Determination of total phenolics, flavonoids and antioxidant and chemopreventive potential of basil (Ocimum basilicum L. and Ocimum tenuiflorum L.)

International Journal of Cancer Research

Volumn 5, Issue 4, 2009, Pages 130-143

  Gajula, D ^a   Verghese, M ^a   Boateng, J ^a   Walker, L T ^a   Shackelford, L ^a   Mentreddy, S R ^a   Cedric, S ^a  

^a ALABAMA A AND M UNIVERSITY   (United States)

Author keywords

Aberrant crypt foci; Azoxymethane; Basil; Colon cancer; Drying; Phytochemicals

Indexed keywords

EID: 79960816244     PISSN: 18119727     EISSN: 18119735     Source Type: Journal    
DOI: 10.3923/ijcr.2009.130.143     Document Type: Article

References (34)

1. Aebi H., 1984. Catalase in vitro. Methods Enzymol., 105: 121-126.
2. Aruna K. and V.M. Sivaramakrishnan, 1990. Plant products as protective agent against cancer. Indian J. Exp. Biol., 28: 1008-1011.
3. Ashokkumar, P. and G. Sudhandiran, 2008. Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Biomed. Pharmacotherapy, 62: 590-597.
4. Beric, T., B. Nikolic, J. Stanojevic, B. Vukovic-Gacic and J. Knezevic-vukcevic, 2008. Protective effect of Basil (Ocimum basilicum L.) against oxidative DNA damage and mutagenesis. Food Chem. Toxicol., 46: 724-732.
5. Bianchi L.K. and C.A. Burke. 2008. Understanding current guidelines for colorectal cancer screening: A case-based approach. Cleve Clin J. Med., 75: 441-448.
6. Bird R.P., 1987. Observation and quantification of aberrant crypt foci in murine colon treated with a colon carcinogen: Preliminary findings. Cancer Lett., 37: 147-151.
7. Block, K.I. and C. Gyllenhaal, 2002. Clinical corner: Herb-drug interactions in cancer chemotherapy: Theoretical concerns regarding drug metabolizing enzymes. Integr Cancer Ther., 1: 83-89.
8. Chamila, J., G. Naohiro, A. Tomako and W. Shun, 2003. Phenolics composition and antioxidant activity of sweet Basil (Ocimum basilicum L.). J. Agric. Food Chem., 51: 4442-4449.
9. Coates, E.M. G Popa, C.I.R. Gill M.J. McCann G.J. McDougall, D. Stewart and I. Rowland, 2007. Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer. J. Carcinog., 6: 4-4.
10. Dasguptha T., R Rao and P.K Yadava, 2004. Chemomodulatory efficacy of Basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes and on carcinogen- induced skin and forestomach papillomagcnesis. Phytomedicinc, II: 139-151.
11. Dewanto, V., X. Wu, K.K. Adorn and R.H. Liu, 2002. Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J. Agric. Food Chem., 50: 3010-3014.
12. Gulcin, I., M. Elmastas and H.Y.A. Enein, 2007. Determination of antioxidant and radical scavenging activity of Basil (Ocimum basilicum L.) assayed by different methodologies. Phytotherapy Res., 21: 354-361.
13. Habig, W.H., M.J. Pabst and W.B. Jakoby, 1974. Glutathione-S-transferases, the first enzymatic step in mercapturic acid formation. J. Biol. Chem., 249: 7130-7139.
14. Hakkim, F.L., C.G. Shankar and S. Girija. 2007. Chemical composition and antioxidant property of holy Basil (Ocimum Sanctum L.) leaves, stems and inflorescence and their in vitro callus cultures. J. Agric. Food Chem., 55: 9109-9117.
15. Issa A.Y., S.R. Volate and M.J. Wargovich., 2006. The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives. J. Food Comp. Anal. 19: 405-419.
16. Johnson J.J. and H. Mukhtar. 2007. Curcumin for cheinoprevention of colon cancer. Cancer Lett., 255: 170-181.
17. Kim D., O. Chun. Y. Kim, H. Moon and C. Lee. 2003. Quantification of phenolics and their antioxidant capacity in fresh plums. J. Agric. Food Chem., 51: 6509-6515.
18. Kim, D.S. H.R. Kim, E.R. Woo, S.T. Hong, H.J. Chae and S.W. Chae. 2005. Inhibitor)' effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-tcrminal kinase and extracellular signal-regulated kinase. Biochem.Pharmacol., 70: 1066-1078.
19. Loughrin, J.H. and M.J. Kasperbauer, 2001. Light reflected from colored mulches affects aroma and phenolic content of sweet Basil (Ocimum basilicum L.) leaves. J. Agric. Food Chem., 49: 1331-1335.
20. Mazza, G. and E. Miniati, 1993. Anthocyanins in Fruits, Vegetables and Grain. 1st Kdn., CRC Press, Boca Raton, FL., ISBN-10: 0849301726.
21. Naoyuki, Y., M. Toshinari, O. Masahiko and E. Hiroyasu, 1994. Increased cell proliferation of azoxymethane- induced aberrant crypt foci of rat colon. J. Cancer Res., 85: 692-698.
22. Phippen, W.B. and J.E. Simon. 1998. Anthocyanins in Basil (Ocimum basilicum L.). J. Agric. Food Chem., 46: 1734-1738.
23. Prakash J and S.K. Gupta, 2000. Chemopreventive activity of ocimum sanctum seed oil. J. Ethnopharmacol., 72: 29-34.
24. Reeves, P.G., F.H. Nielsen and G.C. Fahey Jr., 1993. AIN-93 purified diets for laboratory rodents: Final report of the American institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr., 123: 1939-1951.
25. SAS., 2004. Online Doc®. Version 9.1.2. SAS Software. SAS Institute Inc., Cary, North Carolina, USA.
26. Scalbert, A. and G. Williamson, 2000. Dietary intake and bioavailability of polyphenols. J. Nutr., 130: 2073-2085.
27. Shirtliff, N. and R.P. Bird, 1996. Growth features of aberrant crypt foci that resist modulation by cholic acid. Carcinogenesis, 17: 2093-2096.
28. Simon, J. M. Morales, W. Phippen F. Vicira and Z. Hao, 1999. Basil: A Source of Aroma Compounds and a Popular Culinary and Ornamental Herb. In: Perspectives on New Crops and New Uses, Janick, J. (Ed.). Ashs Press, pp: 499-505.
29. Singelton, V.L., R. Orthofer and R.M. Lamuela-Raventos, 1999. Analysis of total phenolics and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagents. Methods Enzymol., 299: 152-178.
30. Sohn, O.S., F.S. Emerich, S.P. Requeijo, J.H. Weisburger and F.J. Gonzalez, 2001. Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol. Cancer Res., 61: 8435-8440.
31. Suppakul, P. J. Miltz, K. Sonneveld and S.W. Bigger, 2003. Antimicrobial properties of Basil and its possible application in food packaging. J. Agric. Food Chem., 51: 3197-3207.
32. Umadevi, P. 2001. Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy Basil, Ocimum sanctum (Tulasi). Indian J. Exp. biol., 39: 185-190.
33. Verghese, M., D.R. Rao, C.B. Chawan and L. Shackelford, 2002. Dietary inulin suppresses azoxymethane-induced preneoplastic aberrant crypt foci in mature fisher 344 rats. J. Nutr., 132: 2804-2808.
34. Wolfe K., X. Wu and R.H. Liu, 2003. Antioxidant activity of apple peels. J. Agric. Food Chem., 51: 609-614.