A robust model for simultaneously inducing corneal neovascularization and retinal gliosis in the mouse eye

Molecular Vision

Volumn 17, Issue , 2011, Pages 1901-1908

  Paranthan, Riya R ^a   Bargagna Mohan, Paola ^b   Lau, Daniel L ^c   Mohan, Royce ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; EYE DROPS; GLIAL FIBRILLARY ACIDIC PROTEIN; WITHAFERIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; EXPERIMENTAL MODEL; GLIOSIS; IMMUNOHISTOCHEMISTRY; MOUSE; MUELLER CELL; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINAL GLIOSIS; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD31; BLOTTING, WESTERN; CORNEA; CORNEAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; EYE INJURIES; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HUMANS; IMMUNOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; MACULAR DEGENERATION; MICE; MICE, INBRED C57BL; NEUROGLIA; RETINA; SODIUM HYDROXIDE; WITHANOLIDES;

EID: 79960828549     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007; 8:464-78.
2. Figg WD, Folkman J. In angiogenesis: an integrative approach from science to medicine. NY: Springer; 2008:35-44.
3. Carmeliet P. Blood vessels and nerves: common signals, pathways and diseases. Nat Rev Genet 2003; 4:710-20.
4. Tonnesen MG, Feng X, Clark RA. Angiogenesis in wound healing. J Investig Dermatol Symp Proc 2000; 5:40-6.
5. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407:249-57.
6. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1:27-31.
7. Kalaria RN. Small vessel disease and Alzheimer's dementia: pathological considerations. Cerebrovasc Dis 2002; 13:48-5.
8. Gariano RF, Gardner TW. Retinal angiogenesis in development and disease. Nature 2005; 438:960-6.
9. Dyer MA, Cepko CL. Control of Müller glial cell proliferation and activation following retinal injury. Nat Neurosci 2000; 3:873-80.
10. Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005; 50:427-34.
11. Menet V, Giménez y Ribotta M, Chauvet N, Drian MJ, Lannoy J, Colucci-Guyon E, Privat A. Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression. J Neurosci 2001; 21:6147-58.
12. Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci 2004; 5:146-56.
13. Lewis GP, Chapin EA, Luna G, Linberg KA, Fisher SK. The fate of Müller's glia following experimental retinal detachment: nuclear migration, cell division, and subretinal glial scar formation. Mol Vis 2010; 16:1361-72.
14. Wu KH, Madigan MC, Billson FA, Penfold PL. Differential expression of GFAP in early v late AMD: a quantitative analysis. Br J Ophthalmol 2003; 87:1159-66.
15. Sueishi K, Hata Y, Murata T, Nakagawa K, Ishibashi T, Inomata H. Endothelial and glial cell interaction in diabetic retinopathy via the function of vascular endothelial growth factor (VEGF). Pol J Pharmacol 1996; 48:307-16.
16. Guyton MK, Das A, Samantaray S, Wallace GC 4th, Butler JT, Ray SK, Banik NL. Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis. J Neurosci Res 2010; 88:2398-408.
17. Bates KA, Fonte J, Robertson TA, Martins RN, Harvey AR. Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor protein. Neuroscience 2002; 113:785-96.
18. Rogers MS, Birsner AE, D'Amato RJ. The mouse cornea micropocket angiogenesis assay. Nat Protoc 2007; 2:2545-50.
19. Fisher SK, Lewis GP. Müller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent data. Vision Res 2003; 43:887-97.
20. Bargagna-Mohan P, Hamza A, Kim YE, Khuan Abby Ho Y, Mor-Vaknin N, Wendschlag N, Liu J, Evans RM, Markovitz DM, Zhan CG, Kim KB, Mohan R. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol 2007; 14:623-34.
21. Bargagna-Mohan P, Paranthan RR, Hamza A, Dimova N, Trucchi B, Srinivasan C, Elliott GI, Zhan CG, Lau DL, Zhu H, Kasahara K, Inagaki M, Cambi F, Mohan R. Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis. J Biol Chem 2010; 285:7657-69.
22. Mohan R, Hammers HJ, Bargagna-Mohan P, Zhan XH, Herbstritt CJ, Ruiz A, Zhang L, Hanson AD, Conner BP, Rougas J, Pribluda VS. Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 2004; 7:115-22.
23. Bargagna-Mohan P, Ravindranath PP, Mohan R. Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization. Invest Ophthalmol Vis Sci 2006; 47:4138-45.
24. Amano S, Rohan R, Kuroki M, Tolentino M, Adamis AP. Requirement for vascular endothelial growth factor in woundand inflammation-related corneal neovascularization. Invest Ophthalmol Vis Sci 1998; 39:18-22.
25. Ganesh BS, Chintala SK. Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells. PLoS ONE 2011; 6:e18305.
26. Ribatti D. Napoleone Ferrara and the saga of vascular endothelial growth factor. Endothelium 2008; 15:1-8.
27. Anderson OA, Bainbridge JW, Shima DT. Delivery of antiangiogenic molecular therapies for retinal disease. Drug Discov Today 2010; 15:272-82.
28. Petrukhin K. New therapeutic targets in atrophic age-related macular degeneration. Expert Opin Ther Targets 2007; 11:625-39.
29. Friedlander M. Fibrosis and diseases of the eye. J Clin Invest 2007; 117:576-86.
30. Knight ZA, Shokat KM. Chemical genetics: where genetics and pharmacology meet. Cell 2007; 128:425-30.