Highly regioselective palladium-catalyzed C2-amination of 2,4-dichloropyridines: Scope and limitations

Synthesis

Volumn , Issue 15, 2011, Pages 2431-2436

  Delvare, Christian ^a   Koza, Patrice ^a   Morgentin, Rémy ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

amination; cross coupling; palladium; pyridines; regioselectivity

Indexed keywords

CROSS-COUPLINGS; DEPROTECTION; IN-SITU; REGIO-SELECTIVE;

REGIOSELECTIVITY;

AMINES;

2,4 DICHLOROPYRIMIDINE DERIVATIVE; 4 CHLORO 6 (1,3 DIMETHYL 1H PYRAZOL 4 YLAMINO)NICOTINONITRILE; 4 CHLORO 6 (1,3 DIMETHYL 1H PYRAZOL 5 YLAMINO)NICOTINONITRILE; 4 CHLORO 6 (2 METHOXYPHENYLAMINO)NICOTINONITRILE; 4 CHLORO 6 (2 METHYL 6 NITROPHENYLAMINO)NICOTINONITRILE; 4 CHLORO 6 (2 METHYLISOINDOLIN 4 YLAMINO)NICOTINONITRILE; 4 CHLORO 6 (3 CHLOROPHENYLAMINO)NICOTINONITRILE; 4 CHLORO 6 (4 CYANOPHENYLAMINO)NICOTINONITRILE; 4 CHLORO 6 (4 METHOXY 2 METHYLPHENYLAMINO)NICOTINONITRILE; 4 CHLORO 6 (4 NITROPHENYLAMINO)NICOTINONITRILE; 4 CHLORO 6 (6 METHYLPYRIDIN 2 YLAMINO)NICOTINONITRILE; 4 CHLORO 6 (PHENYLAMINO)NICOTINONITRILE; 4 CHLORO 6 ANILINO NICOTINONITRILE DERIVATIVE; 4 CHLORO N (1,3 DIMETHYL 1H PYRAZOL 4 YL)PYRIDIN 2 AMINE; 4 CHLORO N (2 METHOXYPHENYL)PYRIDIN 2 AMINE; 4 CHLORO N (3,4,5 TRIMETHOXYPHENYL)PYRIDIN 2 AMINE; 4 CHLORO N PHENYLPYRIDIN 2 AMINE; 4,6 DICHLORONICOTINONITRILE; 6 (4 ACETYLPHENYLAMINO) 4 CHLORONICOTINONITRILE; 6 (4 BROMOPHENYLAMINO) 4 CHLORONICOTINONITRILE; ANILINE DERIVATIVE; HETEROCYCLIC AMINE; N (1,3 DIMETHYL 1H PYRAZOL 4 YL)ACETAMIDE; NITRILE; PALLADIUM; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CROSS COUPLING REACTION; DEACETYLATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 79960848210     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260080     Document Type: Article

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