Treatment of acute radiodermatitis with an oil-in-water emulsion following radiation therapy for breast cancer: A controlled, randomized trial

Strahlentherapie und Onkologie

Volumn 187, Issue 6, 2011, Pages 378-384

  Jensen, Jens Michael ^a   Gau, Tanja ^a   Schultze, Jürgen ^a   Lemmnitz, Gunter ^b   Fölster Holst, Regina ^a   May, Theodor ^c   Abels, Christoph ^b   Proksch, Ehrhardt ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b Dr August Wolff GmbH and Co KG Arzneimittel   (Germany)

^c Gesellschaft für Biometrie und Psychometrie GbR   (Germany)

Author keywords

Breast cancer; Oil in water emulsion; Radiodermatitis; Skin barrier function; Stratum corneum hydration

Indexed keywords

LINOLEIC ACID; UNCLASSIFIED DRUG; WATER OIL CREAM; WO 1932; DERMATOLOGICAL AGENT;

ACUTE RADIODERMATITIS; ADULT; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MEASUREMENT; OPEN STUDY; PRURITUS; RADIATION DERMATITIS; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SKIN HYDRATION; SKIN WATER LOSS; STRATUM CORNEUM; SWEAT GLAND FUNCTION; BREAST TUMOR; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; EMULSION; EPIDERMIS; RADIOTHERAPY; TIME; TREATMENT OUTCOME;

ADULT; BREAST NEOPLASMS; DERMATOLOGIC AGENTS; EMULSIONS; EPIDERMIS; FEMALE; HUMANS; RADIODERMATITIS; RADIOTHERAPY; TIME FACTORS; TREATMENT OUTCOME;

EID: 79960850434     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-011-2224-8     Document Type: Article

References (40)

