메뉴 건너뛰기




Volumn 22, Issue 12, 2011, Pages 2654-2660

Preclinical and clinical activity of sunitinib in patients with cisplatin-refractory or multiply relapsed germ cell tumors: A Canadian Urologic Oncology Group/German Testicular Cancer Study Group cooperative study

Author keywords

Angiogenesis; Cisplatin resistance; Germ cell tumor; Relapse; Sunitinib

Indexed keywords

ALPHA FETOPROTEIN; BLEOMYCIN; CHORIONIC GONADOTROPIN; CISPLATIN; ETOPOSIDE; GEMCITABINE; IFOSFAMIDE; LACTATE DEHYDROGENASE; OXALIPLATIN; PACLITAXEL; PROTEIN TYROSINE KINASE; SUNITINIB; TETRAZOLIUM; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 79960860865     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdr026     Document Type: Article
Times cited : (78)

References (38)
  • 1
    • 0034018538 scopus 로고    scopus 로고
    • Results of treatment after relapse from high-dose chemotherapy in germ cell tumors
    • Porcu P, Bhatia S, Einhorn LH. Results of treatment after relapse from high-dose chemotherapy in germ cell tumors. J Clin Oncol 2000; 18: 1181-1186.
    • (2000) J Clin Oncol , vol.18 , pp. 1181-1186
    • Porcu, P.1    Bhatia, S.2    Einhorn, L.H.3
  • 2
    • 0025141586 scopus 로고
    • Phase II study of daily oral etoposide in refractory germ cell tumors
    • Miller JC, Einhorn LH. Phase II study of daily oral etoposide in refractory germ cell tumors. Semin Oncol 1990; 17: 36-39.
    • (1990) Semin Oncol , vol.17 , pp. 36-39
    • Miller, J.C.1    Einhorn, L.H.2
  • 3
    • 0027996483 scopus 로고
    • Phase II trial of paclitaxel shows antitumor activity in patients with previously treated germ cell tumors
    • Motzer RJ, Bajorin D, Schwartz LH et al. Phase II trial of paclitaxel shows antitumor activity in patients with previously treated germ cell tumors. J Clin Oncol 1994; 12: 2277-2283.
    • (1994) J Clin Oncol , vol.12 , pp. 2277-2283
    • Motzer, R.J.1    Bajorin, D.2    Schwartz, L.H.3
  • 4
    • 0033044108 scopus 로고    scopus 로고
    • Gemcitabine in patients with relapsed or cisplatin-refractory testicular cancer
    • Bokemeyer C, Gerl A, Schöffski P et al. Gemcitabine in patients with relapsed or cisplatin-refractory testicular cancer. J Clin Oncol 1999; 17: 512-516.
    • (1999) J Clin Oncol , vol.17 , pp. 512-516
    • Bokemeyer, C.1    Gerl, A.2    Schöffski, P.3
  • 5
    • 0033015208 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine in refractory germ cell tumors
    • Einhorn LH, Stender MJ, Williams SD. Phase II trial of gemcitabine in refractory germ cell tumors. J Clin Oncol 1999; 17: 509-511.
    • (1999) J Clin Oncol , vol.17 , pp. 509-511
    • Einhorn, L.H.1    Stender, M.J.2    Williams, S.D.3
  • 6
    • 0037089634 scopus 로고    scopus 로고
    • Activity of oxaliplatin in patients with relapsed or cisplatin-refractory germ cell cancer: a study of the German Testicular Cancer Study Group
    • Kollmannsberger C, Rick O, Derigs H-G et al. Activity of oxaliplatin in patients with relapsed or cisplatin-refractory germ cell cancer: a study of the German Testicular Cancer Study Group. J Clin Oncol 2002; 20: 2031-2037.
    • (2002) J Clin Oncol , vol.20 , pp. 2031-2037
    • Kollmannsberger, C.1    Rick, O.2    Derigs, H.-G.3
  • 7
    • 0036534301 scopus 로고    scopus 로고
    • Phase II trial of paclitaxel and gemcitabine in refractory germ cell tumors
    • Hinton S, Catalano PJ, Einhorn L et al. Phase II trial of paclitaxel and gemcitabine in refractory germ cell tumors. J Clin Oncol 2001; 20: 1859-1863.
    • (2001) J Clin Oncol , vol.20 , pp. 1859-1863
    • Hinton, S.1    Catalano, P.J.2    Einhorn, L.3
  • 8
    • 40149109480 scopus 로고    scopus 로고
    • Combination chemotherapy with gemcitabine, oxaliplatin, and paclitaxel in patients with cisplatin-refractory or multiply relapsed germ-cell tumors: a study of the German Testicular Cancer Study Group
