Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers

Food and Chemical Toxicology

Volumn 49, Issue 9, 2011, Pages 2167-2171

  Kimura, Osamu ^a   Kotaki, Yuichi ^b   Hamaue, Naoya ^a   Haraguchi, Koichi ^c   Endo, Tetsuya ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c DAIICHI UNIVERSITY OF PHARMACY   (Japan)

Author keywords

Caco 2 cells; Chloride ions; DIDS (4,4' diisothiocyanostilbene 2,2' disulfonic acid); Domoic acid; Intestinal transport

Indexed keywords

4 AMINOHIPPURIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; AMINO ACID; BROMSULFOPHTHALEIN; CARBOXYLIC ACID; CHLORIDE ION; CITRIC ACID; DOMOIC ACID; ESTRONE SULFATE; GLUTAMIC ACID; GLYCYLSARCOSINE; PROBENECID; SODIUM; SUCCINIC ACID; TETRYLAMMONIUM;

AMINO ACID TRANSPORT; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL PH; CELL STRAIN CACO 2; CONTROLLED STUDY; INTESTINE ABSORPTION; MONOLAYER CULTURE; TEMPERATURE DEPENDENCE; TRANSCYTOSIS; TRANSPORT KINETICS;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; CACO-2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINES; KAINIC ACID; TEMPERATURE;

EID: 79960841855     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.001     Document Type: Article

References (29)

