Structural characterization of substrates for the anion exchange transporter in Caco-2 cells

Journal of Pharmaceutical Sciences

Volumn 88, Issue 11, 1999, Pages 1217-1221

  Ogihara, Takuo ^a,c   Tamai, Ikumi ^a,b   Tsuji, Akira ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; BICARBONATE; CARBOXYLIC ACID; GLYCOLIC ACID; HYDROXYBUTYRIC ACID; HYDROXYL GROUP; LACTIC ACID; SODIUM AZIDE;

ANION EXCHANGE; ANION TRANSPORT; ARTICLE; CELL STRAIN CACO 2; HUMAN; HUMAN CELL; HYDROXYLATION; INTESTINE EPITHELIUM CELL; MOLECULAR RECOGNITION;

EID: 0032725269     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js9900093     Document Type: Article

References (25)

1. +-cotransport mechanism versus pH-partition hypothesis. J. Pharm. Sci. 1990, 79, 1123-1124.
2. Simanjuntak, M. T.; Tamai, I.; Terasaki, T.; Tsuji, A. Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport. J. Pharmacobio-Dyn. 1990, 13, 301-309.
3. Simanjuntak, M. T.; Terasaki, T.; Tamai, I.; Tsuji, A. Participation of monocarboxylic anion and bicarbonate exchange system for the transport of acetic acid and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles. J. Pharmacobio-Dyn. 1991, 14, 501-508.
4. Tsuji, A.; Takanaga, H.; Tamai, I.; Terasaki, T. Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm. Res. 1994, 11, 30-37.
5. Takanaga, H.; Tamai, I.; Tsuji, A. pH-Dependent and carrier-mediated transport of salicylic acid across Caco-2 cells. J. Pharm. Pharmacol. 1994, 46, 567-570.
6. Tamai, I.; Takanaga, H.; Ogihara, T.; Yoneda M.; Tsuji, A. Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharm. Res. 1996, 12, 1727-1732.
7. Tamai, I.; Takanaga, H.; Maeda, H.; Sai, Y.; Ogihara, T.; Higashida H.; Tsuji, A. Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids, Biochem. Biophys. Res. Commun. 1995, 214, 482-489.
8. Takanaga, H.; Tamai, I.; Inaba, S.; Sai, Y.; Higashida, H.; Yamamoto, H.; Tsuji, A. cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochem. Biophys. Res. Commun. 1995, 217, 370-377.
9. Ogihara, T.; Tamai, I.; Takanaga, H.; Sai, Y.; Tsuji, A. Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells. Pharm. Res. 1996, 13, 1828-1832.
10. Takanaga, H.; Maeda, H.; Yabuuchi, H.; Tamai, I.; Higashida, H.; Tsuji, A. Nicotinic acid transport mediated by pH-dependent anion antiporter and proton cotransporter in rabbit intestinal brush-border membrane. J. Pharm. Pharmacol. 1996, 48, 1073-1077.
11. Tamai, I.; Takanaga, H.; Maeda, H.; Yabuuchi, H.; Sai, Y.; Suzuki, Y.; Tsuji, A. Intestinal brush-border membrane transport of monocarboxylic acids mediated by proton-coupled transport and anion antiport mechanisms. J. Pharm. Pharmacol. 1997, 49, 108-112.
12. Yabuuchi, H.; Tamai, I.; Sai, Y.; Tsuji, A. Possible role of anion exchanger AE2 as the intestinal monocarboxylic acid/ anion antiporter. Pharm. Res. 1998, 15, 411-416.
13. Ogihara, T.; Tamai, I.; Tsuji, A. Application of fractal kinetics for carrier-mediated transport of drug across intestinal epithelial membrane. Pharm. Res. 1998, 16, 620-625.
14. Brodie, B. B.; Hogben, C. A. M.; Some physicochemical factors in drug action. J. Pharm. Pharmacol. 1957, 9, 345-380.
15. Kim, C. M.; Goldstein, J. L.; Brown, M. S.; cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function. J. Biol. Chem. 1992, 267, 23113-23121.
16. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
17. Leo, A.; Hansch, C.; Elkins, D. Partition coefficients and their uses. Chem. Rev. 1971, 71, 525-616.
18. Titus, E.; Ahearn, G. A. Short chain fatty acid transport in the intestine of a herbivorous teleost. J. Exp. Biol. 1988, 135, 77-94.
19. Harig, J. M.; Soergel, K. H.; Barry, J. A.; Ramaswamy, K. Transport of propionate by human ileal brush-border membrane vesicles. Am. J. Physiol. 1991, 260, G776-782.
20. Demuth, D. R.; Showe, L. C.; Ballantine, M.; Palumbo, A.; Fraser, P. J.; Cioe, L.; Rovera, G.; Curtis, P. J. Cloning and structural characterization of human nonerythroid band 3-like protein. EMBO J. 1986, 5, 1205-1214.
21. Alper, S. L.; Kopito, R. R.; Libresco, S. M.; Lodish, H. F. Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. J. Biol. Chem. 1988, 263, 17092-17099.
22. Gehrig, H.; Muler, W.; Appelhans, H. Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney. Biochim. Biophys. Acta 1992, 1130, 326-328.
23. 3- exchanger. J. Biol. Chem. 1990, 265, 462-471.
24. Lindsey, A. E.; Schneider, K.; Simmons, D.; Baron, M. R.; Lee, B. S.; Kopito, R. R. Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 5278-5282.
25. Chow, A.; Dobbins, J. W.; Aronson, P. S.; Igarashi, P. cDNA cloning and localization of band 3-related protein from ileum. Am. J. Physiol. 1992, 263, G345-352.