., Wenkstern D.G., Blaha C.D., Phillips A.G., Fibiger H.C. Sexual behavior enhances central dopamine transmission in the male rat. Brain Res 1990, 530:345-348.
30. Pfaus J.G., Damsma G., Wenkstern D., Fibiger H.C. Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats. Brain Res 1995, 693:21-30.
31. Pirnik Z., Mravec B., Kiss A. Fos protein expression in mouse hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei upon osmotic stimulus: colocalization with vasopressin, oxytocin, and tyrosine hydroxylase. Neurochem Int 2004, 45:597-607.
32. Pleim E.T., Matochik J.A., Barfield R.J., Auerbach S.B. Correlation of dopamine release in the nucleus accumbens with masculine sexual behavior in rats. Brain Res 1990, 524:160-163.
33. Rodriguez-Gomez J.A., Venero J.L., Vizuete M.L., Cano J., Machado A. Deprenyl induces the tyrosine hydroxylase enzyme in the rat dopaminergic nigrostriatal system. Mol Brain Res 1997, 46:31-38.
34. Ruggiero D.A., Baker H., Joh T.H., Reis D.J. Distribution of catecholamine neurons in the hypothalamus and preoptic region of mouse. J Comp Neurol 1984, 223:556-582.
35. Sachs B.D. Placing erection in context: the reflexogenic-psychogenic dichotomy reconsidered. Neurosci Biobehav Rev 1995, 19:211-224.
36. Sachs B.D. Contextual approaches to the physiology and classification of erectile function, erectile dysfunction, and sexual arousal. Neurosci Biobehav Rev 2000, 24:541-560.
37. Sachs B.D., Akasofu K., Citron J.H., Daniels S.B., Natoli J.H. Noncontact stimulation from estrous females evokes penile erection in rats. Physiol Behav 1994, 55:1073-1079.
38. Sawchenko P.E., Swanson L.W. The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat. Brain Res 1982, 257:275-325.
39. Schulz K.M., Richardson H.N., Romeo R.D., Morris J.A., Lookingland K.J., Sisk C.L. Medial preoptic area dopaminergic responses to female pheromones develop during puberty in the male Syrian hamster. Brain Res 2003, 988:139-145.
40. Seguela P., Watkins K.C., Descarries L. Ultrastructural features of dopamine axon terminals in the anteromedial and the suprarhinal cortex of adult rat. Brain Res 1988, 442:11-22.
41. Sloley B.D., Urichuk L.J., Morley P., Durkin J., Shan J.J., Pang P.K., Coutts R.T. Identification of kaempferol as a monoamine oxidase inhibitor and potential neuroprotectant in extracts of Ginkgo biloba leaves. J Pharm Pharmacol 2000, 52:451-459.
42. Su H.S., Bentivoglio M. Thalamic midline cell populations projecting to the nucleus accumbens, amygdala, and hippocampus in the rat. J Comp Neurol 1990, 297:582-593.
43. Succu S., Sanna F., Cocco C., Melis T., Boi A., Ferri G.L., Argiolas A., Melis M.R. Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: role of nitric oxide and cyclic GMP. Eur J Neurosci 2008, 28:813-821.
44. Succu S., Sanna F., Melis T., Boi A., Argiolas A., Melis M.R. Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: involvement of central oxytocin. Neuropharmacology 2007, 52:1034-1043.
45. Swanson L.W., Sawchenko P.E. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu Rev Neurosci 1983, 6:269-324.
46. Tsai H.W., Shui H.A., Liu H.S., Tai M.Y., Tsai Y.F. Monoamine levels in the nucleus accumbens correlate with male sexual behavior in middle-aged rats. Pharmacol Biochem Behav 2006, 83:265-270.
47. Voorn P., Jorritsma-Byham B., Van Dijk C., Buijs R.M. The dopaminergic innervation of the ventral striatum in the rat: a light- and electron-microscopical study with antibodies against dopamine. J Comp Neurol 1986, 251:84-99.
48. Wenkstern D., Pfaus J.G., Fibiger H.C. Dopamine transmission increases in the nucleus accumbens of male rats during their first exposure to sexually receptive female rats. Brain Res 1993, 618:41-46.
49. Witt D.M., Insel T.R. Increased Fos expression in oxytocin neurons following masculine sexual behavior. J Neuroendocrinol 1994, 6:13-18.
50. Yeh K.Y., Liu Y.Z., Tai M.Y., Tsai Y.F. Ginkgo biloba extract treatment increases noncontact erections and central dopamine levels in rats: role of the bed nucleus of the stria terminalis and the medial preoptic area. Psychopharmacology (Berl) 2010, 210:585-590.
51. Yeh K.Y., Pu H.F., Kaphle K., Lin S.F., Wu L.S., Lin J.H., Tsai Y.F. Ginkgo biloba extract enhances male copulatory behavior and reduces serum prolactin levels in rats. Horm Behav 2008, 53:225-231.