Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2355-2361

  Huang, Hui ^a   Hutta, Daniel A ^a   Hu, Huaping ^a   DesJarlais, Renee L ^a   Schubert, Carsten ^a   Petrounia, Ioanna P ^a   Chaikin, Margery A ^a   Manthey, Carl L ^a   Player, Mark R ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

cFMS; Colony stimulating factor 1 receptor; CSF 1; FMS; M CSF; Macrophage; Pyrimidinopyridone

Indexed keywords

AMIDE; ANTIINFLAMMATORY AGENT; COLONY STIMULATING FACTOR RECEPTOR; DIPYRONE; LIPOPOLYSACCHARIDE; PROTEIN TYROSINE KINASE INHIBITOR; PYRIDO[1,2 A]PYRIMIDINE DERIVATIVE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN;

AMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; LIPOPOLYSACCHARIDES; MICE; MODELS, CHEMICAL; PROTEIN KINASE INHIBITORS; PYRIDINES; PYRIDONES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

MUS;

EID: 41349092967     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.070     Document Type: Article

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