1. Bauer A, Kelterer D, Bartsch R et al. Prevention of hand dermatitis in bakers' ap-prentices: different efficacy of skin protection measures and UVB hardening. Int Arch Occup Environ Health 2002;75:491-9. (Pubitemid 36075143)
2. Bauer A, Kelterer D, Bartsch R et al. Skin protection in the food industry. Curr Probl Dermatol 2007;34:138-50.
3. Benomar S, Boutayeb S, Lalya I et al. Treatment and prevention of acute radia-tion dermatitis. Cancer Radiother 2010;14:213-6.
4. Brüning H, Knaußmann HG, Rüther TH et al. Nachtkerzensamenöl-Creme (Linola® Gamma)- ein gutes Basisthera peutikum für Patienten mit atopisch-em und ande rem Ekzem. Akt Der matol 2004;30:204-9
5. Engelke M, Jensen JM, Ekanayake-Mudiyanselage S et al. Effects of xerosis and ageing on epidermal proliferation and differentiation. Br J Dermatol 1997;137:219-25. (Pubitemid 27333355)
6. Hashimoto-Kumasaka K, Takahashi K, Tagami H. Electrical measurement of the water content of the stratum corneum in vivo and in vitro under various conditions: comparison between skin surface hygrometer and corneom-eter in evaluation of the skin surface hydration state. Acta Derm Venereol 1993;73:335-9. (Pubitemid 23310790)
7. Hornstein und Nürnberg: Externe Therapie von Hautkrankheiten. Thieme, Stuttgart, 1985, p 466
8. Hymes SR, Strom EA, Fife C. Radiation dermatitis: clinical presentation, patho-physiology, and treatment 2006. J Am Acad Dermatol 2006;54:28-46. (Pubitemid 41832455)
9. Jensen JM, Fölster-Holst R, Baranowsky A et al. Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J Invest Dermatol 2004;122:1423-31. (Pubitemid 38757224)
10. Jensen JM, Pfeiffer S, Witt M et al. Different effects of pimecrolimus and be-tamethasone on the skin barrier in patients with atopic dermatitis. J Allergy Clin Immunol 2009;123:1124-33
11. and J Allergy Clin Immunol 2009;124(Suppl 2):R19-28. Erratum in: J Allergy Clin Immunol 2009;124:1038.
12. Kärcher KH. Die Wirkung exogener und endogener Faktoren auf die Strahlen-reaktion der Haut. 2. Mitteilung: Der Einfluß lokaler Wirkstoffe auf Ablauf des Röntgenerythems im Tierversuch. Strahlentherapie 1961;114:376-85.
13. Leonardi MC, Gariboldi S, Ivaldi GB et al. A double-blind, randomised, vehicle-controlled clinical study to evaluate the efficacy of MAS065D in limiting the ef-fects of radiation on the skin: interim analysis. Eur J Dermatol 2008;18:317-21. (Pubitemid 351821237)
14. Mai SK, Welzel G, Hermann B et al. Can the radiation dose to CT-enlarged but FDG-PET-negative inguinal lymph nodes in anal cancer be reduced? Strahlen-ther Onkol 2009;185:254-9.
15. Maisin J, Maisin H, Deckers C. Medical care after irradiation: Skin reactions. Handbuch der Medizinischen Radiologie, Springer, Berlin, 1967, pp 530-2.
16. McQuestion M. Evidence-based skin care management in radiation therapy. Semin. Oncol Nurs 2006;22:163-73. (Pubitemid 44163101)
17. McDougall CJ, Franklin LE, Gresle SO. Management of radiation dermatitis in a patient after mastectomy. J Wound Ostomy Continence Nurs 2005;32:337-9. (Pubitemid 41454477)
18. Mizumoto M, Nakayama H, Tokita M et al. Technical considerations for non-coplanar proton-beam therapy of patients with tumors proximal to the optic nerve. Strahlenther Onkol 2010;186:36-9.
19. Morczek A, Neumeister K. Die Nebenreaktionen unter der Bestrahlung und ihre Behandlung. Strahlentherapie 1963;121:349-364
20. Osako T, Oguchi M, Kumada M et al. Acute radiation dermatitis and pneu-monitis in Japanese breast cancer patients with whole breast hypofraction-ated radiotherapy compared to conventional radiotherapy. Jpn J Clin Oncol 2008;38:334-8. (Pubitemid 351753564)
21. Ott OJ, Lotter M, Sauer R et al. Accelerated partial-breast irradiation with inter-stitial implants: the clinical relevance of the calculation of skin doses. Strahlen-ther Onkol 2007;183:426-31. (Pubitemid 47230521)
22. Pardo Masferrer J, Murcia Mejía M, Vidal Fernández M et al. Prophylaxis with a cream containing urea reduces the incidence and severity of radio-induced dermatitis. Clin Transl Oncol 2010;12:43-8.
23. Patyánik M, Nemeskéri C, Póti Z et al. Concomitant radiochemotherapy of cervical cancer: is it justified to reduce the dosage of cisplatin? Strahlenther Onkol 2009;185:582-7.
24. Pinnagoda J, Tupker RA, Agner T et al. Guidelines for transepidermal water loss (TEWL) measurement. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis 1990;22:164-81.
25. Porock D, Kristjanson L. Skin reactions during radiotherapy for breast can-cer: the use and impact of topical agents and dressings, Eur J Cancer Care 1999;8:143-53.
26. Primavera G, Carrera M, Berardesca E et al. A double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis. Cu-tan Ocul Toxicol 2006;25:165-71. (Pubitemid 44410610)
27. Proksch E. Linolsäure-haltige Externa. Theoretische Grundlagen und prak-tische Bedeutung. Internistische Praxis 1998;38:877-83.
28. Proksch E. The role of emollients in the management of diseases with chronic dry skin. Skin Pharmacol Physiol 2008;21:75-80. (Pubitemid 351440525)
29. Proksch E, Fölster-Holst R, Bräutigam M et al. Role of the epidermal barrier in atopic dermatitis. J Dtsch Dermatol Ges 2009;7:899-910.
30. Röper B, Kaisig D, Auer F et al. Thêta-Cream versus Bepanthol lotion in breast cancer patients under radiotherapy. A new prophylactic agent in skin care? Strahlenther Onkol 2004;180:315-22. (Pubitemid 38667752)
31. Schmuth M, Wimmer MA, Hofer S et al. Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br J Dermatol 2002;146:983-91. (Pubitemid 34779478)
32. Schmuth M, Sztankay A, Weinlich G et al. Permeability barrier function of skin exposed to ionizing radiation. Arch Dermatol 2001;137:1019-23. (Pubitemid 32756459)
33. Schreck U, Paulsen F, Bamberg M et al. Intraindividual comparison of two dif-ferent skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? Strahlenther Onkol 2002;178:321-9. (Pubitemid 34632645)
34. Simard PF, Bolton RM, Tarbell NJ. Anti-inflammatory cream reduces skin dam-age induced by ionizing radiation. Oncologist 2009;14:197-8.
35. Tagami H, Kobayashi H, Zhen XS et al. Environmental effects on the functions of the stratum corneum. J Investig Dermatol Symp Proc 2001;6:87-94. (Pubitemid 33758611)
36. Veronesi U, Zurrida S. Preserving life and conserving the breast. Lancet Oncol 2009;10:736
37. Watkins SA, Maibach HI. The hardening phenomenon in irritant contact der-matitis: an interpretative update. Contact Dermatitis 2009;60:123-30.
38. Yoshida K, Yamazaki H, Takenaka T et al. Objective assessment of dermatitis following post-operative radiotherapy in patients with breast cancer treated with breast-conserving treatment. Strahlenther Onkol 2010;186:621-9.
39. Zimmermann JS, Seegenschmiedt MH, Niehoff P et al. Topographic docu-mentation of acute radiation morbidity. Strahlenther Onkol 1998;174(Suppl. 3):30-6. (Pubitemid 28506589)
40. Zimmermann JS, Wilhelm R, Niehoff P et al. Prevention and therapy of acute radiation injuries of the skin and mucosa. I. Results of a German multicenter questionnaire. Strahlenther Onkol 1998;174:142-8. (Pubitemid 28131155)