    • Bokemeyer C, Oechsle K, Honecker F et al. Combination chemotherapy with gemcitabine, oxaliplatin, and paclitaxel in patients with cisplatin-refractory or multiply relapsed germ-cell tumors: a study of the German Testicular Cancer Study Group. Ann Oncol 2008; 19: 448-453.
    • (2008) Ann Oncol , vol.19 , pp. 448-453
    • Bokemeyer, C.1    Oechsle, K.2    Honecker, F.3
  • 9
    • 3142577828 scopus 로고    scopus 로고
    • Combination chemotherapy with gemcitabine plus oxaliplatin in patients with intensively pretreated or refractory germ cell cancer: a study of the German Testicular Cancer Study Group
    • Kollmannsberger C, Beyer J, Liersch R et al. Combination chemotherapy with gemcitabine plus oxaliplatin in patients with intensively pretreated or refractory germ cell cancer: a study of the German Testicular Cancer Study Group. J Clin Oncol 2004; 22: 108-114.
    • (2004) J Clin Oncol , vol.22 , pp. 108-114
    • Kollmannsberger, C.1    Beyer, J.2    Liersch, R.3
  • 10
    • 79960851993 scopus 로고    scopus 로고
    • Long term outcome in patients with cisplatin-refractory or multiply relapsed germ cell tumors following treatment with gemcitabine and oxaliplatin ± paclitaxel
    • (Abstr 4585)
    • Oechsle K, Kollmannsberger C, Honecker F et al. Long term outcome in patients with cisplatin-refractory or multiply relapsed germ cell tumors following treatment with gemcitabine and oxaliplatin ± paclitaxel. J Clin Oncol 2010; 28: 15s (Abstr 4585).
    • (2010) J Clin Oncol , vol.28
    • Oechsle, K.1    Kollmannsberger, C.2    Honecker, F.3
  • 11
    • 65549094095 scopus 로고    scopus 로고
    • Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors
    • Honecker F, Wermann H, Mayer F et al. Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors. J Clin Oncol 2009; 27: 2129-2136.
    • (2009) J Clin Oncol , vol.27 , pp. 2129-2136
    • Honecker, F.1    Wermann, H.2    Mayer, F.3
  • 12
    • 9444223256 scopus 로고    scopus 로고
    • Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor
    • Viglietto G, Romano A, Maglione D et al. Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor. Oncogene 1996; 13: 577-587.
    • (1996) Oncogene , vol.13 , pp. 577-587
    • Viglietto, G.1    Romano, A.2    Maglione, D.3
  • 13
    • 0037294708 scopus 로고    scopus 로고
    • Serum levels of basic fibroblast growth factor reflect disseminated disease in patients with testicular germ cell tumors
    • Bentas W, Beecken W, Glienke W et al. Serum levels of basic fibroblast growth factor reflect disseminated disease in patients with testicular germ cell tumors. Urol Res 2003; 30: 390-393.
    • (2003) Urol Res , vol.30 , pp. 390-393
    • Bentas, W.1    Beecken, W.2    Glienke, W.3
  • 14
    • 0033559229 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in patients with testicular germ cell tumors as an indicator of metastatic disease
    • Fukuda S, Shirahama T, Imazono Y et al. Expression of vascular endothelial growth factor in patients with testicular germ cell tumors as an indicator of metastatic disease. Cancer 1999; 85: 1323-1330.
    • (1999) Cancer , vol.85 , pp. 1323-1330
    • Fukuda, S.1    Shirahama, T.2    Imazono, Y.3
  • 15
    • 0041357120 scopus 로고    scopus 로고
    • Angiogenetic protooncogene ets-1 induced neovascularization is involved in the metastatic process of testicular germ cell tumors
    • Adam M, Schmidt D, Wardelmann E et al. Angiogenetic protooncogene ets-1 induced neovascularization is involved in the metastatic process of testicular germ cell tumors. Eur Urol 2003; 44: 329-336.
    • (2003) Eur Urol , vol.44 , pp. 329-336
    • Adam, M.1    Schmidt, D.2    Wardelmann, E.3
  • 16
    • 0042692888 scopus 로고    scopus 로고
    • Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts
    • Abraham D, Abri S, Hofmann M et al. Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts. J Urol 2003; 170: 1388-1393.
