Phase II trial of gemcitabine in refractory germ cell tumors

Journal of Clinical Oncology

Volumn 17, Issue 2, 1999, Pages 509-511

  Einhorn, Lawrence H ^a   Stender, Michael J ^a   Williams, Stephen D ^a  

^a INDIANA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GEMCITABINE;

ADOLESCENT; ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER REGRESSION; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; GERM CELL TUMOR; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; NAUSEA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; THROMBOCYTOPENIA;

EID: 0033015208     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.2.509     Document Type: Article

References (26)

1. Einhorn LH: Treatment of testicular cancer: A new and improved model. J Clin Oncol 8:1777-1781, 1990
2. Bosl GJ, Motzer RJ: Testicular germ cell cancer. N Engl J Med 337:242-253, 1997
3. Einhorn LH: Testicular cancer: An oncological success story. Clin Cancer Res 3:2630-2632, 1997
4. Loehrer PJ, Gonin R, Nicholas CR, et al: Vinblastine plus ifosfamide plus cisplatin as initial salvage therapy in recurrent germ cell tumor. J Clin Oncol 16:2500-2504, 1998
5. Motzer RJ, Bajorin DF, Vlamis V, et al: Ifosfamide-based chemotherapy for patients with resistant germ cell tumors: The Memorial Sloan-Kettering Cancer Center experience. Semin Oncol 12:8-11, 1992
6. Broun ER, Nichols CR, Kneebone P, et al: Long-term outcome of patients with relapsed and refractory germ cell tumors treated with high-dose chemotherapy and autologous bone marrow rescue. Ann Intern Med 117:124-128, 1992
7. Motzer R, Mazumdar M, Bosl GJ, et al: High-dose carboplatin, etoposide, and cyclophosphamide for patients with refractory germ cell tumors: Treatment results and prognostic factors for survival and toxicity. J Clin Oncol 14:1098-1105, 1996
8. Broun R, Nichols C, Gize G, et al: Tandem high dose chemotherapy with autologous bone marrow transplantation for initial relapse of testicular cancer. Cancer 79:1605-1610, 1997
9. Higby DJ, Wallace HJ, Holland JF: Diamminedichloroplatinum II: A phase I study showing response in testicular and other tumors. Cancer 33:1219-1225, 1974
10. Einhorn LH, Donohue JP: Combination chemotherapy with cis-diamminedichloroplatinum, vinblastine, and bleomycin disseminated testicular cancer. Ann Intern Med 87:293-298, 1977
11. Fitzharris BM, Kaye SB, Saverymuttu S, et al: VP-16 as single agent in advanced testicular tumors. Eur J Cancer 16:1193-1197, 1980
12. Wheeler B, Loehrer PJ, Williams SD, et al: Ifosfamide: An active agent in refractory male germ cell tumors. J Clin Oncol 4:28-34, 1986
13. Williams SD, Einhorn LH, Greco FA, et al: VP-16-213 salvage therapy for refractory germinal neoplasms. Cancer 46:2154-2158, 1980
14. Loehrer PJ, Lauer R, Roth BJ, et al: Salvage therapy in recurrent germ cell cancer: Ifosfamide and cisplatin plus either vinblastine or etoposide. Ann Intern Med 109:540-546, 1988
15. van Moorsel CJA, Peters GJ, Pinedo HM: Gemcitabine: Future prospects of single-agent and combination studies. Oncologist 2:127-134, 1997
16. Maas K, Daikeler T, Kanz L, et al: Activity of gemcitabine in platinum-resistant ovarian germ cell cancer. Eur J Cancer 32:1437-1438, 1996
17. Williams SD, Birch R, Einhorn LH, et al: Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 316:1435-1440, 1987
18. Scheulen ME, Niederle N, Bremer K, et al: Efficacy of ifosfamide in refractory malignant diseases and uroprotection by mesna. Cancer Treat Rev 10:93-101, 1983 (suppl A)
19. Miller JC, Einhorn LH: Phase II study of daily oral etoposide in refractory germ cell tumors. Semin Oncol 17:36-39, 1990
20. Motzer RJ, Bajorin DF, Schwartz LH, et al: Phase II trial of paclitaxel shows antitumor activity in patients with previously treated germ cell tumors. J Clin Oncol 12:2277-2283, 1994
21. Motzer RJ, Bajorin DF, Bosl GJ, et al: Paclitaxel containing first-line salvage therapy selected by risk for patients with germ cell tumors. Proc Am Soc Clin Oncol 16:322a, 1997 (abstr)
22. Sandler AB, Christou A, Fox S, et al: A phase II trial of paclitaxel in refractory germ cell tumors. Cancer 82:1381-1386, 1998
23. Nasario A, Amato RJ, Hutchinson L, et al: Paclitaxel in extensively pretreated nonseminomatous germ cell tumors. Urol Oncol 1:184-187, 1995
24. Bokemeyer C, Beyer J, Metzner B, et al: Phase II study of paclitaxel in patients with relapsed or cisplatin-refractory testicular cancer. Ann Oncol 7:31-34, 1996
25. Bergman A, Ruiz vanHaperen VWT, Veerman G, et al: Synergistic interaction between cisplatin and gemcitabine in vitro. Clin Cancer Res 2:521-530, 1998
26. Einhorn LH, Raghavan D, Kindler H, et al: A phase I trial of gemcitabine plus paclitaxel combination therapy in patients with refractory solid tumors. Proc Am Soc Clin Oncol 17:207a, 1998 (abstr)