Cadmium induces differentiation of RAW264.7 cells into osteoclasts in the presence of RANKL

Food and Chemical Toxicology

Volumn 49, Issue 9, 2011, Pages 2392-2397

  Chen, Xiao ^a   Zhu, Guoying ^a   Jin, Taiyi ^a   Gu, Shuzhu ^a   Xiao, Hanfang ^a   Qiu, Jing ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cadmium; Osteoclasts; RAW264.7 cell; Receptor activated nuclear factor B ligand

Indexed keywords

CADMIUM CHLORIDE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; C SRC GENE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; FOS RELATED ANTIGEN 1 GENE; GENE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; ONCOGENE C FOS; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; PROTEIN EXPRESSION; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B GENE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B LIGAND GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TARTRATE RESISTANT ACID PHOPHATASE GENE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6 GENE; UPREGULATION;

ANIMALS; BASE SEQUENCE; CADMIUM; CELL DIFFERENTIATION; CELL LINE; DNA PRIMERS; MICE; OSTEOCLASTS; RANK LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79960844956     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.053     Document Type: Article

References (40)

1. Åkesson A., Bjellerup P., Lundh T., Lidfeldt J., Nerbrand C., Samsioe G., Skefving S., Vahter M. Cadmium-induced effects on bone in a population-based study of women. Environ. Health Perspect. 2006, 114:830-834.
2. Berglund M., Akesson A., Bjellerup P., Vahter M. Metal-bone interactions. Toxicology 2000, 112-113:219-225.
3. Bodo M., Balloni S., Lumare E., Bacci M., Calvitti M., Dell'Omo M., Murgia N., Marinucci L. Effects of sub-toxic cadmium concentrations on bone gene expression program: results of an in vitro study. Toxicol. In Vitro 2010, 24:1670-1680.
4. Boyce B.F., Xing L. Osteoclasts, no longer osteoblast slaves. Nat. Med. 2006, 12:1356-1358.
5. Boyle W.J., Simonet W.S., Lacey D. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
6. Brzóska M.M., Moniuszko-Jakoniuk J. Bone metabolism of male rats chronically exposed to cadmium. Toxicol. Appl. Pharmacol. 2005, 207:195-211.
7. Chen X., Zhu G., Gu S., Jin T. Effects of cadmium on osteoblasts and osteoclasts in vitro. Environ. Toxicol. Pharmacol. 2009, 28:232-236.
8. Cheong H.K., Kwon H.J., Choi K.H., Jang J.Y., Hong Y.C., Kim D.S., Yu S.D., Kim Y.W., Lee K.Y., Yang S.O., Jung W.C., Kim S.Y. Effect of low level cadmium exposure on the bone density of the residents near a closed copper mine. Epidemiology 2006, 16:s487-s488.
9. Chiappetta G., Ferraro A., Botti G., Monaco M., Asquinelli R.P., Vuttariello E., Arnaldi L., Bonito M., D'Aiuto G., Pierantoni G.M., Fusco P.A. FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders. BMC Cancer 2007, 7:17-28.
10. Chu W.A., Moehlenkamp J.D., Bittel D., Andrews G.K., Johnson J.A. Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1. J. Biol. Chem. 1999, 274:5279-5284.
11. Dakeshita S., Kawai T., Uemura H., Hiyoshi M., Oguma E., Horiguchi H., Kayama F., Aoshima K., Shirahama S., Rokutan K., Arisawa K. Gene expression signatures in peripheral blood cells from Japanese women exposed to environmental cadmium. Toxicology 2009, 257:25-32.
12. Horiguchi H., Oguma E., Sasaki S., Miyamoto K., Ikeda Y., Machida M., Kayama F. Environmental exposure to cadmium at a level insuffcient to induce renal tubular dysfunction does not affect bone density among female Japanese farmers. Environ. Res. 2005, 97:83-92.
13. Hsiao C.J., Stapleton S.R. Early sensing and gene expression profiling under a low dose of cadmium exposure. Biochimie 2009, 91:329-343.
14. Jiang G., Duan W., Xu L., Song S., Zhu C., Wu L. Biphasic effect of cadmium on cell proliferation in human embryo lung fibroblast cells and its molecular mechanism. Toxicol. In Vitro 2009, 23:973-978.
15. Jin T., Nordberg G.F., Ye T., Bo M., Wang H., Zhu G., Kong Q., Bernard A. Osteoporosis and renal dysfunction in general population exposed to cadmium in China. Environ. Res. 2004, 96:353-359.
16. Kjellstrom T. Effects of Cd on bone, on vitamin D, and calcium metabolism. Cadmium and Health: A Toxicological and Epidemiological Appraisal 1986, CRC Press, Boca Raton, FL.