    • (2003) J Urol , vol.170 , pp. 1388-1393
    • Abraham, D.1    Abri, S.2    Hofmann, M.3
  • 17
    • 66149168686 scopus 로고    scopus 로고
    • Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors
    • Castillo-Avila W, Piulats JM, Garcia Del Muro X et al. Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors. Clin Cancer Res 2009; 15: 3384-3395.
    • (2009) Clin Cancer Res , vol.15 , pp. 3384-3395
    • Castillo-Avila, W.1    Piulats, J.M.2    Garcia Del Muro, X.3
  • 18
    • 0021447637 scopus 로고
    • Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro
    • Andrews PW. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev Biol 1984; 103: 285-293.
    • (1984) Dev Biol , vol.103 , pp. 285-293
    • Andrews, P.W.1
  • 19
    • 0023740590 scopus 로고
    • Four new human germ cell tumor cell lines
    • Teshima S, Shimosato Y, Hirohashi S et al. Four new human germ cell tumor cell lines. Lab Invest 1988; 59: 328-336.
    • (1988) Lab Invest , vol.59 , pp. 328-336
    • Teshima, S.1    Shimosato, Y.2    Hirohashi, S.3
  • 20
    • 55249121663 scopus 로고    scopus 로고
    • Comparative proteome, transcriptome, and genome analysis of a gonadal and an extragonadal germ cell tumor cell line
    • Glaesener S, Honecker F, Veltman IM et al. Comparative proteome, transcriptome, and genome analysis of a gonadal and an extragonadal germ cell tumor cell line. J Proteome Res 2008; 7: 3890-3899.
    • (2008) J Proteome Res , vol.7 , pp. 3890-3899
    • Glaesener, S.1    Honecker, F.2    Veltman, I.M.3
  • 21
    • 0024338525 scopus 로고
    • Dose-intensive chemotherapy in refractory germ cell cancer-a phase I/II trial of high-dose carboplatin and etoposide with autologous bone marrow transplantation
    • Nichols CR, Tricot G, Williams SD et al. Dose-intensive chemotherapy in refractory germ cell cancer-a phase I/II trial of high-dose carboplatin and etoposide with autologous bone marrow transplantation. J Clin Oncol 1989; 7: 932-939.
    • (1989) J Clin Oncol , vol.7 , pp. 932-939
    • Nichols, C.R.1    Tricot, G.2    Williams, S.D.3
  • 22
    • 10144262544 scopus 로고    scopus 로고
    • High-dose chemotherapy as salvage treatment in germ cell tumors: a multivariate analysis of prognostic variables
    • Beyer J, Kramar A, Mandanas R et al. High-dose chemotherapy as salvage treatment in germ cell tumors: a multivariate analysis of prognostic variables. J Clin Oncol 1996; 14: 2638-2645.
    • (1996) J Clin Oncol , vol.14 , pp. 2638-2645
    • Beyer, J.1    Kramar, A.2    Mandanas, R.3
  • 23
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205-216.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 24
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials 1989; 10: 1-10.
    • (1989) Control Clin Trials , vol.10 , pp. 1-10
    • Simon, R.1
  • 25
    • 11144355665 scopus 로고    scopus 로고
    • Gemcitabine and oxaliplatin (GEMOX) in patients with cisplatin-refractory germ cell tumors: a phase II study
    • Pectasides D, Pectasides M, Farmakis D et al. Gemcitabine and oxaliplatin (GEMOX) in patients with cisplatin-refractory germ cell tumors: a phase II study. Ann Oncol 2004; 15: 493-497.
    • (2004) Ann Oncol , vol.15 , pp. 493-497
    • Pectasides, D.1    Pectasides, M.2    Farmakis, D.3
  • 28
    • 12144289595 scopus 로고    scopus 로고
    • High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets
    • Muller-Tidow C, Schwable J, Steffen B et al. High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. Clin Cancer Res 2004; 10: 1241-1249.
    • (2004) Clin Cancer Res , vol.10 , pp. 1241-1249
    • Muller-Tidow, C.1    Schwable, J.2    Steffen, B.3
  • 29
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams TJ, Lee LB, Murray LJ et al. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2003; 2: 471-478.
