Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits

Journal of Cell Biology

Volumn 158, Issue 2, 2002, Pages 215-220

  Ueno, Sayaka ^a   Tsukamoto, Masako ^a   Hirano, Tomoya ^a   Kikuchi, Kazuya ^a   Yamada, Maki K ^a   Nishiyama, Nobuyoshi ^a   Nagano, Tetsuo ^a   Matsuki, Norio ^a   Ikegaya, Yuji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Hippocampus; Indicator; Mossy fiber; Synaptic plasticity; Zinc

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; ZINC;

ANIMAL; ARTICLE; ELECTROPHYSIOLOGY; HIPPOCAMPUS; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; RAT; SYNAPTIC TRANSMISSION; WISTAR RAT;

ANIMALS; ELECTROPHYSIOLOGY; MOSSY FIBERS, HIPPOCAMPAL; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION; ZINC;

EID: 0037157834     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.200204066     Document Type: Article

References (32)

1. 2+ from brain tissue during activity. Nature. 308:734-736.
2. Bliss, T.V., and G.L. Collingridge. 1993. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:31-39.
3. Brewer, G.J., J.C. Aster, C.A. Knutsen, and W.C. Kruckeberg. 1979. Zinc inhibition of calmodulin: a proposed molecular mechanism of zinc action on cellular functions. Am. J. Hematol. 7:53-60.
4. Canzoniero, L.M., D.M. Turetsky, and D.W. Choi. 1999. Measurement of intracellular free zinc concentrations accompanying zinc-induced neuronal death. J. Neurosci. 19: RC31.
5. Choi, D.W., and J.Y. Koh. 1998. Zinc and brain injury. Annu. Rev. Neurosci. 21: 347-375.
6. Dreixler, J.C., and J.P. Leonard. 1994. Subunit-specific enhancement of glutamate receptor responses by zinc. Mol. Brain Res. 22:144-150.
7. 2+ induces stimulation of the c-Jun N-terminal kinase signaling pathway through phosphoinositide 3-kinase. Mol. Pharmacol. 59:981-986.
8. Hirano, T., K. Kikuchi, Y. Urano, T. Higuchi, and T. Nagano. 2000. Highly zincselective fluorescent sensor molecules suitable for biological applications. J. Am. Chem. Soc. 122:12399-12400.
9. Hirano, T., K. Kikuchi, Y. Urano, T. Higuchi, and T. Nagano. 2002. Improvement and biological applications of fluorescent probes for zinc, ZnAFs. J. Am. Chem. Soc. In press.
10. Howell, G.A., M.G. Welch, and C.J. Frederickson. 1984. Stimulation-induced uptake and release of zinc in hippocampal slices. Nature. 308:736-738.
11. Hubbard, S.R., W.R. Bishop, P. Kirschmeier, S.J. George, S.P. Cramer, and W.A. Hendrickson. 1991. Identification and characterization of zinc binding sites in protein kinase C. Science. 254:1776-1779.
12. 2+ channel blocker inhibits mossy fiber sprouting and cognitive deficits following pilocarpine seizures in immature mice. Neuroscience. 98:647-659.
13. Kamiya, H., H. Shinozaki, and C. Yamamoto. 1996. Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses. J. Physiol. 493:447-455.
14. Koh, J.Y., S.W. Suh, B.J. Gwag, Y.Y. He, C.Y. Hsu, and D.W. Choi. 1996. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science. 272:1013-1016.
15. Lee, J.Y., T.B. Cole, R.D. Palmiter, and J.Y. Koh. 2000. Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin. J. Neurosci. 20: RC79.
16. 2+. J. Neurosci. 21:8015-8025.
17. 2+ from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation. J. Neurophysiol. 86:2597-2604.
18. Lin, D.D., A.S. Cohen, and D.A. Coulter. 2001. Zinc-induced augmentation of excitatory synaptic currents and glutamate receptor responses in hippocampal CA3 neurons. J. Neurophysiol. 85:1185-1196.
19. 2+ is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses. Synapse. 38:187-197.
20. Martin, S.J., P.D. Grimwood, and R.G. Morris. 2000. Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23:649-711.
21. Park, J.A., and J.Y. Koh. 1999. Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death. J. Neurochem. 73:450-456.
22. Peters, S., J. Koh, and D.W. Choi. 1987. Zinc selectively blocks the action of N-methyl-d-aspartate on cortical neurons. Science. 236:589-593.
23. Paoletti, P., P. Ascher, and J. Neyton. 1997. High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J. Neurosci. 17:5711-5725.
24. Rassendren, F.A., P. Lory, J.P. Pin, and J. Nargeot. 1990. Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes. Neuron 4:733-740.
25. Sensi, S.L., L.M. Canzoniero, S.P. Yu, H.S. Ying, J.Y. Koh, G.A. Kerchner, and D.W. Choi. 1997. Measurement of intracellular free zinc in living cortical neurons: routes of entry. J. Neurosci. 17:9554-9564.
26. Shen, Y., and X.L. Yang. 1999. Zinc modulation of AMPA receptors may be relevant to splice variants in carp retina. Neurosci. Lett. 259:177-180.
27. Shumilla, J.A., KE. Wetterhahn, and A. Barchowsky. 1998. Inhibition of NF-kappa B binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: evidence of a thiol mechanism. Arch. Biochem. Biophys. 349: 356-362.
28. Tonder, N., F.F. Johansen, C.J. Frederickson, J. Zimmer, and N.H. Diemer. 1990. Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat. Neurosci. Lett. 109:247-252.
29. Toth, K, G. Suares, J.J. Lawrence, E. Philips-Tansey, and C.J. McBain. 2000. Differential mechanisms of transmission at three types of mossy fiber synapse. J. Neurosci. 20:8279-8289.
30. Vogt, K., J. Mellor, G. Tong, and R. Nicoll. 2000. The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron. 26:187-196.
31. Weiss, J.H., J.Y. Koh, C.W. Christine, and D.W. Choi. 1989. Zinc and LTP. Nature. 338:212.
32. Westbrook, G.L., and M.L. Mayer. 1987. Micromolar concentrations of Zn + antagonize NMDA and GABA responses of hippocampal neurons. Nature. 328:640-643.