17. Koizumi S., Yamada H. DNA microarray analysis of altered gene expression in cadmium-exposed human cells. J. Occup. Health 2003, 45:331-334.
18. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., Elliott R., Colombero A., Elliott G., Scully S., Hsu H., Sullivan J., Hawkins N., Davy E., Capparelli C., Eli A., Qian Y.X., Kaufman S., Sarosi I., Shalhoub V., Senaldi G., Guo J., Delaney J., Boyle W.J. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998, 93:165-176.
19. Li G.Y., Kim M., Kim J.H., Lee M.O., Chung J.H., Lee B.H. Gene expression profiling in human lung fibroblast following cadmium exposure. Food Chem. Toxicol. 2008, 46:1131-1137.
20. Misra U.K., Gawdi G., Akabani G., Pizzo S.V. Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms. Cell Signal. 2002, 14:327-340.
21. Miyahara T., Takata M., Mori-Uchi S., Miyata M., Nagai M., Segure A., Matsusista M., Kozuka H., Kuze S. Stimulative effects of cadmium on bone resorption in neonatal parental bone resorption. Toxicology 1992, 73:93-99.
22. Nawrot T., Geusens P., Nulens T.S., Nemery B. Occupational cadmium exposure and calcium excretion, bone density, and osteoporosis in men. J. Bone Miner. Res. 2010, 25:1441-1445.
23. Regunathan A., Cerny E.A., Villarreal J., Bhattacharyya M.H. Role of fos and src in cadmium-induced decreases in bone mineral content in mice. Toxicol. Appl. Pharmacol. 2002, 185:25-40.
24. Regunathan K., Glesne D.A., Wilson A.K., Song J., Nicolae D., Flores T., Bhattacharyya M.H. Microarray analysis of changes in bone cell gene expression early after cadmium gavage in mice. Toxicol. Appl. Pharmacol. 2003, 191:272-293.
25. Schutte R., Nawrot T.S., Richart T., Thijs L., Vanderschueren D., Kuznetsova T., Van H.E., Roels H.A., Staessen J.A. Bone resorption and environmental exposure to cadmium in women: a population study. Environ. Health Perspect. 2008, 116:777-783.
26. Shin M., Paek D., Yoon C. The relationship between the bone mineral density and urinary cadmium concentration of residents in an industrial complex. Environ. Res. 2010, 111:101-109.
27. Sirchia R., Luparello C. Short-term exposure to cadmium affects the expression of stress response and apoptosis-related genes in immortalized epithelial cells from the human breast. Toxicol. In Vitro 2009, 23:943-949.
28. Soriano P., Montgomery C., Geske R., Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 1991, 64:693-702.
29. Staessen J.A., Roels H.A., Emelianov D., Kuznetsova T., Thijs L., Vangronsveld J., Fagard R. Environment exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Lancet 1999, 353:1140-1144.
30. Suzuki Y., Morita I., Yamane Y., Murota S. Preventive effect of zinc against cadmium-induced bone resorption. Toxicology 1990, 62:27-34.
31. Teitelbaum S.L. RANKing c-Jun in osteoclast development. J. Clin. Invest. 2004, 114:463-465.
32. Teitelbaum S.L., Ross F.P. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 2003, 4:638-649.
33. Tsangaris G.T., Botsonis A., Politis I., Tzortzatou-Stathopoulou F. Evaluation of cadmium-induced transcriptome alterations by three color cDNA labeling microarray analysis on a T-cell line. Toxicology 2002, 178:135-160.
34. Wang C., Brown S., Bhattacharyya M.H. Effect of cadmium on bone calcium and 45Ca in mouse dams on a calcium-deficient diet: evidence of Itai-Itai-like syndrome. Toxicol. Appl. Pharmacol. 1994, 127:320-330.
35. Wang H., Zhu G., Shi Y., Weng S., Jin T., Kong Q., Nordberg G.F. Influence of environmental cadmium exposure on forearm bone density. J. Bone Miner. Res. 2003, 18:553-560.
36. Wilson A.K., Cerny E.A., Smith B.D., Wagh A., Bhattacharyya M.H. Effects of cadmium on osteoclast formation and activity in vitro. Toxicol. Appl. Pharmacol. 1996, 140:451-460.
37. World Health Organization Cadmium. Environ. Health Crit. 1992, 134:146-151.
38. Yamada H., Uenishi R., Suzuki K., Koizumi S. Cadmium-induced alterations of gene expression in human cells. Environ. Toxicol. Pharmacol. 2009, 28:61-69.
39. Yu X., Filardo E.J., Shaikh Z.A. The membrane estrogen receptor GPR30 mediates cadmium-induced proliferation of breast cancer cells. Toxicol. Appl. Pharmacol. 2010, 245:83-90.
40. Zhao Q., Wang X., Liu Y., He A., Jia R. NFATc1: functions in osteoclasts. Int. J. Biochem. Cell. Biol. 2010, 42:576-579.