    • (2003) Mol Cancer Ther , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3
  • 30
    • 33745098620 scopus 로고    scopus 로고
    • Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248
    • Potapova O, Laird AD, Nannini MA et al. Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248. Mol Cancer Ther 2006; 5: 1280-1289.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1280-1289
    • Potapova, O.1    Laird, A.D.2    Nannini, M.A.3
  • 31
    • 84255164605 scopus 로고    scopus 로고
    • Preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma
    • [Epub ahead of print]
    • Hui EP, Lui VW, Wong CS et al. Preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma. Invest New Drugs 2010. [Epub ahead of print].
    • (2010) Invest New Drugs
    • Hui, E.P.1    Lui, V.W.2    Wong, C.S.3
  • 32
    • 1542784354 scopus 로고    scopus 로고
    • KIT mutations are common in testicular seminomas
    • Kemmer K, Corless CL, Fletcher JA et al. KIT mutations are common in testicular seminomas. Am J Pathol 2004; 164: 305-313.
    • (2004) Am J Pathol , vol.164 , pp. 305-313
    • Kemmer, K.1    Corless, C.L.2    Fletcher, J.A.3
  • 33
    • 36549019974 scopus 로고    scopus 로고
    • Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature
    • Coffey J, Linger R, Pugh J et al. Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature. Genes Chromosomes Cancer 2008; 47: 34-42.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 34-42
    • Coffey, J.1    Linger, R.2    Pugh, J.3
  • 34
    • 77956621875 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with relapsed or refractory germ cell tumors
    • Feldman DR, Turkula S, Ginsberg MS et al. Phase II trial of sunitinib in patients with relapsed or refractory germ cell tumors. Invest New Drugs 2009; 28: 523-528.
    • (2009) Invest New Drugs , vol.28 , pp. 523-528
    • Feldman, D.R.1    Turkula, S.2    Ginsberg, M.S.3
  • 35
    • 82355172848 scopus 로고    scopus 로고
    • Sunitinib improves chemotherapeutic efficacy and ameliorates cisplatin-induced nephrotoxicity in experimental animals
    • [Epub ahead of print]
    • Suddek GM. Sunitinib improves chemotherapeutic efficacy and ameliorates cisplatin-induced nephrotoxicity in experimental animals. Cancer Chemother Pharmacol 2010. [Epub ahead of print].
    • (2010) Cancer Chemother Pharmacol
    • Suddek, G.M.1
  • 36
    • 82355172849 scopus 로고    scopus 로고
    • Phase II study of oxaliplatin (O) and bevacizumab (B) chemotherapy in refractory germ cell tumors (GCT)
    • (Abstr e15054)
    • Ramasubbaiah R, Brames J, Johnston EL et al. Phase II study of oxaliplatin (O) and bevacizumab (B) chemotherapy in refractory germ cell tumors (GCT). J Clin Oncol 2010; 28: (Abstr e15054).
    • (2010) J Clin Oncol , pp. 28
    • Ramasubbaiah, R.1    Brames, J.2    Johnston, E.L.3
  • 37
    • 77958460273 scopus 로고    scopus 로고
    • Phase II study of gemcitabine, cisplatin, and sunitinib in patients with advanced urothelial carcinoma (UC)
    • (Abstr 4573)
    • Galsky MD, Sonpavde G, Hellerstedt BA et al. Phase II study of gemcitabine, cisplatin, and sunitinib in patients with advanced urothelial carcinoma (UC). J Clin Oncol 2010; 28: 15s (Abstr 4573).
    • (2010) J Clin Oncol , vol.28
    • Galsky, M.D.1    Sonpavde, G.2    Hellerstedt, B.A.3
  • 38
    • 77955700137 scopus 로고    scopus 로고
    • Sunitinib in combination with gemcitabine plus cisplatin for advanced non-small cell lung cancer: a phase I dose escalation study
    • Reck M, Frickhofen N, Cedres S et al. Sunitinib in combination with gemcitabine plus cisplatin for advanced non-small cell lung cancer: a phase I dose escalation study. Lung Cancer 2010; 70: 180-187.
    • (2010) Lung Cancer , vol.70 , pp. 180-187
    • Reck, M.1    Frickhofen, N.2    Cedres, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.