1. Alrefai W.A., Tyagi S., Nazir T.M., Barakat J., Anwar S.S., Hadjiagapiou C., Bavishi D., Sahi J., Malik P., Goldstein J., Layden T.J., Ramaswamy K., Dudeja P.K. Human intestinal anion exchanger isoforms: expressio, distribution, and membrane localization. Biochim. Biophys. Acta 2001, 1511:17-27.
2. Hadjiagapiou C., Schmidt L., Dudeja P.K., Layden T.J., Ramaswamy K. Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. Am. J. Physiol. Gastrointest. Liver Physiol. 2000, 279:G775-G780.
3. Hampson D.R., Huang X.P., Wells J.W., Walter J.A., Wright J.L. Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain. Eur. J. Pharmacol. 1992, 218:1-8.
4. Hilgendorf C., Ahlin G., Seithel A., Artursson P., Ungell A.L., Karlsson J. Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab. Dispos. 2007, 35:1333-1340.
5. Hilgers A.R., Conradi R.A., Burton P.S. Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm. Res. 1990, 7:902-910.
6. Jacob P., Rossmann H., Lamprecht G., Kretz A., Neff C., Lin-Wu E., Gregor M., Groneberg D.A., Kere J., Seidler U. Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum. Gastroenterology 2002, 122:709-724.
7. Kimura O., Endo T., Sakata M. Comparison of cadmiun uptakes from apical and basolateral membranes of LLC-PK1 cells. Toxicol. Appl. Pharmacol. 1996, 137:301-306.
8. Kimura, O., Endo, T., Hotta, Y., Sakata, M., 2005. Effects of P-glycoprotein inhibitors on transepithelial transport of cadmium in cultured renal epithelial cells, LLC-PK1 and LLC-GA5-COL 150. Toxicology 208, 123-132.
9. Kimura O., Tsukagoshi K., Endo T. Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter. Toxicol. Appl. Pharmacol. 2008, 227:325-330.
10. Kimura O., Tsukagoshi K., Endo T. Uptake of phenoxyacetic acid derivatives into Caco-2 cells by the monocarboxylic acid transporters. Toxicol. Lett. 2009, 189:102-109.
11. Kotaki Y., Koike K., Sato S., Ogata T., Fukuyo Y., Kodama M. Confirmation of domoic acid production of Pseudo-nitzschia multiseries isolated from Ofunato Bay, Japan. Toxicon 1999, 37:677-682.
12. Lappin G.J., Hardwick T.D., Stow R., Pigott G.H., van Ravenzwaay B. Absorption, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rat and dog. Xenobiotica 2002, 32:153-163.
13. Lecona E., Olmo N., Turnay J., Santiago-Gómez A., López de Silanes I., Gorospe M., Lizarbe M.A. Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms. Biochem. J. 2008, 409:311-320.
14. Lefebvre K.A., Robertson A. Domoic acid and human exposure risks: a review. Toxicon 2010, 56:218-230.
15. Mordrelle A., Huneau J.F., Tomé D. Sodium-dependent and -independent transport of l-glutamate in the rat intestinal crypt-like cell line IEC-17. Biochem. Biophys. Res. Commun. 1997, 233:244-247.
16. Mordrelle A., Jullian E., Costa C., Cormet-Boyaka E., Benamouzig R., Tomé D., Huneau J.F. EAAT1 is involved in transport of L-glutamate during differentiation of the Caco-2 cell line. Am. J. Physiol. Gastrointest. Liver Physiol. 2000, 279:G366-G373.
17. Nicklin P.L., Irwin W.J., Hassan I.F., Mackay M., Dixon H.B.F. The transport of acidic amino acids and their analogues across monolayers of human intestinal absorptive (Caco-2) cells in vitro. Biochim. Biophys. Acta 1995, 1269:176-186.
18. Ogihara T., Tamai I., Tsuji A. Structural characterization of substrates for the anion exchange transporter in Caco-2 cells. J. Pharm. Sci. 1999, 88:1217-1221.
19. Quilliam M.A., Sim P.G., McCulloch A.W., McInnes A.G. High-performance liquid chromatography of domoic acid, a marine neurotoxin, with application to shellfish and plankton. Int. J. Environ. Anal. Chem. 1989, 36:139-154.
20. Rajendran V.M., Harig J.M., Adams M.B., Ramaswamy K. Transport of acidic amino acids by human jejunal brush-border membrane vesicles. Am. J. Physiol. 1987, 252:G33-G39.
21. Ross I.A., Johnson W., Sapienza P.P., Kim C.S. Effects of the seafood toxin domoic acid on glutamate uptake by rat astrocytes. Food Chem. Toxicol. 2000, 38:1005-1011.
22. Sai Y., Kaneko Y., Ito S., Mitsuoka K., Kato Y., Tamai I., Artursson P., Tsuji A. Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Drug Metab. Dispos. 2006, 34:1423-1431.
23. Suzuki C.A.M., Hierlihy S.L. Renal clearance of domoic acid in the rat. Food Chem. Toxicol. 1993, 31:701-706.
24. Truelove J., Iverson F. Serum domoic acid clearance and clinical observations in the cynomolgus monkey and Sprague-Dawley rat following a single i.v. dose. Bull. Environ. Contam. Toxicol. 1994, 52:479-486.
25. Truelove J., Mueller R., Pulido O., Iverson F. Subchronic toxicity study of domoic acid in the rat. Food Chem. Toxicol. 1996, 34:525-529.
26. Truelove J., Mueller R., Pulido O., Martin L., Fernie S., Iverson F. 30-day oral toxicity study of domoic acid in cynomolgus monkeys: lack of overt toxicity at doses approaching the acute toxic dose. Nat. Toxins 1997, 5:111-114.
27. Tsuji A., Tamai I. Carrier-mediated intestinal of drugs. Pharm. Res. 1996, 13:963-977.
28. Weerachayaphorn J., Pajor A.M. Identification of transport pathways for citric acid cycle intermediates in the human colon carcinoma cell line, Caco-2. Biochim. Biophys. Acta 2008, 1778:1051-1059.
29. Wright J.L.C., Boyd R.K., de Freitas A.S.W., Falk M., Foxall R.A., Jamieson W.D., Laycock M.V., McCulloch A.W., McInnes A.G., Odense P., Pathak V.P., Quilliam M.A., Ragan M.A., Sim P.G., Thibault P., Walter J.A., Gilgan M., Richard D.J.A., Dewar D. Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern Prince Edward Island. Can. J. Chem. 1989, 67:481-490.